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41. 发明授权

US07991858B2 Method and device for establishing a route 有权
标题翻译：建立路线的方法和装置
公开(公告)号：US07991858B2
公开(公告)日：2011-08-02
申请号：US12365564
申请日：2009-02-04
申请人： Guangyu Shi , Hao Gong , Jian Chen
发明人： Guangyu Shi , Hao Gong , Jian Chen
IPC分类号： G06F15/177
CPC分类号： H04L67/16 , H04L61/1582 , H04L61/1588 , H04L67/104 , H04L67/1046 , H04L67/1065 , H04L67/1076 , H04W8/08 , H04W40/20
摘要： The embodiment of the present invention provides a method for establishing a route, which includes searching a target node by a node from a first level node group according to first level route information, returning to query a result or data saved by the target node if the target node is found, otherwise executing the following step; searching a target node by the node from a higher level node group according to higher level route information, returning to query a result or the data saved by the target node if the target node is found, otherwise repeating the step. Through the hierarchical communication system, most of the flows of daily service operations in the communication network are limited within a small region, thereby preventing from excessively occupying the band width of a backbone network being originally not wide enough.
摘要翻译：本发明的实施例提供了一种建立路由的方法，其包括根据第一级路由信息从第一级节点组中的节点搜索目标节点，返回查询结果或由目标节点保存的数据，如果找到目标节点，否则执行以下步骤; 根据较高级别的路由信息从上一级节点组中的节点搜索目标节点，如果找到目标节点，返回查询结果或目标节点保存的数据，否则重复该步骤。通过分层通信系统，通信网络中日常业务运行的大部分流量在小区域内受到限制，从而防止过度占据骨干网络的带宽原本不够宽。

42. 发明申请

US20110106805A1 METHOD AND SYSTEM FOR SEARCHING MULTILINGUAL DOCUMENTS 失效
标题翻译：搜索多文档的方法和系统
公开(公告)号：US20110106805A1
公开(公告)日：2011-05-05
申请号：US12914012
申请日：2010-10-28
申请人： Shenghua Bao , Jian Chen , Zhong Su , Dong Wang
发明人： Shenghua Bao , Jian Chen , Zhong Su , Dong Wang
IPC分类号： G06F17/30
CPC分类号： G06F17/30675 , G06F17/30017
摘要： A method, system and computer program product for searching multilingual documents. The method includes the steps of: receiving a search request based on at least one language; searching a first relevant document using the search request where the first relevant document (1) is written in a first language and (2) has a first image; finding a second relevant document having a second image which is similar to the first image and is written in a second language; and searching a second relevant document using the search request.
摘要翻译：用于搜索多语言文档的方法，系统和计算机程序产品。该方法包括以下步骤：基于至少一种语言接收搜索请求; 使用第一相关文档（1）以第一语言书写的搜索请求搜索第一相关文档，以及（2）具有第一图像; 找到具有与第一图像类似并以第二语言写入的第二图像的第二相关文档; 以及使用搜索请求搜索第二相关文档。

43. 发明申请

US20110076742A1 POLYNUCLEOTIDES ENCODING NOVEL PCSK9 VARIANTS 有权
标题翻译：多核苷酸编码新的PCSK9变体
公开(公告)号：US20110076742A1
公开(公告)日：2011-03-31
申请号：US12903658
申请日：2010-10-13
申请人： Gabriel A. Mintier , Jian Chen , John N. Feder , Bowman Miao , Rex Arnold Parker
发明人： Gabriel A. Mintier , Jian Chen , John N. Feder , Bowman Miao , Rex Arnold Parker
IPC分类号： C07H21/00 , C12N15/63 , C12N5/10 , C12N9/50 , C07H21/04
CPC分类号： C07K16/40 , A61K38/00 , C07K2317/41 , C07K2317/76 , C12N9/6424 , C12Y302/01008 , C12Y304/21061 , Y10T436/143333
摘要： The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码PCSK9b和PCSK9c多肽的新型多核苷酸，其片段和同源物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型PCSK9b和PCSK9c多肽应用于与这些多肽相关的各种疾病和/或病症的诊断，治疗和/或预防的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

