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    • 69. 发明申请
    • ION TRAP MASS SPECTROMETERS
    • 离子阱质谱仪
    • WO2015071648A3
    • 2015-11-26
    • PCT/GB2014053334
    • 2014-11-11
    • MICROMASS LTD
    • GILES KEVINGREEN MARTIN RAYMONDRICHARDSON KEITHWILDGOOSE JASON LEE
    • H01J49/00G01N27/62
    • H01J49/06G01N27/622H01J49/004H01J49/38
    • A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing ions towards an ion storage region(10); selecting a target maximum charge desired to be stored within the ion storage region (10) at any given time;and reducing the ion current passing to the ion storage region (10) such that the ions entering the ion storage region (10) do not cause the total charge within the storage region (10) to rise above said target maximum charge. The step of reducing the ion current passing to the ion storage region (10) comprises: temporally separating the ions according to their ion mobility in an ion mobility separator (4); and mass filtering the ions according to mass to charge ratio with a mass filter (6). Said steps of separating and mass filtering the ions result in substantially only target ions having selected combinations of ion mobility and mass to charge ratio being transmitted towards the ion storage region (10). The method further comprises accumulating the target ions within the ion storage region (10) during an ion accumulation period.
    • 公开了一种质谱法或离子迁移谱法的方法,包括:向离子存储区(10)提供离子; 在任何给定时间选择期望存储在离子存储区域(10)内的目标最大电荷;以及减少传递到离子存储区域(10)的离子电流,使得进入离子存储区域(10)的离子不会 导致存储区域(10)内的总电荷上升到所述目标最大电荷以上。 减少通向离子存储区域(10)的离子电流的步骤包括:在离子迁移率分离器(4)中根据离子迁移率暂时分离离子; 并且用质量过滤器(6)根据质荷比过滤离子。 所述对离子进行分离和质量过滤的步骤基本上仅导致目标离子具有向离子存储区域(10)传输的离子迁移率和质荷比的选定组合。 该方法进一步包括在离子累积时段期间在离子存储区域(10)内累积目标离子。
    • 70. 发明申请
    • ION TRAP MASS SPECTROMETERS
    • 离子阱质谱仪
    • WO2015071648A2
    • 2015-05-21
    • PCT/GB2014/053334
    • 2014-11-11
    • MICROMASS UK LIMITED
    • GILES, KevinGREEN, Martin RaymondRICHARDSON, KeithWILDGOOSE, Jason Lee
    • H01J49/06G01N27/622H01J49/004H01J49/38
    • A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing ions towards an ion storage region(10); selecting a target maximum charge desired to be stored within the ion storage region (10) at any given time;and reducing the ion current passing to the ion storage region (10) such that the ions entering the ion storage region (10) do not cause the total charge within the storage region (10) to rise above said target maximum charge. The step of reducing the ion current passing to the ion storage region (10) comprises: temporally separating the ions according to their ion mobility in an ion mobility separator (4); and mass filtering the ions according to mass to charge ratio with a mass filter (6). Said steps of separating and mass filtering the ions result in substantially only target ions having selected combinations of ion mobility and mass to charge ratio being transmitted towards the ion storage region (10). The method further comprises accumulating the target ions within the ion storage region (10) during an ion accumulation period.
    • 公开了一种质谱法或离子迁移光谱法,其包括:向离子存储区域(10)提供离子; 在任何给定时间选择期望存储在离子存储区域(10)内的目标最大电荷;以及减少通过离子存储区域(10)的离子电流,使得进入离子存储区域(10)的离子不 导致存储区域(10)内的总电荷升高到所述目标最大电荷之上。 减少通过离子存储区域(10)的离子电流的步骤包括:在离子迁移率分离器(4)中根据其离子迁移率暂时分离离子; 并且与质量过滤器(6)按照质荷比对离子进行质量过滤。 分离和质量过滤离子的所述步骤基本上仅产生具有选择的离子迁移率和质荷比的组合的目标离子被传递到离子存储区域(10)。 该方法还包括在离子累积期间在离子存储区域(10)内积聚目标离子。