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    • 63. 发明授权
    • Pivotal display for stationary exercise bicycle
    • 固定式自行车的枢轴显示
    • US07445583B2
    • 2008-11-04
    • US11582733
    • 2006-10-17
    • James Chen
    • James Chen
    • A63B22/06
    • A63B71/0622A63B22/0605A63B2022/0652
    • A mechanism mounted on a stationary exercise bicycle including a frame, a rear seat, a front drive mechanism having a pedal at either side, and a numeric display is disclosed. In one embodiment, the mechanism includes a mounting assembly fixedly mounted at one side of the frame and including upper and lower mounting lugs; and an arm including an upper section secured to the display and a lower section having a distal end releasably secured to the upper section and a proximal end pivotably fastened between the mounting lugs. The display is adapted to dispose in a first position in front of the seat, in a second position at one side of the frame or in a position between the first position and the second position by pivoting about the mounting assembly.
    • 公开了一种安装在固定式运动自行车上的机构,其包括框架,后排座椅,在任一侧具有踏板的前驱动机构和数字显示器。 在一个实施例中,该机构包括固定地安装在框架的一侧并且包括上和下安装凸耳的安装组件; 以及包括固定到所述显示器的上部的臂和具有可释放地固定到所述上部的远端的下部,以及可枢转地紧固在所述安装凸耳之间的近端。 显示器适于处于位于座椅前方的第一位置,在框架的一侧的第二位置或通过围绕安装组件枢转而位于第一位置和第二位置之间的位置。
    • 66. 发明申请
    • Energy-activated targeted cancer therapy
    • 能量激活靶向癌症治疗
    • US20080114285A1
    • 2008-05-15
    • US11906110
    • 2007-09-27
    • James Chen
    • James Chen
    • A61M5/00
    • A61K41/0057A61K41/0061A61K41/0071A61K47/6817A61K47/6835A61K47/6849A61K47/6867A61N5/062
    • The present invention is drawn to energy activated targeted delivery systems for administering a therapy to a target tissue or target composition in a mammalian subject, using an energy source that preferably transmits energy to a treatment site transcutaneously. The systems provide for administering to the subject a therapeutically effective amount of a targeted substance, which preferably selectively binds to the target tissue. Energy at a wavelength or waveband corresponding to that which is absorbed by the targeted substance is then administered. The energy intensity is relatively low, but a high total fluence is employed to ensure the activation of the targeted energy-activated agent or targeted prodrug product. The claimed energy-activated targeted therapy is useful in the treatment of specifically selected target tissues, such as vascular endothelial tissue, the abnormal vascular walls of tumors, solid tumors of the head and neck, tumors of the gastrointestinal tract, tumors of the liver, tumors of the breast, tumors of the prostate, tumors of the lung, nonsolid tumors, malignant cells of the hematopoietic and lymphoid tissue and other lesions in the vascular system or bone marrow, and tissue or cells related to autoimmune and inflammatory disease.
    • 本发明涉及能量激活的靶向递送系统,其用于使用优先将能量经由能量传递到治疗部位的能量源向哺乳动物受试者施用对靶组织或靶组成的治疗。 所述系统提供给予受试者治疗有效量的目标物质,其优选选择性地结合靶组织。 然后施用对应于被靶物质吸收的波长或波段的能量。 能量强度相对较低,但是采用高总能量密度来确保目标能量活化剂或靶向前药产品的活化。 所要求的能量激活靶向治疗可用于特异性选择的靶组织如血管内皮组织,肿瘤异常血管壁,头颈部实体瘤,胃肠道肿瘤,肝肿瘤, 乳腺肿瘤,前列腺肿瘤,肺肿瘤,非固体肿瘤,造血和淋巴组织的恶性细胞以及血管系统或骨髓中的其他损伤,以及与自身免疫性和炎性疾病相关的组织或细胞。
    • 70. 发明申请
    • Light transmission system for photoreactive therapy
    • 用于光反应治疗的光传输系统
    • US20070260295A1
    • 2007-11-08
    • US11416783
    • 2006-05-03
    • James ChenSteven DalyZihong GuoLlew KeltnerJeffrey Storm
    • James ChenSteven DalyZihong GuoLlew KeltnerJeffrey Storm
    • A61N5/06
    • A61N5/062A61B50/30A61N5/0601A61N2005/0645A61N2005/0652
    • A light transmission system to provide photodynamic treatment to a patient includes a single use integrated control module and catheter assembly having a plurality of light emitting diodes (LEDs) to transmit light toward target cells within a patient. The integrated light catheter and control module are used in combination with a light activated drug. Selected operating parameters may be programmed into the control module, or it may be wirelessly programmable in situ prior to use to allow user flexibility to tailor treatment for a particular patient or condition. Among the features that prevent reuse are that the control module lacks access to recharge the power source, and it may include a deactivation module that destroys circuitry or software when triggered. To prevent patient interference when in use, the control module may also be configured to selectively deactivate.
    • 向患者提供光动力治疗的光传输系统包括具有多个发光二极管(LED)的单次使用的集成控制模块和导管组件,以将光传送到患者体内的靶细胞。 集成光导管和控制模块与光活化药物组合使用。 所选择的操作参数可以被编程到控制模块中,或者可以在使用之前在现场进行无线可编程,以允许用户灵活地为特定患者或病症定制治疗。 防止重用的功能之一是控制模块缺少对电源进行再充电的功能,并且可能包括在触发时破坏电路或软件的停用模块。 为了在使用时防止患者干扰,控制模块还可以被配置为选择性地停用。