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51. 发明申请

WO2017161348A1 EFFECTIVE OCULAR LENS POSITIONING METHODS AND APPARATUS 审中-公开
标题翻译：有效的透镜定位方法和设备
公开(公告)号：WO2017161348A1
公开(公告)日：2017-09-21
申请号：PCT/US2017/023092
申请日：2017-03-17
申请人： ALEYEGN TECHNOLOGIES, LLC
发明人： HEREKAR, Rajeev , HEREKAR, Satish, V.
IPC分类号： A61F9/007 , A61F9/008 , A61B3/036 , A61B3/103
CPC分类号： A61F9/007 , A61B3/0025 , A61B3/103 , A61B18/12 , A61B2090/3735 , A61F9/00802 , A61F9/00804 , A61F9/00821 , A61F2009/00842 , A61F2009/00844 , A61F2009/00859 , A61F2009/00865 , A61F2009/0087 , A61F2009/00895 , A61N7/02
摘要： The methods and apparatus disclosed herein can be used to adjust the effective lens position ("ELP") of the eye in order to correct refractive error of the eye. The methods and apparatus can be configured to apply energy to the sclera and other regions of the eye in order to adjust the effective lens positon of the eye for far vision. The sclera can be treated in order to shrink or relax the sclera, and combinations thereof in order to adjust the position of the lens of the eye in order to correct vision related to refractive error of the eye. A target location of the lens can be determined to correct the refractive error of the eye, and the energy applied in order to move the lens toward the target location.
摘要翻译：这里公开的方法和装置可以用于调节眼睛的有效透镜位置（“ELP”），以校正眼睛的屈光不正。该方法和设备可以被配置为将能量施加到眼睛的巩膜和其他区域，以便调节用于远视的眼睛的有效透镜位置。可以治疗巩膜以便收缩或松弛巩膜及其组合，以调整眼睛晶状体的位置以矫正与眼睛屈光不正相关的视力。可以确定镜片的目标位置以校正眼睛的屈光不正，以及为了将镜片移向目标位置而施加的能量。

52. 发明申请

WO2016141053A1 PEPTIDES FOR INHIBITING ANGIOGENESIS 审中-公开
标题翻译：抑制血管生成的肽
公开(公告)号：WO2016141053A1
公开(公告)日：2016-09-09
申请号：PCT/US2016/020443
申请日：2016-03-02
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
发明人： KOMAROVA, Yulia, A. , ROSENBLATT, Mark , MALIK, Asrar, B.
IPC分类号： A61K38/08 , A61K38/10 , A61P27/00
CPC分类号： A61K38/10 , A61B3/102 , A61B3/1241 , A61F9/00821 , A61F2009/00851 , A61F2009/00863 , A61F2009/00865 , A61F2009/00872 , A61K38/08 , A61K45/06
摘要： The present invention relates to peptides for inhibiting angiogenesis. The present invention also relates to methods of inhibiting angiogenesis and methods of treating disorders associated with VEGF-induced vascular permeability using the peptides of the invention.
摘要翻译：本发明涉及抑制血管生成的肽。本发明还涉及使用本发明的肽抑制血管发生的方法和治疗与VEGF诱导的血管通透性相关的病症的方法。

