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61. 发明授权

US5435990A Macrocyclic congugates and their use as diagnostic and therapeutic agents 失效
标题翻译：大环偶联物及其作为诊断和治疗剂的用途
公开(公告)号：US5435990A
公开(公告)日：1995-07-25
申请号：US962168
申请日：1992-10-15
申请人： Roberta C. Cheng , William A. Fordyce , William F. Goeckleler , William J. Kruper, Jr. , Richard K. Frank , Joseph R. Garlich , Garry E. Kiefer , Kenneth McMillan , Jaime Simon , David A. Wilson , Sharon Braughman
发明人： Roberta C. Cheng , William A. Fordyce , William F. Goeckleler , William J. Kruper, Jr. , Richard K. Frank , Joseph R. Garlich , Garry E. Kiefer , Kenneth McMillan , Jaime Simon , David A. Wilson , Sharon Braughman
IPC分类号： A61K9/08 , A61K9/107 , A61K31/395 , A61K39/395 , A61K51/00 , A61K51/04 , A61K51/10 , A61P35/00 , C07D257/02 , C07K16/00 , A61M36/06 , C07K16/30
CPC分类号： C07D257/02 , A61K51/0482 , A61K51/1045 , A61K51/109 , A61K2121/00 , A61K2123/00
摘要： A group of functionalized macrocyclic polyaminocarboxylate chelants that form complexes with rare earth-type metal ions are disclosed. The complexes, covalently attached to an antibody or antibody fragment, can be used for therapeutic and/or diagnostic purposes for cancer.
摘要翻译：公开了与稀土类金属离子形成络合物的一组官能化的大环多胺羧酸盐螯合剂。与抗体或抗体片段共价连接的复合物可用于癌症的治疗和/或诊断目的。

62. 发明授权

US5342593A Process for absorption of sulfur compounds from fluids 失效
标题翻译：从流体中吸收硫化合物的工艺
公开(公告)号：US5342593A
公开(公告)日：1994-08-30
申请号：US927584
申请日：1992-08-10
申请人： Steven H. Christiansen , Dane Chang , David A. Wilson
发明人： Steven H. Christiansen , Dane Chang , David A. Wilson
IPC分类号： B01D53/14 , B01D53/50 , B01D53/77 , C07D233/72 , C07D239/10 , C07D251/32 , C07D251/34 , C07D263/22 , C07D263/24 , C07D263/44 , C10K1/14 , B01D53/34
CPC分类号： B01D53/1493 , B01D53/507 , C10K1/14
摘要： Sulfur dioxide is removed from a fluid containing SO.sub.2 by employing as an absorbent therefor an aqueous solution of compound represented by Formula I: ##STR1## wherein X is --O--, --NR.sup.1 --, or --N.dbd.; each Y is independently --(CR.sup.2.sub.2)--, --(C.dbd.O)--, --O--, --NR.sup.1 --, --N.dbd., or --C(R.sup.2).dbd.; each R.sup.1 or R.sup.2 is independently hydrogen; an alkyl group; a hydroxyalkyl group; an aldehyde group; a carboxylic acid or salt group; or an alkyl group containing an aldehyde group, a carboxylic acid or salt group, ketone, carboxylic ester, ether, or sulfoxide group; and m is an integer preferably of from 2 to about 4. The absorbent solution preferably can be thermally regenerated by heating to remove SO.sub.2.
摘要翻译：通过使用式I表示的化合物的水溶液作为吸收剂从含有SO 2的流体中除去二氧化硫：-N =; 每个Y独立地为 - （CR22） - ， - （C = O） - ， - O - ， - NR1 - ， - N =或-C（R2）每个R 1或R 2独立地是氢; 烷基; 羟基烷基; 醛基; 羧酸或盐基; 或含有醛基，羧酸或盐基的烷基，酮，羧酸酯，醚或亚砜基; m优选为2〜4的整数。吸收剂溶液优选通过加热热再生以除去SO 2。

