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61. 发明申请

WO2012099747A3 RADIATION TREATMENT DELIVERY SYSTEM WITH RING GANTRY 审中-公开
标题翻译：环带机舱的辐射处理输送系统
公开(公告)号：WO2012099747A3
公开(公告)日：2012-10-04
申请号：PCT/US2012020795
申请日：2012-01-10
申请人： ACCURAY INC , MAURER CALVIN R JR , LINDQUIST ERIC P
发明人： MAURER CALVIN R JR , LINDQUIST ERIC P
IPC分类号： A61N5/10 , A61N5/00
CPC分类号： A61B6/032 , A61B5/055 , A61B6/4085 , A61B6/4405 , A61N5/10 , A61N5/1045 , A61N5/1048 , A61N5/1049 , A61N5/1067 , A61N5/1081 , A61N5/1082 , A61N2005/0633 , A61N2005/1055 , A61N2005/1061 , A61N2005/1062 , A61N2005/1063
摘要： Systems, methods, and related computer program products for image-guided radiation treatment (IGRT) are described. For one preferred embodiment, an IGRT apparatus is provided comprising a ring gantry having a central opening and a radiation treatment head coupled to the ring gantry that is rotatable around the central opening in at least a 180 degree arc. For one preferred embodiment, the apparatus further comprises a gantry translation mechanism configured to translate the ring gantry in a direction of a longitudinal axis extending through the central opening. Noncoplanar radiation treatment delivery can thereby be achieved without requiring movement of the patient. For another preferred embodiment, an independently translatable 3D imaging device distinct from the ring gantry is provided for further achieving at least one of pre-treatment imaging and setup imaging of the target tissue volume without requiring movement of the patient.
摘要翻译：描述了用于图像引导放射治疗（IGRT）的系统，方法和相关的计算机程序产品。对于一个优选实施例，提供了一种IGRT设备，其包括具有中心开口的环形台架和联接到环形台架的辐射处理头，辐射处理头可围绕中心开口以至少180度的弧度旋转。对于一个优选实施例，所述设备进一步包括机架平移机构，所述机架平移机构构造成沿延伸穿过所述中心开口的纵向轴线的方向平移所述环形机架。由此可以实现非共面放射治疗的输送而不需要患者移动。对于另一个优选实施例，提供了不同于环形门架的可独立平移的3D成像装置，用于进一步实现目标组织体积的预处理成像和设置成像中的至少一个，而不需要患者的移动。

62. 发明申请

WO2012118228A1 System for Facilitating Operation of Treatment Delivery System and Method for Controlling Operation of Treatment Delivery System 审中-公开
标题翻译：治疗输送系统运行系统及治疗分娩系统运行方法
公开(公告)号：WO2012118228A1
公开(公告)日：2012-09-07
申请号：PCT/JP2012/055735
申请日：2012-02-29
申请人： MITSUBISHI ELECTRIC CORPORATION , MITSUBISHI ELECTRIC RESEARCH LABORATORIES, INC. , PORIKLI, Fatih, M.
发明人： PORIKLI, Fatih, M.
IPC分类号： A61N5/10
CPC分类号： A61N5/1068 , A61B5/1114 , A61B5/1128 , A61B5/113 , A61B5/1135 , A61B5/4836 , A61B6/12 , A61B6/4458 , A61B6/5288 , A61N5/1037 , A61N5/1049 , A61N5/1067 , A61N5/1083 , A61N2005/1058 , A61N2005/1059 , A61N2005/1061 , A61N2005/1062 , A61N2005/1074 , A61N2005/1087
摘要： A system and method for tracking a tumor includes a regression module for selecting, using a motion signal and a regression function, a feature signal from a set of feature signals, each feature signal in the set of feature signals represents a medical image of the body of the patient, wherein the motion signal represents a motion of a surface of a skin of the patient caused by the respiration, and wherein the regression function is trained based on a set of observations of the motion signal synchronized with the set of feature signals; and a registration module for determining the location of the target object using the feature signal and a registration function, wherein the registration function registers each feature signal to a breath-hold location of the target object identified.
摘要翻译：用于跟踪肿瘤的系统和方法包括用于从一组特征信号中选择使用运动信号和回归函数的特征信号的回归模块，所述特征信号组中的每个特征信号表示身体的医学图像其中所述运动信号表示由所述呼吸引起的患者皮肤表面的运动，并且其中所述回归函数基于与所述特征信号组同步的运动信号的一组观察结果进行训练; 以及登记模块，用于使用所述特征信号和登记功能来确定所述目标对象的位置，其中所述登记功能将每个特征信号登记到所识别的所述目标对象的呼吸保持位置。

