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31. 发明授权

US07495020B2 2-aryloxy-2-arylalkanoic acids for diabetes and lipid disorders 失效
标题翻译： 2-芳氧基-2-芳基链烷酸用于糖尿病和脂质疾病
公开(公告)号：US07495020B2
公开(公告)日：2009-02-24
申请号：US11334152
申请日：2006-01-18
申请人： Alan D. Adams , A. Brian Jones , Joel P. Berger , James F. Dropinski , Alexander Elbrecht , Kun Liu , Karen Lamb MacNaul , Guo-Qiang Shi , Derek J. Von Langen , Gaochao Zhou
发明人： Alan D. Adams , A. Brian Jones , Joel P. Berger , James F. Dropinski , Alexander Elbrecht , Kun Liu , Karen Lamb MacNaul , Guo-Qiang Shi , Derek J. Von Langen , Gaochao Zhou
IPC分类号： A61K31/428 , A61K31/423
CPC分类号： C07D257/04 , C07C59/90 , C07D213/55 , C07D261/20 , C07D263/32 , C07D263/58 , C07D413/12 , C07D417/12
摘要： A class of 2-aryloxy-2-arylalkanoic acids comprises compounds that are potent agonists of PPAR alpha and/or gamma, and are therefore useful in the treatment, control or prevention of non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, atherosclerosis, obesity, vascular restenosis, inflammation, and other PPAR alpha and/or gamma mediated diseases, disorders and conditions.
摘要翻译：一类2-芳氧基-2-芳基链烷酸包括作为PPARα和/或γ的有效激动剂的化合物，因此可用于治疗，控制或预防非胰岛素依赖型糖尿病（NIDDM），高血糖症，血脂异常高脂血症，高胆固醇血症，高甘油三酯血症，动脉粥样硬化，肥胖症，血管再狭窄，炎症和其他PPARα和/或γ介导的疾病，病症和病症。

32. 发明申请

US20070161689A1 Indoles having anti-diabetic activity 有权
公开(公告)号：US20070161689A1
公开(公告)日：2007-07-12
申请号：US11714341
申请日：2007-03-06
申请人： John Acton , Sheryl Debenham , Kun Liu , Peter Meinke , Harold Wood , Regina Black
发明人： John Acton , Sheryl Debenham , Kun Liu , Peter Meinke , Harold Wood , Regina Black
IPC分类号： A61K31/425 , A61K31/42 , A61K31/416 , A61K31/405 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D209/10 , C07D209/12 , C07D209/14 , C07D209/30 , C07D209/36 , C07D401/04 , C07D401/06 , C07D403/12 , C07D405/06 , C07D413/04
摘要： Indoles having aryloxyalkanoic acid substituents or arylalkanoic acid substituents are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

33. 发明授权

US07242472B2 Biochip detection system 失效
标题翻译：生物芯片检测系统
公开(公告)号：US07242472B2
公开(公告)日：2007-07-10
申请号：US10866747
申请日：2004-06-15
申请人： Yan Rung Lin , Teh Ho Tao , Zu Sho Chow , Ding Kun Liu
发明人： Yan Rung Lin , Teh Ho Tao , Zu Sho Chow , Ding Kun Liu
IPC分类号： G01J3/30
CPC分类号： G01N21/6428 , G01N21/6456 , G01N2021/6419 , G01N2021/6441 , G01N2201/0631
摘要： The present invention discloses a biochip detection system for detecting a biochip labeled with multiple fluorophores. The biochip detection system comprises a broadband light source for generating a light beam, a stand for supporting the biochip, a light integrator positioned between the broadband light source and the biochip, a lens set for adjusting the cross-sectional area of the light beam, a first filter module positioned on the optical path of the light beam, a detector, e.g., CCD camera, photodiode array, for detecting a fluorescence beam emitted from the biochip, and a second filter module positioned on the optical path of the fluorescence beam. The light integrator can be a light tunnel, a lens array or a holographic diffuser for uniforming the intensity distribution of the light beam and changing the cross-sectional shape of the light beam into a rectangle.
摘要翻译：本发明公开了一种用于检测用多种荧光团标记的生物芯片的生物芯片检测系统。生物芯片检测系统包括用于产生光束的宽带光源，用于支撑生物芯片的支架，位于宽带光源和生物芯片之间的光积分器，用于调节光束横截面积的透镜组，定位在光束的光路上的第一滤光器模块，用于检测从生物芯片发射的荧光束的CCD相机，光电二极管阵列的检测器和位于荧光束的光路上的第二滤光器模块。光积分器可以是光通道，透镜阵列或全息漫射器，用于使光束的强度分布均匀并将光束的横截面形状改变成矩形。

