会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 67. 发明授权
    • Troponyl piperazines as dopamine D4 receptor ligands
    • 托膦酰基哌嗪作为多巴胺D4受体配体
    • US5998414A
    • 1999-12-07
    • US907672
    • 1997-08-08
    • Xin WangJian-min FuAdi M. Treasurywala
    • Xin WangJian-min FuAdi M. Treasurywala
    • C07D243/38C07D295/116C07D317/58C07D409/12A61K31/495C07D295/155C07D405/06
    • C07D295/116C07D243/38C07D317/58C07D409/12
    • Described herein are compounds of the general formula: ##STR1## a stereoisomer, solvate, or pharmaceutically acceptable salt thereof, wherein:R.sub.1 is H, halo, aryl or aryl substituted with one or two groups independently selected from halo, C.sub.1-4 alkyl, C.sub.1-4 -alkoxy, nitro, trifluoromethyl, trifluoromethoxy or cyano;R.sub.2 is C.sub.4-9 alkyl; phenyl or phenyl substituted with one or two groups selected independently from OH, cyano, halo, C.sub.1-4 alkoxy, C.sub.1-4 alkyl, trifluoromethyl, trifluoromethoxy, nitro or phenyl; naphthyl;phenyl fused to a 5 or 6-membered heterocycle; the coumarin moiety ##STR2## wherein R.sub.3 and R.sub.4 are selected independently from H, C.sub.1-4 alkyl and C.sub.1-4 alkoxy;or 1,2-methylenedioxy phenyl;with the proviso that R.sub.2 is not phenyl or 3,4-dimethoxyphenyl when R.sub.1 is H.Also described is their use as pharmaceuticals to treat indications in which the D4 receptor is implicated, such as schizophrenia and anxiety.
    • 本文描述的是下列通式的化合物:其立体异构体,溶剂化物或其药学上可接受的盐,其中:R 1是被一个或两个独立地选自卤素,C 1-4烷基,C 1-4 - 烷氧基,硝基,三氟甲基,三氟甲氧基或氰基; R2是C4-9烷基; 苯基或被一个或两个独立地选自OH,氰基,卤素,C 1-4烷氧基,C 1-4烷基,三氟甲基,三氟甲氧基,硝基或苯基的基取代的苯基; 萘基; 与5或6元杂环稠合的苯基; 香豆素部分,其中R 3和R 4独立地选自H,C 1-4烷基和C 1-4烷氧基; 或1,2-亚甲二氧基苯基; 条件是当R 1为H时,R 2不是苯基或3,4-二甲氧基苯基。还描述了它们作为药物治疗其中涉及D4受体的适应症的用途,例如精神分裂症和焦虑症。