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51. 发明申请

US20170176401A1 Secondary Ultrasonic Nebulisation 审中-公开
公开(公告)号：US20170176401A1
公开(公告)日：2017-06-22
申请号：US15387133
申请日：2016-12-21
申请人： Micromass UK Limited
发明人： Stevan BAJIC , David S DOUCE , Gordon A JONES
IPC分类号： G01N30/72 , H01J49/04 , B05B17/06 , G01N30/06
CPC分类号： G01N30/724 , B05B17/0607 , B05B17/0623 , G01N30/06 , G01N2030/8447 , G01N2030/8452 , G01N2030/8458 , H01J49/0445 , H01J49/045 , H01J49/0454
摘要： A secondary ultrasonic nebulisation device is disclosed comprising: a liquid sample delivery capillary; a sample receiving surface arranged for receiving a liquid sample from the capillary; and an ultrasonic transducer configured for oscillating the surface so as to nebulise the liquid sample received thereon, wherein the device is configured such that the oscillations of the surface by the ultrasonic transducer cause charged droplets and/or gas phase ions to be generated from the sample.

52. 发明申请

US20160377636A1 MASS SPECTROMETRY ASSAY FOR ESTROGENIC COMPOUNDS 审中-公开
标题翻译：雌激素化合物的质谱分析
公开(公告)号：US20160377636A1
公开(公告)日：2016-12-29
申请号：US15251224
申请日：2016-08-30
申请人： QUEST DIAGNOSTICS INVESTMENTS INCORPORATED
发明人： Midred GOLDMAN , Nigel CLARKE
IPC分类号： G01N33/74 , H01J49/00 , G01N30/72
CPC分类号： G01N33/743 , G01N30/724 , G01N33/6848 , G01N33/6851 , G01N2458/15 , H01J49/00 , H01J49/0027
摘要： Methods are provided for detecting the amount of one or more HRT panel analytes (i.e., estrone (E1), estrone sulfate (E1s), 17α-estradiol (E2a), 17β-estradiol (E2b), estradiol sulfate (E2s), estriol (E3), equilin (EQ), 17α-dihydroequilin (EQa), 17β-dihydroequilin (EQb), Equilenin (EN), 17α-dihydroequilenin (ENa), 17β-dihydroequilenin (ENb), and Δ8,9-dehydroestrone (dE1)) in a sample by mass spectrometry. The methods generally involve ionizing one or more HRT panel analytes in a sample and quantifying the generated ions to determine the amount of one or more HRT panel analytes in the sample. In methods where amounts of multiple HRT panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection.
摘要翻译：提供了用于检测一种或多种HRT面板分析物（即雌酮（E1），硫酸雌酮（E1s），17α-雌二醇（E2a），17β-雌二醇（E2b）），硫酸雌二醇（E2s），雌三醇 E3），平衡（EQ），17α-二氢等位基因（EQa），17β-二氢比例蛋白（EQb），平衡蛋白（EN），17α-二氢马来西林（ENa），17β-二氢马来西林（ENb）和Δ8,9-脱氢雌酮（dE1））在样品中通过质谱法测定。所述方法通常涉及将样品中的一种或多种HRT面板分析物离子化并量化产生的离子以确定样品中一种或多种HRT面板分析物的量。在检测到多个HRT面板分析物的量的方法中，在相同的样品注入中检测到多种分析物的量。

53. 发明授权

US09400267B2 Versatile ambient ionization-based interface for LC/MS 有权
标题翻译：用于LC / MS的通用环境电离接口
公开(公告)号：US09400267B2
公开(公告)日：2016-07-26
申请号：US14889625
申请日：2013-10-02
申请人： Ohio University
发明人： Hao Chen , Yi Cai
IPC分类号： G01N30/72
CPC分类号： G01N30/724 , G01N30/7233 , G01N2030/8429 , H01J49/145
摘要： An apparatus (10) for coupling liquid chromatography with mass spectrometry and for splitting and analyzing a liquid sample includes a fluid conduit (16), which defines a flow passage (18) and is configured to supply the liquid sample. The fluid conduit (16) has an outer surface and a micro-hole (30) through the outer surface into the flow passage (18). The apparatus (10) also includes an ambient ionizer (40) configured to generate and direct a charged solvent (44) toward the micro-hole (30) at the outer surface for ionizing a portion of the liquid sample (32) that emerges out of the micro-hole (30). The apparatus (10) further includes a mass spectrometer (60) having a sample entrance (62) adjacent the micro-hole (30) configured to analyze an ionized portion of the liquid sample (54).
摘要翻译：用于将液相色谱与质谱耦合并用于分离和分析液体样品的装置（10）包括限定流路（18）并被配置为供应液体样品的流体导管（16）。流体管道（16）具有外表面和穿过外表面进入流动通道（18）的微孔（30）。设备（10）还包括环境离子发生器（40），其被配置为在外表面处向带电溶剂（44）产生并引导微孔（30），用于离开出现的液体样品（32）的一部分的微孔（30）。装置（10）还包括质谱仪（60），其具有邻近微孔（30）的样品入口（62），该样品入口构造成分析液体样品（54）的离子化部分。

