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41. 发明授权

US09681669B2 Plant extracts comprising at least a phenolic compound, for inducing the natural defense of a plant against a pathogen, such as Phytophthora infestans 有权
公开(公告)号：US09681669B2
公开(公告)日：2017-06-20
申请号：US14426837
申请日：2013-09-10
申请人： Erik Andreasson , Marit Lenman
发明人： Erik Andreasson , Marit Lenman , Laith Moushib
IPC分类号： A01N65/08 , A01N37/40 , A01N43/16 , C13B20/06 , C05G3/00 , C05D9/02 , C05F11/10
CPC分类号： A01N65/08 , A01N37/40 , A01N43/16 , C05D9/02 , C05G3/00 , C13B20/06 , Y02E50/343 , Y02W30/47 , C05F11/10 , C05G3/02
摘要： A sugar beet extract (SBE) induced defense in potato plants under green-house conditions and in field trial, without apparent toxicity for the plant. Treatment with SBE resulted in significant reduction of the size of Phytophthora infestans infection lesions and lower sporangia production. SBE had no apparent toxic effect, neither on the hyphal growth of the pathogennor on the germination of sporangia. SBE triggered PR-1 protein induction which suggests that the defense mechanism conferred by SBE could be via direct induced resistance. An array of phenolic metabolites and minerals was found in the SBE and constitutes potential inducers of the defense.

42. 发明授权

US09656015B2 Selective chemokine modulation 有权
公开(公告)号：US09656015B2
公开(公告)日：2017-05-23
申请号：US14312557
申请日：2014-06-23
申请人： Prophy Med AB
发明人： Lars Bruce , Staale Petter Lyngstadaas
IPC分类号： A61K9/00 , A61M1/38 , A61K33/24 , B01J20/02 , B01J20/06 , A61M1/36 , A61K9/14
CPC分类号： A61M1/38 , A61K9/14 , A61K33/24 , A61M1/3679 , B01J20/02 , B01J20/06 , Y02A50/387
摘要： A body fluid purifying arrangement comprises a purifying chamber having a fluid input and a fluid output, a first filter arranged in connection the fluid input, and a second filter arranged in connection with the fluid output. In another embodiment, a body fluid purifying arrangement in the form of a syringe comprises a purifying chamber having a common fluid input and fluid output, and a filter arranged in connection with the common fluid input and output. Granules or particles made of a metal or an oxide of a metal are retained within the purifying chamber by the respective filter(s) to purify a body fluid passing through the purifying chamber from 10 kDa interferon-γ inducible protein, IP-10, wherein said metal is a metal of group 4 or 5 of the periodic table of the elements and selected from the group consisting of titanium, zirconium, hafnium, niobium and tantalum.

43. 发明授权

US09492529B2 Method for priming of T cells 有权
标题翻译： T细胞引发的方法
公开(公告)号：US09492529B2
公开(公告)日：2016-11-15
申请号：US14110899
申请日：2012-04-12
申请人： Alex Karlsson-Parra , Anna-Carin Wallgren , Bengt Andersson
发明人： Alex Karlsson-Parra , Anna-Carin Wallgren , Bengt Andersson
IPC分类号： A61K39/145 , A61K39/12 , A61K35/17 , C12N5/0783 , A61K39/00
CPC分类号： C12N5/0636 , A61K35/17 , A61K39/12 , A61K39/145 , A61K2039/5158 , C12N2502/11 , C12N2502/1121 , C12N2710/16134 , C12N2710/16234 , C12N2760/16134
摘要： The present invention relates to an in vitro method for priming T cells suitable for administration to a patient having a viral infection. The invention is also directed to the composition obtained by the method and uses thereof.
摘要翻译：本发明涉及用于引发适合于具有病毒感染的患者的T细胞的体外方法。本发明还涉及通过其方法和用途获得的组合物。