34. 发明申请

US20050227484A1 System for modifying small structures 有权
标题翻译：修改小结构的系统
公开(公告)号：US20050227484A1
公开(公告)日：2005-10-13
申请号：US11081934
申请日：2005-03-16
申请人： George Gu , Neil Bassom , Thomas Gannon , Kun Liu
发明人： George Gu , Neil Bassom , Thomas Gannon , Kun Liu
IPC分类号： H01L21/3205 , H01L21/768 , H01L23/52 , H01L21/00 , H01L21/44
CPC分类号： H01L21/76894 , C25D3/665 , C25D5/02 , C25F3/12 , C25F3/14 , H01L21/2885 , H01L21/32134 , H01L21/76892
摘要： A charge transfer mechanism is used to locally deposit or remove material for a small structure. A local electrochemical cell is created without having to immerse the entire work piece in a bath. The charge transfer mechanism can be used together with a charged particle beam or laser system to modify small structures, such as integrated circuits or micro-electromechanical system. The charge transfer process can be performed in air or, in some embodiments, in a vacuum chamber.
摘要翻译：电荷转移机构用于局部沉积或去除小结构的材料。产生局部电化学电池，而不必将整个工件浸入浴中。电荷转移机构可以与带电粒子束或激光系统一起使用以修改小结构，例如集成电路或微机电系统。电荷转移过程可以在空气中或在一些实施方案中在真空室中进行。

35. 发明申请

US20230054411A1 7-, 8-, and 10-SUBSTITUTED AMINO TRIAZOLO QUINAZOLINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE 有权
公开(公告)号：US20230054411A1
公开(公告)日：2023-02-23
申请号：US17294836
申请日：2019-11-26
申请人： Yonglian ZHANG , Amjad ALI , Jared CUMMING , Duane DEMONG , Qiaolin DENG , Thomas H. GRAHAM , Elisabeth HENNESSY , Matthew A. LARSEN , Kun LIU , Ping LIU , Umar Faruk MANSOOR , Jianping PAN , Christopher W. PLUMMER , Aaron SATHER , Uma SWAMINATHAN , Huijun WANG , Merck Sharp & Dohme Corp.
发明人： Yonglian Zhang , Amjad Ali , Jared Cumming , Duane DeMong , Qiaolin Deng , Thomas H. Graham , Elisabeth Hennessy , Matthew A. Larsen , Kun Liu , Ping Liu , Umar Faruk Mansoor , Jianping Pan , Christopher W. Plummer , Aaron Sather , Uma Swaminathan , Huijun Wang
IPC分类号： A61K31/519 , A61K39/395 , C07D471/04 , C07D519/00 , A61K31/55
摘要： In its many embodiments, the present invention provides certain 7-, 8-, and 10-substituted amino triazolo quinazoline derivatives of Formula (I): or a pharmaceutically acceptable salt thereof, wherein ring A, R1, R2, and R4 are as defined herein, pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other therapeutic agents), and methods for their preparation and use, alone and in combination with other therapeutic agents, as antagonists of A2a and/or A2b receptors, and their use in the treatment of a variety of diseases, conditions, or disorders that are mediated, at least in part, by the adenosine A2a receptor and/or the adenosine A2b receptor.

