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41. 发明申请

US20180154183A1 Normal Tissue Toxicity Reducing Microbeam-Broadbeam Radiotherapy, Skin's Radio-Response Immunotherapy and Mutated Molecular Apheresis Combined Cancer Treatments 审中-公开
公开(公告)号：US20180154183A1
公开(公告)日：2018-06-07
申请号：US15846208
申请日：2017-12-19
申请人： Velayudhan Sahadevan
发明人： Velayudhan Sahadevan
IPC分类号： A61N5/10 , A61M1/34 , A61M1/36
CPC分类号： A61N5/1084 , A61M1/3496 , A61M1/3615 , A61M1/3693 , A61N5/1045 , A61N5/1067 , A61N5/1081 , A61N2005/1088 , A61N2005/1089 , A61N2005/109 , A61N2005/1094
摘要： Normal tissue complications limit curative broadbeam radiotherapy to tumors including lung cancer. Radiation retinitis causing blindness limits quality of life and long term survival for patients with ocular melanoma. This invention pertains to alternative, normal tissue sparing 100 to 1,000 Gy microbeam radiations with least normal tissue complications and concomitant radio-immunotherapy by innate immune response of epidermis and dermis to low dose radiation with 50 kV X-rays. Total body skin radiation with former airport passenger screening machines with 50 kV X-ray is disclosed. Microbeams are generated without contaminating scatter and neutron radiations from collinear gamma ray and electron beam produced by inverse Compton interaction with high energy laser and electron beam and from proton and carbon ion beams in tissue equivalent cylindrical collimators. Extracorporeal immunotherapy and chemotherapy and apheresis of mutated subcellular particles released into circulation in response to cancer-therapies are by clinical continuous flow ultracentrifugation combined chromatography.

42. 发明申请

US20170165504A1 A Method and Apparatus for Determining an Energy Deposition of an Ion Beam 审中-公开
公开(公告)号：US20170165504A1
公开(公告)日：2017-06-15
申请号：US15327056
申请日：2015-07-17
申请人： Ludwig-Maximilians-Universität München , Universität der Bundeswehr München
发明人： Günther Dollinger , Katia Parodi , Walter Assmann , Vasilis Ntziachristos , Stephan Kellnberger
IPC分类号： A61N5/10
CPC分类号： A61N5/1049 , A61N5/1048 , A61N2005/1058 , A61N2005/1087 , A61N2005/1088 , A61N2005/1095
摘要： Disclosed is a method of determining information regarding the location of energy deposition of an ion beam, in particular a proton beam, in an absorptive medium, in particular in the tissue of a patient undergoing radiation therapy, comprising the following steps: generating an intensity modulated ion beam, wherein the intensity modulation comprises one or more modulation frequency components, detecting an acoustic signal attributable to the time dependent energy deposition in said absorptive medium by said intensity modulated ion beam using at least one detection apparatus, said detection apparatus being preferably configured for extracting at least one modulation frequency component of the acoustic signal corresponding to a respective one of the one or more modulation frequency components of said intensity modulation, or a harmonic thereof, and deriving information regarding the location of the energy deposition based, at least in part, on a time lag between the timing of the intensity modulation of said ion beam and said acoustic signal.

43. 发明申请

US20160287899A1 INTEGRATED TARGET STRUCTURE FOR GENERATING CHARGED PARTICLE AND DRIVING METHOD OF MEDICAL APPLIANCE USING THE SAME 有权
标题翻译：用于产生充电颗粒的集成目标结构和使用其的医疗器具的驱动方法
公开(公告)号：US20160287899A1
公开(公告)日：2016-10-06
申请号：US15082685
申请日：2016-03-28
申请人： ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
发明人： Hyung Ju PARK , Moon Youn JUNG , Won Bae CHO , Ji Su LEE
IPC分类号： A61N5/10 , G21K5/00
CPC分类号： A61N5/10 , A61N5/1049 , A61N5/1075 , A61N2005/1072 , A61N2005/1074 , A61N2005/1088 , G21K5/04 , H05H6/00 , H05H2245/122
摘要： Provided herein is an integrated target structure for generating charged particles. The integrated target structure according to an embodiment of the present disclosure includes a target layer emitting charged particles depending on an irradiation of a laser beam, an optical component controlling at least one of the laser beam and the charged particles, and a support body supporting the target layer and the optical component using one structure.
摘要翻译：本文提供了一种用于产生带电粒子的集成目标结构。根据本公开的实施例的集成目标结构包括根据激光束的照射发射带电粒子的目标层，控制激光束和带电粒子中的至少一个的光学部件以及支撑体目标层和使用一个结构的光学部件。

