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    • 59. 发明申请
    • DEVICE FOR ACCOMMODATING A FREEZE-DRIED PHARMACEUTICAL PRODUCT AND METHOD OF MANUFACTURING A SEALED VESSEL ACCOMMODATING A FREEZE-DRIED PHARMACEUTICAL PRODUCT
    • 用于容纳冷冻干燥药用产品的装置以及制造冷冻干燥药用产品的密封容器的方法
    • US20150041498A1
    • 2015-02-12
    • US14374971
    • 2013-02-11
    • Arte Corporation
    • Makoto KakiuchiSeiji ShimazakiTeruo MatsudaAndreas Schuetz
    • B65D83/00A61J1/20B65B63/08A61J3/00B65B7/28
    • B65D83/005A61J1/20A61J3/00A61M5/284A61M2005/3123B65B3/003B65B7/2821B65B63/08B65B2220/14B65B2230/02
    • A device for accommodating a freeze-dried pharmaceutical product (S) for reconstitution, comprising: a vessel (1) having at its opening end (3) an opening edge (4) and an adjoining longitudinal portion (5) with an evenly formed inner cross section, a front plunger (2) to be positioned inside the vessel (1) at the longitudinal portion (5), wherein the front plunger (2) is configured to be positioned inside the vessel (1) in a sealing state, in which the front plunger (2) is fully inserted in the vessel (1), or in an exchange state, in which the front plunger (2) is inserted partly in the vessel (1) and partly protrudes over the opening edge (4) of the vessel (1), and wherein the front plunger (2) comprises sealing means that are configured to seal the inside of the vessel (1) against the outside when the front plunger (2) is positioned in the sealing state, and one or more communicating grooves (2i) that are configured to place the inside and outside of the vessel (1) in communication with each other when the front plunger (2) is positioned in the exchange state, is characterized in that the sealing means are dimensioned and/or structured in such a way that the front plunger (2), when an underpressure of predefined strength is applied to the outer environment of the vessel (1), is caused to move inside the vessel (1) toward its opening end (3). Furthermore, a method of manufacturing a sealed vessel (1) accommodating a freeze-dried pharmaceutical product (S) is disclosed.
    • 一种用于容纳用于重构的冷冻干燥药物(S)的装置,包括:容器(1),其开口端(3)具有开口边缘(4)和相邻的纵向部分(5),所述容器 横截面,在纵向部分(5)处定位在容器(1)内部的前柱塞(2),其中前柱塞(2)构造成处于密封状态位于容器(1)的内部, 其中前柱塞(2)完全插入容器(1)中,或者处于交换状态,其中前柱塞(2)部分地插入容器(1)中并且部分地突出在开口边缘(4)上, ,并且其中所述前柱塞(2)包括密封装置,所述密封装置构造成当所述前柱塞(2)处于密封状态时将所述容器(1)的内部抵靠在外部密封,并且一个 或更多的连通槽(2i),其构造成将容器(1)的内部和外部放置在通信w中 当前柱塞(2)位于交换状态时彼此相对的特征在于,密封装置的尺寸和/或结构使得当前柱塞(2)施加预定强度的负压时 使容器(1)的外部环境朝向其开口端(3)移动到容器(1)内。 此外,公开了一种制造容纳冷冻干燥药物(S)的密封容器(1)的方法。