36. 发明授权

US11319283B2 Substituted cyclobutylbenzene compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors 有权
公开(公告)号：US11319283B2
公开(公告)日：2022-05-03
申请号：US16753035
申请日：2018-10-04
申请人： MERCK SHARP & DOHME CORP. , Meredeth Ann McGowan , Abdelghani Achab , Xavier Fradera , Yongxin Han , Derun Li , Jongwon Lim , Kun Liu , Nunzio Sciammetta , Catherine M. White , Wensheng Yu , Hongjun Zhang , Hua Zhou
发明人： Meredeth Ann McGowan , Abdelghani Achab , Xavier Fradera , Yongxin Han , Derun Li , Jongwon Lim , Kun Liu , Nunzio Sciammetta , Catherine M. White , Wensheng Yu , Hongjun Zhang , Hua Zhou
IPC分类号： C07D205/04 , C07C237/42 , C07D213/75 , C07D213/82 , C07D231/14 , C07D233/90 , C07D237/20 , C07D239/28 , C07D241/24 , C07D263/34 , C07D277/56 , C07D285/06 , C07D307/14 , C07D309/14 , C07D487/04
摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: (Formula (I)). Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.

37. 发明授权

US11034661B2 Substituted N′-hydroxycarbamimidoyl-1,2,5-oxadiazole compounds as indoleamine 2,3-dioxygenase IDO inhibitors 有权
公开(公告)号：US11034661B2
公开(公告)日：2021-06-15
申请号：US16495883
申请日：2018-03-23
申请人： Merck Sharp & Dohme Corp. , Liangqin Guo , Yongxin Han , Kun Liu , Shuwen He , Joseph Kozlowski , Ravi Nargund , Wensheng Yu , Hongjun Zhang , Qinglin Pu , Derun Li , Abdelghani Achab , Guoqing Li
发明人： Liangqin Guo , Yongxin Han , Kun Liu , Shuwen He , Joseph Kozlowski , Ravi Nargund , Wensheng Yu , Hongjun Zhang , Qinglin Pu , Derun Li , Abdelghani Achab , Guoqing Li
IPC分类号： C07D271/08 , C07D413/12
摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof. Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

38. 发明授权

US09316657B2 Apparatus and method for loading samples in an analyzer 有权
标题翻译：在分析仪中装载样品的装置和方法
公开(公告)号：US09316657B2
公开(公告)日：2016-04-19
申请号：US12760374
申请日：2010-04-14
申请人： Hua Xiao , Qisong Liu , Ping Tian , Kun Liu
发明人： Hua Xiao , Qisong Liu , Ping Tian , Kun Liu
IPC分类号： G01N35/10 , G01N35/04 , G01N35/02 , G01N35/00
CPC分类号： G01N35/04 , G01N35/025 , G01N2035/00287 , G01N2035/00316 , G01N2035/0465
摘要： What is disclosed are methods and apparatus for loading or removing samples for testing. The apparatus comprises a sample disk body for holding a sample for testing, a sample disk lid configured to cover at least a part of the sample disk body and comprising a fixed lid which is fixedly attached to the sample disk body and a movable gate which is movable relatively to the fixed lid, and a locking mechanism to lock the movable gate into a closed position. The opening and closing of the movable gate is controlled by the locking mechanism to prevent inadvertent opening of the sample lid while the sample disk is operating.
摘要翻译：公开的是用于装载或移除样品进行测试的方法和装置。该装置包括用于保持用于测试的样本的样本盘体，被配置为覆盖至少一部分样本盘体并包括固定地附接到样本盘体的固定盖的样品盘盖，以及可移动的门，可移动地相对于固定盖，以及锁定机构，以将可移动门锁定到关闭位置。可动门的打开和关闭由锁定机构控制，以防止在样品盘运行时样品盖的意外打开。