44. 发明申请

US20110064728A1 IL-17 Homologous Polypeptides and Therapeutic Uses Thereof 审中-公开
标题翻译： IL-17同源多肽及其治疗用途
公开(公告)号：US20110064728A1
公开(公告)日：2011-03-17
申请号：US12825263
申请日：2010-06-28
申请人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gumey , Hanzhong Li , Kenneth Hillan , Sarah G. Hymowitz , Daniel Tumas , Melissa A. Starovasnik , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
发明人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gumey , Hanzhong Li , Kenneth Hillan , Sarah G. Hymowitz , Daniel Tumas , Melissa A. Starovasnik , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
IPC分类号： A61K39/395 , A61K38/16 , A61P1/00 , A61P11/06 , A61P17/00 , A61P19/00
CPC分类号： A61K38/20 , C07K14/54 , C07K14/7155 , C07K2319/30 , C12N15/1136 , C12N2310/11 , C12N2310/12 , C12N2310/15
摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
摘要翻译：本发明涉及与IL-17，IL-17受体和编码那些多肽的核酸分子具有序列同一性的新型多肽。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。

45. 发明授权

US07876468B2 Line utilization in integrated document delivery method and apparatus 有权
标题翻译：集成文件传送方式和装置中的线路利用
公开(公告)号：US07876468B2
公开(公告)日：2011-01-25
申请号：US12567656
申请日：2009-09-25
申请人： Kevin Phillips , Eric C. Chen , Curtis R. Powell , Jian Chen , Kamal Punn
发明人： Kevin Phillips , Eric C. Chen , Curtis R. Powell , Jian Chen , Kamal Punn
IPC分类号： G06F3/12
CPC分类号： H04N1/00209 , H04L12/66 , H04L51/066 , H04N1/00244 , H04N1/00395 , H04N1/32523 , H04N1/32529 , H04N1/32545 , H04N1/32561 , H04N1/32587 , H04N2201/0093
摘要： A document delivery network server having a set of integrated functions including sending, receiving, routing and filing of FAXes and e-mails to other users which achieves numerous advantages over the prior art. The document delivery system is based on a client/server model having both analog and digital Fax line capabilities. The server side provides very highly integrated systems functionality based on industry standard, commercially available hardware and a mix of industry standard and proprietary software components including integrated FAX/modem modules, an embedded OS, embedded plug-and-play driver sets, embedded e-mail gateways, an embedded FAX archive, embedded back-up/restore, proprietary high efficiency line utilization and highly efficient load balancing.
摘要翻译：一种文档传送网络服务器，其具有一组集成功能，包括向其他用户发送，接收，路由和归档传真和电子邮件，这相对于现有技术实现了许多优点。文档传送系统基于具有模拟和数字传真线路功能的客户端/服务器模型。服务器端提供非常高度集成的系统功能，基于行业标准，市售硬件以及业界标准和专有软件组件的混合，包括集成的传真/调制解调器模块，嵌入式操作系统，嵌入式即插即用驱动程序集，邮件网关，嵌入式FAX归档，嵌入式备份/恢复，专有的高效率线路利用率和高效负载平衡。

46. 发明授权

US07846706B2 PCSK9 polypeptides 有权
标题翻译： PCSK9多肽
公开(公告)号：US07846706B2
公开(公告)日：2010-12-07
申请号：US12456798
申请日：2009-06-23
申请人： Gabriel A. Mintier , Jian Chen , John N. Feder , Bowman Miao , Rex Arnold Parker
发明人： Gabriel A. Mintier , Jian Chen , John N. Feder , Bowman Miao , Rex Arnold Parker
IPC分类号： C12N9/00 , C12N9/50 , C12N1/20 , C12N15/00 , C07H21/02 , C07H21/04
CPC分类号： C07K16/40 , A61K38/00 , C07K2317/41 , C07K2317/76 , C12N9/6424 , C12Y302/01008 , C12Y304/21061 , Y10T436/143333
摘要： The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码PCSK9b和PCSK9c多肽的新型多核苷酸，其片段和同源物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型PCSK9b和PCSK9c多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