53. 发明申请

WO2016061454A1 CORNEAL TOPOGRAPHY MEASUREMENTS AND FIDUCIAL MARK INCISIONS IN LASER SURGICAL PROCEDURES 审中-公开
标题翻译：激光手术过程中的角膜测量和FIDUCAL MARK INCISIONS
公开(公告)号：WO2016061454A1
公开(公告)日：2016-04-21
申请号：PCT/US2015/055936
申请日：2015-10-16
申请人： OPTIMEDICA CORPORATION
发明人： SRINIVASAN, Rajeshwari , GOLDA, Jeffrey, A. , GONZALEZ, Javier, G. , SCOTT, David, D. , DEWEY, David, A. , BAREKET, Noah , SCHUELE, Georg
IPC分类号： A61F9/008
CPC分类号： A61F9/00825 , A61F2009/00865 , A61F2009/0087 , A61F2009/00872 , A61F2009/00882
摘要： A method of cataract surgery in an eye of a patient includes identifying a feature selected from the group consisting of an axis, a meridian, and a structure of an eye by corneal topography and forming fiducial mark incisions with a laser beam along the axis, meridian or structure in the cornea outside the optical zone of the eye. A laser cataract surgery system a laser source, a topography measurement system, an integrated optical subsystem, and a processor in operable communication with the laser source, corneal topography subsystem and the integrated optical system. The processor includes a tangible non- volatile computer readable medium comprising instructions to determine one of an axis, meridian and structure of an eye of the patient based on the measurements received from topography measurement system, and direct the treatment beam so as to incise radial fiducial mark incisions.
摘要翻译：在患者眼睛中的白内障手术的方法包括通过角膜形貌识别选自由轴，子午线和眼睛结构组成的组的特征，并且沿着轴线形成具有激光束的基准标记切口，子午线或在眼睛的光学区域外的角膜中的结构。激光白内障手术系统，激光源，地形测量系统，集成光学子系统和与激光源，角膜地形子系统和集成光学系统可操作地通信的处理器。处理器包括有形的非易失性计算机可读介质，其包括用于基于从地形测量系统接收的测量值来确定患者的眼睛的轴线，子午线和结构之一的指令，并且引导治疗束以切割径向基准标记切口。

54. 发明申请

WO2014150601A2 SCLERAL TRANSLOCATION ELASTO-MODULATION METHODS AND APPARATUS 审中-公开
公开(公告)号：WO2014150601A2
公开(公告)日：2014-09-25
申请号：PCT/US2014/023763
申请日：2014-03-11
申请人： BRIDGE LABS, LLC
发明人： HEREKAR, Satish , HEREKAR, Rajeev
IPC分类号： A61N5/067
CPC分类号： A61F9/00821 , A61F9/008 , A61F2009/00865 , A61F2009/00868 , A61F2009/00895
摘要： A laser delivery system is configured to delivery light energy to soften and realign the tissue of the eye in order to increase accommodation and treat glaucoma. The laser system can be configured to increase a circumlental space of the eye and increase movement of a posterior vitreous zonule in order to increase accommodation. The light energy may comprise wavelengths strongly absorbed by collagen of the sclera. In many embodiments a heat sink is provided to couple to the conjunctiva and the heat sink comprises a material transmissive to the light energy absorbed by collagen, for example Zinc Selenide. The heat sink can be chilled to inhibit damage to the conjunctiva of the eye. In many embodiments, one or more layers of the epithelium of the eye remain substantially intact above the zone where the eye has been treated when the heat sink has been removed.
摘要翻译：激光输送系统被配置为递送光能以软化和重新对准眼睛的组织，以便增加住院和治疗青光眼。激光系统可以被配置为增加眼睛的周围空间并增加后玻璃体区的运动，以增加适应度。光能可以包括由巩膜的胶原强烈吸收的波长。在许多实施例中，提供散热器以耦合到结膜，并且散热器包括透射由胶原吸收的光能的材料，例如硒化锌。可以冷却散热器以抑制对眼结膜的损伤。在许多实施方案中，眼睛的上皮的一层或多层在已经去除了散热器的地方已经被处理的区域上保持基本完整。