39. 发明申请

US20150214594A1 BANDPASS FILTER AND METHOD OF FABRICATING THE SAME 有权
标题翻译： BANDPASS过滤器及其制造方法
公开(公告)号：US20150214594A1
公开(公告)日：2015-07-30
申请号：US14406211
申请日：2012-06-21
申请人： Bo Zhou , Junyou Chen , Kun Liu
发明人： Bo Zhou , Junyou Chen , Kun Liu
IPC分类号： H01P1/203
CPC分类号： H01P1/20309 , H01P1/20345 , H01P5/028 , H01P11/007
摘要： The invention provides a bandpass filter, comprising: a substrate with a plurality of dielectric layers; a plurality of resonators; and a plurality of ground layers each having one slot arranged on; wherein the plurality of resonators are arrayed vertically each on respective one of the plurality of dielectric layers alternately without any of offsets, and each of the plurality of ground layers is between adjacent dielectric layers. Adjacent slots are arranged in opposite sides of the ground layers. The invention also provides a method of fabricating the bandpass filter.
摘要翻译：本发明提供了一种带通滤波器，包括：具有多个电介质层的衬底; 多个谐振器; 以及多个接地层，每个接地层具有布置在其上的一个槽; 其中所述多个谐振器在所述多个电介质层中的相应一个电介质层上垂直地排列，而没有任何偏移，并且所述多个接地层中的每一个在相邻的电介质层之间。相邻的槽布置在接地层的相对侧。本发明还提供一种制造带通滤波器的方法。

40. 发明授权

US09009054B2 Program endpoint time detection apparatus and method, and program information retrieval system 有权
标题翻译：程序端点时间检测装置和方法，以及程序信息检索系统
公开(公告)号：US09009054B2
公开(公告)日：2015-04-14
申请号：US12914346
申请日：2010-10-28
申请人： Kun Liu , Weiguo Wu , Li Lu , Qingwei Zhao , Yonghong Yan , Hongbin Suo
发明人： Kun Liu , Weiguo Wu , Li Lu , Qingwei Zhao , Yonghong Yan , Hongbin Suo
IPC分类号： G10L21/00 , G10L11/06 , G06F17/30
CPC分类号： G06F17/30743 , G06F17/30749
摘要： This invention relates to retrieval for multimedia content, and provides a program endpoint time detection apparatus for detecting an endpoint time of a program by performing processing on audio signals of said program, comprising an audio classification unit for classifying said audio signals into a speech signal portion and a non-speech signal portion; a keyword retrieval unit for retrieving, as a candidate endpoint keyword, an endpoint keyword indicating start or end of the program from said speech signal portion; a content analysis unit for performing content analysis on context of the candidate endpoint keyword retrieved by the keyword retrieval unit to determine whether the candidate endpoint keyword is a valid endpoint keyword; and a program endpoint time determination unit for performing statistics analysis based on the retrieval result of said keyword retrieval unit and the determination result of said content analysis unit, and determining the endpoint time of the program. In addition, this invention also provides a program information retrieval system. With present invention, program information regarding a program attended by user can be rapidly obtained.
摘要翻译：本发明涉及用于多媒体内容的检索，并提供一种程序端点时间检测装置，用于通过对所述节目的音频信号执行处理来检测节目的终点时间，包括用于将所述音频信号分类成语音信号部分的音频分类单元和非语音信号部分; 关键词检索单元，用于从所述语音信号部分检索表示节目开始或结束的终点关键字作为候选终点关键词; 内容分析单元，用于对关键词检索单元检索到的候选端点关键字的上下文进行内容分析，以确定候选端点关键字是否是有效的端点关键字; 以及程序端点时间确定单元，用于基于所述关键词检索单元的检索结果和所述内容分析单元的确定结果执行统计分析，以及确定程序的终点时间。此外，本发明还提供了一种节目信息检索系统。通过本发明，可以快速获得关于用户所关注的节目的节目信息。

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