47. 发明申请

US20100192308A1 METHOD FOR SCOURING AND BLEACHING COTTON FABRIC WITH COMPOSITE ENZYME PREPARATION IN ONE BATH 审中-公开
标题翻译：一次浴中复合酶制剂的洗涤和漂白棉织物的方法
公开(公告)号：US20100192308A1
公开(公告)日：2010-08-05
申请号：US12667577
申请日：2008-06-16
申请人： Jian Chen , Guocheng Du , Hejing Yan , Jianghua Li
发明人： Jian Chen , Guocheng Du , Hejing Yan , Jianghua Li
IPC分类号： D06L3/14
CPC分类号： D06M16/003 , D06L4/40 , D06L4/75 , D06M2101/06
摘要： A method for scouring and bleaching cotton fabric with composite enzyme preparation in one bath is provided. The method relates to the application of composite alkaline enzyme preparation in scouring and bleaching processes of cotton fabric. The enzyme preparation for scouring and bleaching cotton fabric is compounded from cutinase, alkaline pectase, alkaline xylanase, alkaline cellulose, and carbohydrate oxidase. The method includes: scouring the cotton fabric by adding the composite enzyme preparation, glucose, oxidation bleaching stabilizer RB-3, penetrant JFC, and Triton X-100 in a treating bath at 55-70° C. and pH 8-10, and then bleaching the cotton fabric for 30 min by directly adding tetraacetyl ethylenediamine (TAED) in the scouring bath to activate hydrogen peroxide. After being treated by the method of the present invention, the cotton fabric has high impurity removal ratio, favorable wettability, and high whiteness. The present invention has the advantages of low power consumption, short process flow, and being environment friendly, and may be used to replace conventional chemical treatment process under the condition of concentrated alkali and high temperature.
摘要翻译：提供了在一个浴中用复合酶制剂冲洗和漂白棉织物的方法。该方法涉及复合碱性酶制剂在棉织物的漂洗和漂白过程中的应用。用于冲洗和漂白棉织物的酶制剂由角质酶，碱性果胶酶，碱性木聚糖酶，碱性纤维素和碳水化合物氧化酶组合。该方法包括：通过在55-70℃和pH8-10的处理浴中加入复合酶制剂，葡萄糖，氧化漂白稳定剂RB-3，渗透剂JFC和Triton X-100来洗涤棉织物，以及然后通过在洗涤浴中直接加入四乙酰乙二胺（TAED）来活化过氧化氢，使棉织物漂白30分钟。在通过本发明的方法处理之后，棉织物具有高杂质去除率，良好的润湿性和高白度。本发明具有功耗低，工艺流程短，环保的优点，可用于在浓碱和高温条件下代替常规化学处理工艺。

48. 发明授权

US07718770B2 PRO1305-polypeptides 有权
标题翻译： PRO1305-多肽
公开(公告)号：US07718770B2
公开(公告)日：2010-05-18
申请号：US10183012
申请日：2002-06-26
申请人： Kevin P. Baker , Jian Chen , Luc Desnoyers , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , James Pan , Victoria Smith , Colin K. Watanabe , William I. Wood , Zemin Zhang
发明人： Kevin P. Baker , Jian Chen , Luc Desnoyers , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , James Pan , Victoria Smith , Colin K. Watanabe , William I. Wood , Zemin Zhang
IPC分类号： C07K14/435 , C07H21/00
CPC分类号： C07K14/47 , A01K2217/075 , A01K2227/105 , A61K38/00 , A61K39/00 , C07K14/4748 , C07K14/705 , C07K14/82 , C07K16/00 , C07K16/18 , C07K16/28 , C07K2319/30 , C12N9/90 , C12N2799/026 , C12Q1/6816 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5082 , G01N33/5308 , G01N33/574 , G01N33/57411 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57434 , G01N33/57484 , G01N33/57488 , G01N33/57492 , G01N2500/10 , C12Q2563/131 , C12Q2527/137
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：本发明涉及新型多肽和编码那些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。