63. 发明授权

US5320829A Oral compositions for inhibiting plaque formation 失效
标题翻译：用于抑制斑块形成的口服组合物
公开(公告)号：US5320829A
公开(公告)日：1994-06-14
申请号：US805598
申请日：1991-12-10
申请人： Joseph R. Garlich , R. Keith Frank , Jaime Simon , Garry E. Kiefer , David A. Wilson
发明人： Joseph R. Garlich , R. Keith Frank , Jaime Simon , Garry E. Kiefer , David A. Wilson
IPC分类号： A61K8/41 , A61K8/49 , A61K8/55 , A61Q11/00 , A61K7/16 , A61K7/22
CPC分类号： A61Q11/00 , A61K8/416 , A61K8/4926 , A61K8/55
摘要： Oral compositions and methods effective in promoting oral hygiene containing in an effective amount at least one cyclic alkylamine or cyclic amine as an antiplaque and/or antigingivitis agent.
摘要翻译：有效地促进口腔卫生的口服组合物和方法含有至少一种环状烷基胺或环状胺作为抗菌斑和/或抗原血栓形成剂。

64. 发明授权

US5268129A Layered mixed metal hydroxides for the stabilization of radioactive colloids 失效
标题翻译：层状混合金属氢氧化物用于稳定放射性胶体
公开(公告)号：US5268129A
公开(公告)日：1993-12-07
申请号：US878645
申请日：1992-05-05
申请人： Jaime Simon , Kenneth McMillan , David A. Wilson , Harrell L. Huff
发明人： Jaime Simon , Kenneth McMillan , David A. Wilson , Harrell L. Huff
IPC分类号： A61K51/12 , A61K43/00 , C09K11/04
CPC分类号： A61K51/1217 , A61K2121/00 , A61K2123/00
摘要： A stabilized radionuclide-colloid composition useful in therapeutic radiation ablation therapies is disclosed. The composition contains a viscosity modifier layered mixed metal hydroxide and optionally an ion exchange medium to stabilize the radioactive colloid.
摘要翻译：公开了一种稳定的放射性核素 - 胶体组合物，用于治疗放射线消融治疗。组合物含有粘度调节剂层状混合金属氢氧化物和任选的离子交换介质以稳定放射性胶体。

65. 发明授权

US5064633A Macrocyclic aminophosphonic acid complexes, their formulations and use 失效
标题翻译：大环氨基膦酸复合物，其制剂及用途
公开(公告)号：US5064633A
公开(公告)日：1991-11-12
申请号：US452848
申请日：1989-12-19
申请人： Jaime Simon , David A. Wilson , Joseph R. Garlich , David E. Troutner
发明人： Jaime Simon , David A. Wilson , Joseph R. Garlich , David E. Troutner
IPC分类号： A61K51/04 , C07F9/38
CPC分类号： C07F9/3817 , A61K51/0478 , A61K51/0482 , A61K51/0489 , A61K2121/00
摘要： Particle emitting radionuclides, e.g. X-90, have been complexed with certain macrocyclic aminophosphonic acids wherein the nitrogen and phosphorus are interconnected by an alkylene group or substituted alkylene group. These complexes have been found useful in compositions and formulations for the therapeutic treatment of calcific tumors and the relief of bone pain in animals.
摘要翻译：颗粒发射放射性核素，例如 X-90与某些大环氨基膦酸络合，其中氮和磷通过亚烷基或取代的亚烷基互连。已经发现这些复合物可用于治疗钙化肿瘤的组合物和制剂，并减轻动物的骨痛。

