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    • 63. 发明申请
    • METHODS FOR CANCER THERAPY AND STEM CELL MODULATION
    • 癌症治疗方法和干细胞调控方法
    • WO2007100304A1
    • 2007-09-07
    • PCT/SG2006/000350
    • 2006-11-15
    • AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHYU, QiangTAN, JingYANG, Xiao Jing
    • YU, QiangTAN, JingYANG, Xiao Jing
    • A61K31/52A61K31/519A61P35/00
    • A61K31/519A61K31/52
    • The present invention relates to a method of inducing apoptosis in a tumour cell as well as modulating pluripotency and/or self-renewing characteristics of a stem/progenitor cell. The method comprises administering to the respective cell a compound of general formula (I). In general formula A is C or N. R 1 , R 4 and R 5 are, independently selected, H or aliphatic, cycloaliphatic, aromatic, arylaliphatic, or arylcycloaliphatic hydrocarbyl groups, that comprise 0 - 3 heteroatoms being N, O, S, or Si. R 4 and R 5 may optionally be linked so as to define an aliphatic hydrocarbyl bridge. R 2 is H or a halogen, such as F or Cl. R 3 is H, or an aliphatic or arylaliphatic hydrocarbyl group comprising 1 - 8 main chain carbon atoms and 0 - 3 heteroatoms being N, O, S, Si, or a halogen such as Cl or F. Also provided is a pharmaceutical composition for inducing apoptosis in a tumour cell and/or modulating pluripotency and/or self-renewing characteristics of a stem/progenitor cell. The pharmaceutical composition comprises a compound as defined above or a pharmaceutically acceptable salt thereof and a carrier or diluent.
    • 本发明涉及诱导肿瘤细胞凋亡的方法以及调节干细胞/祖细胞的多能性和/或自我更新特性。 该方法包括向各细胞施用通式(I)的化合物。 通式A是C或N.R 1,R 4和R 5独立地选自H或脂族的,脂环族的,芳族的 ,芳基脂族基或芳基环脂族烃基,其包含0-3个杂原子是N,O,S或Si。 R 4和R 5可以任选地被连接以便限定脂族烃基桥。 R 2是H或卤素,例如F或Cl。 R 3是H或包含1-8个主链碳原子和0-3个杂原子的脂族或芳脂脂族烃基是N,O,S,Si或卤素如Cl或F. 还提供了用于诱导肿瘤细胞凋亡和/或调节干细胞/祖细胞的多能性和/或自我更新特征的药物组合物。 药物组合物包含如上所定义的化合物或其药学上可接受的盐和载体或稀释剂。
    • 68. 发明申请
    • ELECTRONIC ARTICLE SURVEILLANCE TAG
    • 电子文章监督标签
    • WO2004102495A2
    • 2004-11-25
    • PCT/US2004/014104
    • 2004-05-06
    • FUSS, Arthur, BradleyYANG, Xiao, Hui
    • FUSS, Arthur, BradleyYANG, Xiao, Hui
    • G08B
    • E05B73/0017G08B13/2434
    • An electronic article surveillance tag features a spindle assembly which anchors and retains a set of ball bearings which are used to clutch and retain the shaft of a tack. The spindle features an operational tab which may be contacted by the appropriate probe to turn the spindle about a central axis. The spindle is seated in a retaining means with a graduated lip around the perimeter. The turning of the spindle serves to raise a portion of the spindle from the retaining means, loosening the ball bearing grip on the shaft of the tack. The electronic article surveillance tga may be used with either a smoothed or grooved tack shaft and may be operated by either mechanical probe actuation or by the use of a magnetic detachment means applied to the spindle.
    • 电子物品监视标签具有主轴组件,该主轴组件锚固并保持用于离合并保持杆的轴的一组球轴承。 主轴具有可操作的接头,该接头可由适当的探针接触,以绕主轴转动心轴。 主轴位于固定装置上,周边设有刻度唇。 主轴的转动用于将主轴的一部分从保持装置上升,松开球杆的轴上的球轴承把手。 电子物品监视tga可以与平滑的或带槽的粘性轴一起使用,并且可以通过机械探针致动或通过使用施加到主轴的磁性分离装置来操作。
    • 69. 发明申请
    • EFFICIENT VIDEO TRANSMISSION
    • 有效的视频传输
    • WO2004012458A3
    • 2004-05-06
    • PCT/SG0200168
    • 2002-07-26
    • UNIV NANYANGYANG XIAO KANGYU RONG SHANZHU CELIM KENG PANGLI ZHENG GUOPAN FENGFENG GE NANWU DA JUNWU SI
    • YANG XIAO KANGYU RONG SHANZHU CELIM KENG PANGLI ZHENG GUOPAN FENGFENG GE NANWU DA JUNWU SI
    • H04N7/26
    • H04N19/51H04N19/557
    • A method and system for reducing the complexity of block motion estimation is described. According to the invention, the block distortion measure is determined by calculating a partial error result using a proportion of pixels in the block, comparing the partial error result with a threshold value and rejecting blocks where the partial error result is greater than the threshold value, and calculating a full error result for non-rejected blocks only. The threshold value is a function of the current minimum partial error result, and is preferably the current minimum partial error result multiplied by a threshold constant lambda. Another aspect of the invention provides a video transport scheme which exploits the different importance of both GOP and re-synchronisation levels. According to this aspect, an unequal loss protection (ULP) philosophy is utilized. That is, the bit stream data is partitioned into several parts according to different importance, and the parts are unequally protected against packet loss using forward error correction codes.
    • 描述了用于降低块运动估计的复杂度的方法和系统。 根据本发明,通过使用块中的像素的比例来计算部分错误结果,将部分错误结果与阈值进行比较并且在部分错误结果大于阈值的情况下拒绝块,来确定块失真度量, 并且只计算未拒绝块的完整错误结果。 阈值是当前最小部分误差结果的函数,并且优选地是当前最小部分误差结果乘以阈值常数λ。 本发明的另一方面提供了一种利用GOP和再同步级别的不同重要性的视频传输方案。 根据这个方面,利用不平等损失保护(ULP)理念。 也就是说,根据不同的重要性将比特流数据分成几个部分,并且使用前向纠错码对这些部分进行不相等的保护以防止丢包。