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61. 发明申请

US20060225143A1 Animal exhibiting ptsd-like behavior, per pct rule 4.3 失效
标题翻译：动物表现出类似ptsd的行为，每页规则4.3
公开(公告)号：US20060225143A1
公开(公告)日：2006-10-05
申请号：US10549596
申请日：2004-03-18
申请人： Gal Yadid , Joseph Zohar
发明人： Gal Yadid , Joseph Zohar
IPC分类号： A01K67/027
CPC分类号： A61K49/0008 , A01K15/02 , A01K29/00 , A01K29/005 , A01K67/02 , A01K2227/105 , A01K2267/03 , A01K2267/0356 , G01N33/5088
摘要： The invention relates to production of maladapted animals characterized by PTSD like behavior from a population by behavioral conditioning. The method includes determining a baseline behavioral level for individual under defined conditions; exposing each individual animal to trauma event and further determining a posttraumatic event behavioral level; re-exposing each individual to a trauma related event and further determining an individual post trauma related event behavioral level and evaluating the individual post trauma related event behavioral level for each individual animal with respect to a baseline value according to a predetermined rule in order to determine which individuals are maladapted animals charcterized by PTSD like behavior. Use of the method for assaying efficacy of PTSD treatment is within the scoape of the invention, as are animals produced by claimed methods. Once the method is established, biological parameters may be employed in addition to, or in lieu of behavioral parameters.
摘要翻译：本发明涉及以通过行为调节方式从群体中以PTSD类似行为为特征的不适应的动物的生产。该方法包括确定个体在确定条件下的基线行为水平; 将每个动物暴露于创伤事件并进一步确定创伤后事件行为水平; 将每个个体重新暴露于创伤相关事件，并进一步确定个体后创伤相关事件行为水平，并根据预定规则评估每个单独动物相对于基线值的个体后创伤相关事件行为水平，以便确定哪些人是由PTSD喜欢的行为蒙蔽的动物。用于测定PTSD治疗功效的方法的使用在本发明的覆盖范围内，以及由所要求保护的方法产生的动物也是如此。一旦建立了该方法，除了行为参数之外或代替行为参数，可以采用生物学参数。

62. 发明申请

US20050221322A1 Multiple closed nucleus breeding for swine production 审中-公开
标题翻译：多重闭合核养殖猪生产
公开(公告)号：US20050221322A1
公开(公告)日：2005-10-06
申请号：US10512900
申请日：2003-05-12
申请人： James Fox
发明人： James Fox
IPC分类号： A01K20060101 , A01K67/00 , A01K67/02 , A01K67/027 , C12Q1/68
CPC分类号： A01K67/027 , A01K67/02 , A01K2227/108 , A01K2267/02
摘要： The invention comprises use of first and second, and optionally additional further, genetically and information-linked swine nucleus breeding herds to transmit genetic improvement from the first herd to each of the other herds which can be closed to live animal introduction to provide benefits in addition to genetic improvement to both the first and second and any additional herds.
摘要翻译：本发明包括使用第一和第二以及任选地进一步的遗传和信息链接的猪细胞核繁殖群以将遗传改良从第一群体传播到每个可以关闭以进行动物介导以提供益处的其他群体对第一和第二和任何其他畜群进行遗传改良。

63. 发明申请

US20040200420A1 Method of producing avian eggs and birds of germ-free status 有权
公开(公告)号：US20040200420A1
公开(公告)日：2004-10-14
申请号：US10788338
申请日：2004-03-01
发明人： Leonard Moran
IPC分类号： A01K045/00
CPC分类号： A01K45/007 , A01K45/00 , A01K67/02
摘要： The invention provides a method of rearing a bird of germ-free status. The method comprises housing a bird as a parent bird, surgically removing an egg in its shell from the parent bird prior to transfer of the egg to the cloaca in the parent bird, incubating the egg still in its shell and hatching the egg to produce a laying bird. The invention also relates to the production of avian eggs of germ-free status.

