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71. 发明授权

US08784845B2 Selective chemokine modulation 有权
标题翻译：选择性趋化因子调节
公开(公告)号：US08784845B2
公开(公告)日：2014-07-22
申请号：US12441000
申请日：2007-09-11
申请人： Lars Bruce , Staale Petter Lyngstadaas
发明人： Lars Bruce , Staale Petter Lyngstadaas
IPC分类号： A61K9/00
CPC分类号： A61M1/38 , A61K9/14 , A61K33/24 , A61M1/3679 , B01J20/02 , B01J20/06 , Y02A50/387
摘要： The present invention teaches the use of a metal or an oxide of a metal having a capability of reducing the amount of the chemokine IP-IO in a sample and/or reducing the production of IP-IO in cells. The metal is a metal of group 4 or 5 in the periodic table of the elements and preferably titanium. These metals and metal oxides can selectively bind IP-IO to its surface to thereby scavenge IP-IO from the surrounding medium. In addition, a metal-cell contact induces a reduction in the production of IP-IO from IP-IO producing cells. The metals and metal oxides of the present invention can therefore be used for treating and/or preventing medical conditions characterized by adverse IP-IO expression, such as inflammatory reactions.
摘要翻译：本发明教导了具有降低样品中趋化因子IP-IO量的金属或金属的氧化物和/或减少细胞中IP-10的产生的用途。金属是元素周期表中第4或5族的金属，优选为钛。这些金属和金属氧化物可以选择性地将IP-IO结合到其表面上，从而从周围介质中清除IP-IO。此外，金属电池接触引起IP-IO生产电池的IP-IO生产的降低。因此，本发明的金属和金属氧化物可用于治疗和/或预防以不利的IP-IO表达为特征的医学病症，例如炎性反应。

72. 发明授权

US08759488B2 High stability streptavidin mutant proteins 有权
标题翻译：高稳定性链霉抗生物素蛋白突变蛋白
公开(公告)号：US08759488B2
公开(公告)日：2014-06-24
申请号：US13504540
申请日：2010-10-28
申请人： Mark Howarth
发明人： Mark Howarth
IPC分类号： C07K17/00
CPC分类号： C07K14/36
摘要： The present invention provides a mutant streptavidin subunit which comprises one or more amino acid substitutions compared to a wildtype streptavidin subunit at any one of residue positions equivalent to positions (50, 51, 52, 53) and (54) of SEQ ID NO. 2 and wherein amino acid residues at positions equivalent to positions (23, 27, 43, 45, 49, 79, 88, 90, 92, 108, 110) and (128) of SEQ ID NO. 2, in said mutant streptavidin subunit, are wildtype, wherein (i) when said mutant streptavidin subunit unit is comprised in streptavidin, said streptavidin has a lower off rate for biotin or for a biotin conjugate than wildtype streptavidin or (ii) when said mutant streptavidin subunit is in monomelic form said mutant monomelic streptavidin has a lower off rate for biotin or a biotin conjugate than monomelic streptavidin. The invention also encompasses nucleic acid molecules comprising a nucleotide sequence encoding the mutant streptavidin subunit and vectors and cells comprising the nucleic acid. Further, methods of capturing biotinylated molecules and cells and therapeutic methods are encompassed.
摘要翻译：本发明提供了与野生型链霉抗生物素蛋白亚基相当的任何一个等位于SEQ ID NO的位置（50,51,52,53）和（54）的任何一个位置上的一个或多个氨基酸取代的突变链霉亲和素亚基。 2，并且其中相当于SEQ ID NO.1的位置（23,27,43,45,49,79,88,90,92,108,110）和（128）的位置处的氨基酸残基。 2，在所述突变链霉亲和素亚基中，是野生型，其中（i）当所述突变链霉亲和素亚单位包含在链霉亲和素中时，所述链霉抗生物素蛋白与野生型链霉抗生物素蛋白相比，生物素或生物素缀合物的脱除率较低，或（ii）链霉抗生物素蛋白亚基是单体形式，所述突变单体链霉抗生物素蛋白与生物素或生物素缀合物比单体链霉亲和素具有较低的脱除率。本发明还包括包含编码突变链亲和素亚基的核苷酸序列和包含该核酸的载体和细胞的核酸分子。此外，包括捕获生物素化分子和细胞的方法以及治疗方法。

