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71. 发明申请

WO2008103970A3 LOW-NOISE WIDEBAND PREAMPLIFIER FOR FOURIER TRANSFORM MASS SPECTROMETRY 审中-公开
标题翻译：用于FOURIER变换质谱的低噪声宽带前置放大器
公开(公告)号：WO2008103970A3
公开(公告)日：2009-06-04
申请号：PCT/US2008054815
申请日：2008-02-23
申请人： UNIV BOSTON , O'CONNOR PETER B , MATHUR RAMAN
发明人： O'CONNOR PETER B , MATHUR RAMAN
IPC分类号： H01J49/02 , H01J49/38
CPC分类号： H01J49/022 , H01J49/38
摘要： An ion cyclotron resonance (ICR) mass spectrometer includes an ICR cell having detection plates generating a detection current signal, detection circuitry generating a digital signal from the detection current signal, and a processor calculating a mass spectrum from the digital signal, wherein the detection circuitry includes a preamplifier having a differential pair of input junction field effect transistors (JFETs) receiving the detection current signal from the ICR cell, a pair of second JFETs in cascode configuration with the input JFETs, and an analog to digital converter generating the digital signal from a differential voltage signal generated by the second JFETs.
摘要翻译：离子回旋共振（ICR）质谱仪包括具有产生检测电流信号的检测板的ICR单元，从检测电流信号产生数字信号的检测电路，以及从数字信号计算质谱的处理器，其中检测电路包括具有接收来自ICR单元的检测电流信号的输入结场效应晶体管（JFET）的差分对的前置放大器，与输入JFET的共源共栅配置的一对第二JFET以及从数字转换器产生数字信号的模数转换器由第二JFET产生的差分电压信号。

72. 发明申请

WO2008134887A1 METHODS FOR PENNING TRAP MASS SPECTROSCOPY 审中-公开
标题翻译： NING NING。。。。。。。。。。。。。。。。
公开(公告)号：WO2008134887A1
公开(公告)日：2008-11-13
申请号：PCT/CA2008/000859
申请日：2008-05-05
申请人： TRIUMF, OPERATING AS A JOINT VENTURE BY THE GOVERNORS OF THE UNIVERSITY OF ALBERTA, THE UNIVERSITY OF BRITISH COLUMBIA, CARLETON UNIVERSITY, SIMON FRASER UNIVERSITY, , RYJKOV, Vladimir L.
发明人： RYJKOV, Vladimir L.
IPC分类号： H01J49/26 , H01J49/42
CPC分类号： H01J49/38 , H01J49/025
摘要： A method of mass spectroscopy according to example embodiments may include injecting ions into a Penning trap and exciting the ions into cyclotron and/or magnetron motions. The cyclotron motions and magnetron motions may be converted to one another with external radio frequency signals. The ions may be ejected from the Penning trap onto a position sensitive charged particle detector to determine the phases and amplitudes of the motions. Ion cyclotron resonance frequencies may be determined based on the phases and amplitudes of the motions of the ejected ions.
摘要翻译：根据示例性实施例的质谱法的方法可以包括将离子注入Penning阱并将离子激发成回旋加速器和/或磁控管运动。回旋加速器运动和磁控管运动可以通过外部射频信号彼此转换。离子可以从Penning陷阱喷射到位置敏感的带电粒子检测器上，以确定运动的相位和振幅。离子回旋共振频率可以基于所排出的离子的运动的相位和振幅来确定。

73. 发明申请

WO2006058198A3 METHOD OF PROCESSING MASS SPECTROMETRY DATA 审中-公开
标题翻译：处理大量光谱数据的方法
公开(公告)号：WO2006058198A3
公开(公告)日：2006-11-23
申请号：PCT/US2005042714
申请日：2005-11-23
申请人： THERMO FINNIGAN LLC , LANGE OLIVER , SENKO MICHAEL W
发明人： LANGE OLIVER , SENKO MICHAEL W
IPC分类号： G06K9/00 , H01J49/38
CPC分类号： H01J49/38 , G06K9/00523 , H01J49/0036
摘要： A method of processing Fourier Transform Mass Spectrometry (FTMS) data comprises carrying out a Fourier Transform of a part of a time domain transient and identifying from that transformed data signal peaks representative of the presence of ions. Once the peaks have been identified, the full transient is then transformed, and the peaks identified in the partial transient transform are used to locate true peaks in the transformed full transient. The number of 'false' peaks resulting from random noise has been found to correlate to the resolution, so that using a partial transient to identify true peaks reduces the risk of false peaks being included; nevertheless this information can then be applied to the full data set when transformed. As an alternative, different parts of the full data set can be transformed and then correlated; because any noise will be random, false peaks should occur at different places in the two partial transforms.
摘要翻译：一种处理傅里叶变换质谱（FTMS）数据的方法包括进行一部分时域瞬态的傅里叶变换，并从该变换后的数据信号识别表示离子存在的峰值。一旦确定了峰值，则完全瞬态然后被转换，并且部分瞬态变换中识别出的峰值被用于定位转换完全瞬态中的真实峰值。已经发现由随机噪声引起的“假”峰值与分辨率相关，因此使用部分瞬态来识别真实峰值可降低包含假峰值的风险; 然而，当变换时，该信息可以应用于完整的数据集。作为替代，完整数据集的不同部分可以被转换然后相关; 因为任何噪声将是随机的，所以在两个部分变换的不同位置应该出现假峰值。

