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21. 发明专利

JPS6463569A HETEROARYL DERIVATIVE 失效
公开(公告)号：JPS6463569A
公开(公告)日：1989-03-09
申请号：JP6412588
申请日：1988-03-17
申请人： SANKYO CO
发明人： HIRAI KOICHI , IWANO YUJI , FUJIMOTO KATSUMI , MATSUI YOSHIKI
IPC分类号： C07D401/06 , A61K31/34 , A61K31/341 , A61K31/357 , A61K31/36 , A61K31/495 , A61K31/505 , A61P25/28 , C07D209/02 , C07D209/44 , C07D213/46 , C07D215/08 , C07D239/42 , C07D241/04 , C07D241/08 , C07D243/06 , C07D277/20 , C07D277/46 , C07D295/14 , C07D307/52 , C07D317/66 , C07D417/12 , C07D521/00
摘要： NEW MATERIAL:A compound of formula I [M is 5-7 membered heterocyclic group which contains 2N atoms and may be substituted, on its cyclic carbon atoms, with alkyl and oxo; A is formula II (X , X are H, halogen, where they are not H simultaneously); B is formula III (R is H, alkyl; R , R are H, or incorporate to form oxo; Y is NR ; R , R are H, aryl, aralkyl, alkyl); A, B are different substituents of M on N atoms]. EXAMPLE:1-[Bis(4-fluorophenyl)methyl]-4-(1-naphthylaminocarbonylmethyl )pipe razine. USE:Cerebral metabolism improver. It has excellent calcium-inhibiting action and hypoxia-antagonistic action. PREPARATION:The reaction of an amino compound of the formula: A-M-H with an alkylating agent of formula IV (Xa is halogen, alkanesulfonyl, or the like) gives the compound of formula I.

22. 发明专利

JPS5989661A PHENYLINDENE DERIVATIVE, ACID ADDITION SALT AND MANUFACTURE 失效
公开(公告)号：JPS5989661A
公开(公告)日：1984-05-23
申请号：JP18714383
申请日：1983-10-07
申请人： KEFALAS AS
发明人： IENSU KURISUTEIAN PEREGAARUTO
IPC分类号： A61K31/4409 , A61K31/4418 , A61K31/4425 , A61K31/4427 , A61K31/445 , A61K31/4465 , A61K31/451 , A61P25/18 , A61P25/24 , A61P25/26 , C07D211/12 , C07D211/14 , C07D211/18 , C07D211/20 , C07D211/22 , C07D211/24 , C07D211/34 , C07D211/70 , C07D213/30 , C07D243/06 , C07D401/06 , C07D413/06 , C07D417/06

23. 发明专利

JPS5948467A Preparation of homopiperazine derivative 失效
标题翻译：双酚A衍生物的制备
公开(公告)号：JPS5948467A
公开(公告)日：1984-03-19
申请号：JP15883782
申请日：1982-09-14
申请人： Nisshin Flour Milling Co Ltd , Nisshin Kagaku Kk
发明人： KIKUCHI HARUHIKO
IPC分类号： C07D243/08 , A61K31/55 , A61P9/08 , A61P9/10 , B01J29/06 , B01J31/02 , C07B61/00 , C07D243/06
CPC分类号： Y02P20/52
摘要： PURPOSE: To prepare the titled compound, in high yield, by the ester-exchange of N,N'-bis(3-hydroxypropyl)homopiperazine with a 3,4,5-trimethoxybenzoic acid ester under basic condition while removing the produced lower alcohol.
CONSTITUTION: The homopiperazine derivative of formula III {e.g. N,N'-bis[3- (3',4',5'-trimethoxybenzoyloxy)propyl]homopiperazine} is prepared by the ester- exchange reaction of the N,N'-bis(3-hydroxypropyl)-homopiperazine of formula I with the 3,4,5-trimethoxybenzoic acid ester of formula II (R is lower alkyl) in the presence of a base (e.g. sodium ethoxide) while absorbing and removing the by-produced lower alcohol from the system with a molecular sieve.
USE: A drug having coronary vessel dilating activity.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：通过在碱性条件下，通过N，N'-双（3-羟丙基）高哌嗪与3,4,5-三甲氧基苯甲酸酯的酯交换，高产率制备标题化合物，同时除去产生的低级醇。构成：式III的高哌嗪衍生物（例如， N，N'-双[3-（3'，4'，5'-三甲氧基苯甲酰氧基）丙基]高哌嗪}是通过式（I）的N，N'-双（3-羟丙基） - 高密度哌嗪的酯交换反应 I在碱（例如乙醇钠）存在下与式II的3,4,5-三甲氧基苯甲酸酯（R是低级烷基），同时用分子筛吸收并除去副产物的低级醇。使用：具有冠状血管扩张活性的药物。