73. 发明授权

US08745378B1 System and method for validating SCEP certificate enrollment requests 有权
标题翻译：用于验证SCEP证书注册请求的系统和方法
公开(公告)号：US08745378B1
公开(公告)日：2014-06-03
申请号：US13762890
申请日：2013-02-08
申请人： Gary A. Galehouse , Wayne A. Harris , Edward R. Shorter , Kevin M. Tambascio
发明人： Gary A. Galehouse , Wayne A. Harris , Edward R. Shorter , Kevin M. Tambascio
IPC分类号： H04L29/06
CPC分类号： H04L63/0823 , H04L29/06 , H04L63/08 , H04L63/205
摘要： A system and method for validating SCEP certificate enrollment that enforces the pairing of a SCEP challenge password and a set of expected certificate request content. A SCEP Validation Service or software residing in another system component whether a certificate request is legitimate by comparing it to registered SCEP challenges and associated expected certificate request content. This system and method addresses a privilege-escalation vulnerability in prior SCEP-based systems that could lead to a practical attack.
摘要翻译：用于验证执行SCEP挑战密码和一组预期证书请求内容的配对的SCEP证书注册的系统和方法。通过将证书申请与注册的SCEP挑战和相关的预期证书请求内容进行比较，驻留在另一个系统组件中的SCEP验证服务或软件是否合法。该系统和方法解决了先前基于SCEP的系统中的特权升级漏洞，可能导致实际攻击。

74. 发明授权

US08740732B2 Discus training device 有权
标题翻译：铁饼训练装置
公开(公告)号：US08740732B2
公开(公告)日：2014-06-03
申请号：US13278529
申请日：2011-10-21
申请人： Dominic Finelli
发明人： Dominic Finelli
IPC分类号： A63B49/00 , A63B47/02 , A63B71/14 , A41D19/00
CPC分类号： A63B65/10 , A63B71/141 , A63B2209/10
摘要： A training device for use with a regulation discus includes a glove body sized and shaped for receiving at least a portion of a hand of a discus thrower therein and an attachment for securing the regulation discus to the glove body at a front of the glove body such that the discus thrower can grasp the regulation discus and practice throwing the discus without releasing the regulation discus from the glove body. The glove body has a wrist opening, at least one thumb opening, and at least one finger opening. Thus, even if the discus thrower inadvertently lets go of the regulation discus, the regulation discus is not thrown because it is secured to the glove body worn by the discus thrower. The attachment can be straps that are secured about the regulation discus.
摘要翻译：一种与调节铁饼一起使用的训练装置包括：手套体，其大小和形状用于容纳铁饼投掷器的手的至少一部分，以及用于将调节铁饼固定在手套本体前部的手套体上的附件，铁饼人可以掌握调节铁饼和练习抛掷铁饼，而不会从手套身体释放调节铁饼。手套主体具有手腕开口，至少一个拇指开口和至少一个手指开口。因此，即使铁饼投掷者无意中放弃调节铁饼，调节铁饼也不会因为被铁饼扔掉的手套身体固定而被抛出。附件可以是围绕调节铁饼固定的带子。

