专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明授权

US09255289B2 Geometric patterns and lipid bilayers for DNA molecule organization and uses thereof 有权
标题翻译：用于DNA分子组织的几何图案和脂双层及其用途
公开(公告)号：US09255289B2
公开(公告)日：2016-02-09
申请号：US12911528
申请日：2010-10-25
申请人： Eric C. Greene
发明人： Eric C. Greene
IPC分类号： C40B40/06 , C40B99/00 , C40B20/02 , C40B30/00 , C40B30/04 , C12Q1/68 , B01J19/00 , B01L3/00
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/00317 , B01J2219/00513 , B01J2219/00529 , B01J2219/00596 , B01J2219/00608 , B01J2219/00621 , B01J2219/00637 , B01J2219/00702 , B01J2219/00722 , B01J2219/00734 , B01L3/502761 , B01L2200/0663 , B01L2400/0421 , B01L2400/0487 , C12Q1/6874
摘要： The invention is related to nucleic acid arrays and methods of using nucleic acid arrays.
摘要翻译：本发明涉及核酸阵列和使用核酸阵列的方法。

32. 发明授权

US08802600B2 Articles having localized molecules disposed thereon and methods of producing same 有权
公开(公告)号：US08802600B2
公开(公告)日：2014-08-12
申请号：US11731748
申请日：2007-03-29
申请人： David R. Rank , Jeffery Wegener , Jonas Korlach , Daniel Roitman , Yue Xu , John Lyle , Stephen Turner , Paul Peluso , Geoff Otto , Ron Cicero
发明人： David R. Rank , Jeffery Wegener , Jonas Korlach , Daniel Roitman , Yue Xu , John Lyle , Stephen Turner , Paul Peluso , Geoff Otto , Ron Cicero
IPC分类号： C40B99/00
CPC分类号： C12Q1/6874 , B01J19/0046 , B01J2219/00427 , B01J2219/0045 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00639 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y20/00 , B82Y30/00 , C12Q1/6837 , Y10T29/49002 , C12Q2565/629 , C12Q2527/127
摘要： Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.

33. 发明授权

US08772202B2 Articles having localized molecules disposed thereon and methods of producing same 有权
标题翻译：具有位于其上的局部分子的制品及其制备方法
公开(公告)号：US08772202B2
公开(公告)日：2014-07-08
申请号：US13487978
申请日：2012-06-04
申请人： David R. Rank , Jeffrey Wegener , Jonas Korlach , Daniel Roitman , Yue Xu , John Lyle , Stephen Turner , Paul Peluso , Geoff Otto , Ronald L. Cicero
发明人： David R. Rank , Jeffrey Wegener , Jonas Korlach , Daniel Roitman , Yue Xu , John Lyle , Stephen Turner , Paul Peluso , Geoff Otto , Ronald L. Cicero
IPC分类号： C40B99/00
CPC分类号： C12Q1/6874 , B01J19/0046 , B01J2219/00427 , B01J2219/0045 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00639 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y20/00 , B82Y30/00 , C12Q1/6837 , Y10T29/49002 , C12Q2565/629 , C12Q2527/127
摘要： Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
摘要翻译：通过使用底物的元素来辅助活性化学基团在基底的所需区域中的定位来制备具有选定的活性化学区域的基底的方法。所述方法可以包括用于沉积，去除，激活和/或去活衬底的选定区域中的化学基团的光学，化学和/或机械方法，以提供衬底的选择性活性区域。

34. 发明申请

US20120329673A1 VECTORS AND METHODS FOR SELECTING OPEN READING FRAMES 审中-公开
标题翻译：选择开放阅读框架的向量和方法
公开(公告)号：US20120329673A1
公开(公告)日：2012-12-27
申请号：US12516256
申请日：2007-10-24
申请人： Geoffrey S. Waldo
发明人： Geoffrey S. Waldo
IPC分类号： C40B30/06 , C40B99/00
CPC分类号： C12N15/1051 , C12N15/70
摘要： The invention provides vectors and methods designed for screening large random DNA fragment libraries for the presence of open reading frames that are free of both internal ribosome binding sites (IRBS) and stop codons. The invention overcomes the principal limitation of known ORF-selector systems, namely the potential for ORF-induced folding interference of the downstream fused reporter, by not fusing the reporter to the ORF, but rather by providing a mechanism for coupled translation of an unfused downstream reporter.
摘要翻译：本发明提供了用于筛选大型随机DNA片段文库以存在不含内部核糖体结合位点（IRBS）和终止密码子的开放阅读框的载体和方法。本发明克服了已知ORF选择器系统的主要限制，即下游融合记者的ORF引起的折叠干扰的潜力，不是将记者融合到ORF，而是通过提供一种未融合的下游记者。