54. 发明申请

US20150371837A1 METHOD AND DEVICE FOR MASS SPECTROMETRY 有权
标题翻译：用于质谱分析的方法和装置
公开(公告)号：US20150371837A1
公开(公告)日：2015-12-24
申请号：US14762916
申请日：2014-01-27
申请人： HITACHI HIGH-TECHNOLOGIES CORPORATION
发明人： Hiroyuki YASUDA , Shinya ITO , Akira FUJII , Yasushi TERUI
IPC分类号： H01J49/04 , G01N30/72
CPC分类号： H01J49/0445 , G01N30/724 , H01J49/165
摘要： A mass spectrometry is equipped with a liquid specimen supply part which supplies a liquid specimen sandwiched between bubbles, an ion source part ionizes the specimen, and a mass spectrometry part which detects ions separated in accordance with mass. In particular the ion source part is configured so as to include a liquid supply tube for transporting a specimen from the liquid specimen supply part, a degassing/liquid retention part in which bubbles are removed, a spraying part which ionizes the specimen, and a high-voltage power supply part which applies a high voltage to the spraying part. The device is further characterized in that after removing the bubbles, a Taylor cone is formed from the resultant pre-solution, and the specimen is ionized thereafter. Thus, the ionization of an intended specimen is stabilized, and the measurement reproducibility is improved.
摘要翻译：质谱仪配备有液体试样供给部件，其供给夹在气泡之间的液体试样，离子源部件将样品离子化，以及检测根据质量分离的离子的质谱部分。特别地，离子源部构成为包括用于从液体试样供给部输送试样的液体供给管，除去气泡的脱气/液体滞留部，使样本电离的喷射部， - 对喷涂部施加高电压的电压电源部。该装置的特征还在于，在除去气泡之后，由所得预溶液形成泰勒锥体，然后将样品电离。因此，期望的样品的电离稳定，并且测量再现性提高。

55. 发明申请

US20150309001A1 METHODS OF ANALYZING CRUDE OIL 有权
标题翻译：分析原油的方法
公开(公告)号：US20150309001A1
公开(公告)日：2015-10-29
申请号：US14426879
申请日：2014-01-23
申请人： PURDUE RESEARCH FOUNDATION
发明人： Robert Graham Cooks , Fred Paul Mark Jjunju , Anyin Li , Iman S. Roqan
IPC分类号： G01N33/28 , H01J49/10 , H01J49/00
CPC分类号： G01N33/2823 , G01N30/724 , G01N30/7266 , H01J49/0031 , H01J49/04 , H01J49/10 , H01J49/164
摘要： The invention generally relates to methods of analyzing crude oil. In certain embodiments, methods of the invention involve obtaining a crude oil sample, and subjecting the crude oil sample to mass spectrometry analysis. In certain embodiments, the method is performed without any sample pre-purification steps.
摘要翻译：本发明一般涉及分析原油的方法。在某些实施方案中，本发明的方法涉及获得原油样品，并对原油样品进行质谱分析。在某些实施方案中，该方法在没有任何样品预纯化步骤的情况下进行。

