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51. 发明授权

US07144985B2 Methods and reagents for diagnosis and treatment of diabetes 有权
标题翻译：诊断和治疗糖尿病的方法和试剂
公开(公告)号：US07144985B2
公开(公告)日：2006-12-05
申请号：US10308393
申请日：2002-12-02
申请人： Jeffrey D. Johnson , John E. Blume , John F. Palma , Yun-Ping Zhou
发明人： Jeffrey D. Johnson , John E. Blume , John F. Palma , Yun-Ping Zhou
IPC分类号： C07K4/12 , C07K16/18 , A16K38/01 , A16K38/28 , C12N5/08 , G01N33/48 , C12P21/06
CPC分类号： C07K14/47
摘要： The invention relates to methods of determining islet cell activity by detecting the level of Archipelin or a fragment thereof and comparing the level to a baseline level or range associated with a known islet cell activity. Such methods are useful in diagnosing and studying the development of diabetes.
摘要翻译：本发明涉及通过检测群岛蛋白或其片段的水平来确定胰岛细胞活性的方法，并将该水平与与已知胰岛细胞活性相关联的基线水平或范围进行比较。这些方法可用于诊断和研究糖尿病的发展。

52. 发明授权

US07087394B2 Methods and compositions for treating and diagnosing diabetes and related diseases involving beta-TRP 失效
标题翻译：用于治疗和诊断涉及β-TRP的糖尿病和相关疾病的方法和组合物
公开(公告)号：US07087394B2
公开(公告)日：2006-08-08
申请号：US10794897
申请日：2004-03-04
申请人： Jeffrey D. Johnson , Yun-Ping Zhou
发明人： Jeffrey D. Johnson , Yun-Ping Zhou
IPC分类号： G01N33/53 , C12N15/63 , A01N38/00
CPC分类号： C07K14/705 , A61K48/00 , G01N33/507 , G01N33/5088 , G01N33/6872 , G01N33/74 , G01N2333/62
摘要： Expression of beta-TRP is enriched in islet cells. Introduction of expression cassettes encoding beta-TRP into diabetic islet cells improved glucose-stimulated insulin production. Therefore, the invention provides methods of identifying beta-TRP modulators for treating diabetic individuals and introducing beta-TRP into islet cells
摘要翻译： β-TRP的表达富含胰岛细胞。将编码β-TRP的表达盒引入糖尿病胰岛细胞改善了葡萄糖刺激的胰岛素产生。因此，本发明提供鉴定用于治疗糖尿病个体并将β-TRP引入胰岛细胞的β-TRP调节剂的方法

53. 发明授权

US07053180B2 Isolated islet beta-cell two-pore domain potassium channel 有权
标题翻译：分离的胰岛β细胞双孔结构域钾通道
公开(公告)号：US07053180B2
公开(公告)日：2006-05-30
申请号：US10459190
申请日：2003-06-10
申请人： Jeffrey D. Johnson , John F. Palma , Anthony C. Schweitzer , John E. Blume
发明人： Jeffrey D. Johnson , John F. Palma , Anthony C. Schweitzer , John E. Blume
IPC分类号： C07K14/00 , A61K38/17
CPC分类号： G01N33/6872 , C07K14/705 , G01N2500/04 , G01N2500/10
摘要： The present invention provides polynucleotides encoding potassium channels as well as methods of using the potassium channels to treat and diagnose diabetes and a predisposition for diabetes.
摘要翻译：本发明提供编码钾通道的多核苷酸以及使用钾通道治疗和诊断糖尿病和糖尿病倾向的方法。