35. 发明申请

US20080293596A1 Systems and Methods for the Generation of Crystalline Polymorphs 审中-公开
标题翻译：用于生成晶体多晶型物的系统和方法
公开(公告)号：US20080293596A1
公开(公告)日：2008-11-27
申请号：US12121448
申请日：2008-05-15
申请人： Adam J. Matzger
发明人： Adam J. Matzger
IPC分类号： C40B99/00
CPC分类号： G01N33/15 , A61K31/167 , A61K31/55 , C07D223/22 , G01N25/147
摘要： The present invention relates to systems and methods for generating polymorphs of compounds. In particular, the present invention provides high throughput systems and methods for generating and identifying new crystalline polymorphs that find use as improved drugs, pigments, explosives, nonlinear optical crystals, solid-state reactive compounds, and other polymorphic materials.
摘要翻译：本发明涉及产生化合物多晶型物的系统和方法。特别地，本发明提供用于产生和鉴定发现用作改进的药物，颜料，爆炸物，非线性光学晶体，固态反应性化合物和其它多晶型物质的新结晶多晶型物的高通量系统和方法。

36. 发明申请

US20120329681A1 System and method for multiplex liquid handling 审中-公开
标题翻译：多重液体处理的系统和方法
公开(公告)号：US20120329681A1
公开(公告)日：2012-12-27
申请号：US13524265
申请日：2012-06-15
申请人： Chuan Gao , Melvin Yamamoto , Devin Nguyen
发明人： Chuan Gao , Melvin Yamamoto , Devin Nguyen
IPC分类号： C40B60/00 , C40B99/00
CPC分类号： B01F13/1013 , B01F11/0071 , B01F13/0059 , B01F13/1022 , B01L3/502707 , B01L3/502715 , B01L3/502738 , B01L7/52 , B01L2200/027 , B01L2200/0605 , B01L2200/10 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0487 , B01L2400/0638 , B01L2400/0655 , B01L2400/0694 , G01N35/08 , G01N2035/00158
摘要： The present invention generally relates to microfabricated devices for carrying out and controlling chemical reactions and analysis. In particular, the present invention provides systems, methods, devices and computer software products related to multiplex liquid handling systems utilizing lab cards related to biological assays.
摘要翻译：本发明一般涉及用于进行和控制化学反应和分析的微制造装置。特别地，本发明提供了与使用与生物测定相关的实验卡的多重液体处理系统相关的系统，方法，装置和计算机软件产品。

37. 发明授权

US08241539B2 Method of patterning and product(s) obtained therefrom 有权
标题翻译：图案化方法和由其获得的产品
公开(公告)号：US08241539B2
公开(公告)日：2012-08-14
申请号：US12298504
申请日：2007-04-24
申请人： Yong Zhang , Meihua Lu
发明人： Yong Zhang , Meihua Lu
IPC分类号： B05D5/00 , C40B99/00
CPC分类号： B01J19/0046 , B01J2219/00317 , B01J2219/00466 , B01J2219/005 , B01J2219/00576 , B01J2219/00641 , B01J2219/00648 , B01J2219/00722 , B01J2219/00725 , B01L3/5023
摘要： The present invention provides a method of patterning, the method comprising the steps of: (a) providing a porous film; and (b) adding at least one structure to the porous film. The present invention also provides a patterned film prepared according to the method of the invention. The present invention also provides a method of preparing a porous film, and a porous film prepared according to the method of the invention.
摘要翻译：本发明提供一种图案化方法，该方法包括以下步骤：（a）提供多孔膜; 和（b）向多孔膜中加入至少一种结构。本发明还提供根据本发明的方法制备的图案化膜。本发明还提供了制备多孔膜的方法和根据本发明的方法制备的多孔膜。

38. 发明申请

US20110301058A1 MICROFLUIDIC DEVICE 审中-公开
标题翻译：微流体装置
公开(公告)号：US20110301058A1
公开(公告)日：2011-12-08
申请号：US13156250
申请日：2011-06-08
申请人： Ji-Yen Cheng , Joel Chia-Yeh Chang , Ching-Wen Yang
发明人： Ji-Yen Cheng , Joel Chia-Yeh Chang , Ching-Wen Yang
IPC分类号： C40B30/04 , C40B99/00 , C40B60/12
CPC分类号： G01N33/54366 , B01L3/5027 , B01L2300/0636 , B01L2300/0877 , B01L2400/086
摘要： A novel approach for fabricating Monolithic Internal micro Pillars (MIPi) made of SU-8 photoresist is described. A microfluidic chip with the internal pillars (a MIPi chip) was used for cell capturing study. The surface of MIPi was coated with specific antibody and then used for capturing cells by affinity binding. An antibody, anti-EGFR, which has high affinity to lung cancer cells, CL1-5, was coated on the micro pillars. The coated MIPi chip specifically captured the cancer cells that were pumped through the MIPi chip. Simulation and experiment was carried out to compare the effect of different geometry of the micro pillars on the cell capturing rate.
摘要翻译：描述了一种用于制造由SU-8光致抗蚀剂制成的单片内微型支柱（MIPi）的新方法。使用具有内部柱的微流控芯片（MIPi芯片）用于细胞捕获研究。用特异性抗体包被MIPi的表面，然后用于通过亲和结合捕获细胞。将对肺癌细胞CL1-5具有高亲和力的抗体，抗EGFR，涂覆在微柱上。涂覆的MIPi芯片专门捕获通过MIPi芯片泵送的癌细胞。进行模拟和实验，比较微柱不同几何对细胞捕获率的影响。