56. 发明申请

US20150290644A1 Electromechanical and Fluidic Interface To A Microfluidic Substrate 审中-公开
标题翻译：机电和流体界面到微流体底物
公开(公告)号：US20150290644A1
公开(公告)日：2015-10-15
申请号：US14747074
申请日：2015-06-23
申请人： Waters Technologies Corporation
发明人： David P. Prentice , Russell L. Keene , Stanislaw Koziol , Joseph D. Michienzi , Paul E. Linderson , Gary W. Bertone
IPC分类号： B01L3/00
CPC分类号： B01D15/10 , B01L3/5027 , B01L3/502715 , B01L3/502753 , B01L3/563 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2300/0816 , B01L2300/0883 , B05B1/00 , B05B1/02 , G01N27/44791 , G01N30/6095 , G01N30/72 , G01N30/7233 , G01N30/724 , G01N30/7266 , H01J49/167 , Y10T137/598 , Y10T436/24
摘要： A liquid-chromatography module includes a microfluidic cartridge housing a microfluidic substrate with a channel for transporting fluid. The microfluidic substrate has fluidic apertures through which fluid is supplied to the channel. One side of the cartridge has nozzle openings, each aligning with a fluidic aperture in the microfluidic substrate and receiving a fluidic nozzle. A clamping assembly has a plunger that is movable into a clamped position and an end housing that defines a chamber. One wall of the end housing has a fluidic block with fluidic nozzles extending into the chamber. A second wall has a slot through which the cartridge enters the chamber. When moved into the clamped position while the cartridge is in the chamber, the plunger urges the cartridge against the fluidic block such that each fluidic nozzle enters one nozzle opening and establishes fluidic communication with one fluidic aperture in the microfluidic substrate.
摘要翻译：液相色谱模块包括容纳具有用于输送流体的通道的微流体基板的微流体盒。微流体衬底具有流体孔，通道将流体供应到通道。墨盒的一侧具有喷嘴开口，每个与微流体基板中的流体孔对准并且接收流体喷嘴。夹紧组件具有可移动到夹紧位置的柱塞和限定腔室的端部壳体。端部壳体的一个壁具有流体块，流体喷嘴延伸到腔室中。第二壁具有狭槽，盒通过该槽进入腔室。当墨盒在腔室中移动到夹紧位置时，柱塞将墨盒推向流体块，使得每个流体喷嘴进入一个喷嘴开口并且与微流体衬底中的一个流体孔隙建立流体连通。

57. 发明授权

US08035088B2 Device, apparatus and methods for mass spectrometry 有权
标题翻译：用于质谱的装置，装置和方法
公开(公告)号：US08035088B2
公开(公告)日：2011-10-11
申请号：US12593313
申请日：2008-03-19
申请人： Michael J. Tomany , Joseph A. Jarrell , Stanislaw Koziol , Wade P. Leveille
发明人： Michael J. Tomany , Joseph A. Jarrell , Stanislaw Koziol , Wade P. Leveille
IPC分类号： H01J49/04 , H01J49/26 , B01D59/44
CPC分类号： G01N30/724 , H01J49/0445 , Y10T29/49718 , Y10T137/85938
摘要： The invention comprises apparatus for use with atmospheric pressure ionization sources in which an aerosol is formed from a solution of a sample. The aerosol is received in a hollow member and discharged outside the chamber of the ionization source in order to reduce contamination of the ionization source itself by involatile material in the solution and by previously analysed samples. The hollow member is easily removable from the ionization source to facilitate cleaning and replacement. Ionization sources, mass spectrometers, and ion mobility spectrometers comprising the apparatus are also described.
摘要翻译：本发明包括与大气压电离源一起使用的装置，其中气溶胶由样品溶液形成。气溶胶被容纳在中空构件中并且排出到电离源的室外，以便通过溶液中的非挥发性材料和先前分析的样品来减少电离源本身的污染。中空构件容易从电离源移除，以便于清洁和更换。还描述了包括该装置的电离源，质谱仪和离子迁移谱仪。

58. 发明授权

US07897917B2 Methods and apparatus for performing chromatography and mass spectroscopy with supercritical fluid samples 有权
标题翻译：用超临界流体样品进行色谱和质谱的方法和装置
公开(公告)号：US07897917B2
公开(公告)日：2011-03-01
申请号：US12127313
申请日：2008-05-27
申请人： Joseph A. Jarrell
发明人： Joseph A. Jarrell
IPC分类号： H01J49/10
CPC分类号： G01N30/724 , G01N30/7246 , H01J49/165 , B01D15/40
摘要： Embodiments of the present invention are directed to devices and methods for receiving NSC Fluids having at least one analyte from a chromatograph and directing analyte ions into the vacuum regions of a mass spectrometer. The device has a housing having at least one wall defining a chamber, sample inlet, an ionization media inlet and an outlet. The sample inlet has a position in communication with a chromatograph receiving a NSC Fluid. The sample inlet receives the NSC Fluid and directs the NSC Fluid into the chamber to form a sample jet of NSC Fluid. The ionization media inlet is placed in fluid communication with a source of ionization media and directs the ionization media into the chamber and the sample jet to create analyte ions. The analyte ions are received in the mass spectrometer vacuum region orifice.
摘要翻译：本发明的实施方案涉及用于接收具有来自色谱仪的至少一种分析物并将分析物离子导入质谱仪的真空区域的NSC流体的装置和方法。该装置具有壳体，该壳体具有限定腔室，样品入口，离子化介质入口和出口的至少一个壁。样品入口具有与接收NSC流体的色谱仪连通的位置。样品入口接收NSC流体并将NSC流体引导到室中以形成NSC Fluid的样品射流。离子化介质入口与离子化介质源流体连通，并将电离介质引导到室中，并将样品射流引导以产生分析物离子。分析离子被接收在质谱仪真空区域孔中。

