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71. 发明授权

US5583009A Method of preparing recombinant proteins in transgenic animals containing metallothionein gene elements that bestow tissue-independent copy number-dependent, position-indepedent gene expression 失效
标题翻译：在含有金属硫蛋白基因元件的转基因动物中制备重组蛋白的方法，所述金属硫蛋白基因元件赋予组织非依赖性拷贝数依赖性，位置独立基因表达
公开(公告)号：US5583009A
公开(公告)日：1996-12-10
申请号：US986963
申请日：1992-12-08
申请人： Richard Palmiter , Eric P. Sandgren , Ralph L. Brinster
发明人： Richard Palmiter , Eric P. Sandgren , Ralph L. Brinster
IPC分类号： A01K67/027 , C07K14/825 , C12N15/85 , C12P21/02 , C07H21/04 , C12N15/09 , C12P21/00
CPC分类号： A01K67/0278 , A01K67/0275 , C07K14/825 , C12N15/85 , C12N15/8509 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/20 , A01K2227/105 , C12N2830/002 , C12N2830/008 , C12N2830/85
摘要： Vertebrate gene locus control regions linked to a structural gene of interest and inserted into a transgenic animal are capable of bestowing tissue-independent, copy number-dependent, position-independent gene expression. Recombinant proteins of interest encoded by structural genes linked to the metallothionein locus control regions may be prepared following expression in transgenic animal hosts.
摘要翻译：与感兴趣的结构基因连接并插入转基因动物的脊椎动物基因位点控制区域能够赋予组织依赖性，拷贝数依赖性，位置无关基因表达。通过与金属硫蛋白基因座对照区连接的结构基因编码的重组蛋白质可以在转基因动物宿主中表达后制备。

72. 发明公开

EP3283633A2 PLANT PROMOTER FOR TRANSGENE EXPRESSION 无效
公开(公告)号：EP3283633A2
公开(公告)日：2018-02-21
申请号：EP16758308.7
申请日：2016-04-13
申请人： Dow AgroSciences LLC
发明人： KUMAR, Sandeep , HEMINGWAY, Daren , AUSMUS, Carla , WORDEN, Andrew F. , ASBERRY, Andrew
IPC分类号： C12N15/82 , C07K14/825
CPC分类号： C12N15/8227 , C07K14/825 , C12N15/8216
摘要： This disclosure concerns compositions and methods for promoting transcription of a nucleotide sequence in a plant or plant cell, employing a promoter from a Panicum virgatum metallothionein-like gene (mtl). Some embodiments relate to a promoter from a Panicum virgatum metallothionein-like gene (mtl) that functions in plants to promote transcription of operably linked nucleotide sequences.

73. 发明公开

EP2891661A1 MITOCHONDRIAL TARGETING PEPTIDE 审中-公开
标题翻译：线粒体靶向肽
公开(公告)号：EP2891661A1
公开(公告)日：2015-07-08
申请号：EP13832591.5
申请日：2013-08-30
申请人： University-Industry Cooperation Group of Kyung Hee University
发明人： KIM, Young Mi , KANG, Young Cheol , KIM, Yong Hee
IPC分类号： C07K7/06 , C07K7/08 , C07K19/00 , C12N15/62
CPC分类号： C07K14/005 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/825 , C07K2319/10 , C07K2319/21 , C12N9/0065 , C12N9/0089 , C12N9/1205 , C12N9/93
摘要： The present invention relates to a mitochondria targeting peptide, a fusion protein in which the peptide is bound to the carboxyl terminus of a protein transduction domain, a fusion protein in which the peptide is bound to the carboxyl terminus of a protein transduction domain and an antioxidant is bound to the carboxyl terminus of the peptide, an antioxidant composition and a composition for preventing or treating Parkinson's disease including the fusion protein in which the antioxidant is bound, a recombinant polynucleotide in which a polynucleotide coding a protein transduction domain, a polynucleotide coding the peptide, and a polynucleotide coding an antioxidant protein are sequentially bound, to an expression vector including the polynucleotide, and to a transformed host cell including the expression vector.
The mitochondria targeting peptide according to the present invention targets mitochondria with high efficiency not only when the peptide exists alone but also when the peptide is bound to a protein transduction domain and/or to an antioxidant. Further, the peptide has a small size and is thus a very suitable targeting carrier. The peptide becomes processed when introduced into mitochondria, and thus stably delivers the drug carried by the peptide.