55. 发明申请

WO2013126498A1 DEVICE AND METHOD FOR TREATMENT OF RETINAL DETACHMENT AND OTHER MALADIES OF THE EYE 审中-公开
标题翻译：用于治疗眼睛剥离和眼睛的其他疾病的装置和方法
公开(公告)号：WO2013126498A1
公开(公告)日：2013-08-29
申请号：PCT/US2013/027016
申请日：2013-02-21
申请人： SCHACHAR, Ira, H. , SCHACHAR, Ronald, A.
发明人： SCHACHAR, Ira, H. , SCHACHAR, Ronald, A.
IPC分类号： A61F9/007 , A61F9/00 , A61L31/02
CPC分类号： A61F9/00727 , A61F2/14 , A61F2/147 , A61F2/91 , A61F9/007 , A61F9/00781 , A61F2009/00863 , A61F2009/00865 , A61F2210/0004 , A61F2240/001 , A61F2250/0067
摘要： [0066] The present invention relates generally to a device and method for the treatment of retinal detachment, ocular hypertension and glaucoma, and increasing the amplitude of accommodation. In an illustrative embodiment, the device includes a tapered, mesh tube. Once the device is within the sclera, the mesh expands to deform the sclera. When the device is placed within the posterior sclera for the treatment of a retinal tear, the device expands deforming the sclera so that the retinal pigment epithelium comes in contact with the retinal tear to seal the tear. For the treatment of ocular hypertension, glaucoma and to increase the amplitude of accommodation, the device is placed within the anterior sclera over the posterior plicata of the ciliary body, which upon expansion causes the underlying ciliary body to deform, resulting in traction on the trabecular meshwork and deformation of the ciliary body, which causes lowering of intraocular pressure, and increases the amplitude of accommodation in patients with ocular hypertension or decreased accommodation.
摘要翻译：本发明一般涉及用于治疗视网膜脱离，眼高压和青光眼以及增加调节幅度的装置和方法。在说明性实施例中，该装置包括锥形网眼管。一旦装置在巩膜内，则网孔膨胀以使巩膜变形。当装置放置在后巩膜内用于治疗视网膜撕裂时，该装置扩张巩膜变形，使得视网膜色素上皮与视网膜撕裂接触以密封泪液。为了治疗高眼压症，青光眼和增加调节幅度，装置放置在睫状体后面的前巩膜内，在扩张后使下睫状体发生变形，导致小梁上的牵引睫状体的网状和变形，导致眼内压降低，并增加患有高眼压症或适应性降低的患者的适应范围。

56. 发明申请

WO2010046987A1 眼球の強膜伸展性低下補完方法、及びその方法に使用されるフェムト秒レーザの制御方法、並びにその方法で使用されるスペーサ审中-公开
标题翻译：完成OCARA SCLERA可扩展性降低的方法，控制在方法中使用的FEMTOSECOND激光的方法和方法中使用的间隔
公开(公告)号：WO2010046987A1
公开(公告)日：2010-04-29
申请号：PCT/JP2008/069268
申请日：2008-10-23
申请人：吉田憲次 , 志村好美
发明人：吉田憲次
IPC分类号： A61F9/007 , A61F2/14 , A61F9/00
CPC分类号： A61F9/008 , A61F2/14 , A61F9/00827 , A61F9/00838 , A61F2009/00865 , A61F2009/00872
摘要：　角膜輪部（７）の近傍における角膜実質層（９１）内に角膜表面（９２）と平行な輪状又は円弧状の第１切開創面（１０）と、この第１切開創面（１０）から角膜表面（９２）にまで達する第２切開創面（２０）とを、フェムト秒レーザにより形成する。これによって角膜周辺部から角膜輪部（７）の間に柔軟性の高い部位を作成し、外眼筋（２）の眼球付着部（３）と角膜輪部（７）との間に位置する強膜（５）の伸展性の低下を補完する。
摘要翻译：在靠近角膜环（7）的角膜的实质层（91）中，平行于角膜表面（92）的环形或弧形的第一切割面（10）和从角膜表面延伸的第二切口面用飞秒激光形成到角膜表面（92）的第一切割面（10）。因此，在角膜周边和角膜环（7）之间形成高柔性部分，使得位于外眼睛的眼球附着部位（3）之间的眼巩膜（5）的伸展性降低 2）和角膜环（7）相互补充。