66. 发明授权

US5059412A Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors 失效
标题翻译：用于治疗钙化肿瘤的大环氨基膦酸复合物
公开(公告)号：US5059412A
公开(公告)日：1991-10-22
申请号：US284876
申请日：1988-12-19
申请人： Jaime Simon , David A. Wilson , Joseph R. Garlich , David E. Troutner
发明人： Jaime Simon , David A. Wilson , Joseph R. Garlich , David E. Troutner
IPC分类号： C07D257/02 , A61K31/395 , A61K31/555 , A61K51/00 , A61K51/04 , A61P35/00 , C07B59/00 , C07F9/38 , C07F9/6524
CPC分类号： A61K51/0482 , A61K51/0489 , C07F9/3817 , A61K2121/00 , Y10S424/06
摘要： Particle emitting radionuclides, e.g. Samarium-153, have been complexed with certain macrocyclic aminophosphonic acids wherein the nitrogen and phosphorus are interconnected by an alkylene group or substituted alkylene group. These complexes have been found useful in compositions and formulations for the therapeutic treatment of calcific tumors in animals.
摘要翻译：颗粒发射放射性核素，例如钐 - 153与某些大环氨基膦酸络合，其中氮和磷通过亚烷基或取代的亚烷基互连。已经发现这些复合物可用于治疗动物钙化肿瘤的组合物和制剂中。

67. 发明授权

US4568469A Use of methylene phosphonic acid compositions derived from aminohydrocarbyl piperazine-urea adducts to inhibit scale 失效
标题翻译：使用衍生自氨基烃基哌嗪 - 脲加合物的亚甲基膦酸组合物抑制结垢
公开(公告)号：US4568469A
公开(公告)日：1986-02-04
申请号：US697291
申请日：1985-02-01
申请人： Druce K. Crump , David A. Wilson
发明人： Druce K. Crump , David A. Wilson
IPC分类号： C02F5/14 , C07F9/6509 , C07F9/6558
CPC分类号： C02F5/14 , C07F9/650958 , C07F9/65583
摘要： Certain methylene phosphonic acid derivatives of aminohydrocarbyl piperazine-urea adducts are good threshold agents to prevent metal ion precipitation in aqueous solutions.These derivatives have the formula ##STR1## wherein A is ##STR2## or X and wherein X is ##STR3## or H and wherein R is H, ammonium, an alkali or alkaline earth metal, m is 0-2, n is 2 or 3 and wherein at least one X is ##STR4##
摘要翻译：氨基烃基哌嗪 - 脲加成物的某些亚甲基膦酸衍生物是防止水溶液中金属离子沉淀的良好阈值剂。这些衍生物具有其中A为X或X且其中X为H或H且其中R为H，铵，碱金属或碱土金属，m为0-2，n为2或 3，并且其中至少一个X是

68. 发明授权

US4482834A Acoustic imaging transducer 失效
标题翻译：声学成像传感器
公开(公告)号：US4482834A
公开(公告)日：1984-11-13
申请号：US052705
申请日：1979-06-28
申请人： J. Fleming Dias , H. Edward Karrer , John D. Larson, III , David A. Wilson , Amin M. Hanafy
发明人： J. Fleming Dias , H. Edward Karrer , John D. Larson, III , David A. Wilson , Amin M. Hanafy
IPC分类号： H04R1/46 , A61B8/00 , B06B1/06 , G01N29/24 , G01S7/521 , G10K11/00 , G10K11/02 , G10K11/26 , H04R17/00 , H01L41/08
CPC分类号： G01N29/2437 , B06B1/0622 , G10K11/002 , G10K11/02 , G10K11/26
摘要： The acoustic imaging transducer described herein incorporates an acoustic stack contained in an alumina housing which also provides structure for electrically connecting the transducer array elements to system signal processing electronics.
摘要翻译：本文所述的声学成像换能器包括包含在氧化铝壳体中的声学堆叠，其还提供用于将换能器阵列元件电连接到系统信号处理电子器件的结构。