39. 发明申请

US20110053790A1 METHOD AND KIT FOR DETECTION OF MICROORGANISM 有权
标题翻译：用于检测微生物的方法和工具包
公开(公告)号：US20110053790A1
公开(公告)日：2011-03-03
申请号：US12445506
申请日：2008-08-01
申请人： Shinichi Yoshida , Takashi Soejima
发明人： Shinichi Yoshida , Takashi Soejima
IPC分类号： C40B30/04 , C12Q1/68 , C40B99/00
CPC分类号： C12Q1/68 , C12Q1/689 , C12Q2523/101
摘要： A live cell of microorganism in a test sample is detected by the following steps of: a) adding a cross-linker capable of cross-linking a DNA by irradiation with light having a wavelength of 350 nm to 700 nm to the test sample; b) irradiating the test sample to which the cross-linker is added with light having a wavelength of 350 nm to 700 nm; c) removing the cross-linker contained in the test sample irradiated with light; d) adding a medium to the test sample from which the cross-linker is removed and incubating the test sample; e) adding again the cross-linker capable of cross-linking a DNA by irradiation with light having a wavelength of 350 nm to 700 nm to the incubated test sample; f) irradiating the test sample to which the cross-linker is added with light having a wavelength of 350 nm to 700 nm; g) extracting a DNA from the test sample and amplifying a target region of the extracted DNA by a nucleic acid amplification method; and h) analyzing the amplified product.
摘要翻译：通过以下步骤检测测试样品中微生物的活细胞：a）通过用波长为350nm至700nm的光照射能够将DNA交联的交联剂加入到测试样品中; b）用波长为350nm至700nm的光照射加入交联剂的测试样品; c）除去用光照射的测试样品中所含的交联剂; d）向测试样品中加入培养基，从中除去交联剂并培养测试样品; e）再次加入能够通过用波长为350nm至700nm的光照射到孵育的测试样品的DNA来交联DNA的交联剂; f）用波长为350nm至700nm的光照射加入交联剂的测试样品; g）从测试样品中提取DNA并通过核酸扩增方法扩增提取的DNA的靶区域; 和h）分析扩增产物。

40. 发明申请

US20090170714A1 MULTIWELL INCUBATION APPARATUS AND METHOD OF ANALYSIS USING THE SAME 有权
标题翻译： MULTIWELL INCUBATION装置及其分析方法
公开(公告)号：US20090170714A1
公开(公告)日：2009-07-02
申请号：US12297011
申请日：2007-04-13
申请人： Nobuo Shimamoto
发明人： Nobuo Shimamoto
IPC分类号： C40B30/00 , C40B60/00 , C40B99/00
CPC分类号： C12M27/16 , B01F11/0017 , B01L3/50853 , B01L7/54 , B01L2300/0654 , B01L2300/0829 , B01L2300/185 , B01L2300/1883 , C12M23/12 , C12M37/00 , C12M41/14
摘要： A continuous temperature-gradient incubation apparatus designed to solve the problem of moving of liquid vapor generated on the high-temperature side toward the low-temperature side to thereby cause condensation.There is provided a multiwell incubation apparatus having a well-housing vessel made of a heat conducting material and, detachably housed therein, liquid-storing wells, the wells being arranged in transverse rows and longitudinal rows, the multiwell incubation apparatus being also provided with a liquid or gas flow channel or bath for supply of a gas saturated with vapor of the liquid, the multiwell incubation apparatus being capable of maintaining incubation temperatures differing between individual transverse rows of wells with a predetermined temperature difference, so as to realize a temperature series which forms a predetermined temperature difference profile along the longitudinal rows, characterized in that the multiwell incubation apparatus includes a heat source for realizing a temperature which is the lowest in the given temperature series, the heat source being disposed outside the well rows and along the transversely lined up wells close to a first side of the housing vessel; another heat source for realizing a temperature which is the highest in the given temperature series, the heat source being disposed outside the well rows and along a side opposite to the first side; and a separator provided for each transverse row of a certain temperature.
摘要翻译：一种连续的温度梯度培养装置，其设计用于解决在高温侧产生的液体蒸气向低温侧移动从而导致冷凝的问题。提供了一种多孔培养装置，其具有由导热材料制成的井口容纳容器，并且可拆卸地容纳在其中的储液孔，井排列成横排和纵排，多孔培养装置还设置有用于供应饱和液体蒸气的气体的液体或气体流动通道或浴，所述多孔培养装置能够保持具有预定温度差异的各个横列排之间的孵育温度，从而实现温度系列沿纵排形成预定的温度差异分布，其特征在于，多孔培养装置包括用于实现在给定温度系列中最低温度的热源，热源设置在井排之外并沿着横向排列靠近壳体第一侧的井 l; 用于实现在给定温度系列中最高的温度的另一个热源，热源设置在井排外部并且沿着与第一侧相对的一侧; 以及为一定温度的每个横排提供的隔板。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式