64. 发明申请

US20040158881A1 Animal selected for lacking heparan sulfate 3-0-sulfotransferase-1 and uses thereof 有权
标题翻译：动物选择缺乏硫酸乙酰肝素3-0-磺基转移酶-1及其用途
公开(公告)号：US20040158881A1
公开(公告)日：2004-08-12
申请号：US10365140
申请日：2003-02-10
发明人： Nicholas W. Shworak , Robert D. Rosenberg , Robert T. Palac
IPC分类号： A01K067/00
CPC分类号： A01K67/0276 , A01K67/02 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N9/10 , C12N15/8509 , C12Q1/48 , G01N33/6893 , G01N2500/00 , G01N2800/32
摘要： An animal selected for lacking heparan sulfate 3-O-sulfotransferase-1 activity is provided. This animal exhibits characteristics associated with myxomatous valvular disease and is useful for identifying agents which prevent, delay or treat myxomatous valvular disease. Methods of diagnosing myxomatous valvular disease are also provided.
摘要翻译：选择缺乏硫酸乙酰肝素3-O-磺基转移酶-1活性的动物。该动物表现出与粘液性瓣膜疾病相关的特征，并且可用于鉴定预防，延迟或治疗粘液性瓣膜病的药剂。还提供诊断粘液性瓣膜病的方法。

65. 发明申请

US20030159169A1 Cell culture system and methods of use 审中-公开
标题翻译：细胞培养系统及使用方法
公开(公告)号：US20030159169A1
公开(公告)日：2003-08-21
申请号：US10319221
申请日：2002-12-13
申请人： Purdue Research Foundation
发明人： Paul Collodi , Lianchun Fan , Chunguang Ma
IPC分类号： A01K067/027 , C12N005/06
CPC分类号： A01K67/02 , A01K67/0271 , C12N15/873
摘要： The present invention is directed to methods of making a fish embryo cell line that can give rise to germ cells when introduced to a fish embryo. The present invention is further directed to methods of using the fish embryo cell line, making germ line chimeric fish, and to a cell culture medium.
摘要翻译：本发明涉及制备当引入鱼胚时能产生生殖细胞的鱼胚细胞系的方法。本发明还涉及使用鱼胚细胞系，制造生殖系嵌合鱼以及细胞培养基的方法。

66. 发明申请

US20030047143A1 Method for Identifying Fast- Growing Fish 失效
标题翻译：识别快速生长鱼的方法
公开(公告)号：US20030047143A1
公开(公告)日：2003-03-13
申请号：US10190163
申请日：2002-07-03
发明人： Jeffrey Todd Streelman , Thomas David Kocher
IPC分类号： A01K061/00
CPC分类号： A01K67/02 , A01K61/10 , C12Q1/6888 , C12Q2600/124 , C12Q2600/156 , C12Q2600/158 , Y02A40/81
摘要： Methods of selecting fish for breeding and optimum growth in conditions of various salinity are disclosed. Fish are selected for growth in specific salinity based on their prolactin 1 genotype. A simple sequence repeat polymorphism (microsatellite) in the tilapia prolactin (prl 1) promoter is associated with differences in prl 1 expression and differences in growth in nullsalt-challengednull or nullsalt-effectednull fishes. This discovery suggests that dinucleotide microsatellites may represent an under-appreciated source of genetic variation for regulatory evolution, and belie the textbook interpretation that non-coding microsatellite length variation lacks functional consequences. Thus, the methods of the invention include determining or selecting the salinity of the environment in which the fish will be grown; determining the prolactin genotype of at least one male and at least one female fish being considered for breeding; breeding male and female fish having the desired genotype(s) to result in offspring having known, predictable genotypes; and raising the fish in a salinity environment compatible with the fishes' genotype(s).
摘要翻译：公开了在各种盐度条件下选择鱼类进行育种和最佳生长的方法。基于它们的催乳素1基因型，选择鱼以特定盐度生长。罗非鱼催乳素（prl 1）启动子中的简单序列重复多态性（微卫星）与pr1表达的差异和“盐胁迫”或“盐胁迫”鱼的生长差异相关。这一发现表明，二核苷酸微卫星可能代表了对于调节进化的遗传变异不足的来源，并认为教科书解释非编码微卫星长度变异缺乏功能性后果。因此，本发明的方法包括确定或选择鱼种植的环境的盐度; 确定正在考虑用于育种的至少一种雄性和至少一种雌性鱼的催乳素基因型; 培育具有所需基因型的雄性和雌性鱼以产生具有已知的可预测基因型的后代; 并在与鱼的基因型相适应的盐度环境中饲养鱼。