44. 发明授权

US09476880B2 Methods, devices and kits for detecting or monitoring acute kidney injury 有权
标题翻译：用于检测或监测急性肾损伤的方法，装置和试剂盒
公开(公告)号：US09476880B2
公开(公告)日：2016-10-25
申请号：US13130456
申请日：2009-11-23
申请人： Per Venge
发明人： Per Venge
IPC分类号： G01N33/543 , G01N33/573
CPC分类号： G01N33/573 , G01N2800/347
摘要： Methods for detecting acute kidney injury in an individual comprise (a) contacting a body fluid sample from the individual with an assay device including neutrophil gelatinase-associated lipocalin (NGAL) antibody and a detectable label, to allow complexing of NGAL protein in the sample with NGAL antibody, and determining an amount of complex formed between NGAL protein from the sample and NGAL antibody in the assay device using the detectable label, wherein NGAL antibody in the device has binding capacity with more than two NGAL protein epitopes, and wherein the amount of the formed complex represents a level of acute kidney injury. Methods for determining an origin of NGAL protein in a sample from an individual include the step of determining relative amounts of monomeric, dimeric and heterodimeric forms of NGAL protein in the sample and allow improved diagnosis and therefore better targeted treatment.
摘要翻译：用于检测个体中急性肾损伤的方法包括（a）使来自个体的体液样品与包括嗜中性粒细胞明胶酶相关的脂质运载蛋白（NGAL）抗体和可检测标记的测定装置接触，以使样品中的NGAL蛋白质与 NGAL抗体，并且使用所述可检测标记确定所述样品中的NGAL蛋白质与所述测定装置中的NGAL抗体之间形成的复合物的量，其中所述装置中的NGAL抗体具有与两个以上NGAL蛋白质表位的结合能力，并且其中形成的复合体代表急性肾损伤的水平。用于确定来自个体的样品中NGAL蛋白来源的方法包括确定样品中NGAL蛋白的单体，二聚体和异二聚体形式的相对量的步骤，并允许改进的诊断并因此进行更好的靶向治疗。

45. 发明授权

US09445900B2 Implants and methods for correcting tissue defects 有权
标题翻译：用于矫正组织缺陷的植入物和方法
公开(公告)号：US09445900B2
公开(公告)日：2016-09-20
申请号：US14328797
申请日：2014-07-11
申请人： OssDsign AB
发明人： Håkan Engqvist , Thomas Engstrand , Jonas Åberg , Jan Bohlin
IPC分类号： A61F2/28 , A61B17/80 , A61L31/02 , A61F2/30 , A61B17/00
CPC分类号： A61F2/28 , A61B17/8085 , A61B2017/00004 , A61B2017/00526 , A61B2090/037 , A61F2/2875 , A61F2/30965 , A61F2002/30143 , A61F2002/30462 , A61F2002/3092 , A61L31/022 , A61L31/026
摘要： An implant comprises a plurality of discrete biocompatible molded cement mosaic plates of maximum width w and thickness d connected by wire arms molded into and extending substantially laterally from the mosaic plates. Neighboring mosaic plates are separated by a gap of width t, and at least some of the mosaic plates have a hexagon shape.
摘要翻译：植入物包括多个离散的生物相容性模制的水泥镶嵌板，其最大宽度w和厚度d通过线臂模制成并从镶嵌板基本上横向延伸。相邻的马赛克板由宽度为t的间隙分开，并且至少一些马赛克板具有六边形形状。