44. 发明授权

US09386683B2 Particle accelerator and medical equipment 有权
标题翻译：粒子加速器和医疗设备
公开(公告)号：US09386683B2
公开(公告)日：2016-07-05
申请号：US14171910
申请日：2014-02-04
申请人： Kabushiki Kaisha Toshiba
发明人： Akiko Kakutani , Kiyokazu Sato , Takeshi Yoshiyuki , Takashi Yazawa
IPC分类号： A61N5/10 , H05H13/04
CPC分类号： H05H13/04 , A61N5/1077 , A61N2005/1088
摘要： One embodiment of a particle accelerator includes: a particle source from which a particle beam is extracted with a beam pulse width of not greater than 2 μsec; a linear accelerator for accelerating the particle beam extracted from the particle source; a synchrotron for receiving the particle beam transported thereto from the linear accelerator and causing the particle beam to circulate in order to accelerate it until it gets to a predetermined energy level; a bump electromagnet for shifting the circulating path of the particle beam each time it makes a full turn; and a control unit for controlling the extent of magnetic excitation of the bump electromagnet and for controlling the timing of magnetic excitation of the bump electromagnet according to the pulse timing of the particle source.
摘要翻译：粒子加速器的一个实施例包括：粒子束以束脉冲宽度不大于2微秒从其中提取出的粒子束; 用于加速从粒子源提取的粒子束的线性加速器; 同步加速器，用于接收从线性加速器传送到其上的粒子束，并使粒子束循环，以加速它直至达到预定的能级; 用于在每次完全转动时移动粒子束的循环路径的凸块电磁体; 以及控制单元，用于控制凸块电磁体的磁激励程度，并根据粒子源的脉冲定时来控制凸块电磁体的磁激励定时。

45. 发明申请

US20150272677A1 LIGHT TRANSMITTING CABLE AND LASER SYSTEM INCLUDING THE SAME 有权
标题翻译：光发射电缆和激光系统，包括它们
公开(公告)号：US20150272677A1
公开(公告)日：2015-10-01
申请号：US14663085
申请日：2015-03-19
申请人： Electronics and Telecommunications Research Institute
发明人： Moon Youn JUNG , Dong Hoon SONG , Won Bae CHO
IPC分类号： A61B18/22 , H04N7/18 , H04N5/44
CPC分类号： A61B18/22 , A61B2018/2266 , A61B2090/3614 , A61B2090/373 , A61N5/1014 , A61N2005/1022 , A61N2005/1059 , A61N2005/1088 , H04N5/2256 , H04N7/185 , H04N2005/2255
摘要： Provided herein is a light transmitting cable for laser treatment, the cable including a first optical fiber configured to generate a high energy particle by a laser beam transmitted from a light source and to transmit the high energy particle to a target; and an image transmitting cable configured to transmit an image surrounding the target, thereby being capable of treating a tumor with relatively low power output while identifying a location of the tumor.
摘要翻译：本文提供了一种用于激光处理的光传输电缆，该电缆包括：第一光纤，其被配置为通过从光源传输的激光束产生高能量粒子并将高能粒子传输到目标; 以及图像传输电缆，被配置为传送围绕所述目标的图像，从而能够在识别所述肿瘤的位置的同时，以相对低的功率输出来治疗肿瘤。

