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61. 发明专利

GB1136317A Process for the preparation of tropylium salts and substitution products derived therefrom 未知
公开(公告)号：GB1136317A
公开(公告)日：1968-12-11
申请号：GB1777067
申请日：1967-04-18
申请人： SHELL INT RESEARCH
发明人： BORG ARNE PIETER TER , RAZENBERG ELISA
IPC分类号： C07C13/24
摘要： 1,136,317. Tropylium salts. SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ N.V. 18 April, 1967, No. 17770/67. Heading C5E. Substituted or unsubstituted tropylium salts are prepared by autoxidation of substituted or unsubstituted oycloheptatriene (the methylene group carrying at most one substituent) by contact in an acid medium with oxygen or an oxygen-containing gas in the presence of a phenol. Numerous phenols are specified. The medium may be a solution of a strong acid in a weak acid. Fe ions may be present, preferably as FeCl 3 . Examples describe the preparation of tropylium perchlorate and tropylium tetrafluoroborate.

62. 发明专利

FR6502M 未知
公开(公告)号：FR6502M
公开(公告)日：1968-12-02
申请号：FR6502D
申请日：1967-05-10
IPC分类号： A61K20060101 , C07C13/24

63. 发明专利

BE698198A 未知
公开(公告)号：BE698198A
公开(公告)日：1967-11-09
申请号：BE698198D
申请日：1967-05-09
IPC分类号： A61K20060101 , C07C13/24

64. 发明专利

NL6605256A 未知
公开(公告)号：NL6605256A
公开(公告)日：1967-10-23
申请号：NL6605256
申请日：1966-04-20
IPC分类号： C07C13/24

65. 发明专利

CH415610A Procédé de préparation de 5-hydroxy-5-amino-alcoyl-10,11-dihydro-5H-dibenzo-(a,d)cycloheptènes 未知
公开(公告)号：CH415610A
公开(公告)日：1966-06-30
申请号：CH1456763
申请日：1963-11-28
申请人： PHARMACIA AB
发明人： NILS SIXTEN HJELTE , RAGNVALD ERIK LINDBLOM
IPC分类号： C07D295/08 , C07C13/24 , C07C87/40

66. 发明专利

GB775113A Improvements in or relating to recovery of cyclodiene monomers 未知
公开(公告)号：GB775113A
公开(公告)日：1957-05-22
申请号：GB2033554
申请日：1954-07-12
申请人： EXXON RESEARCH ENGINEERING CO
IPC分类号： C07C4/04 , C07C13/15 , C07C13/24
摘要： Cyclic dienes are obtained by cracking a mixture containing cyclopentadiene and its homologues mainly in the form of dimers and codimers; removing a cracking product containing cyclopentadiene, methyl cyclopentadiene and C7 cyclodienes in the form of monomers, dimers and codimers; subjecting the cracking product to distillation and recovering as separate fractions (a) cyclopentadiene and methylcyclopentadiene monomers; (b) C7 cyclodiene monomers; and (c) a heavy material containing dimers and codimers of cyclopentadiene and methyl cyclopentadiene, and recycling fraction (c) to the cracking step. In a preferred embodiment, mixed dimer and codimer concentrates comprising principally in dimerised form, about 30 to 50 per cent of cyclopentadiene, 25-40 per cent of methyl cyclopentadiene, 5-10 per cent of acyclic dienes, and 5 to 10 per cent of C7 cyclodienes obtained from the high temperature cracking of naphtha and gas oil fractions was mixed with at least four times its weight of recycle gas and fed through a heat-exchange vessel 6 to a cracking vessel 3 and then to a first fractionator 1, residual liquid is recycled through a pipe 14, C7-C9 components are removed through a pipe 13, and the C5 and C6 monomer vapour stream which leaves through pipe 17 is passed into second fractionator 2 in which the C5 and C6 cyclodienes are separated, the C5 fraction leaving via pipe 21 and the C6 fraction via pipe 22. Residual liquid containing dimers is withdrawn via pipe 23 and re-cycled.ALSO:Cyclic dienes are obtained by cracking a mixture containing cyclopentadiene and its homologues mainly in the form of dimers and codimers; removing a cracking product containing cyclopentadiene, methyl cyclopentadiene and C7 cyclodienes in the form of monomers, dimers and codimers; subjecting the cracking product to distillation and recovering as separate fractions (a) cyclopentadiene and methylcyclopentadiene monomers (b) C7 cyclodiene monomers and (c) a heavy material containing dimers and codimers of cyclopetadiene and methyl cyclopentadiene, and recycling fraction (c) to the cracking step. In a preferred embodiment, mixed dimer and codimer concentrates comprising principally in dimerized form, about 30 to 50 per cent of cyclopentadiene, 25-40 per cent of methyl cyclopentadiene, 5-10 per cent of acyclic dienes, and 5 to 10 per cent of C7 cyclodienes obtained from the high temperature cracking of naphtha and gas oil fractions was mixed with at least four times its weight of recycle gas and fed through a heat exchange vessel 6 to a cracking vessel 3 and then to a first fractionator 1, residual liquid is recycled through a pipe 14, C7-C9 components are removed through a pipe 13, and the C5 and C6 monomer vapour stream which leaves through pipe 17 is passed into a second fractionator 2 in which the C5 and C6 cyclodienes are separated, the C5 fraction leaving via pipe 21 and the C6 fraction via pipe 22. Residual liquid containing dimers is withdrawn va pipe 23 and recycled.

