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31. 发明授权

US07820196B2 Physiologically active agents containing vicinal dithioglycols and use thereof in various branches of economy 有权
标题翻译：含有邻位二硫代乙二醇的生理活性剂及其在各种经济部门中的应用
公开(公告)号：US07820196B2
公开(公告)日：2010-10-26
申请号：US11732080
申请日：2007-04-02
申请人： Sergei Mikhailovich Zenovich , Boris Khaimovich Strelets
发明人： Sergei Mikhailovich Zenovich , Boris Khaimovich Strelets
IPC分类号： A61K47/00 , A61K9/70 , A61K9/20 , A23K1/17
CPC分类号： A23G3/36 , A21D2/08 , A21D13/80 , A23B4/20 , A23C2230/10 , A23K20/105 , A23K50/10 , A23K50/75 , A23L2/385 , A23L17/00 , A23L29/055 , A23L29/284 , A23L33/10 , A23V2002/00 , A61K8/46 , A61K8/466 , A61K9/0019 , A61K9/0024 , A61K9/0095 , A61K9/2095 , A61K31/095 , A61K2800/51 , A61K2800/522 , A61Q19/00 , C12G3/04 , A23V2250/30
摘要： The invention relates to the food and medical industries, medical cosmetics, dermatology, agriculture and the mixed feed industry. According to the invention vicinal dithioglycole (common formula RCH(SH)CH(SH)R−1 (I)) is used as a food additive, a food product, physiologically-active substances and active ingredients of forage additives and of forage, in cosmetic and/or dermatological and skin-therapeutic remedies. The invention comprises methods for producing such additives, products and remedies. The substance of formula (I) stimulates physiological processes, increases human and animal immunity, inhibits undesirable process in organisms and food products, produces curative and preventive action of skin, hair and nails and after vicinal dithioglycole is administered the intoxication effect of alcohol consumption known as hang-over is completely removed.
摘要翻译：本发明涉及食品医疗工业，医药化妆品，皮肤病学，农业和混合饲料工业。根据本发明，邻位二硫代乙二醇（通式RCH（SH）CH（SH）R-1（I））用作食品添加剂，食品，生理活性物质和饲料添加剂和饲料中的活性成分化妆品和/或皮肤病学和皮肤治疗药物。本发明包括生产这些添加剂，产品和补救措施的方法。式（I）的物质刺激生理过程，增加人和动物免疫力，抑制生物体和食品中的不良过程，产生皮肤，毛发和指甲的治疗和预防作用，并且在连位二硫糖醇之后施用酒精消耗的中毒作用因为挂机被完全删除。

32. 发明申请

US20100178381A1 POPULATION OF DAIRY COWS PRODUCING MILK WITH DESIRABLE CHARACTERISTICS AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：生产具有要求特征的奶的奶制品的种群以及制造和使用它们的方法
公开(公告)号：US20100178381A1
公开(公告)日：2010-07-15
申请号：US12709137
申请日：2010-02-19
申请人： Alastair Kenneth Hugh MacGibbon , Norm Thomson
发明人： Alastair Kenneth Hugh MacGibbon , Norm Thomson
IPC分类号： A23K1/18
CPC分类号： A01K67/00 , A01K67/02 , A01K2227/101 , A01K2267/02 , A23C2230/10 , G01N33/06
摘要： The invention relates to cows capable of producing milk low in total saturated fatty acids and high in mono- and poly-unsaturated fatty acids.
摘要翻译：本发明涉及能够产生低饱和脂肪酸和高单一和多不饱和脂肪酸的奶的奶牛。