63. 发明申请

WO2012099747A2 RADIATION TREATMENT DELIVERY SYSTEM WITH RING GANTRY 审中-公开
标题翻译：具有戒指的辐射处理系统
公开(公告)号：WO2012099747A2
公开(公告)日：2012-07-26
申请号：PCT/US2012/020795
申请日：2012-01-10
申请人： ACCURAY, INC. , MAURER, Calvin R. JR. , LINDQUIST, Eric P.
发明人： MAURER, Calvin R. JR. , LINDQUIST, Eric P.
IPC分类号： A61N5/10 , A61N5/00
CPC分类号： A61B6/032 , A61B5/055 , A61B6/4085 , A61B6/4405 , A61N5/10 , A61N5/1045 , A61N5/1048 , A61N5/1049 , A61N5/1067 , A61N5/1081 , A61N5/1082 , A61N2005/0633 , A61N2005/1055 , A61N2005/1061 , A61N2005/1062 , A61N2005/1063
摘要： Systems, methods, and related computer program products for image-guided radiation treatment (IGRT) are described. For one preferred embodiment, an IGRT apparatus is provided comprising a ring gantry having a central opening and a radiation treatment head coupled to the ring gantry that is rotatable around the central opening in at least a 180 degree arc. For one preferred embodiment, the apparatus further comprises a gantry translation mechanism configured to translate the ring gantry in a direction of a longitudinal axis extending through the central opening. Noncoplanar radiation treatment delivery can thereby be achieved without requiring movement of the patient. For another preferred embodiment, an independently translatable 3D imaging device distinct from the ring gantry is provided for further achieving at least one of pre-treatment imaging and setup imaging of the target tissue volume without requiring movement of the patient.
摘要翻译：描述了用于图像引导辐射治疗（IGRT）的系统，方法和相关计算机程序产品。对于一个优选实施例，提供了一种IGRT装置，其包括具有中心开口的环形台架和耦合到所述环形台架的辐射处理头，所述辐射处理头可以在至少180度的弧度中围绕所述中心开口旋转。对于一个优选实施例，该装置还包括一台架架平移机构，其构造成沿着延伸穿过中心开口的纵向轴线的方向平移环形台架。从而可以实现非平面放射治疗递送，而不需要患者的移动。对于另一个优选实施例，提供了不同于环形台架的可独立平移的3D成像装置，用于进一步实现目标组织体积的预处理成像和建立成像中的至少一个，而不需要患者的移动。

64. 发明申请

WO2008086430A9 METHOD FOR DEPOSITING RADIATION IN HEART MUSCLE 审中-公开
标题翻译：心肌放射治疗的方法
公开(公告)号：WO2008086430A9
公开(公告)日：2008-09-25
申请号：PCT/US2008050652
申请日：2008-01-09
申请人： CYBERHEART INC , ADLER JOHN , SUMANAWEERA THILAKA , MAGUIRE PATRICK
发明人： ADLER JOHN , SUMANAWEERA THILAKA , MAGUIRE PATRICK
IPC分类号： A61N5/10 , A61B17/00 , A61B19/00
CPC分类号： A61N5/1049 , A61B5/1135 , A61B34/10 , A61B34/30 , A61B90/10 , A61B90/36 , A61B2017/00243 , A61B2017/00703 , A61B2034/301 , A61B2090/101 , A61B2090/363 , A61B2090/364 , A61N5/1037 , A61N5/1067 , A61N5/1068 , A61N2005/1062
摘要： Radiosurgical treatment of tissues of the heart to mitigate arrhythmias such as atrial fibrillation or the like. Radiosurgical targeting of the relatively rapid movement of heart tissues may be enhanced by generating a moving model volume using a time-sequence of three dimensional acquired tissue volumes. A digitally reconstructed radiograph (DRR) may be generated from the model at a desired cardiac and/or respiration motion phase and compared to an X-ray or the like taken immediately before or during treatment. When a series of radiation beams will be directed to a heart tissue to alleviate an arrhythmia, the treatment system may alter the radiation beam series in response to the type of the arrhythmia.
摘要翻译：心脏组织的放射外科手术治疗以缓解心律失常如心房纤颤等。通过使用三维采集组织体积的时间序列生成移动模型体积，可以增强心脏组织的相对快速移动的放射外科瞄准。可以在期望的心脏和/或呼吸运动阶段从模型生成数字重建射线照片（DRR），并且将其与在治疗之前或治疗期间紧接着拍摄的X射线等进行比较。当一系列辐射束将被引导至心脏组织以缓解心律失常时，治疗系统可响应于心律失常的类型而改变辐射束系列。