57. 发明申请

WO2008052081A2 PHOTOCHEMICAL THERAPY TO AFFECT MECHANICAL AND/OR CHEMICAL PROPERTIES OF BODY TISSUE 审中-公开
标题翻译：影响身体组织的机械和/或化学特性的光化学治疗
公开(公告)号：WO2008052081A2
公开(公告)日：2008-05-02
申请号：PCT/US2007082435
申请日：2007-10-24
申请人： CALIFORNIA INST OF TECHN , UNIV CALIFORNIA
发明人： SCHWARTZ DANIEL M , MATISON MATTHEW S , KORNFIELD JULIA A , MALONEY ROBERT K , GRUBBS ROBERT H
IPC分类号： A61M5/00
CPC分类号： A61K9/0048 , A61F9/0079 , A61F9/008 , A61F2009/00865 , A61F2009/00872 , A61F2009/00893 , A61K9/0051 , A61K9/19 , A61K31/00
摘要： The disclosure concerns altering the mechanical and/or chemical property of a body tissue, particularly an ocular tissue. In specific cases, it concerns altering or stabilizing the shape of the cornea, such as in a subject suffering or at risk for ectasia or keratoconus. In other specific cases, it concerns strengthening the sclera in a subject suffering or at risk for myopia. The invention employs light irradiation of a photoactivatable compound, such as one that applies crosslinking to the tissue, for example.
摘要翻译：本公开涉及改变身体组织，特别是眼组织的机械和/或化学性质。在具体情况下，它涉及改变或稳定角膜的形状，例如患有或具有扩张或圆锥角膜风险的受试者。在其他具体情况下，它涉及加强遭受或面临近视眼的受试者的巩膜。本发明使用例如对组织进行交联的可光活化化合物的光照射。

58. 发明申请

WO2006099594A2 SYSTEM AND METHOD FOR TREATING CONNECTIVE TISSUE 审中-公开
标题翻译：用于治疗连接组织的系统和方法
公开(公告)号：WO2006099594A2
公开(公告)日：2006-09-21
申请号：PCT/US2006/009867
申请日：2006-03-15
申请人： ACE VISION USA, INC. , HIPSLEY, AnnMarie
发明人： HIPSLEY, AnnMarie
IPC分类号： A61B18/18
CPC分类号： A61F9/008 , A61F9/00802 , A61F9/00808 , A61F9/00821 , A61F9/00825 , A61F9/00838 , A61F2009/00865
摘要： A method and system of treating connective tissue to increase flexibility of the connective tissue or decrease tension in the connective tissue includes forming perforations in the connective tissue to at least 90% of the depth or thickness of the connective tissue and maintaining the perforations in the connective tissue. The method alters the tissue to enhance the . fundamental mechanisms involved the immunology, biochemistry, and molecular genetics of the metabolism of the connective tissue. The connective tissue may be any desired connective tissue, such as scleral tissue of the eye. The connective tissue of the eye may be removed to form a first desired pattern of perforations in the connective tissue of the eye at a first distance from the corneal center of the eye. The first desired pattern of perforations may have a plurality of perforations. Connective tissue is removed from the eye to form a second desired pattern of perforations in the tissue of the eye at a second distance from the corneal center of the eye. The second desired pattern of perforations may have a plurality of perforations.
摘要翻译：治疗结缔组织以增加结缔组织的柔性或降低结缔组织中的张力的方法和系统包括将结缔组织中的穿孔形成结缔组织的深度或厚度的至少90％并保持结缔组织中的穿孔组织。该方法改变组织以增强。基本机制涉及结缔组织代谢的免疫学，生物化学和分子遗传学。结缔组织可以是任何期望的结缔组织，例如眼睛的巩膜组织。可以去除眼睛的结缔组织，以在距离眼睛的角膜中心的第一距离处在眼睛的结缔组织中形成第一期望的穿孔图案。第一期望的穿孔图案可以具有多个穿孔。从眼睛去除结缔组织，以在距离眼睛的角膜中心的第二距离处在眼组织中形成第二期望的穿孔图案。穿孔的第二期望图案可以具有多个穿孔。