33. 发明申请

US20100021555A1 Compositions containing high omega-3 and low saturated fatty acid levels 审中-公开
标题翻译：含有高ω-3和低饱和脂肪酸含量的组合物
公开(公告)号：US20100021555A1
公开(公告)日：2010-01-28
申请号：US11665445
申请日：2005-10-14
申请人： Karl Geiringer , Karen Manson , Garth James Smith Cooper
发明人： Karl Geiringer , Karen Manson , Garth James Smith Cooper
IPC分类号： A61K35/20 , C12P7/64 , A61K31/202 , C12N1/00 , A61P25/18 , A61P25/28 , A61P3/10 , A61P35/00 , A23L1/30 , A23K1/16
CPC分类号： C12P7/6427 , A23C9/1528 , A23C2230/10 , A23K20/158 , A23L33/12 , A23V2002/00 , A61K31/20 , A61K31/202 , A61K36/02 , C11B1/10 , C12P7/6472 , A61K2300/00 , A23V2250/187 , A23V2250/1868
摘要： Food products and supplements comprising the essential unsaturated fatty acids EPA or DHA at high concentrations relative to other n-3 HUFAs and with relatively low levels of saturated fatty acids (myristic and palmitic acids) are provided. These compositions can be made in commercial quantities in a cost effective manner by culture of selected microorganisms. The food products and supplements are suited to human health needs which are unable to be met from fish oil origins. Also provided are EPA containing food products obtained from animals.
摘要翻译：提供了包含相对于其他n-3 HUFA并且具有相对低水平的饱和脂肪酸（肉豆蔻酸和棕榈酸）的高浓度的必需不饱和脂肪酸EPA或DHA的食品和补充剂。这些组合物可以通过选择的微生物的培养以成本有效的方式以商业量制备。食品和补品适用于鱼油来源无法满足的人类健康需求。还提供了EPA含有从动物获得的食品。

34. 发明申请

US20080166422A1 Population of dairy cows producing milk with desirable characteristics and methods of making and using same 审中-公开
标题翻译：生产牛奶的奶牛人口具有理想的特点和使用方法
公开(公告)号：US20080166422A1
公开(公告)日：2008-07-10
申请号：US11806158
申请日：2007-05-30
申请人： Alastair Kenneth Hugh MacGibbon , Norm Thomson , David Johnson , Garth J.S. Cooper
发明人： Alastair Kenneth Hugh MacGibbon , Norm Thomson , David Johnson , Garth J.S. Cooper
IPC分类号： A61K35/20 , A23C9/00 , A23C9/156 , A23C9/16 , A61P9/00 , A23C13/12 , A23C19/00 , A23C15/00
CPC分类号： A01K67/00 , A01K67/02 , A01K2227/101 , A01K2267/02 , A23C2230/10 , G01N33/06
摘要： The invention relates to cows capable of producing milk low in total saturated fatty acids and high in mono- and poly-unsaturated fatty acids.
摘要翻译：本发明涉及能够产生低饱和脂肪酸和高单一和多不饱和脂肪酸的奶的奶牛。

35. 发明授权

US06288114B1 Method of altering nutritional components of milk produced by a lactating animal 失效
标题翻译：改变哺乳动物产生的牛奶的营养成分的方法
公开(公告)号：US06288114B1
公开(公告)日：2001-09-11
申请号：US09103366
申请日：1998-06-23
申请人： Dale E. Bauman , Mark A. McGuire , Mikko Griinari , P. Yvan Chouinard
发明人： Dale E. Bauman , Mark A. McGuire , Mikko Griinari , P. Yvan Chouinard
IPC分类号： A61K31202
CPC分类号： A61K31/201 , A23C9/1528 , A23C2230/10 , A23V2002/00 , A61K31/202 , A23V2200/308 , A23V2250/1866
摘要： The present invention alters mammary synthesis of fat to improve milk quality. These changes in milk composition represent improvements in nutritional quality consistent with contemporary dietary recommendations. Of special importance is the disclosure of new data relating to specific conjugated linoleic acids (CLA), potent naturally occurring anti-carcinogens. In the course of an investigation to enhance milk content of conjugated linoleic acid, it was discovered that abomasal infusion of a single TFA isomer caused a marked milk fat depression. This observation was unexpected because the prior art has consistently shown that body fat and milk fat always show reciprocal changes in lactating cows and indicated that CLA's generally reduced body fat in growing animals. The current disclosure demonstrates that an increase in milk fat content of a specific TFA isomer, trans-10 C18:1. (Griinari et al., 1997, 1998) causes MFD. This observation is in conflict with the prior art that taught that an increase in total TFA caused MFD. These results are applicable to other domestic lactating mammals (e.g., pigs). Upon the infusion of CLA, a portion of the CLA is transferred to the mammary gland and incorporated into milk fat. Hence, the methods disclosed increase the levels of CLA found in milk, thereby improving the nutritional benefits to human health associated with CLA.
摘要翻译：本发明改变乳脂肪的合成以提高乳品质量。牛奶组合中的这些变化代表了与当代饮食建议一致的营养质量的改善。特别重要的是披露与特定共轭亚油酸（CLA）有关的天然存在的抗致癌物质的新数据。在研究提高共轭亚油酸的牛奶含量的过程中，发现单次TFA异构体的腹腔输注导致明显的乳脂肪抑制。这种观察是意想不到的，因为现有技术一直表明，身体脂肪和乳脂肪总是显示哺乳牛的相互变化，并且表明CLA通常在生长的动物中降低身体脂肪。目前的公开内容表明，特定TFA异构体，反式-10 C18：1的乳脂肪含量增加。（Griinari等，1997，1998）导致MFD。这一观察结果与现有技术相冲突，该技术教导了总TFA的增加引起MFD。这些结果适用于其他国内哺乳哺乳动物（如猪）。在输注CLA时，将CLA的一部分转移到乳腺并且并入乳脂中。因此，所公开的方法增加了在牛奶中发现的CLA水平，从而改善了与CLA相关的人体健康的营养益处。