65. 发明申请

WO2005024721A3 2D/3D IMAGE REGISTRATION IN IMAGE-GUIDED RADIOSURGERY 审中-公开
标题翻译：图像导向放射治疗中的2D / 3D图像注册
公开(公告)号：WO2005024721A3
公开(公告)日：2005-11-17
申请号：PCT/US2004027158
申请日：2004-08-20
申请人： ACCURAY INC , KUDUVALLI GOPINATH , FU DONGSHAN , QURESHI SHEHRZAD
发明人： KUDUVALLI GOPINATH , FU DONGSHAN , QURESHI SHEHRZAD
IPC分类号： A61N5/10 , G01N23/04 , G06T7/00 , G06T7/20 , A61B5/05
CPC分类号： A61N5/1049 , A61N5/1067 , A61N5/107 , A61N2005/1061 , A61N2005/1062 , G01N23/04 , G06T7/254 , G06T7/32 , G06T7/38 , G06T2207/10124 , G06T2207/30004
摘要： An image-guided radiosurgery method and system are presented that use 2D/3D image registration to keep the radiosurgical beams properly focused onto a treatment target. A pre-treatment 3D scan of the target is generated at or near treatment planning time (CT DATA). A set of 2D DRRs are generated (DDR GENERATION A and DDR GENERATION B), based on the pretreatment 3D scan (CT DATA). At least one 2D x-ray image of the target is generated in near real time during treatment (X-RAY IMAGE A). The DRRs are registered with the x-ray images, by computing a set of 3D transformation parameters that represent the change in target position between the 3D scan and the x-ray images (IMAGE REGISTRATION). The relative position of the radiosurgical beams and the target is continuously adjusted in near real time in accordance with the 3D transformation parameters (GEOMETRIC TRANSFORMATION). A hierarchical and iterative 2D/3D registration algorithm is used, in which the transformation parameters that are in-plane with respect to the image plane of the x-ray images are computed separately from the out-of-plane transformation parameters.
摘要翻译：提出了一种使用2D / 3D图像配准的图像引导放射外科手术方法和系统，将放射外科手术束适当地聚焦到治疗目标上。在治疗计划时间（CT DATA）处或其附近产生目标的预处理3D扫描。基于预处理3D扫描（CT DATA），生成一组2D DRR（DDR GENERATION A和DDR GENERATION B）。在治疗期间（X-RAY IMAGE A）近似实时地产生目标的至少一个2D X射线图像。通过计算表示3D扫描和X射线图像（图像注册）之间的目标位置的变化的一组3D变换参数，将DRR注册到X射线图像中。根据3D变换参数（GEOMETRIC TRANSFORMATION），放射外科手术束和目标物的相对位置以近实时的方式连续调整。使用分层和迭代的2D / 3D注册算法，其中相对于x射线图像的像面在平面内的变换参数与面外变换参数分开计算。