74. 发明公开

EP2021480A4 METHOD FOR PREPARING METAL NANOPARTICLE USING METAL BINDING PROTEIN 审中-公开
标题翻译：一种用于生产金属纳米粒子使用金属结合蛋白
公开(公告)号：EP2021480A4
公开(公告)日：2010-10-20
申请号：EP07746028
申请日：2007-04-17
申请人： KOREA ADVANCED INST SCI & TECH
发明人： LEE SANG YUP , PARK TAE JUNG
IPC分类号： C12N9/10 , C07K14/825 , C12P3/00 , G01N33/531 , G01N33/58
CPC分类号： C07K14/825 , B82Y5/00 , B82Y15/00 , C12N9/104 , C12P3/00 , G01N33/531 , G01N33/588 , Y10T428/2982

75. 发明公开

EP1056864A2 CONSTITUTIVE MAIZE PROMOTERS 有权
标题翻译：构玉米发起人
公开(公告)号：EP1056864A2
公开(公告)日：2000-12-06
申请号：EP99909638.1
申请日：1999-02-25
申请人： PIONEER HI-BRED INTERNATIONAL, INC.
发明人： RICE, Douglas, A.
IPC分类号： C12N15/29 , C12N15/53 , C12N15/82 , C12N5/10 , A01H5/00 , A01H5/10
CPC分类号： C12N9/0008 , C07K14/415 , C07K14/825 , C12N15/8216 , C12N15/8237
摘要： The present invention provides compositions and methods for regulating expression of heterologous nucleotide sequences in a plant. Compositions are novel nucleotide sequences for constitutive promoters isolated from maize genes encoding histone H2B, metallothionein, alpha-tubulin 3, elongation factor efla, ribosomal protein rps8, chlorophyll a/b binding protein, and glyceraldehyde-3-phosphate dehydrogenase. A method for constitutively expressing a heterologous nucleotide sequence in a plant using the promoter sequences disclosed herein is provided. The method comprises transforming a plant cell to comprise a heterologous nucleotide sequence operably linked to one of the constitutive promoters of the present invention and regenerating a stably transformed plant from the transformed plant cell.

76. 发明公开

EP0953049A2 NOVEL HUMAN METALLOTHIONEIN 失效
标题翻译：人金属
公开(公告)号：EP0953049A2
公开(公告)日：1999-11-03
申请号：EP97954648.0
申请日：1997-12-30
申请人： INCYTE PHARMACEUTICALS, INC.
发明人： HILLMAN, Jennifer, L. , GOLI, Surya, K.
IPC分类号： C12N15 , A61K38 , A61P35 , A61P37 , A61P39 , C07K14 , C07K16 , C12N1 , C12N5 , C12Q1
CPC分类号： C07K14/825 , A61K38/00
摘要： The present invention provides a human metallothionein (HMBP-I) and polynucleotides which identify and encode HMBP-I. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HMBP-I and a method for producing HMBP-I. The invention also provides for agonists, antibodies, or antagonists specifically binding HMBP-I, and their use, in the prevention and treatment of diseases associated with expression of HMBP-I. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HMBP-I for the treatment of diseases associated with the expression of HMBP-I. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HMBP-I.

77. 发明公开

EP0096491A2 Eukaryotic metallothionein promoter system 失效
标题翻译：要为金属硫蛋白核启动系统。
公开(公告)号：EP0096491A2
公开(公告)日：1983-12-21
申请号：EP83302879.8
申请日：1983-05-19
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： Fogel, Seymour , Welch, Juliet W. , Karin, Michael
IPC分类号： C12N15/00 , C12P21/02 , C07C103/52 , C07H21/04 , C12N1/16
CPC分类号： C12N15/67 , C07K14/825 , C12N15/81
摘要： Yeast metallothionein (copper chelatin) and DNA sequences having the gene encoding the polypeptide are provided. The DNA sequences find use in producing copper chelatin and in amplifying downstream flanking regions.