36. 发明授权

US06242013B1 Method and composition for enhancing oleic acid content of milk produced by ruminants 有权
标题翻译：用于提高反刍动物产生的牛奶油酸含量的方法和组合物
公开(公告)号：US06242013B1
公开(公告)日：2001-06-05
申请号：US09362082
申请日：1999-07-27
申请人： Cindie M. Luhman , Ping Feng , Phil Kerr
发明人： Cindie M. Luhman , Ping Feng , Phil Kerr
IPC分类号： A23K118
CPC分类号： A23C9/20 , A23C2230/10 , A23K20/158 , A23K40/35 , A23K50/10 , Y10S426/807
摘要： A method of enhancing the oleic acid content of milk produced by a ruminant, the method including processing a high oleic material to form a ruminally-protected high oleic material that is resistant to degradation in the rumen of the ruminant, orally feeding the ruminally-protected high oleic material to the ruminant, and milking the ruminant to produce milk.
摘要翻译：一种增强反刍动物产生的乳的油酸含量的方法，该方法包括加工高油酸材料以形成耐反刍动物瘤胃降解的抗油性高油酸材料，口服给予反刍动物向反刍动物提供高油酸材料，并将反刍动物挤奶以生产牛奶。

37. 发明申请

US20170013851A1 PELLETED RUMINANT FEED ENRICHED WITH RUMEN-AVAILABLE INGREDIENTS 审中-公开
标题翻译：有价值的发酵饲料可以与可利用的成分一起使用
公开(公告)号：US20170013851A1
公开(公告)日：2017-01-19
申请号：US15124403
申请日：2015-03-11
申请人： BASF SE
发明人： Arnulf TRÖSCHER , Uwe OBERFRANK
IPC分类号： A23C9/14 , A61K9/00 , A23K40/10 , A23K40/20 , A23K50/10 , A61K31/201 , A23K20/158
CPC分类号： A23C9/14 , A23C2230/10 , A23K20/158 , A23K40/10 , A23K40/20 , A23K40/25 , A23K50/10 , A61K9/0053 , A61K31/20 , A61K31/201 , A61K31/202 , A61K45/06 , A61K2300/00
摘要： The invention relates to pelleted ruminant feed, comprising, in pelleted or else subsequently re-crumbled form, a mixture of at least one solid particulate feed component with at least one rumen-unstable constituent which has been added to the mixture; to processes for their preparation and to their use in methods of altering the milk fat concentration.
摘要翻译：本发明涉及颗粒状反刍动物饲料，其包括至少一种固体颗粒饲料组分与至少一种已经加入到该混合物中的瘤胃不稳定组分的沉淀或随后重新粉碎形式的混合物; 其制备方法及其在改变乳脂浓度的方法中的用途。