24. 发明专利

JP2966004B2 失效
公开(公告)号：JP2966004B2
公开(公告)日：1999-10-25
申请号：JP23609589
申请日：1989-09-12
申请人： KYOTO YAKUHIN KOGYO KK
发明人： NISHIZAWA SUSUMU , FUKADA FUMIO , KAKEYA SENJI
IPC分类号： C07D243/06 , C07D211/90 , C07D233/02 , C07D247/00 , C07D295/08 , C07D295/10 , C07D295/18 , C07D295/20 , C07D521/00

25. 发明专利

JP2795677B2 失效
公开(公告)号：JP2795677B2
公开(公告)日：1998-09-10
申请号：JP12773789
申请日：1989-05-20
申请人： IIRAI RIRII ANDO CO
发明人： JEIMUZU AASAA NIKUSON , RICHAADO HOORU PIOTSUCHI , JON MEENAATO SHAUSU , ROBAATO DANIERU TEITOSU
IPC分类号： C07D243/06 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/55 , A61P25/00 , A61P43/00 , C07D243/08 , C07D295/02 , C07D295/033 , C07D295/04 , C07D295/073 , C07D295/096 , C07D295/112 , C07D295/155

26. 发明专利

JPH06503568A 失效
公开(公告)号：JPH06503568A
公开(公告)日：1994-04-21
申请号：JP50234892
申请日：1991-11-25
IPC分类号： A61K31/55 , A61K38/00 , A61K38/55 , A61P9/12 , A61P31/12 , A61P43/00 , C07C69/757 , C07D223/04 , C07D223/06 , C07D223/08 , C07D223/10 , C07D233/54 , C07D243/06 , C07D243/08 , C07K1/113 , C07K5/06 , C07K5/078 , C07K5/08 , C07K5/097 , C07K7/02 , C07K14/81 , C12N9/99 , A61K37/64

27. 发明专利

JPH0625177B2 失效
公开(公告)号：JPH0625177B2
公开(公告)日：1994-04-06
申请号：JP28938491
申请日：1991-10-09
申请人： JANSSEN PHARMACEUTICA NV
发明人： GUSUTAAFU MARIA BETSUKUSU , ARUFUONSU HERUMAN MARUGAREETA REIMEKAASU , BIKUTORU SHIPIDO
IPC分类号： A61K31/53 , A01N37/34 , A01N43/707 , A61P33/02 , C07C67/00 , C07C239/00 , C07C253/00 , C07C271/20 , C07C313/00 , C07C315/04 , C07C317/48 , C07C323/57 , C07C323/63 , C07D243/06 , C07D253/06 , C07D253/075

28. 发明专利

JPH0378385B2 失效
公开(公告)号：JPH0378385B2
公开(公告)日：1991-12-13
申请号：JP15883782
申请日：1982-09-14
申请人： NISSHIN FLOUR MILLING CO
发明人： KIKUCHI HARUHIKO
IPC分类号： C07D243/08 , A61K31/55 , A61P9/08 , A61P9/10 , B01J29/06 , B01J31/02 , C07B61/00 , C07D243/06

29. 发明专利

JPS5010871B1 失效
公开(公告)号：JPS5010871B1
公开(公告)日：1975-04-24
申请号：JP1149571
申请日：1971-03-02
IPC分类号： C07D243/06 , A61K31/55 , C07D495/04

30. 发明授权

US11566025B2 Viral replication inhibitors 有权
公开(公告)号：US11566025B2
公开(公告)日：2023-01-31
申请号：US16798859
申请日：2020-02-24
申请人： Katholieke Universiteit Leuven
发明人： Dorothée Bardiot , Gunter Carlens , Kai Dallmeier , Suzanne Kaptein , Mohamed Koukni , Arnaud Marchand , Johan Neyts , Wim Smets
IPC分类号： C07D471/04 , A61K31/34 , C07D207/06 , A61K31/381 , A61K31/40 , A61K31/415 , A61K31/437 , A61K31/4439 , A61K45/06 , C07D207/323 , C07D207/335 , C07D211/06 , C07D211/16 , C07D223/04 , C07D241/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D231/12 , C07D333/22 , C07D401/04 , C07D401/06 , C07D403/04 , C07D405/04 , C07D405/06 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D261/08 , C07D265/30 , C07D267/10 , C07D275/02 , C07D498/04 , C07D279/12 , C07D409/12 , C07D403/06 , C07D405/12 , C07D407/06 , C07D271/04 , C07D285/06 , C07D403/12 , C07D243/06 , C07D513/04 , C07D407/04 , C07D307/46 , C07D243/08 , C07D263/32 , C07D271/08 , C07D277/28 , C07D285/10 , C07D307/52 , C07D413/12 , C07D487/04
摘要： The present invention relates to a series of novel compounds, methods to prevent or treat viral infections in animals by using the novel compounds and to said novel compounds for use as a medicine, more preferably for use as a medicine to treat or prevent viral infections, particularly infections with RNA viruses, more particularly infections with viruses belonging to the family of the Flaviviridae, and yet more particularly infections with the Dengue virus. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the novel compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of viral infections. The invention also relates to processes for preparation of the compounds.

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