74. 发明申请

WO2004081968A3 Mass spectrometer 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2004081968A3
公开(公告)日：2006-02-16
申请号：PCT/EP2004002486
申请日：2004-03-09
申请人： THERMO FINNIGAN LLC , MALEK ROBERT H , MEYER KAI JURGEN , SEEDORF SILKE , HORNING STEVAN ROY
发明人： MALEK ROBERT H , MEYER KAI JURGEN , SEEDORF SILKE , HORNING STEVAN ROY
IPC分类号： H01J49/38 , H01J49/42
CPC分类号： H01J49/063 , H01J49/38
摘要： An improved FT-ICR Mass Spectrometer has an ion source (10) which generates ions that are transmitted through a series of multipoles (20) to an ion trap (30). Ions are ejected from the trap (30), through a series of lens and multipolar ion guide stages (40-90), and into a measurement cell (100) via an exit/gate lens (110). The measurement cell is mounted in a vacuum chamber (240) and this assembly is slideably moveable into a bore of a superconducting magnet (400) which provides the magnetic filed to cause cyclotron motion of the generated ions in the cell (100). By minimising the distance between the source (10) and cell (100), and by careful alignment of the ion optics, the ions can travel at high energies right up to the front of the measurement cell (100). The cell (100) extends in the longitudinal direction of the magnet bore and is coaxial with that. The ratio of the sectional area of the magnet bore to the sectional area of the cell volume is small (less than 3). The magnet is asymmetric and is relatively short on the ion injection side. The cell (100) is supported from in front of the cell and electrical contact is from the rear thereof.

75. 发明申请

WO2005100974A1 高分子分析装置および高分子分析方法审中-公开
标题翻译：用于分析聚合物的装置和方法
公开(公告)号：WO2005100974A1
公开(公告)日：2005-10-27
申请号：PCT/JP2005/007063
申请日：2005-04-12
申请人：独立行政法人産業技術総合研究所 , 高橋勝利 , 福井一彦
发明人：高橋勝利 , 福井一彦
IPC分类号： G01N27/62
CPC分类号： H01J49/38
摘要：【課題】　高分子を切断して質量分析を行う場合に、切断される箇所を変化させることにより、種々のフラグメントを得、これを質量分析することにより、効率的に高分子を分析することができる装置を提供する。【解決手段】　波長可変の赤外線レーザー出力部と、イオン化された試料を保持するイオントラップ部と、前記イオントラップ部に保持された試料の質量分析を行う質量分析部と、を備え、前記赤外線レーザー出力部から出力されたレーザーは、前記イオントラップ部に保持された試料に照射され、前記照射されたレーザーによって試料が切断されることを特徴とする、高分子の分析装置を用いる。
摘要翻译： [问题]提供一种通过切割聚合物进行质谱分析时通过改变切割位置有效地分析聚合物，然后对由此获得的各种片段进行质谱分析的装置。解决问题的手段聚合物分析装置包括可调谐红外激光输出部，用于保持电离样品的离子阱部分和用于对保持在离子阱部分的样品进行质谱分析的部分，其特征在于因为保持在离子阱部分的样品被从红外激光输出部分输出的激光束照射，从而被切割。