38. 发明授权

US08741297B2 Preparation of isolated agonist anti-EDAR monoclonal antibodies 有权
标题翻译：制备分离的激动剂抗EDAR单克隆抗体
公开(公告)号：US08741297B2
公开(公告)日：2014-06-03
申请号：US13791055
申请日：2013-03-08
申请人： Edimer Pharmaceuticals, Inc. , Universite de Lausanne
发明人： Pascal Schneider , Nathalie Dunkel , Stéphane Demotz
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2863 , A23C9/20 , A23C9/206 , A23C2230/10 , A61K39/39541 , A61K39/3955 , A61K2039/505 , C07K16/2878 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/92 , C07K2317/94
摘要： The present invention concerns the preparation of substantially purified agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof. The invention further relates to isolated agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof as well as their use in the treatment of X-linked hypohidrotic ectodermal dysplasia and tooth agenesis. The invention also relates to a pharmaceutical composition comprising said isolated agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof and to a method of treating X-linked hypohidrotic ectodermal dysplasia and tooth agenesis. Finally, the present invention concerns a pharmaceutical kit comprising said isolated agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof.
摘要翻译：本发明涉及基本纯化的激动剂抗EDAR单克隆抗体或分离的单克隆抗体片段或抗原结合部分或其片段的制备。本发明还涉及分离的激动剂抗EDAR单克隆抗体或分离的单克隆抗体片段或抗原结合部分或其片段，以及它们在治疗X连锁的hypohidrotic外胚层发育不良和牙齿发育不良中的用途。本发明还涉及包含所述分离的激动剂抗EDAR单克隆抗体或分离的单克隆抗体片段或抗原结合部分或其片段的药物组合物，以及治疗X连锁的hypohidrotic外胚层发育不良和牙齿发育不全的方法。最后，本发明涉及包含所述分离的激动剂抗EDAR单克隆抗体或分离的单克隆抗体片段或抗原结合部分或其片段的药物试剂盒。

39. 发明授权

US08496937B2 Preparation of isolated agonist anti-EDAR monoclonal antibodies 有权
标题翻译：制备分离的激动剂抗EDAR单克隆抗体
公开(公告)号：US08496937B2
公开(公告)日：2013-07-30
申请号：US13260937
申请日：2010-03-30
申请人： Pascal Schneider , Nathalie Dunkel , Stephane Demotz
发明人： Pascal Schneider , Nathalie Dunkel , Stephane Demotz
IPC分类号： A61K39/395
CPC分类号： C07K16/2863 , A23C9/20 , A23C9/206 , A23C2230/10 , A61K39/39541 , A61K39/3955 , A61K2039/505 , C07K16/2878 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/92 , C07K2317/94
摘要： The present invention concerns the preparation of substantially purified agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof. The invention further relates to isolated agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof as well as their use in the treatment of X-linked hypohidrotic ectodermal dysplasia and tooth agenesis. The invention also relates to a pharmaceutical composition comprising said isolated agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof and to a method of treating X-linked hypohidrotic ectodermal dysplasia and tooth agenesis. Finally, the present invention concerns a pharmaceutical kit comprising said isolated agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof.
摘要翻译：本发明涉及基本纯化的激动剂抗EDAR单克隆抗体或分离的单克隆抗体片段或抗原结合部分或其片段的制备。本发明还涉及分离的激动剂抗EDAR单克隆抗体或分离的单克隆抗体片段或抗原结合部分或其片段，以及它们在治疗X连锁的hypohidrotic外胚层发育不良和牙齿发育不良中的用途。本发明还涉及包含所述分离的激动剂抗EDAR单克隆抗体或分离的单克隆抗体片段或抗原结合部分或其片段的药物组合物，以及治疗X连锁的hypohidrotic外胚层发育不良和牙齿发育不全的方法。最后，本发明涉及包含所述分离的激动剂抗EDAR单克隆抗体或分离的单克隆抗体片段或抗原结合部分或其片段的药物试剂盒。

40. 发明申请

US20110300229A1 TREATING OR PREVENTING ROTAVIRUS INFECTION 审中-公开
标题翻译：治疗或预防罗非鱼感染
公开(公告)号：US20110300229A1
公开(公告)日：2011-12-08
申请号：US12672480
申请日：2008-08-08
申请人： Glenn Stuart Buchan , Kerry Therese Buchan , Michelle Avril McConnell , Clare Elizabeth Fitzpatrick , Alastair Kenneth Hugh MacGibbon
发明人： Glenn Stuart Buchan , Kerry Therese Buchan , Michelle Avril McConnell , Clare Elizabeth Fitzpatrick , Alastair Kenneth Hugh MacGibbon
IPC分类号： A61K31/201 , A61P1/12 , A61P31/12 , A61K31/202 , A61K38/40
CPC分类号： A61K31/201 , A23C2230/10 , A23K20/158 , A23L33/12 , A23L33/40 , A61K35/20 , A61K38/40 , A61K2300/00
摘要： Use of one or more of conjugated linoleic acid (CLA), high CLA milk fat, or one or more bovine milk lipid compositions to treat or prevent rotavirus infection.
摘要翻译：使用一种或多种共轭亚油酸（CLA），高CLA乳脂肪或一种或多种牛乳脂质组合物来治疗或预防轮状病毒感染。

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