67. 发明申请

US20020012655A1 CLONED UNGULATE EMBRYOS AND ANIMALS, USE OF CELLS, TISSUES AND ORGANS THEREOF FOR TRANSPLANTATION THERAPIES INCLUDING PARKINSON'S DISEASE 无效
标题翻译：克隆发布的胚胎和动物，细胞，组织及其用于包括帕金森病的移植治疗的组织的使用
公开(公告)号：US20020012655A1
公开(公告)日：2002-01-31
申请号：US09066652
申请日：1998-04-27
发明人： STEVEN L. STICE , JOSE CIBELLI , JAMES M. ROBL
IPC分类号： A61K048/00
CPC分类号： A01K67/0275 , A01K67/02 , A01K67/027 , A01K67/0273 , A01K2217/05 , A01K2227/101 , A61K35/12 , A61K38/00 , C12N5/0603 , C12N15/8771 , C12N15/8778 , C12N2510/00 , C12N2517/02 , C12N2517/04
摘要： Methods and cell lines for cloning ungulate embryos and offspring, in particular bovines and porcines, are provided. The resultant fetuses, embryos or offspring are especially useful for the expression of desired heterologous DNAs, and may be used as a source of cells or tissue for transplantation therapy for the treatment of diseases such as Parkinson's disease.
摘要翻译：提供用于克隆有蹄类胚胎和后代的方法和细胞系，特别是牛和猪。所产生的胎儿，胚胎或后代对于所需的异源DNA的表达特别有用，并且可以用作用于治疗诸如帕金森病之类疾病的移植治疗的细胞或组织来源。

68. 发明申请

US20010027569A1 Method of fertilizing an avian egg in the shell 失效
标题翻译：在壳中施用鸡蛋的方法
公开(公告)号：US20010027569A1
公开(公告)日：2001-10-04
申请号：US09784803
申请日：2001-02-15
发明人： Tim Cantrell , Andrew Wooten
IPC分类号： A01K067/00
CPC分类号： A01K67/02 , A01K45/007 , A61D19/00
摘要： The present invention relates to the field of avian egg fertilization. In particular, the present invention provides a method of fertilizing an egg in a shell. The invention also provides a method of fertilizing an egg in a shell, whereby a live chick is hatched. The invention also provides developmentally early stage oviposited avian eggs.
摘要翻译：本发明涉及禽卵受精领域。特别地，本发明提供了一种在壳中施用卵的方法。本发明还提供了在壳中施用卵的方法，由此孵出活鸡。本发明还提供发育早期产卵的禽卵。