78. 发明公开

KR1020140032896A 미토콘드리아 타겟팅 펩타이드 有权
标题翻译： MITOCHONDRIAL TARGETING PEPTIDE
公开(公告)号：KR1020140032896A
公开(公告)日：2014-03-17
申请号：KR1020130104307
申请日：2013-08-30
申请人： 경희대학교 산학협력단
发明人： 김영미 , 강영철 , 김용희
IPC分类号： C07K7/06 , C07K7/08 , C07K19/00 , A61K38/00
CPC分类号： C07K14/005 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/825 , C07K2319/10 , C07K2319/21 , C12N9/0065 , C12N9/0089 , C12N9/1205 , C12N9/93
摘要： The present invention relates to mitochondirial targeting peptide, to fusion protein to which the peptide is combined at carboxy terminal of protein transduction domain and antioxidant is combined at carboxy terminal of the peptide, to a composition for antioxidant which includes the fusion protein to which the antioxidant is combined, to a composition for preventing or treating Parkinson′s disease, to polynucleotide which codes the protein transduction domain, to polynucleotide which codes the peptide, to recombinant polynucleotide to which polynucleotide coding the antioxidant protein are successively combined, to an impression vector which includes the polynucleotide, and to a transformed host cell which includes the impression vector. The mitochondrial targeting peptide according to the present invention is targeted by mitochondria with high efficiency if existing as a single, and is targeted by the mitochondria with high efficiency even when the peptide is combined with the protein transduction domain and/or antioxidant. In addition, the peptide is suitable for a target carrier by having small size, and is processed when entered into mitochondria so that carried drug can be stably delivered.
摘要翻译：本发明涉及线粒体靶向肽，与蛋白质转导结构域的羧基末端肽结合的融合蛋白和抗氧化剂在肽的羧基末端结合成抗氧化剂的组合物，其包含抗氧化剂的融合蛋白与将编码蛋白质转导结构域的多核苷酸，编码该肽的多核苷酸组合成抗体蛋白质连续组合的重组多核苷酸与编码抗体蛋白质的多核苷酸组合，包括多核苷酸，以及包含该印象载体的转化的宿主细胞。本发明的线粒体靶向肽如果以单一方式存在，则以高效率的线粒体靶向，即使当肽与蛋白质转导结构域和/或抗氧化剂结合时，也可以高效率地被线粒体靶向。此外，肽通过小尺寸适用于靶载体，并且在进入线粒体时被加工，从而能够稳定地输送载体药物。

79. 发明授权

KR101196103B1 포유동물 세포용 무？혈청 세포 배양 배지 有权
标题翻译：无血清细胞培养液用于乳清细胞
公开(公告)号：KR101196103B1
公开(公告)日：2012-11-01
申请号：KR1020077008456
申请日：2005-10-28
申请人： 아레스 트레이딩 에스.에이.
发明人： 카사토레스헤르난데즈,죠세 , 마틴피에라,칼로스
IPC分类号： C12N5/02
CPC分类号： C07K14/825 , C07K14/61 , C12N5/0043 , C12N5/005 , C12N2500/12 , C12N2500/20 , C12N2500/22 , C12N2500/24 , C12N2500/32 , C12N2500/36 , C12N2510/02 , C12N2510/04
摘要： 본 발명은 무-혈청 배지에서 배양된 포유동물 세포에서 단백질을 제조하는 방법에 관한 것이다.

80. 发明授权

US09914934B2 Root-preferred promoter from a Panicum virgatum metallothionein-like gene 有权
公开(公告)号：US09914934B2
公开(公告)日：2018-03-13
申请号：US15097349
申请日：2016-04-13
申请人： Dow AgroSciences LLC
发明人： Sandeep Kumar , Daren Hemingway , Carla Ausmus , Andrew F. Worden , Andrew Asberry
IPC分类号： C12N15/82 , C07K14/825
CPC分类号： C12N15/8227 , C07K14/825 , C12N15/8216
摘要： This disclosure concerns compositions and methods for promoting transcription of a nucleotide sequence in a plant or plant cell, employing a promoter from a Panicum virgatum metallothionein-like gene (mtl). Some embodiments relate to a promoter from a Panicum virgatum metallothionein-like gene (mtl) that functions in plants to promote transcription of operably linked nucleotide sequences.

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