66. 发明申请

WO2004044612A3 A METHOD AND APPARATUS FOR TRACKING AN INTERNAL TARGET REGION WITHOUT AN IMPLANTED FIDUCIAL 审中-公开
标题翻译：用于跟踪内部目标区域的方法和装置，没有固定的FIDUCIAL
公开(公告)号：WO2004044612A3
公开(公告)日：2004-09-23
申请号：PCT/US0335801
申请日：2003-11-12
申请人： ACCURAY INC
发明人： SCHWEIKARD ACHIM , ADLER JOHN R
IPC分类号： A61B6/12 , A61B19/00 , A61N5/10 , A61B5/05
CPC分类号： A61N5/1049 , A61B5/7285 , A61B6/12 , A61B6/469 , A61B6/541 , A61B8/543 , A61B34/20 , A61B90/361 , A61B2034/2055 , A61B2034/2072 , A61B2090/364 , A61B2090/376 , A61B2090/3762 , A61N5/1064 , A61N5/1067 , A61N2005/1061 , A61N2005/1062
摘要： A method and apparatus for locating an internal target region during treatment without implanted fiducials is presented. The method comprises producing a plurality of first images that show an internal volume including the internal target region, then producing a live image of the internal volume during treatment and matching this live image to one of the plurality of first images. Since the first images show the internal target region, matching the live image to one of the first images identifies the position of the target region regardless of whether the second image itself shows the position of the target region. The first images may be any threedimensional images such as CT scans, magnetic resonance imaging, and ultrasound. The live image may be, for example, an x-ray image. The invention may be used in conjunction with a real-time sensor to track the position of the target region on a real-time basis.
摘要翻译：提出了一种用于在没有植入基准的治疗期间定位内部目标区域的方法和装置。该方法包括产生多个第一图像，其显示包括内部目标区域的内部体积，然后在治疗期间产生内部体积的实况图像，并将该实时图像与多个第一图像之一相匹配。由于第一图像显示内部目标区域，所以将实时图像与第一图像中的一个匹配，识别目标区域的位置，而不管第二图像本身是否显示目标区域的位置。第一图像可以是任何三维图像，例如CT扫描，磁共振成像和超声。实时图像可以是例如x射线图像。本发明可以与实时传感器一起使用以实时地跟踪目标区域的位置。

67. 发明申请

WO1991000057A1 RADIOTHERAPIC SYSTEM 审中-公开
标题翻译：放射治疗系统
公开(公告)号：WO1991000057A1
公开(公告)日：1991-01-10
申请号：PCT/JP1990000856
申请日：1990-06-29
申请人： YOKOGAWA MEDICAL SYSTEMS, LTD. , HARA, Hukihiro
发明人： YOKOGAWA MEDICAL SYSTEMS, LTD.
IPC分类号： A61B06/03
CPC分类号： A61B6/0457 , A61B6/032 , A61B6/06 , A61B6/08 , A61B6/4085 , A61B6/548 , A61N5/1049 , A61N5/1065 , A61N2005/1062
摘要： A radiotherapic system which can conduct streamlined and labor-saving operations ranging from a stage in which a patient is diagnozed, the position, size and shape of the affected part, etc, are identified and a remedial plan such as radiation field is determined, to positioning of the radiation field for the patient and the execution of radiation. In the present invention, tomographic pictures are taken by use of X-ray CT, three-dimensional coordinates of the center position of an interested region subjected to radiotherapy and a fluoroscopic image of the interested region equivalent to a fluoroscopic image obtained by an X-ray simulator are obtained by the calculation of image data of the tomogram by a computer. The reference position of the therapy is marked on the patient on the basis of the three-dimensional coordinates of the center position of the interested region by use of a positioning apparatus, and the radiation collimator of the therapeutic apparatus is controlled on the basis of the calculated fluoroscopic image of the interested region by a therapeutic apparatus controller.