67. 发明专利

ES2729305T3 Derivado de aminoalquilbenzotiazepina novedoso y uso del mismo 未知
公开(公告)号：ES2729305T3
公开(公告)日：2019-10-31
申请号：ES15851901
申请日：2015-08-28
申请人： CJ HEALTHCARE CORP
发明人： JUNG WON-HYUK , KIM SEUNG IN , JI SEUNG HEE , KO DONG HYUN , SONG SEOG BEOM , LEE KEUN HO , JUN HYUNG JIN , KIM DONG KYU , KIM DONG HYUN
IPC分类号： C07D417/12 , A61K31/554 , C07C13/24 , C07C13/32 , C07C317/06 , C07D281/08 , C07D281/10
摘要： Un compuesto representado por la Fórmula 1 siguiente, o una sal farmacéuticamente aceptable del mismo:**Fórmula** en la que R1 es hidroxi, carboxi, o hidroxisulfonil(alquilo C1-4); R2 y R3 son cada uno independientemente hidrógeno, alquilo C1-4, hidroxi(alquilo C 1-4), carbamoil(alquilo C1-4), carboxi, carboxi(alquilo C1-4), (heteroaril C5-10)(alquilo C1-4) o (aril C 5-10)(alquilo C1-4) o R2 y R3, tomados junto con el respectivo átomo de carbono al que están enlazados, forman cicloalquileno C3-7, o R2 y R3 son cada uno independientemente hidrógeno, carboxi, metilo, isobutilo, carbamoilmetilo, carboximetilo, carboxietilo, hidroximetilo, imidazolilmetilo, indolilmetilo, o etilo, o R2 y R3, tomados junto con el átomo de carbono respectivo al que están enlazados, forman ciclopropileno; R4 es hidrógeno o carboxi(alquilo C1-4); R5 es hidrógeno, halógeno, (alquil C1-4)tio, (alquil C1-4)amino o di (alquil C1-4)amino; R6 y R7 son cada uno independientemente alquilo C1-6; R8 y R9 son cada uno independientemente hidrógeno, hidroxi, alcoxi C1-4, alquilo C1-4, halógeno, nitro, ciano, amino, (alquil C1-4)amino, di(alquil C1-4)amino, acetamido, formilo, alcanoílo C1-4, carboxi, carbamoílo, (alquil C1-4)carbamoílo, di(alquil C1-4)carbamoílo, carbamoiloxi, (alquil C1-4)carbamoiloxi, di(alquil C1- 4)carbamoiloxi, (alquil C1-4)sulfoniloxi, sulfamoiloxi, (alquil C1-4)sulfamoiloxi o di(alquil C1- 4)sulfamoiloxi; Q es arilo C5-10 o heteroarilo C5-10. o Q es fenilo, piridinilo, pirimidinilo, o tiofenilo; y n es un número entero de 0 a 3.

68. 发明专利

DK3210977T3 Hidtil ukendt aminoalkylbenzothiazepinderivat og anvendelse deraf 未知
公开(公告)号：DK3210977T3
公开(公告)日：2019-07-01
申请号：DK15851901
申请日：2015-08-28
申请人： CJ HEALTHCARE CORP
发明人： KIM SEUNG IN , JI SEUNG HEE , KO DONG HYUN , SONG SEOG BEOM , LEE KEUN HO , JUN HYUNG JIN , KIM DONG KYU , KIM DONG HYUN , JUNG WON-HYUK
IPC分类号： C07D417/12 , A61K31/554 , C07C13/24 , C07C13/32 , C07C317/06 , C07D281/08 , C07D281/10

