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31. 发明申请

US20130261299A1 PYRIDAZINYL DERIVATIVES AS SMO INHIBITORS 审中-公开
标题翻译：吡咯烷酮衍生物作为SMO抑制剂
公开(公告)号：US20130261299A1
公开(公告)日：2013-10-03
申请号：US13905686
申请日：2013-05-30
申请人： Feng He , Stefan Peukert , Karen Marie Miller-Moslin , Naeem Yusuff , Zhuoliang Chen , Bharat Lagu
发明人： Feng He , Stefan Peukert , Karen Marie Miller-Moslin , Naeem Yusuff , Zhuoliang Chen , Bharat Lagu
IPC分类号： C07D237/20 , C07D401/12 , C07D237/26 , C07D403/12 , C07D413/14 , C07D403/14 , C07D401/14
CPC分类号： C07D237/20 , A61K31/4427 , A61K31/4523 , A61K31/501 , C07D237/26 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14 , C07D471/04
摘要： The present invention relates to compounds of formula I: in which L, W, X, Y, Z, m, p, R1, R2, R3, R4 and R7 are defined in the Summary of the Invention; capable of inhibiting the Hedgehog and Smo signaling pathway. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the diagnosis and treatment of pathologies relating to the Hedgehog and Smo signaling pathway, for example, tumor formation, cancer, neoplasia and non-malignant hyperproliferative disorders.
摘要翻译：本发明涉及式I化合物：其中L，W，X，Y，Z，m，p，R 1，R 2，R 3，R 4和R 7在发明概述中定义; 能够抑制Hedgehog和Smo信号通路。本发明还提供了制备本发明化合物的方法，包含这些化合物的药物制剂以及使用这些化合物和组合物诊断和治疗与Hedgehog和Smo信号传导途径有关的病理学的方法，例如肿瘤形成，癌症，瘤形成和非恶性过度增生性疾病。

32. 发明授权

US08546336B2 SMAC peptidometics useful as IAP inhibitors 有权
标题翻译： SMAC肽酶用作IAP抑制剂
公开(公告)号：US08546336B2
公开(公告)日：2013-10-01
申请号：US13606676
申请日：2012-09-07
申请人： Zhuoliang Chen , Mark G. Charest , Christine Hiu-Tung Chen , Miao Dai , Feng He , Huangshu Lei , Ly Luu Pham , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming David Wang , Fan Yang , Leigh Zawel
发明人： Zhuoliang Chen , Mark G. Charest , Christine Hiu-Tung Chen , Miao Dai , Feng He , Huangshu Lei , Ly Luu Pham , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming David Wang , Fan Yang , Leigh Zawel
IPC分类号： A61K38/00
CPC分类号： C07D417/04 , A61K31/427 , A61K45/06 , C07K5/06191
摘要： The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.
摘要翻译：本发明涉及下式的化合物或其药学上可接受的盐，以及在哺乳动物中用于治疗增殖性疾病例如癌症的用途。

33. 发明授权

US08481542B2 Pyridazinyl derivatives as smo inhibitors 有权
标题翻译：哒嗪衍生物作为抑制剂
公开(公告)号：US08481542B2
公开(公告)日：2013-07-09
申请号：US13553870
申请日：2012-07-20
申请人： Feng He , Stefan Peukert , Karen Miller-Moslin , Naeem Yusuff , Zhuoliang Chen , Bharat Lagu
发明人： Feng He , Stefan Peukert , Karen Miller-Moslin , Naeem Yusuff , Zhuoliang Chen , Bharat Lagu
IPC分类号： C07D403/14 , C07D401/14 , A61K31/501 , A61P35/00
CPC分类号： C07D237/20 , A61K31/4427 , A61K31/4523 , A61K31/501 , C07D237/26 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14 , C07D471/04
摘要： The present invention relates to compounds of formula I: in which R11 and R12 are defined in the Summary of the Invention; capable of inhibiting the Hedgehog and Smo signaling pathway. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the diagnosis and treatment of pathologies relating to the Hedgehog and Smo signaling pathway, for example, tumor formation, cancer, neoplasia and non-malignant hyperproliferative disorders.
摘要翻译：本发明涉及式I化合物：其中R11和R12在发明概述中定义; 能够抑制Hedgehog和Smo信号通路。本发明还提供了制备本发明化合物的方法，包含这些化合物的药物制剂以及使用这些化合物和组合物诊断和治疗与Hedgehog和Smo信号传导途径有关的病理学的方法，例如肿瘤形成，癌症，瘤形成和非恶性过度增生性疾病。