69. 发明授权

US5994616A Targeted synthesis of protein in mammary gland of a non-human transgenic mammal 失效
标题翻译：在非人转基因哺乳动物的乳腺中靶向合成蛋白质
公开(公告)号：US5994616A
公开(公告)日：1999-11-30
申请号：US186836
申请日：1994-01-25
申请人： Jeffrey M. Rosen
发明人： Jeffrey M. Rosen
IPC分类号： C12N15/09 , A01K67/00 , A01K67/02 , A01K67/027 , A01K67/033 , A23C9/00 , A23C9/152 , A23C9/20 , A61K31/70 , A61K48/00 , A61P15/00 , A61P43/00 , C07H21/04 , C07K14/47 , C12N1/00 , C12N9/10 , C12N15/85 , C12N15/89 , C12P21/02 , C12P21/00
CPC分类号： A01K67/0275 , A01K67/02 , A23C9/20 , C07K14/4732 , C12N15/85 , C12N15/8509 , C12N15/89 , C12N9/1033 , A01K2217/05 , A01K2217/20 , A01K2227/10 , A01K2227/105 , A01K2227/108 , A01K2267/01 , A23C2230/05 , C07K2319/00 , C07K2319/02 , C07K2319/61 , C12N2830/008 , C12N2830/42 , C12N2830/85
摘要： Described are methods of targeting specific genes or DNA sequences encoding biologically active proteins to the mammary gland such that the DNA sequence is expressed in the mammary gland and the protein is secreted into the milk of the mammal. Also described is the production of transgenic nonhuman mammals whose germ line comprises a DNA gene complex containing a casein promoter, a casein enhancer, a DNA sequence which encodes a signal peptide and a DNA sequence encoding a biologically active protein. The milk containing the biologically active protein or the biologically active protein itself can be used in the making of diary products.
摘要翻译：描述了将编码生物活性蛋白质的特定基因或DNA序列靶向乳腺的方法，使得DNA序列在乳腺中表达，并且蛋白质分泌到哺乳动物的乳中。还描述了其生殖系包含含有酪蛋白启动子，酪蛋白增强子，编码信号肽的DNA序列和编码生物活性蛋白质的DNA序列的DNA基因复合物的转基因非人类哺乳动物的生产。含有生物活性蛋白质或生物活性蛋白质本身的牛奶可用于制作日记产品。

70. 发明授权

US5575237A Method of hatching avian eggs 失效
标题翻译：孵化禽蛋的方法
公开(公告)号：US5575237A
公开(公告)日：1996-11-19
申请号：US481428
申请日：1995-08-23
申请人： Mark W. J. Ferguson
发明人： Mark W. J. Ferguson
IPC分类号： A01K41/00 , A01K67/02
CPC分类号： A01K41/00 , A01K67/02
摘要： A method of hatching eggs of avian species, especially chickens, which comprises carrying out at least one cycle of steps (a) and (c) as follows: (a) incubating the eggs in a first, baseline ambient environment which is normal for hatchery incubation of the eggs of the avian species in the prevailing climatic conditions and then during a sex-sensitive time window of embryonic development, (b) altering the ambient environment to shifted conditions for a period of time effective to bias the normal phenotypic sex ratio of the embryos, without significant adverse effect on the average mortality rate, and (c) thereafter restoring the incubation conditions to or towards normal and allowing the eggs to hatch. Preferably the ambient environment comprises a temperature of 37.5.degree.-38.degree. C. and the shifted conditions comprise reduced temperature, especially a temperature maintained at about 22.degree. C. for a period of from 18 to 42 hours. The method may be used to produce birds which are chromosomally male (ZZ) but phenotypically female or chromosomally female (ZW) but phenotypically male.
摘要翻译： PCT No.PCT / GB93 / 02565 Sec。 371日期1995年8月23日 102（e）日期1995年8月23日PCT 1993年12月16日PCT公布。公开号WO94 / 13132 日期1994年6月23日一种用于孵化禽类，特别是鸡的鸡蛋的方法，其包括如下步骤（a）和（c）进行至少一个循环：（a）在第一基线周围环境中孵育卵在当前气候条件下，然后在性别敏感的胚胎发育时期窗口孵化孵化禽类物种的孵化场是正常的，（b）将环境环境改变为转移条件一段有效的时间以偏向于胚胎的正常表型性别比例，对平均死亡率没有显着的不利影响，（c）此后将培养条件恢复到正常水平或使之正常孵化，并允许卵孵化。优选地，周围环境包括37.5℃-38℃的温度，并且转移的条件包括降低的温度，特别是在约22℃下保持18至42小时的温度。该方法可用于产生染色体雄性（ZZ）但表型为雌性或染色体雌性（ZW）但表型雄性的鸟。

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