49. 发明申请

US20100104584A1 GENES INVOLVED IN MITOCHONDRIAL BIOGENESIS 审中-公开
标题翻译：基因涉及生物生物学
公开(公告)号：US20100104584A1
公开(公告)日：2010-04-29
申请号：US12526674
申请日：2008-02-14
申请人： Jian Chen , Dan Garza , Hao Li , Susan C. Stevenson , Zhidan Wu
发明人： Jian Chen , Dan Garza , Hao Li , Susan C. Stevenson , Zhidan Wu
IPC分类号： A61K39/395 , A61P3/10 , A61K31/7052 , C12Q1/68 , G01N33/68 , A61P35/00
CPC分类号： G01N33/5079 , C12N15/111 , C12N2310/14 , C12N2320/12 , C12N2330/31 , G01N2800/52
摘要： The invention discloses suitable gene and polypeptide targets for the development of new therapeutics to treat, prevent or ameliorate conditions associated with mitochondrial dysfunction. The invention also relates to methods to treat, prevent or ameliorate said conditions and pharmaceutical compositions therefor, as well as to a method to identify compounds with therapeutic usefulness to treat conditions associated with mitochondrial dysfunction.
摘要翻译：本发明公开了用于开发治疗，预防或改善与线粒体功能障碍相关的病症的新治疗剂的合适的基因和多肽靶标。本发明还涉及治疗，预防或改善所述病症及其药物组合物的方法，以及鉴定具有治疗用途以治疗与线粒体功能障碍相关的病症的化合物的方法。

50. 发明申请

US20100067262A1 Switching power source device, switching power source control circuit, and switching power source device control method 有权
标题翻译：开关电源装置，开关电源控制电路和开关电源装置控制方式
公开(公告)号：US20100067262A1
公开(公告)日：2010-03-18
申请号：US12461593
申请日：2009-08-18
申请人： Jian Chen , Koji SONOBE
发明人： Jian Chen , Koji SONOBE
IPC分类号： H02M3/335
CPC分类号： H02M3/33592 , Y02B70/1433 , Y02B70/1475
摘要： A switching power source device for supplying power to a load includes a series resonant circuit, a plurality of main switch elements or main switch element groups for switching a current. path of the series resonant circuit, a transformer for inducing a secondary current from the series resonant circuit, a plurality of synchronous rectification switch elements for rectifying the secondary current, a maximum on width control circuit for ordering a start and a completion of a maximum on width to the synchronous rectification switch element in synchronization with a timing of turning on the main switch elements Or the main switch element groups, and a synchronous control circuit. The circuit controls an on period of the synchronous rectification switch element so as to turn on the synchronous rectification switch element in synchronization with a particular timing, and turn off in synchronization with another timing.
摘要翻译：用于向负载供电的开关电源装置包括串联谐振电路，用于切换电流的多个主开关元件或主开关元件组。串联谐振电路的路径，用于从串联谐振电路感应次级电流的变压器，用于整流二次电流的多个同步整流开关元件，用于排序开始和完成最大值的最大宽度控制电路同步整流开关元件的宽度与打开主开关元件或主开关元件组的定时同步，以及同步控制电路。电路控制同步整流开关元件的导通周期，以与特定定时同步地接通同步整流开关元件，并与另一定时同步地关断。

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