59. 发明授权

US07815798B2 Discrete drop dispensing device and method of use 有权
标题翻译：离散点滴装置及其使用方法
公开(公告)号：US07815798B2
公开(公告)日：2010-10-19
申请号：US12170775
申请日：2008-07-10
申请人： Arthur Schliefer
发明人： Arthur Schliefer
IPC分类号： B01D15/08
CPC分类号： G01N30/724 , B05B17/0646 , G01N30/32 , G01N30/34 , G01N30/7273
摘要： A discrete drop dispensing device comprises a substrate comprising an upper surface and a lower surface and orifices extending from the upper surface to the lower surface, adapted to receive a fluid at a flow rate. The discrete drop dispensing device also comprises an oscillator disposed adjacent to the substrate and configured to vibrate the substrate to expel drops having a substantially equal volume of the fluid. The flow rate is substantially identical to a drop dispensing rate. A method and a device for performing liquid chromatography are also described. The method comprises automatically adjusting the drop dispensing rate to a change in the flow rate or a change in a composition of a mobile phase of the fluid.
摘要翻译：离散液滴分配装置包括包括上表面和下表面的基底以及从上表面延伸到下表面的孔口，适于以流量接收流体。离散液滴分配装置还包括与基底相邻设置的振荡器，并被配置为振动基底以排出具有基本相等体积流体的液滴。流速基本上与滴液分配速率相同。还描述了用于进行液相色谱的方法和装置。该方法包括自动调节滴液分配速率以改变流速或流体流动相的组成变化。

60. 发明授权

US07626162B2 Mass spectrometry system and mass spectrometry method 失效
标题翻译：质谱系统和质谱法
公开(公告)号：US07626162B2
公开(公告)日：2009-12-01
申请号：US12038829
申请日：2008-02-28
申请人： Shuhei Hashiba , Takeshi Sakamoto
发明人： Shuhei Hashiba , Takeshi Sakamoto
IPC分类号： B01D59/44 , H01J49/26 , H01J49/42
CPC分类号： H01J49/0027 , G01N30/724 , Y10T436/13
摘要： When a liquid mixture of two samples such as biological samples labeled with stable isotopes is subjected to a relative quantitative analysis using a liquid chromatography-tandem mass spectrometry system, various constituents are simultaneously ionized. Accordingly, sufficient time required for second mass spectrometry is not ensured, whereby some ions remain unanalyzed after measurement. To address this problem, after second mass spectrometry, amino acid sequencing is performed using the analysis data of the second mass spectrometry, which enables determination on the presence/absence of a specific amino acid labeled with a stable isotope. When the specific amino acid is present, the m/z value of an isotopically-labeled-paired ion in an MS spectrum is calculated, and non-target information for use in second mass spectrometry is created using the calculated m/z information. This avoids redundant second mass spectrometry on sample components derived from the same peptide while allowing second mass spectrometry to be efficiently performed.
摘要翻译：当使用液相色谱 - 串联质谱系统进行相对定量分析，将诸如用稳定同位素标记的生物样品的两个样品的液体混合物进行相对定量分析时，同时电离各种成分。因此，不能确保第二质谱所需的足够的时间，从而在测量之后一些离子保持未分析。为了解决这个问题，在第二次质谱法之后，使用第二质谱分析数据进行氨基酸测序，其能够确定用稳定同位素标记的特定氨基酸的存在/不存在。当存在特定氨基酸时，计算MS谱中同位素标记配对离子的m / z值，并使用所计算的m / z信息产生用于第二质谱的非目标信息。这避免了来自相同肽的样品组分的冗余第二质谱，同时允许有效地进行第二质谱。

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