75. 发明授权

US08730154B2 Display apparatus 有权
标题翻译：显示装置
公开(公告)号：US08730154B2
公开(公告)日：2014-05-20
申请号：US13567976
申请日：2012-08-06
申请人： Kenneth A. Dean , Jason C. Heikenfeld
发明人： Kenneth A. Dean , Jason C. Heikenfeld
IPC分类号： G09G3/34 , G02B26/00
CPC分类号： G09G3/344 , G09G3/3446 , G09G2300/0456 , G09G2300/0469 , G09G2300/0866 , G09G2320/0252
摘要： A device, an electrode configuration and a sequence for activating those electrodes for the purpose of switching device states quickly with minimum flicker during bi-stable image reset. The disclosure addresses the constraints of electrofluidic technology: 1) the polar fluid can be attracted to a position with voltage, but it cannot be repelled, and 2) because the polar fluid translates, changing its area against an electrode and thereby changing the capacitance, the time to discharge the capacitor formed by area contact with a polar fluid is significantly smaller than the time to charge a capacitor, which requires translation of the fluid. Setting the grayscale is based on discharging, not charging, when possible. In addition, the use of pixel-level partial reset states reduces the appearance of flicker further by minimizing the change in pixel state during data write/update.
摘要翻译：用于在双稳态图像复位期间以最小的闪烁快速切换器件状态来激活这些电极的器件，电极配置和序列。本发明涉及电流技术的约束：1）极性流体可以被吸引到具有电压的位置，但不能被排斥，并且2）由于极性流体平移，相对于电极改变其面积，从而改变电容，通过与极性流体区域接触而形成的电容器放电的时间显着小于对电容器充电的时间，这需要液体的平移。设置灰度是基于放电，而不是充电。此外，使用像素级部分复位状态通过在数据写入/更新期间最小化像素状态的变化来进一步减少闪烁的出现。

76. 发明授权

US08709727B2 Magnetic detection of small entities 有权
标题翻译：小实体的磁检测
公开(公告)号：US08709727B2
公开(公告)日：2014-04-29
申请号：US12678171
申请日：2008-09-17
申请人： Mattias Strömberg , Jenny Göransson , Klas Gunnarsson , Mats Nilsson , Peter Svedlindh , Maria Strçmme
发明人： Mattias Strömberg , Jenny Göransson , Klas Gunnarsson , Mats Nilsson , Peter Svedlindh , Maria Strçmme
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： G01N33/542 , C12Q1/6825 , C12Q1/6844 , C12Q1/6851 , G01N2458/10 , C12Q2563/155 , C12Q2563/143 , C12Q2531/125 , C12Q2545/114
摘要： A novel detection or quantifying method for biological entities or molecules such as, but not limited to, DNA, microorganisms and pathogens, proteins and antibodies, that by themselves are target molecules or from which target molecules are extracted, comprises the steps of i) forming target molecule-dependent volume-amplified entities, ii) allowing magnetic nanoparticles to bind to said volume-amplified entities, and iii) measuring changes in dynamic magnetic response of the magnetic nanoparticles caused by the increase in hydrodynamic volume of said magnetic nanoparticles.
摘要翻译：用于生物实体或分子的新型检测或定量方法，例如但不限于DNA，微生物和病原体，蛋白质和抗体，其本身是靶分子或从其中提取靶分子的步骤包括以下步骤：i）形成靶分子依赖性体积扩增实体，ii）允许磁性纳米粒子结合到所述体积扩增实体，以及iii）测量由所述磁性纳米颗粒的流体动力学体积增加引起的磁性纳米颗粒的动态磁响应的变化。

77. 发明授权

US08709404B2 Immunotherapy in cancer treatment 有权
标题翻译：癌症治疗中的免疫治疗
公开(公告)号：US08709404B2
公开(公告)日：2014-04-29
申请号：US10530738
申请日：2003-10-08
申请人： Ola Winqvist , Magnus Thörn
发明人： Ola Winqvist , Magnus Thörn
IPC分类号： A01N63/00
CPC分类号： C12N5/0636 , A61K2039/5158 , C12N5/0651
摘要： The present invention relates to a novel method of cancer immuno-therapy and to a kit for use in this method. Specifically, the present invention relates to a novel method of collecting lymphocytes from sentinel lumph nodes and in vitro culture for the multiplication thereof lymphocytes.
摘要翻译：本发明涉及一种癌症免疫治疗的新方法以及用于该方法的试剂盒。具体地说，本发明涉及从前哨淋巴结收集淋巴细胞和体外培养用于增殖淋巴细胞的新方法。