46. 发明申请

US20140135561A1 PROTON BEAM GENERATION APPARATUS AND TREATMENT METHOD USING THE APPARATUS 审中-公开
标题翻译：原子生成装置和使用装置的处理方法
公开(公告)号：US20140135561A1
公开(公告)日：2014-05-15
申请号：US13916419
申请日：2013-06-12
申请人： Electronics and Telecommunications Research Institute
发明人： Dong Hoon SONG , Moon Youn JUNG
IPC分类号： G21K5/04 , A61N5/10
CPC分类号： G21B3/006 , A61N5/10 , A61N2005/1088
摘要： Provided is a proton beam generation apparatus. The apparatus includes a laser system providing a laser pulse, a phase shift plate polarizing the laser pulse to be spirally radial to be transduced to be a spirally radial shape polarized laser pulse, and a target for generating a proton beam, generating a proton beam due to the spirally radial shape polarized laser pulse.
摘要翻译：提供了一种质子束产生装置。该装置包括提供激光脉冲的激光系统，将激光脉冲偏振以使其被旋转成螺旋放射状的偏振激光脉冲的相移板和用于产生质子束的目标，产生质子束到螺旋形径向形状的偏振激光脉冲。

47. 发明申请

US20130289331A1 TARGETS FOR GENERATING IONS AND TREATMENT APPARATUSES INCLUDING THE TARGETS 有权
标题翻译：用于产生离子和处理装置的目标，包括目标
公开(公告)号：US20130289331A1
公开(公告)日：2013-10-31
申请号：US13868976
申请日：2013-04-23
申请人： Electronics and Telecommunications Research Institute
发明人： Moon Youn JUNG , Hyung Ju PARK , Hyeon-Bong PYO , Nam Soo MYUNG , Seunghwan KIM
IPC分类号： A61N5/10 , H01J27/02
CPC分类号： A61N5/1077 , A61N2005/1088 , H01J27/02 , H01J27/24
摘要： Provided are an ion generation target and a treatment apparatus including the target. The treatment apparatus includes a grid having a net shape of nano wires, an ion generation thin film attached to a side of the grid and generating ions by means of an incident laser beam, and a laser for emitting a laser beam into the nano wire of the grid to generate ions from the ion generation thin film and project the ions onto a tumor portion of a patient. The laser beam emitted into the nano wire forms a near field, the intensity of which is higher than that of the laser beam through a nanoplasmonics phenomenon, and the near field emits the ions from the ion generation thin film.
摘要翻译：提供了一种离子产生靶和包括靶的处理装置。处理装置包括具有纳米线的净形状的栅格，附着在栅格的一侧的离子产生薄膜，并且通过入射的激光束产生离子，以及用于将激光束发射到纳米线的纳米线中的激光该网格从离子产生薄膜产生离子并将离子投射到患者的肿瘤部分上。发射到纳米线中的激光束形成近场，其强度高于激光束的强度，并且近场从离子产生薄膜发射出离子。

48. 发明申请

US20110198516A1 SHIELDING FOR COMPACT RADIATION SOURCES 审中-公开
标题翻译：紧凑辐射源的屏蔽
公开(公告)号：US20110198516A1
公开(公告)日：2011-08-18
申请号：US12681019
申请日：2008-10-01
申请人： Jiajin Fan , Chang Ming Ma
发明人： Jiajin Fan , Chang Ming Ma
IPC分类号： G21F1/12
CPC分类号： G21F1/125 , A61N2005/1087 , A61N2005/1088 , A61N2005/1094 , G21F7/00
摘要： Disclosed are radiation shields substantially enclosing a source of polyenergetic positive ions. The shielding layers are spatially arranged to absorb substantially all unwanted radiation arising directly or indirectly from the polyenergetic positive Also disclosed are methods of shielding unwanted radiation leaking from a system providing a therapeutic dose of polyenergetic positive radiation, as well as shielded polyenergetic positive ion selection systems.
摘要翻译：公开了基本上包围多能正离子源的辐射屏蔽。屏蔽层在空间上被布置成吸收基本上从多能量阳极直接或间接产生的所有不需要的辐射。还公开了屏蔽从提供治疗剂量的多能正阳性辐射的系统泄漏的不需要的辐射的方法以及屏蔽多能正离子选择系统。