34. 发明申请

US20130033991A1 METHOD AND SYSTEM FOR RADIO LINK FAILURE INFORMATION PROCESSING 审中-公开
标题翻译：无线链路故障信息处理方法与系统
公开(公告)号：US20130033991A1
公开(公告)日：2013-02-07
申请号：US13641097
申请日：2011-02-12
申请人： Yin Gao , Feng He
发明人： Yin Gao , Feng He
IPC分类号： H04W24/00
CPC分类号： H04L69/40 , H04W24/02 , H04W24/08
摘要： Disclosed in the present invention are a method and system for processing radio link failure information. In the above method, a network device managing a cell notifies the peer of the RLF information processing ability of the network device for the peer to carry out RLF information processing according to the RLF information processing ability, wherein the RLF information processing ability comprises: whether or not each cell managed by the network device supports RLF reporting information processing. By way of the technical solution provided by the present invention, not only meaningless waste of resources of the terminal is avoided, but also the network side is avoided to carry out meaningless processing and forwarding after receiving the RLF information, thus reducing the overhead of air interface signaling resources, and reducing the memory and power consumption waste for the terminal and network element to carry out RLF information processing.
摘要翻译：在本发明中公开了一种处理无线电链路故障信息的方法和系统。在上述方法中，管理小区的网络装置向对方通知对等体的网络装置的RLF信息处理能力，根据RLF信息处理能力进行RLF信息处理，其中RLF信息处理能力包括：是否或者由网络设备管理的每个小区不支持RLF报告信息处理。通过本发明提供的技术方案，不仅避免了终端资源的无意义的浪费，而且避免了网络侧在接收到RLF信息后进行无意义的处理和转发，从而减少了空中的开销接口信令资源，减少终端和网元进行RLF信息处理的内存和功耗浪费。

35. 发明申请

US20130017834A1 Method and user equipment for reporting handover scenario judgment parameter and base station for handover scenario judgment 有权
公开(公告)号：US20130017834A1
公开(公告)日：2013-01-17
申请号：US13637027
申请日：2011-06-28
申请人： Lifeng Han , Feng He
发明人： Lifeng Han , Feng He
IPC分类号： H04W36/30
CPC分类号： H04W36/0083 , H04W8/26 , H04W28/04 , H04W88/08
摘要： The disclosure provides a method and user equipment for reporting a handover scenario judgment parameter and a base station for a handover scenario judgment; the method includes: an uplink message transmitted by the User Equipment (UE) includes an Evolved Cell Global Identifier (ECGI) so that a network side performs a handover scenario judgment based on the ECGI, wherein the uplink message is a message that includes Radio Link Failure (RLF)-related measurement information, or the uplink message is a message that includes an indication of RLF-related measurement information. Therefore, the disclosure enables an accurate handover scenario judgment, thus avoiding the problem in the related art that the error rate of a handover scenario judgment is high.

