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    • 32. 发明授权
    • Virtual machine migration
    • 虚拟机迁移
    • US07484208B1
    • 2009-01-27
    • US10319217
    • 2002-12-12
    • Michael Nelson
    • Michael Nelson
    • G06F9/455G06F12/00
    • G06F9/45558G06F3/0604G06F3/0647G06F3/0683G06F9/4856G06F2009/4557G06F2009/45583G06F2009/45595H04L47/783H04L67/148
    • A source virtual machine (VM) hosted on a source server is migrated to a destination VM on a destination server without first powering down the source VM. After optional pre-copying of the source VM's memory to the destination VM, the source VM is suspended and its non-memory state is transferred to the destination VM; the destination VM is then resumed from the transferred state. The source VM memory is either paged in to the destination VM on demand, or is transferred asynchronously by pre-copying and write-protecting the source VM memory, and then later transferring only the modified pages after the destination VM is resumed. The source and destination servers preferably share common storage, in which the source VM's virtual disk is stored; this avoids the need to transfer the virtual disk contents. Network connectivity is preferably also made transparent to the user by arranging the servers on a common subnet, with virtual network connection addresses generated from a common name space of physical addresses.
    • 托管在源服务器上的源虚拟机(VM)将迁移到目标服务器上的目标VM,而无需首先关闭源虚拟机。 在将源虚拟机的内存可选地预先复制到目标虚拟机之后,源虚拟机被暂停,其非内存状态被传送到目标虚拟机; 目的地VM然后从转移状态恢复。 根据需要将源VM内存分页到目标虚拟机,或通过预源复制和写保护源虚拟机内存异步传输,然后在目标虚拟机恢复之后稍后传输修改的页面。 源服务器和目标服务器优选地共享存储源虚拟机的虚拟盘的公共存储器; 这避免了传输虚拟磁盘内容的需要。 优选地,通过将​​服务器布置在公共子网上,通过从物理地址的公共名称空间生成的虚拟网络连接地址,网络连接性也对用户透明。
    • 34. 发明申请
    • 2-Amino-o4-substituted pteridines and their use as inactivators of o6-alkylguanine-dna alkyltransferase
    • 2-氨基-4-取代的蝶啶及其作为O-烷基鸟嘌呤 - dna烷基转移酶的灭活剂的用途
    • US20070155752A1
    • 2007-07-05
    • US10585566
    • 2004-12-10
    • Rorbert MoschelMichael NelsonAnthony PeggNatalia Loktionova
    • Rorbert MoschelMichael NelsonAnthony PeggNatalia Loktionova
    • A61K31/525C07D475/02
    • C07D475/04
    • Disclosed are pteridine derivatives of formula (I): (I), wherein, for example, R1 and R2 are hydrogen, C1-C6 alkyl, carboxyl, formyl, C1-C6 hydroxyalkyl, C1-C6 carboxyalkyl, C1-C6 formyl alkyl, C1-C6 alkoxy, acyloxy, acyloxyalkyl wherein the alkyl is C1-C6, halogen, or hydroxy, or a group of formula II: (II); and R3 is (a) phenyl or (b) a cyclic group having at least one 5 or 6-membered heterocyclic ring, optionally with a carbocyclic or heterocyclic ring fused thereto, wherein each heterocyclic ring has at least one hetero atom chosen from O, N, or S; or (c) a phenyl group or a cyclic group, the cyclic group optionally with a carbocyclic or heterocyclic ring fused thereto, which is substituted with 1 to 5 substituents. Disclosed also are pharmaceutical compositions, a method of enhancing the chemotherapeutic effectiveness of cancer treatment agents, a method of deactivating the O6-alkylguanine-DNA alkyltransferase enzyme, and a method of inhibiting the reaction of O6-alkylguanine-DNA alkyltransferase enzyme with an alkylated DNA.
    • 公开了式(I)的蝶啶衍生物:(I),其中例如R 1和R 2是氢,C 1〜 -C 6烷基,羧基,甲酰基,C 1 -C 6羟烷基,C 1 -C 3 C 6 -C 6烷基,C 1 -C 6烷基,C 1 -C 6烷氧基 ,酰氧基,酰氧基烷基,其中烷基是C 1 -C 6 - ,卤素或羟基,或式II的基团:(II); 和R 3是(a)苯基或(b)具有至少一个5或6元杂环的环状基团,任选地与其中稠合的碳环或杂环,其中每个杂环具有 至少一个选自O,N或S的杂原子; 或(c)苯基或环状基团,所述环状基团任选具有稠合到其上的碳环或杂环,其被1至5个取代基取代。 还公开了药物组合物,增强癌症治疗剂的化学治疗效力的方法,使O-烷基鸟嘌呤-DNA烷基转移酶失活的方法,以及抑制O