49. 发明授权

US07755068B2 Laser-accelerated proton therapy units and superconducting electromagnet systems for same 有权
标题翻译：激光加速质子治疗单元和超导电磁体系统相同
公开(公告)号：US07755068B2
公开(公告)日：2010-07-13
申请号：US11720873
申请日：2005-12-21
申请人： Chang Ming Ma , Eugene S Fourkal , Jinsheng Li , Wei Luo
发明人： Chang Ming Ma , Eugene S Fourkal , Jinsheng Li , Wei Luo
IPC分类号： G21K5/04
CPC分类号： A61N5/10 , A61N2005/1087 , A61N2005/1088 , G21K1/093 , G21K5/04 , H05H15/00
摘要： Compact particle selection and collimation devices are disclosed for delivering beams of ions with desired energy spectra. These devices are useful with laser-accelerated ion therapy systems, in which the initial ions have broad energy and angular distributions. Superconducting electromagnet systems produce a desired magnetic field configuration to spread the ions with different energies and emitting angles for particle selection. The simulation of ion transport in the presence of the magnetic field shows that the selected ions are successfully refocused on the beam axis after passing through the magnetic field. Dose distributions are also provided using Monte Carlo simulations of the laser-accelerated ion beams for radiation therapy applications.
摘要翻译：公开了紧凑的粒子选择和准直装置，用于以期望的能谱输送离子束。这些装置对于激光加速离子治疗系统是有用的，其中初始离子具有宽的能量和角分布。超导电磁体系统产生期望的磁场结构，以便以不同的能量和发射角来扩散离子以进行粒子选择。在存在磁场的情况下，离子迁移的模拟表明，所选择的离子在通过磁场后成功地重新聚焦在光束轴上。使用激光加速离子束的蒙特卡罗模拟也可以提供剂量分布，用于放射治疗应用。

50. 发明申请

US20100127183A1 LASER-DRIVEN PARTICLE BEAM IRRADIATION APPARATUS AND METHOD 有权
标题翻译：激光驱动颗粒光束辐射装置和方法
公开(公告)号：US20100127183A1
公开(公告)日：2010-05-27
申请号：US12509116
申请日：2009-07-24
申请人： Yasushi ISEKI , Takeshi Yoshiyuki , Hiroyuki Daido , Masahiro Ikegami , Mamiko Nishiuchi , Akira Noda
发明人： Yasushi ISEKI , Takeshi Yoshiyuki , Hiroyuki Daido , Masahiro Ikegami , Mamiko Nishiuchi , Akira Noda
IPC分类号： H01J1/50 , H01J3/14
CPC分类号： A61N5/1043 , A61N2005/1087 , A61N2005/1088
摘要： A laser-driven particle beam irradiation apparatus includes: a particle beam generator irradiating a target with pulsed laser light to emit a laser-driven particle ray; a beam converging unit forming a transportation path which guides the emitted laser-driven particle ray to an object and spatially converging the laser-driven particle ray; an energy selector selecting an energy and an energy width of the laser-driven particle ray; an irradiation port causing the laser-driven particle ray to scan the object to adjust an irradiation position in the object; and an irradiation controller controlling operation of the particle beam generator, the beam converging unit, the energy selector and the irradiation port. The beam converging unit generates a magnetic field on a trajectory of the laser-driven particle ray and converging the laser-driven particle ray by the magnetic field, the magnetic field forcing divergence components of the laser-driven particle ray that go away from a center of the trajectory back to the center of the trajectory.
摘要翻译：激光驱动的粒子束照射装置包括：粒子束发生器，用脉冲激光照射靶，发射激光驱动的粒子射线; 光束会聚单元，其形成将发射的激光驱动的粒子射线引导到物体并将激光驱动的粒子射线空间收敛的输送路径; 选择激光驱动粒子射线的能量和能量的能量选择器; 照射端口，使激光驱动的粒子射线扫描物体以调节物体中的照射位置; 以及照射控制器，其控制粒子束发生器，束会聚单元，能量选择器和照射端口的操作。光束会聚单元在激光驱动的粒子射线的轨迹上产生磁场并通过磁场会聚激光驱动的粒子射线，迫使离开中心的激光驱动的粒子射线的发散分量的磁场强迫的轨迹回到轨迹的中心。

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