78. 外观设计

USD702043S1 Handbag organizer insert 有权
公开(公告)号：USD702043S1
公开(公告)日：2014-04-08
申请号：US29430246
申请日：2012-08-23
申请人： Christy Anne Johnson , Brandi Lynn Osterman
设计人： Christy Anne Johnson , Brandi Lynn Osterman

79. 发明授权

US08679807B2 Covalent immobilization of molecules comprising an amino group 有权
标题翻译：包含氨基的分子的共价固定化
公开(公告)号：US08679807B2
公开(公告)日：2014-03-25
申请号：US13812101
申请日：2011-07-27
申请人： Sven Oscarsson , Kristofer Eriksson , Leif Nyholm
发明人： Sven Oscarsson , Kristofer Eriksson , Leif Nyholm
IPC分类号： C12N11/00 , C12N11/06 , C12N11/04
CPC分类号： C07K17/10 , C07K17/14 , C12N11/00 , G01N33/54353
摘要： There is provided a method for covalent immobilization of at least one molecule comprising at least one amino group, said method comprising the sequential steps of: a) providing a surface comprising —SH groups, b) oxidizing the surface comprising —SH groups using redox reactions in the presence of noble metal ions, and c) contacting the surface with at least one molecule comprising at least one amino group to obtain a covalent binding of the at least one molecule to the surface, wherein said at least one amino group is involved in obtaining said covalent bond. The immobilized molecules are immobilized via stable covalent bonds. The method is more versatile since it can be performed as a one step method. All reaction steps are performed in aqueous solution. All steps can be performed at room temperature. The chemicals used are less expensive and less toxic compared to the prior art.
摘要翻译：提供了至少一种包含至少一个氨基的分子共价固定的方法，所述方法包括以下顺序步骤：a）提供包含-SH基团的表面，b）使用氧化还原反应氧化包含-SH基团的表面在贵金属离子的存在下，和c）使所述表面与至少一个包含至少一个氨基的分子接触，以获得所述至少一个分子与所述表面的共价结合，其中所述至少一个氨基参与获得所述共价键。固定化的分子通过稳定的共价键固定。该方法更通用，因为它可以作为一步法进行。所有反应步骤均在水溶液中进行。所有步骤均可在室温下进行。与现有技术相比，使用的化学品便宜且毒性较小。

80. 发明授权

US08636754B2 Clip applicator 有权
标题翻译：夹子施放器
公开(公告)号：US08636754B2
公开(公告)日：2014-01-28
申请号：US12944430
申请日：2010-11-11
申请人： James David Hughett, Sr. , Matthew Monti , Adam Harp , Jason Iain Glithero , Kenneth Lance Miller , Philip P. Resig , Salvatore Privitera
发明人： James David Hughett, Sr. , Matthew Monti , Adam Harp , Jason Iain Glithero , Kenneth Lance Miller , Philip P. Resig , Salvatore Privitera
IPC分类号： A61B17/08
CPC分类号： A61B17/1285 , A61B17/1227 , A61B2017/2926 , A61B2034/305 , Y10T24/44256 , Y10T29/49826
摘要： A clamp assembly comprising: (a) a clamping device biased toward a closed position; (b) a first retainer bar removably coupled to the clamping device; (c) a second retainer bar removably coupled to the clamping device, where the first retainer bar and the second retainer bar are oriented in parallel to one another.
摘要翻译：一种夹具组件，包括：（a）朝向关闭位置偏压的夹紧装置; （b）可拆卸地联接到夹紧装置的第一保持杆; （c）可移除地联接到夹紧装置的第二保持杆，其中第一保持杆和第二保持杆彼此平行地取向。

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