36. 发明申请

US20120115532A1 METHOD AND BASE STATION FOR DETERMINING AN INITIAL TRANSMISSION POWER 有权
标题翻译：用于确定初始传输功率的方法和基站
公开(公告)号：US20120115532A1
公开(公告)日：2012-05-10
申请号：US13259780
申请日：2010-05-31
申请人： Feng He , Jianmin Fang
发明人： Feng He , Jianmin Fang
IPC分类号： H04W52/04
CPC分类号： H04W52/50 , H04B17/382 , H04W36/0077 , H04W36/30 , H04W52/146 , H04W52/241 , H04W52/242 , H04W52/283 , H04W52/325 , H04W52/367 , H04W92/20
摘要： A method for determining an initial transmission power and a base station is provided. The method comprises: a base station acquiring a measurement result of a second cell reported by said user equipment, wherein a first cell in which a user equipment (UE) is located belongs to the base station, and said first cell and said second cell belong to different base stations; and determining an initial transmission power of said user equipment when initiating a random access in said second cell according to a reference signal power of said second cell, said measurement result and a random access initial received target power of said second cell. Success rate of handover of user equipment is improved.
摘要翻译：提供了一种用于确定初始发送功率的方法和基站。所述方法包括：基站获取由所述用户设备报告的第二小区的测量结果，其中用户设备（UE）所在的第一小区属于所述基站，并且所述第一小区和所述第二小区属于到不同的基站; 以及根据所述第二小区的参考信号功率，所述测量结果和所述第二小区的随机接入初始接收目标功率，在所述第二小区中发起随机接入时确定所述用户设备的初始发送功率。用户设备切换成功率提高。

37. 发明申请

US20120008550A1 Relay-Node, Donor-eNB and method for receiving and sending system information 审中-公开
标题翻译：中继节点，Donor-eNB以及接收和发送系统信息的方法
公开(公告)号：US20120008550A1
公开(公告)日：2012-01-12
申请号：US13257611
申请日：2010-04-28
申请人： Si Chen , Feng He
发明人： Si Chen , Feng He
IPC分类号： H04B7/14
CPC分类号： H04B7/155 , H04W48/08 , H04W84/047
摘要： The present invention discloses a Relay-Node (RN), a Donor-eNB and a method for the RN to receive and send system information, which avoid a conflict between simultaneously receiving system information by the RN from the donor-eNB and sending system information to a UE by the RN. The method comprises: setting an offset between a radio frame border of the RN and a radio frame border of a Donor-eNB by the Donor-eNB or the RN itself, so that the radio frame border of the RN is staggered from the radio frame border of the Donor-eNB; receiving and sending system information by the RN according to a sending period specified in a Long Term Evolution (LTE); so as to avoid a conflict between receiving and sending the system information by the RN.
摘要翻译：本发明公开了一种用于接收和发送系统信息的中继节点（RN），Donor-eNB和RN的方法，该方法避免了RN从馈送者eNB同时接收系统信息和发送系统信息之间的冲突通过RN到UE。该方法包括：通过Donor-eNB或RN本身在RN的无线帧边界与Donor-eNB的无线帧边界之间设置偏移，使得RN的无线帧边界与无线帧交错捐助方的边界; 根据长期演进（LTE）中指定的发送周期，由RN接收和发送系统信息; 以避免RN接收和发送系统信息之间的冲突。

38. 发明申请

US20110250882A1 Resource Measurement and Reporting Method in Long Term Evolution System 有权
标题翻译：长期演进系统资源测量与报告方法
公开(公告)号：US20110250882A1
公开(公告)日：2011-10-13
申请号：US13133794
申请日：2008-12-30
申请人： Yin Gao , Feng He
发明人： Yin Gao , Feng He
IPC分类号： H04W24/00
CPC分类号： H04W24/10
摘要： A method for measuring and reporting resource in a long term evolution system comprises: a source base station encapsulating a resource status request message and sending the message to a target base station; after receiving the resource status request message, the target base station processing the message, and sending a resource status success response to the source base station if the processing is successful, or else sending a resource status failure response if the processing is failed; the source base station encapsulating at least a message type (2), a measurement request type (3), a source base station global identifier (4) and measurement configuration information (5) in the resource status request message, wherein, the measurement request type (3) is one or more of start, modify and end (7); the measurement configuration information (5) is measurement configuration information (5) in current measurement request type (3).
摘要翻译：一种用于在长期演进系统中测量和报告资源的方法包括：源基站封装资源状态请求消息并将消息发送到目标基站; 在接收到资源状态请求消息之后，目标基站处理该消息，并且如果处理成功则向源基站发送资源状态成功响应，或者如果处理失败则发送资源状态失败响应; 所述源基站在资源状态请求消息中至少封装消息类型（2），测量请求类型（3），源基站全局标识符（4）和测量配置信息（5），其中，所述测量请求类型（3）是开始，修改和结束（7）中的一个或多个; 测量配置信息（5）是当前测量请求类型（3）中的测量配置信息（5）。