59. 发明申请

WO2005096766A2 METHODS AND APPARATUS FOR TREATMENT OF OCULAR MELANOSIS 审中-公开
标题翻译：用于治疗眼部黑色素瘤的方法和设备
公开(公告)号：WO2005096766A2
公开(公告)日：2005-10-20
申请号：PCT/US2005/011438
申请日：2005-04-04
申请人： THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL , ANDERSON, Richard, Rox , AKITA, Hirotaka
发明人： ANDERSON, Richard, Rox , AKITA, Hirotaka
IPC分类号： A61B18/20 , A61F9/009 , A61N5/067
CPC分类号： A61F9/009 , A61B18/203 , A61B2018/00452 , A61F9/008 , A61F2009/00865
摘要： The invention entails a novel system and method for modifying scleral pigmentation. More particularly, the invention entails a novel system and method for treating Ocular Melanosis (OM). The invention contemplates a system and method for treating OM that uses lasers with modified pulse widths and low power to whiten the sclera without causing damage to the retina. Ultimately, a system has been developed that uses of low laser pulse fluences considerably less than those used for treating nevus of Ota on the skin. The system limits the risk of retinal injury by use of (a) a small exposure spot size and (b) a high numerical aperture (NA) optical beam with fluences of between about 0.5 J/cm 2 and 5.0 J/Am 2 , significantly lower than many currently available laser treatments. In a preferred embodiment, the system of the invention uses a laser with a wavelength in the visible and near-infrared spectrum and a pulse width from about 1 ns - 100 microseconds.
摘要翻译：本发明需要一种用于修饰巩膜色素沉着的新系统和方法。更具体地说，本发明涉及用于治疗眼部黑色素病（OM）的新颖系统和方法。本发明设想了一种用于治疗OM的系统和方法，该系统和方法使用具有改变的脉宽和低功率的激光来增白巩膜而不会损伤视网膜。最终，已经开发了一种系统，该系统使用低于用于治疗皮肤上太田痣的激光脉冲通量的低激光脉冲通量。该系统通过使用（a）小曝光点尺寸和（b）高数值孔径（NA）光束以及约0.5J / cm 2和 5.0 J / Am <2>，明显低于许多现有的激光治疗。在一个优选实施例中，本发明的系统使用具有可见光和近红外光谱波长以及约1ns-100微秒的脉冲宽度的激光器。

60. 发明申请

WO1992014415A1 METHOD AND DEVICE FOR MONITORING TISSUE TREATMENT BY MEANS OF PULSED LASER LIGHT 审中-公开
标题翻译：通过脉冲激光监测组织治疗的方法和装置
公开(公告)号：WO1992014415A1
公开(公告)日：1992-09-03
申请号：PCT/DE1992000054
申请日：1992-01-25
申请人： MEDIZINISCHES LASERZENTRUM LÜBECK GMBH , SCHEU, Manfred , ENGELHARDT, Ralf , WETZEL, Wolfgang
发明人： MEDIZINISCHES LASERZENTRUM LÜBECK GMBH
IPC分类号： A61B17/36
CPC分类号： B23K26/032 , A61B18/20 , A61B2018/00636 , A61F9/008 , A61F2009/00844 , A61F2009/00865
摘要： In the method disclosed, the laser light is led up to the tissue on which it is intended to operate by means of a fibre-optic cable. Light is reflected for measurement purposes from the end of the fibre-optic cable and this measurement light fed to a processing unit (6) which determines the intensity of the reflected light in relation to the timing of the laser pulse to measure a property characteristic of the tissue. After one laser pulse, measurement light is directed through the fiber-optic cable (2) at the tissue. Alternatively, the measurement light may be directed at the tissue continuously. Immediately following the laser pulse, a property characteristic of the tissue is determined from the reflected measurement light.

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