46. 发明授权

US09325442B2 Externally connected time port changeover method and device 有权
标题翻译：外部连接的时间端口切换方式和设备
公开(公告)号：US09325442B2
公开(公告)日：2016-04-26
申请号：US14116393
申请日：2012-03-20
申请人： Xiaoxia Li , Hailiang Zhan
发明人： Xiaoxia Li , Hailiang Zhan
IPC分类号： H04J3/06 , H04L12/24 , H04L12/40
CPC分类号： H04J3/0638 , H04J3/0641 , H04J3/0644 , H04J3/0658 , H04L12/40176 , H04L41/0654
摘要： Disclosed are externally connected time port changeover method and device. The method includes: a node serving as a GM node transmitting time information via a first externally connected time port of the node; if the first externally connected time port fails, the node updating current node priority and GM node priority of the node as preset node priority which is node priority configured for the node when the node is activated; and the node judging whether a second externally connected time port of the node is up and the priority of the second externally connected time port is higher than the current GM node priority, if so, activating the second externally connected time port to transmit the time information. The problem that when the currently selected time access port has failed, changeover among ports cannot be completed in time is solved, thus improving the stability of the time synchronization network.
摘要翻译：公开了外部连接的时间端口切换方法和装置。该方法包括：作为GM节点的节点经由节点的第一外部连接的时间端口发送时间信息; 如果第一个外部连接的时间端口出现故障，节点将该节点的当前节点优先级和GM节点优先级更新为预定节点优先级，该节点优先级是节点激活时为该节点配置的节点优先级; 并且所述节点判断所述节点的第二外部连接时间端口是否up，并且所述第二外部连接时间端口的优先级高于当前GM节点优先级，如果是，则激活所述第二外部连接的时间端口以发送所述时间信息。当当前选定的时间接入端口出现故障时，端口间的切换无法及时完成，从而提高了时间同步网络的稳定性。

47. 发明授权

US09315569B2 Antibodies and vaccines for use in therapeutic and diagnostic methods for α-synuclein-related disorders 有权
标题翻译：用于α-突触核蛋白相关疾病的治疗和诊断方法的抗体和疫苗
公开(公告)号：US09315569B2
公开(公告)日：2016-04-19
申请号：US14336634
申请日：2014-07-21
申请人： BioArctic Neuroscience AB
发明人： Lars Lannfelt , Joakim Bergström , Martin Ingelsson , Pär Gellerfors
IPC分类号： C07K16/18 , A61K39/395 , G01N33/68 , A61K38/17
CPC分类号： A61K51/1018 , A61K38/1709 , C07K16/18 , C07K2317/92 , G01N33/6896 , G01N2333/4709 , Y10S530/839
摘要： Methods of treating or delaying onset of a neurodegenerative disorder with α-synuclein pathology in an individual comprise administering an antibody which is produced from a stabilized soluble α-synuclein oligomer and capable of binding a stabilized soluble α-synuclein oligomer, the stabilized soluble α-synuclein oligomer having a lower formation rate to a non-soluble aggregated form than a non-stabilized soluble oligomer of the α-synuclein. The antibody has been collected from a non-human animal to which stabilized soluble α-synuclein oligomer had been administered or has been produced by hybridoma technology, phage display, ribosome display, mammalian cell display or bacterial display, and the disorder with α-synuclein pathology is characterized by deposition of Lewy bodies and Lewy neurites or is selected from the group consisting of Parkinson's disease (PD), dementia with Lewy bodies (DLB), the Lewy body variant of Alzheimer's disease, and multiple system atrophy (MSA).
摘要翻译：在个体中用α-突触核蛋白病理学治疗或延缓神经变性疾病发作的方法包括施用由稳定的可溶性α-突触核蛋白寡聚物产生并能够结合稳定的可溶性α-突触核蛋白寡聚体的稳定的可溶性α- 具有比非稳定的α-突触核蛋白可溶性低聚物低的形成速率与非可溶性聚集形式的突触核蛋白寡聚物。已经从已经施用稳定的可溶性α-突触核蛋白寡聚体的非人动物收集抗体，或已经通过杂交瘤技术，噬菌体展示，核糖体展示，哺乳动物细胞展示或细菌展示以及α-突触核蛋白的病症产生抗体病理学特征在于路易体和路易体神经突的沉积，或选自帕金森病（PD），路易体痴呆（DLB），阿尔茨海默病的路易体变体和多系统萎缩（MSA）。

48. 外观设计

USD752861S1 Utility tote panel insert 有权
标题翻译：实用工具面板插件
公开(公告)号：USD752861S1
公开(公告)日：2016-04-05
申请号：US29493802
申请日：2014-06-13
申请人： Thirty-One Gifts LLC
设计人： Cynthia M. Monroe , Elizabeth Ann Swartzel