69. 发明授权

US4446740A Frequency controlled hybrid ultrasonic imaging arrays 失效
标题翻译：频率混合超声波成像阵列
公开(公告)号：US4446740A
公开(公告)日：1984-05-08
申请号：US356467
申请日：1982-03-09
申请人： David A. Wilson , James L. Buxton , Philip S. Green
发明人： David A. Wilson , James L. Buxton , Philip S. Green
IPC分类号： G01S7/52 , G01S15/89 , G01N29/00
CPC分类号： G01S7/52085 , G01S15/8918 , G01S7/52046 , G01S7/5206
摘要： This ultrasonic imaging apparatus has an array (44, 52 or 100) of transducer elements (44, 50 or 104) for transmitting ultrasonic signals having a first predetermined center frequency (fc1) into an object (12) to be analyzed through use of the transmitted signals reflected from within the object. A means (150, 116-1 through 116-X and 120-1 through 120-X) is connected to transmit the ultrasonic signals from the array (44, 52 or 104) in a stepped array mode. A means (150, 116-1 through 116-X and 120-1 through 120-X) is connected to transmit the ultrasonic signals from the array (44, 52 or 104) in an angle scanning mode. There is a means (150, 128-1 through 128-X) for focusing the transmitted signals at a desired depth within the object (12). The reflected signals sensed by the apparatus have a second center frequency (fc2) less than the first center frequency (fc1) as a result of signal attenuation by the object (12). There is a means connected to select between the stepped array transmission mode and the angle scanning transmission mode for operating the array elements based on the second center frequency (fc2). Varying the operating mode of the apparatus on this basis gives improved image resolution over a wider operating range than with prior art systems.
摘要翻译：该超声波成像装置具有用于将具有第一预定中心频率（fc1）的超声波信号发送到待分析的物体（12）的换能器元件（44,50或104）的阵列（44,452或100）从物体内反射的发射信号。连接装置（150,116-1至116-X和120-1至120-X）以分阶阵列模式从阵列（44,452或104）传送超声波信号。连接装置（150,116-1至116-X和120-1至120-X）以角度扫描模式从阵列（44,452或104）传送超声波信号。存在用于将所发送的信号聚焦在物体（12）内的期望深度的装置（150,128-1至128-X）。作为由物体（12）的信号衰减的结果，由装置感测到的反射信号具有小于第一中心频率（fc1）的第二中心频率（fc2）。连接有用于基于第二中心频率（fc2）在步进阵列传输模式和用于操作阵列元件的角度扫描传输模式之间进行选择的装置。在此基础上改变设备的操作模式在现有技术的系统中，在更宽的操作范围内提供了改进的图像分辨率。

70. 发明授权

US4442713A Frequency varied ultrasonic imaging array 失效
标题翻译：频率变化超声波成像阵列
公开(公告)号：US4442713A
公开(公告)日：1984-04-17
申请号：US356498
申请日：1982-03-09
申请人： David A. Wilson , James L. Buxton
发明人： David A. Wilson , James L. Buxton
IPC分类号： A61B8/00 , G01N29/04 , G01S7/52 , G01S15/89 , G10K11/34 , G01N29/00
CPC分类号： G10K11/341 , G01S15/8954 , G01S7/52046
摘要： An ultrasonic imaging apparatus has an array (10 or 100) of transducer elements (14 or 104) for transmitting ultrasonic signals into an object (12) to be analyzed through use of the transmitted signals reflected from the object and sensed by the apparatus. The transmitted signals have a first predetermined center frequency. The reflected signals sensed by the apparatus have a second center frequency less than the first center frequency as a result of signal attenuation by the object. A means (70, 62 or 150, 152-1 through 152-X) is connected to select a number of transducers (14 or 104) in the array (10 or 100) for transmitting and/or receiving the ultrasonic signals based on the second center frequency. Adjusting the number of transmitting and/or receiving transducers (14 or 104) with changes in frequency produced by signal attenuation gives improved image resolution under a wider variety of use conditions than with prior art ultrasonic imaging apparatus.
摘要翻译：超声波成像设备具有用于通过使用从物体反射并由设备感测的发射信号将超声波信号发射到物体（12）中的换能器元件（14或104）的阵列（10或100）。所发送的信号具有第一预定中心频率。该装置感测到的反射信号由于物体的信号衰减而具有小于第一中心频率的第二中心频率。连接装置（70,62或150,152-1至152-X）以选择阵列（10或100）中的多个换能器（14或104），用于基于所述阵列（10或100）发送和/或接收超声波信号第二中心频率。通过信号衰减产生的频率变化来调节发射和/或接收换能器（14或104）的数量，可以在现有技术的超声波成像装置的各种使用条件下提高图像分辨率。

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