69. 发明专利

BR0200114A 未知
公开(公告)号：BR0200114A
公开(公告)日：2002-10-22
申请号：BR0200114
申请日：2002-01-17
申请人： SERVIER LAB
发明人： CASARA PATRICK , DIGUARHER THIERRY LE , DOREY GILBERT , HICKMAN JOHN , PIERRE ALAIN , TUCKER GORDON , GUILBAUD NICOLAS
IPC分类号： C07C317/00 , A61K31/4164 , A61K31/417 , A61K31/4178 , A61K31/4406 , A61K31/4409 , A61K31/454 , A61P9/00 , A61P9/10 , A61P25/00 , A61P35/00 , C07D213/36 , C07D213/38 , C07D213/57 , C07D233/54 , C07D233/58 , C07D233/61 , C07D233/64 , C07D401/06 , C07C13/24 , A61K31/015 , A61P25/28
摘要： Compound of formula (I):wherein:X represents a bond or alkylene, CO, S(O)n, -S(O)n-A1-, -CO-A1-, -A-S(O)n-A'1- or -A1-CO-A'1-,Y represents aryl, heteroaryl, cycloalkyl or heterocycloalkyl, each unsubstituted or substituted,R1, R2, R3 and R4 each independently of the others represent hydrogen or aryl, heteroaryl, cycloalkyl or heterocycloalkyl, each unsubstituted or substituted,or R1, R2, R3 and R4, taken in pairs, together form a bond, or form a fused benzene ring or a fused aromatic or partially unsaturated heterocycle,T represents -CH(R5)-, -N(R5)- or -N(R5)CO-,V represents hydrogen or unsubstituted or substituted aryl or heteroaryl,A2 represents [C(R6)(R'6)]p,R7 and R8 are as defined in the description,their isomers and addition salts thereof with a pharmaceutically acceptable acid or base and medicinal products containing the same are useful as farnesyl transferase inhibitors.

70. 发明专利

CA2367306A1 NOUVEAUX COMPOSES CYCLOHEPTENE, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 未知
公开(公告)号：CA2367306A1
公开(公告)日：2002-07-18
申请号：CA2367306
申请日：2002-01-17
申请人： SERVIER LAB
发明人： HICKMAN JOHN , CASARA PATRICK , PIERRE ALAIN , LE DIGUARHER THIERRY , DOREY GILBERT , GUILBAUD NICOLAS , TUCKER GORDON
IPC分类号： C07C317/00 , A61K31/4164 , A61K31/417 , A61K31/4178 , A61K31/4406 , A61K31/4409 , A61K31/454 , A61P9/00 , A61P9/10 , A61P25/00 , A61P35/00 , C07D213/36 , C07D213/38 , C07D213/57 , C07D233/54 , C07D233/58 , C07D233/61 , C07D233/64 , C07D401/06 , C07C13/24 , A61K31/015 , C07D233/56
摘要： L'invention concerne de nouveaux composés répondant à la formule formule (I ): dans laquelle X représente une liaison ou un groupement alkylène, CO, S(O)n, *- S(O)n-A1-, *-CO-A1-, -A1-S(O)n-A'1- et -A1-CO-A'1- dans lesquels A1 et A'1, identiques ou différents, représentent un groupement alkylène et n vaut 0, 1 ou 2, le symbole "*" représentant le point de rattachement du groupement au cycloheptène; Y représente un groupement aryle, hétéroaryle, cycloalkyle ou hétérocycloalkyle; R1, R2, R3 et R4 représentent indépendamment l'un de l'autre un atome d'hydrogène ou un groupement aryle, hétéroaryle, cycloalkyle ou hétérocycloalkyle, ou bien R1, R2, R3 et R4, pris deux à deux , forment ensemble une liaison, ou bien R1 et R2, ou R2 et R3 ou R3 et R4, pris deux à deux avec les atomes de carbone auxquels ils sont liés, forment un cycle benzénique fusion né ou un hétérocycle fusionné aromatique ou partiellement hydrogéné; T représente un groupement -CH(R5)-, -N(R5)- ou *-N(R5)CO- dans lesquels R5 représente un atome d'hydrogène ou un groupement alkyle, aryle, hétéroaryle, arylalkyle ou hétéroarylalkyle, le symbole "*" représentant le point de rattachement du groupement au cycloheptène; V représente un atome d'hydrogène ou un groupement aryle ou hétéroaryle; A2 représente un groupement [C(R6)(R'6)]p où p vaut 0, 1, 2, 3 ou 4 lorsque T représente un groupement - CH(R5)- ou *-N(R5)CO- où p vaut 1, 2, 3 ou 4 lorsque T représente un groupement -N(R5)- , et R6 et R'6, identiques ou différents, représentent un atome d'hydrogène ou un groupement alkyle, alkényle, alkynyle, aryle, hétéroaryle, hétérocycloalkyle, arylalkyle éventuellement substitué, hétéroarylalkyle, hétérocycloalkylalkyle, R9 ou alkyle substitué par un groupement R9 où R9 représente un groupement -OR5,-N(R5)(R'5), -S(O)m R5, -CON(R5)(R'5), -N(R5)COR'5, -N(R5)SO2R'5, -SO2N(R5)(R'5), -N(R5)COO(R'5), m étant égal à 0, 1 ou 2, et R'5 prenant toutes les valeurs de R5. L'invention vise également les énantiomères et diastéréoisomères des composés de formule (I), ainsi que leu rs sels -52- d'addition à un acide ou à une base pharmaceutiquement acceptable. Les composés selon l'invention sont utiles à titre de médicaments pour le traitement des maladi es cancéreuses ainsi que pour le traitement de la resténose après angioplastie ou chirurgie vasculaire, et de la neurofibromatose de type I.

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