39. 发明申请

US20070203388A1 In Situ Immobilization of Metals in Contaminated Sites Using Stabilized Nanoparticles 失效
标题翻译：使用稳定纳米颗粒原位固定在污染场所的金属
公开(公告)号：US20070203388A1
公开(公告)日：2007-08-30
申请号：US11680266
申请日：2007-02-28
申请人： Dongye Zhao , Zhong Xiong , Mark Barnett , Ruiqiang Liu , Willie Harper , Feng He
发明人： Dongye Zhao , Zhong Xiong , Mark Barnett , Ruiqiang Liu , Willie Harper , Feng He
IPC分类号： B09B3/00
CPC分类号： C01G13/00 , B09C1/002 , B09C1/08 , B09C1/10 , B82Y30/00 , C01G49/12 , C02F1/281 , C02F1/5263 , C02F2101/20 , C02F2103/007 , C02F2103/06 , C02F2305/08 , C22B3/0097 , C22B13/00 , C22B43/00 , Y02P10/234
摘要： A method for preparing a class of highly stabilized and soil-dispersible nanoparticles and using the nanoparticles as a remediation technology for immobilizing toxic metals at toxic metal contaminated sites. The method employs a composition containing select polysaccharides (starch or cellulose) as a stabilizer for the nanoparticles in a liquid carrier, and results in suspensions of nanoparticles of desired size and mobility in water, soils or sediments. The stabilizer can facilitate controlling the dispersibility of the nanoparticles in the liquid carrier. An effective amount of the composition is delivered to a contaminated site so that the nanoparticles can immobilize one or more toxic metals of the contaminated site.
摘要翻译：一种制备一类高度稳定和可分散土壤的纳米颗粒的方法，并使用纳米颗粒作为固定有毒金属在有毒金属污染场所的修复技术。该方法使用含有选择性多糖（淀粉或纤维素）作为液体载体中纳米颗粒的稳定剂的组合物，并且导致在水，污垢或沉积物中具有所需尺寸和迁移率的纳米颗粒的悬浮液。稳定剂可以有助于控制纳米颗粒在液体载体中的分散性。将有效量的组合物输送到污染部位，使得纳米颗粒可以固定受污染部位的一种或多种有毒金属。

40. 发明申请

US20060046983A1 Inhibitors of HCV replication 有权
公开(公告)号：US20060046983A1
公开(公告)日：2006-03-02
申请号：US11181639
申请日：2005-07-14
申请人： Thomas Hudyma , Xiaofan Zheng , Feng He , Min Ding , Carl Bergstrom , Piyasena Hewawasam , Scott Martin , Robert Gentles
发明人： Thomas Hudyma , Xiaofan Zheng , Feng He , Min Ding , Carl Bergstrom , Piyasena Hewawasam , Scott Martin , Robert Gentles
IPC分类号： A61K31/553 , A61K31/55 , A61K31/551 , A61K31/4745 , A61K31/407 , C07D491/04 , C07D487/04
CPC分类号： C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/14 , C07D513/14
摘要： Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions comprising the compounds are also described as well as methods of preparing the compounds.

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