54. 发明授权

US07014780B2 Stand alone water purifier system 有权
公开(公告)号：US07014780B2
公开(公告)日：2006-03-21
申请号：US10682596
申请日：2003-10-09
申请人： Joseph A. King , Jeffrey D. Johnson
发明人： Joseph A. King , Jeffrey D. Johnson
IPC分类号： C02F1/00
CPC分类号： B01F1/0027 , B01F5/0413 , B01F5/0496 , C02F1/50 , C02F1/688 , C02F2103/003 , C02F2103/42 , C02F2303/04 , Y10T137/4891
摘要： A water treatment device, method and system with the water treatment device having a container for holding a water treatment material therein with the water treatment device including a shroud extending in a direction generally normal to a flow of debris laden water with the shroud inhibiting direct flow of debris into a water inlet in the water treatment device by directing water and debris over the shroud and around the water treatment device while a portion of the water can be directed laterally into the water treatment material within the water treatment device to thereby purify the water that flows over the water treatment materials with the water treatment device including multiple spaced and positioned water inlets so that the likelihood of the water inlet being completely obstructed is remote.

55. 发明授权

US06562242B2 Stand alone water purifier 有权
公开(公告)号：US06562242B2
公开(公告)日：2003-05-13
申请号：US10104854
申请日：2002-03-22
申请人： Joseph A. King , Jeffrey D. Johnson
发明人： Joseph A. King , Jeffrey D. Johnson
IPC分类号： C02F176
CPC分类号： B01F1/0027 , B01F5/0413 , B01F5/0496 , C02F1/50 , C02F1/688 , C02F2103/003 , C02F2103/42 , C02F2303/04 , Y10T137/4891
摘要： A water purification device, method and system with the water purification device having a container for holding a water purification material therein with the water purification device including a shroud extending in a direction generally normal to a flow of debris laden water with the shroud inhibiting direct flow of debris into a water inlet in the water purification device by directing water and debris over the shroud and around the water purification device while a portion of the water can be directed laterally into the water purification material within the water purification device to thereby purify the water that flows over the water purification materials with the water purification device including multiple spaced and positioned water inlets so that the likelihood of the water inlet being completely obstructed is remote.

56. 发明授权

US4799140A Majority vote sequencer 失效
标题翻译：多数投票顺序
公开(公告)号：US4799140A
公开(公告)日：1989-01-17
申请号：US837059
申请日：1986-03-06
申请人： Ronald P. Dietz , Jeffrey D. Johnson
发明人： Ronald P. Dietz , Jeffrey D. Johnson
IPC分类号： G06F11/18 , G06F11/08
CPC分类号： G06F11/185 , G06F11/187
摘要： An electronic sequencing system comprised of two groups of three identically operating sequencers and circuitry that combines the outputs of these sequencers so that accurate, flexible and reliable sequencing of devices is obtained. Each sequencer is comprised of a microprocessor, memory, and peripheral circuits. The individual sequencer outputs are combined such that at least one of the corresponding system outputs will activate the device to be sequenced if at least two of three corresponding individual sequencer outputs signal that the device should be activated. Additional reliability is obtained by combining the outputs of each group of the identically operating sequencers to control the devices to be sequenced. Reset circuitry is also provided to simultaneously reset the sequencers and to prevent premature outputs from activating the devices to be sequenced.
摘要翻译：电子测序系统由两组三个相同操作的顺控程序和电路组成，组合了这些定序器的输出，从而获得了器件的精确，灵活和可靠的排序。每个定序器由微处理器，存储器和外围电路组成。组合各个定序器输出使得如果三个相应的单独定序器输出中的至少两个输出信号表明该设备应该被激活，则相应的系统输出中的至少一个将激活要被排序的设备。通过组合各组相同操作的顺控程序的输出来控制要排序的设备，可以获得额外的可靠性。还提供复位电路以同时复位定序器并防止过早输出激活要排序的设备。

