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61. 发明授权

US07419975B2 Organic compounds 有权
标题翻译：有机化合物
公开(公告)号：US07419975B2
公开(公告)日：2008-09-02
申请号：US11099941
申请日：2005-04-06
申请人： Mark Gabriel Palermo , Sushil Kumar Sharma , Christopher Straub , Run-Ming Wang , Leigh Scott Zawel , Yanlin Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark G. Charest , Feng He
发明人： Mark Gabriel Palermo , Sushil Kumar Sharma , Christopher Straub , Run-Ming Wang , Leigh Scott Zawel , Yanlin Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark G. Charest , Feng He
IPC分类号： A61K31/407 , A61K31/437 , A61K31/55 , C07D487/04 , C07D471/04
CPC分类号： C07D207/16 , C07D207/06 , C07D207/08 , C07D207/09 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
摘要： Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula I
摘要翻译：抑制Smac蛋白与抑制凋亡蛋白抑制剂（IAP）的新型化合物

62. 发明申请

US20060166964A1 Inhibitors of HCV replication 有权
标题翻译： HCV复制抑制剂
公开(公告)号：US20060166964A1
公开(公告)日：2006-07-27
申请号：US11347765
申请日：2006-02-03
申请人： Thomas Hudyma , Xiaofan Zheng , Feng He , Min Ding , Carl Bergstrom , Piyasena Hewawasam , Scott Martin , Robert Gentles
发明人： Thomas Hudyma , Xiaofan Zheng , Feng He , Min Ding , Carl Bergstrom , Piyasena Hewawasam , Scott Martin , Robert Gentles
IPC分类号： A61K31/553 , A61K31/551 , A61K31/55 , C07D487/02 , C07D491/02
CPC分类号： C07D471/04 , A61K31/13 , A61K31/4745 , A61K31/7056 , A61K38/13 , A61K38/2013 , A61K38/204 , A61K38/208 , A61K38/21 , A61K45/06 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/14 , C07D498/14 , C07D513/14 , A61K2300/00
摘要： Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions comprising the compounds are also described as well as methods of preparing the compounds.
摘要翻译：描述式I的吲哚化合物。该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。还描述了包含化合物的不同形式和组合物以及制备化合物的方法。

63. 发明授权

US6071700A Heterologous polypeptide production in the absence of nonsense-mediated MRNA decay functions 有权
标题翻译：在没有无义介导的MRNA衰变功能的情况下产生异源多肽
公开(公告)号：US6071700A
公开(公告)日：2000-06-06
申请号：US177431
申请日：1998-10-21
申请人： Feng He , Allan S. Jacobson
发明人： Feng He , Allan S. Jacobson
IPC分类号： C07K14/395 , C12N1/15 , C12N15/12 , C12N15/67 , C12Q1/68 , C12N15/31
CPC分类号： C07K14/395 , C12N15/67
摘要： The invention relates to the discovery of a gene, NMD2, named after its role in the Nonsense-Mediated mRNA Decay pathway, and the protein, Nmd2p, encoded by the NMD2 gene. The amino acid sequence of Nmd2p and the nucleotide sequence of the NMD2 gene encoding it are disclosed. Nmd2p is shown herein to bind to another protein in the decay pathway, Upf1p. A C-terminal fragment of the protein is also shown to bind Upf1p and, when overexpressed in the host cell, the fragment inhibits the function of Upf1p, thereby inhibiting the nonsense-mediated mRNA decay pathway. The invention also relates to methods of inhibiting the nonsense-mediated mRNA decay pathway to stabilize mRNA transcripts containing a nonsense codon which normally would cause an increase in the transcript decay rate. Such stabilization of a transcript is useful for the production of a recombinant protein or fragment thereof. The invention also relates to methods of identifying molecules that inhibit the nonsense-mediated mRNA decay pathway, and the use of such molecules for treatment of disorders associated with nonsense mutations.
摘要翻译：本发明涉及以其在无义介导的mRNA衰变途径中的作用命名的NMD2基因和由NMD2基因编码的蛋白质Nmd2p的发现。公开了Nmd2p的氨基酸序列和编码它的NMD2基因的核苷酸序列。 Nmd2p在本文中显示为与衰老途径Upf1p中的另一种蛋白结合。蛋白质的C末端片段还显示结合Upf1p，并且当在宿主细胞中过表达时，该片段抑制Upf1p的功能，从而抑制无义介导的mRNA衰减途径。本发明还涉及抑制无义介导的mRNA衰减途径以稳定含有无义密码子的mRNA转录物的方法，其通常将导致转录物衰减率的增加。转录物的这种稳定化对于重组蛋白质或其片段的产生是有用的。本发明还涉及鉴定抑制无义介导的mRNA衰变途径的分子的方法，以及这些分子用于治疗与无义突变相关的病症的用途。

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