49. 发明授权

US09304102B2 Amperometric electrochemical sensors, sensor systems and detection methods 有权
标题翻译：电流电化学传感器，传感器系统和检测方法
公开(公告)号：US09304102B2
公开(公告)日：2016-04-05
申请号：US13791815
申请日：2013-03-08
申请人： NEXTECH MATERIALS, LTD.
发明人： Michael J. Day , Scott L. Swartz , Lora B. Thrun , Buddy E. McCormick
IPC分类号： G01N27/407 , C04B35/495 , C04B35/01 , C04B35/486 , C04B35/50 , G01N33/00
CPC分类号： G01N27/4075 , C04B35/01 , C04B35/486 , C04B35/495 , C04B35/50 , C04B2235/3206 , C04B2235/3208 , C04B2235/3213 , C04B2235/3215 , C04B2235/3224 , C04B2235/3225 , C04B2235/3227 , C04B2235/3229 , C04B2235/3262 , C04B2235/3272 , C04B2235/3275 , C04B2235/3279 , C04B2235/3281 , C04B2235/3284 , C04B2235/3286 , C04B2235/3296 , C04B2235/404 , C04B2235/405 , C04B2235/408 , C04B2235/5409 , F01N2560/026 , G01N33/0037 , Y02A50/245
摘要： An amperometric electrochemical sensor configured to be operable in an oxidizing atmosphere and under an applied bias to exhibit enhanced reduction of oxygen molecules at the sensing electrode in the presence of one or more target gas species and a resulting measurable increase in oxygen ion flux through the cell. The sensor has an electrolyte membrane, a sensing electrode on the electrolyte membrane, and a counter electrode on the electrolyte membrane, wherein the sensing electrode includes at least one molybdate or tungstate compound. An electrochemical sensor system is also provided, along with a method of detecting the concentration of one or more of NOx and NH3 in a gas sample or stream.
摘要翻译：电化学电化学传感器被配置为在氧化气氛中和在施加的偏压下可操作以在存在一种或多种目标气体种类的情况下显示在感测电极处的氧分子的增强的减少，并且由此导致通过电池的氧离子通量的可测量的增加。传感器具有电解质膜，电解质膜上的感测电极和电解质膜上的对电极，其中感测电极包括至少一种钼酸盐或钨酸盐化合物。还提供了一种电化学传感器系统，以及检测气体样品或流中的一种或多种NOx和NH 3的浓度的方法。

50. 发明授权

US09265486B2 Surgical device 有权
标题翻译：手术装置
公开(公告)号：US09265486B2
公开(公告)日：2016-02-23
申请号：US13586737
申请日：2012-08-15
申请人： James David Hughett, Sr. , Keith Edward Martin , Salvatore Privitera
发明人： James David Hughett, Sr. , Keith Edward Martin , Salvatore Privitera
IPC分类号： A61B17/04 , A61B17/00 , A61B17/122 , A61B17/128
CPC分类号： A61B17/10 , A61B17/00 , A61B17/00234 , A61B17/083 , A61B17/1227 , A61B17/1285 , A61B2017/00367
摘要： A medical instrument comprising: (A) a first joint comprising a first member and a second member, the first member configured to be repositionable with respect to the second member in an X-Y plane; (B) a second joint operatively coupled to the first joint, the second joint comprising a third member and a fourth member, the third member configured to be repositionable with respect to the fourth member in a Y-Z plane perpendicular to the X-Y plane; and, (C) a controller operatively coupled to the first joint and the second joint, the controller including a first control configured to direct repositioning of at least one of the first member and the second member, and a second control configured to direct repositioning of at least one of the third member and the fourth member.
摘要翻译：一种医疗器械，包括：（A）包括第一构件和第二构件的第一接头，所述第一构件构造成在X-Y平面中可相对于所述第二构件重新定位; （B）可操作地联接到所述第一接头的第二接头，所述第二接头包括第三部件和第四部件，所述第三部件被配置为在垂直于所述X-Y平面的Y-Z平面中相对于所述第四部件重新定位; 和（C）可操作地联接到第一关节和第二关节的控制器，所述控制器包括构造成引导重新定位所述第一构件和所述第二构件中的至少一个的第一控制，以及第二控制，所述第二控制被配置为直接重新定位第三成员和第四成员中的至少一个。

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