68. 发明公开

EP3299064A1 RADIATION TREATMENT DELIVERY SYSTEM WITH RING GANTRY 审中-公开
标题翻译：环带机舱的辐射处理输送系统
公开(公告)号：EP3299064A1
公开(公告)日：2018-03-28
申请号：EP17199454.4
申请日：2012-01-10
申请人： Accuray Incorporated
发明人： MAURER, Calvin R. Jr. , LINDQUIST, Eric P.
IPC分类号： A61N5/10 , A61N5/00
CPC分类号： A61B6/032 , A61B5/055 , A61B6/4085 , A61B6/4405 , A61N5/10 , A61N5/1045 , A61N5/1048 , A61N5/1049 , A61N5/1067 , A61N5/1081 , A61N5/1082 , A61N2005/0633 , A61N2005/1055 , A61N2005/1061 , A61N2005/1062 , A61N2005/1063
摘要： Systems, methods, and related computer program products for image-guided radiation treatment (IGRT) are described. For one preferred embodiment, an IGRT apparatus is provided comprising a ring gantry having a central opening and a radiation treatment head coupled to the ring gantry that is rotatable around the central opening in at least a 180 degree arc. For one preferred embodiment, the apparatus further comprises a gantry translation mechanism configured to translate the ring gantry in a direction of a longitudinal axis extending through the central opening. Noncoplanar radiation treatment delivery can thereby be achieved without requiring movement of the patient. For another preferred embodiment, an independently translatable 3D imaging device distinct from the ring gantry is provided for further achieving at least one of pre-treatment imaging and setup imaging of the target tissue volume without requiring movement of the patient.
摘要翻译：描述了用于图像引导放射治疗（IGRT）的系统，方法和相关的计算机程序产品。对于一个优选实施例，提供了一种IGRT设备，其包括具有中心开口的环形台架和联接到环形台架的辐射处理头，辐射处理头可围绕中心开口以至少180度的弧度旋转。对于一个优选实施例，所述设备进一步包括机架平移机构，所述机架平移机构构造成沿延伸穿过所述中心开口的纵向轴线的方向平移所述环形机架。由此可以实现非共面放射治疗的输送而不需要患者移动。对于另一个优选实施例，提供了不同于环形门架的可独立平移的3D成像装置，用于进一步实现目标组织体积的预处理成像和设置成像中的至少一个，而不需要患者的移动。

69. 发明授权

EP1664752B1 PATIENT POSITIONING SYSTEM FOR RADIATION THERAPY SYSTEM 有权
标题翻译：放射治疗系统的患者定位系统
公开(公告)号：EP1664752B1
公开(公告)日：2017-06-14
申请号：EP04780850.6
申请日：2004-08-12
申请人： LOMA LINDA UNIVERSITY MEDICAL CENTER
发明人： RIGNEY, Nick , ANDERSON, Dan , LESYNA, David , MILLER, Dan , MOYERS, Michael , CHENG, Chieh , BAUMANN, Mike , MCALLASTER, Steven , SLATER, Jerry
IPC分类号： A61N5/10
CPC分类号： A61N5/1049 , A61B6/0442 , A61B6/4092 , A61B2090/3937 , A61N5/1067 , A61N5/1069 , A61N5/1078 , A61N2005/105 , A61N2005/1059 , A61N2005/1061 , A61N2005/1062 , A61N2005/1087 , A61N2005/1097 , B25J9/1666 , G05B15/02 , G05B2219/45117

70. 发明授权

EP2664360B1 Gantry image guided radiotherapy system and related tracking methods 有权
标题翻译：图像引导的辐射治疗系统台架和相关联的跟踪方法
公开(公告)号：EP2664360B1
公开(公告)日：2015-09-09
申请号：EP13164560.8
申请日：2011-02-23
申请人： Accuray Incorporated
发明人： Maurer, Calvin
IPC分类号： A61N5/10 , A61N5/00
CPC分类号： A61N5/1039 , A61B5/0035 , A61B5/0059 , A61B5/055 , A61B6/025 , A61B6/032 , A61B6/06 , A61B6/4014 , A61B6/4085 , A61B6/4435 , A61B6/4452 , A61B6/488 , A61N5/10 , A61N5/1037 , A61N5/1042 , A61N5/1048 , A61N5/1049 , A61N5/1065 , A61N5/1067 , A61N5/1081 , A61N5/1082 , A61N2005/1061 , A61N2005/1062 , A61N2005/1092 , G01N2223/308
摘要： Systems, methods, and related computer program products for image-guided radiation treatment (IGRT) are described. Provided according to one preferred embodiment is an IGRT apparatus including a barrel-style rotatable gantry structure that provides high mechanical stability, versatility in radiation delivery, and versatility in target tracking. Methods for treatment radiation delivery using the IGRT apparatus include conical non-coplanar rotational are therapy and cono-helical non-coplanar rotational are therapy. A radiation treatment head (MV source) and treatment guidance imaging system including a kV imaging source are mounted to and rotatable with a common barrel-style rotatable gantry structure, or alternatively the MV and kV sources are mounted to separate barrel-style rotatable gantry structures independently rotatable around a common axis of rotation. Methods for intra-fraction target tracking in a gantry-style IGRT system based on comparisons between a pre-acquired planning image and intrafraction x-ray tomosynthesis images and/or intrafraction cone beam CT (CBCT) images are also described.

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