57. 发明申请

US20190322557A1 Floating dispensers 审中-公开
公开(公告)号：US20190322557A1
公开(公告)日：2019-10-24
申请号：US15932790
申请日：2018-04-24
申请人： Joseph A. King , Paul Freeberg , Jeffrey D. Johnson , Lyle Enderson , Donald Dalland , Terry Goeman
发明人： Joseph A. King , Paul Freeberg , Jeffrey D. Johnson , Lyle Enderson , Donald Dalland , Terry Goeman
IPC分类号： C02F1/68 , C02F1/76 , B01F1/00 , B01F13/00
摘要： A floating dispenser having an external float or an internal float for supporting a cartridge or cartridges for floatingly delivering a dispersant or dispersants to a body of water with the floating dispenser having cartridges rotationally positionable with respect to one another to control the rate of dispensing while the dispenser floats in an upright condition with the floating dispenser changing its flotation orientation in response to consumption of the dispersant or dispersants in the a cartridge to thereby provide a visual alert to replace a spent cartridge with a fresh cartridge. In addition, the inventions described herein permit changing the dispensing nature of the system from a multiple dispensing system to a single dispensing system without changing the floating characteristics of the floating dispensers through replacement of a dispersant in one of the cartridges with an inert or ballast material that has no effect on the water characteristics.

58. 发明授权

US10047535B2 Dispenser and multi-cartridge systems 有权
公开(公告)号：US10047535B2
公开(公告)日：2018-08-14
申请号：US14544677
申请日：2015-02-03
申请人： Joseph A. King , Jeffrey D. Johnson , Lyle Enderson , Paul Freeberg , Donald Dalland , Terry Goeman
发明人： Joseph A. King , Jeffrey D. Johnson , Lyle Enderson , Paul Freeberg , Donald Dalland , Terry Goeman
IPC分类号： E04H4/16 , C02F1/00 , C02F1/68 , E04H4/12 , C02F1/50 , C02F1/76 , C02F9/00 , C02F103/42
摘要： A dispenser system for delivering various combinations of dispersants to a body of water with the various combinations of dispersants supplied to the body of water through the interchanging of dispensing cartridges which are attachable to a main dispensing cartridge where a condition for interchanging of dispensing cartridges may be triggered by an event.

59. 发明申请

US20170216783A1 DISPENSING SYSTEM 审中-公开
公开(公告)号：US20170216783A1
公开(公告)日：2017-08-03
申请号：US15530222
申请日：2016-12-13
申请人： David Guy , Jeffrey D. Johnson , Paul Freeberg , Terry Goeman , Lyle Enderson
发明人： David Guy , Jeffrey D. Johnson , Paul Freeberg , Terry Goeman , Lyle Enderson
IPC分类号： B01F1/00
CPC分类号： B01F1/0027 , B01F1/0033 , B01F2215/0052 , Y10T137/4891
摘要： A dispensing system for delivery of a dispersant from a canister containing an erodible but cakeable water dispersant wherein the cakeable water dispersant in a one piece caked condition falls to a bottom of a divergent walled canister so the water flowing through a bottom portion of the canister continues to maintain erodible contact with the dispersant as the water disperant is consumed.

60. 发明授权

US09039903B2 Method of conditioning a body of water by delivering different dispersant combinations through a floating generally spherical dispenser system 有权
标题翻译：通过一种漂浮的大体上球形的分配器系统递送不同的分散剂组合来调节水体的方法
公开(公告)号：US09039903B2
公开(公告)日：2015-05-26
申请号：US13694209
申请日：2012-11-07
申请人： Joseph A. King , Jeffrey D. Johnson , Lyle Enderson , Paul Freeberg , Donald Dalland
发明人： Joseph A. King , Jeffrey D. Johnson , Lyle Enderson , Paul Freeberg , Donald Dalland
IPC分类号： B01D11/00 , B01D12/00 , C02F1/00 , C02F1/68 , E04H4/12 , A01K63/04
CPC分类号： E04H4/1281 , C02F1/505 , C02F1/688 , C02F1/76 , C02F2103/42 , C02F2201/006
摘要： A dispenser system for delivering various combinations of dispersants to a body of water with the various combinations of dispersants supplied to the body of water through the interchanging of dispensing cartridges which are attachable to a main dispensing cartridge where a condition for interchanging of dispensing cartridges may be triggered by an event.
摘要翻译：一种分配器系统，用于将分散剂的各种组合递送到水体中，其中分散剂的各种组合通过可连接到主分配盒的分配盒的互换而供应到水体中，其中分配盒的互换条件可以是由事件触发。

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