76. 发明申请

WO2005093782A2 A METHOD OF IMPROVING A MASS SPECTRUM 审中-公开
标题翻译：改进质谱的方法
公开(公告)号：WO2005093782A2
公开(公告)日：2005-10-06
申请号：PCT/EP2005/003367
申请日：2005-03-24
申请人： THERMO FINNIGAN LLC , HORNING, Stevan, Roy , LANGE, Oliver , MALEK, Robert , WIEGHAUS, Andreas
发明人： HORNING, Stevan, Roy , LANGE, Oliver , MALEK, Robert , WIEGHAUS, Andreas
IPC分类号： H01J49/00
CPC分类号： H01J49/38 , H01J49/0009
摘要： The present invention provides a method of improving a mass spectrum collected from a mass spectrometer comprising a detector for collecting a mass spectrum from ions stored in or released from an ion trapping volume, wherein assignment of masses to peaks appearing in the mass spectrum is sensitive to an experimental parameter related to the mass spectrometer or the operation thereof, such as ion abundance, the method comprising: determining a positional value of a peak; determining the experimental parameter associated with the mass spectrum; comparing the determined positional value with positional values of peaks contained in a calibration dataset; and improving the determined positional value of the peak from adjacent peak positional values by interpolation thereby to provide a corrected mass assignment for the peak. The present invention also provides a method of calibrating such a mass spectrometer.
摘要翻译：本发明提供了一种改进从质谱仪收集的质谱的方法，该质谱仪包括用于从离子捕获体积存储或释放的离子中收集质谱的检测器，其中质谱对质谱中出现的峰的分配对与质谱仪或其操作相关的实验参数，例如离子丰度，该方法包括：确定峰的位置值; 确定与质谱相关的实验参数; 将确定的位置值与校准数据集中包含的峰的位置值进行比较; 并且通过内插从相邻的峰值位置值改善确定的峰值的位置值，从而为峰值提供校正的质量分配。本发明还提供了一种校准这种质谱仪的方法。

77. 发明申请

WO2004021394A3 METHOD, SYSTEM, AND DEVICE FOR OPTIMIZING AN FTMS VARIABLE 审中-公开
标题翻译：用于优化FTMS变量的方法，系统和设备
公开(公告)号：WO2004021394A3
公开(公告)日：2004-07-08
申请号：PCT/US0326785
申请日：2003-08-28
申请人： SIEMENS ENERGY & AUTOMAT
发明人： DAVIS DEAN VINSON
IPC分类号： H01J49/00 , H01J49/38 , H01J49/42
CPC分类号： H01J49/0031 , H01J49/38
摘要： Certain exemplary embodiments provide a method for automatically optimizing an FTMS. The method can comprise a plurality of potential activities, some of which can be automatically, repeatedly, and/or nestedly performed, and some of which follow. A composite amplitude relating to an FTMS spectral output signal for each of a plurality of FTMS samples can be obtained, each of the samples having an substantially similar number of molecules. The FTMS variable can be changed repeatedly and the composite amplitude re-obtained until a value of an optimization parameter substantially converges, the optimization parameter a function of the composite amplitude
摘要翻译：某些示例性实施例提供了一种用于自动优化FTMS的方法。该方法可以包括多个潜在活动，其中一些活动可以自动地，重复地和/或嵌套地执行，并且其中一些可以跟随。可以获得与多个FTMS样本中的每一个的FTMS光谱输出信号相关的复合幅度，每个样本具有基本相似数量的分子。可以重复地改变FTMS变量，并重新获得复合幅度，直到优化参数的值基本上收敛，优化参数a是复合幅度的函数

78. 发明申请

WO2003056299A2 LABELING REAGENT AND METHODS OF USE 审中-公开
标题翻译：标签试剂和使用方法
公开(公告)号：WO2003056299A2
公开(公告)日：2003-07-10
申请号：PCT/US2002/035581
申请日：2002-11-05
申请人： IRM LLC , PETERS, Eric, C. , BROCK, Ansgar , ERICSON, Christer
发明人： PETERS, Eric, C. , BROCK, Ansgar , ERICSON, Christer
IPC分类号： G01N
CPC分类号： C07K1/13 , C07K14/805 , G01N33/6848 , G01N2035/00158 , G01N2458/15 , G06F19/22 , G06F19/28 , H01J49/00 , H01J49/0027 , H01J49/38 , Y10T436/24
摘要： The present invention provides compounds which are useful as multifunctional labels in proteomics studies. The labels of the present invention are both lysine specific and increase the overall sequence coverage obtained in polypeptide mapping experiments, by for example, increasing the ionization efficiencies of lysine-terminated tryptic fragments. In certain aspects, the labels of the present invention can be used to measure differential quantitation, as for example, deuterium(s) can easily be introduced during their synthesis. In one aspect, a C-terminal derivatized lysine biases the fragment ion intensities strongly toward C-terminal fragment ions, resulting in a highly simplified tandem mass spectrum. In further aspects, the number of lysine residues can be determined in a polypeptide.
摘要翻译：本发明提供在蛋白质组学研究中可用作多功能标记的化合物。本发明的标记物都是赖氨酸特异性的，并且通过例如增加赖氨酸终止的胰蛋白酶片段的电离效率来增加在多肽测绘实验中获得的整体序列覆盖率。在某些方面，本发明的标记可以用于测量差异定量，例如，在合成过程中可以容易地引入氘。在一个方面，C末端衍生的赖氨酸强烈地将片段离子强度偏向C末端片段离子，导致高度简化的串联质谱。在另外的方面，可以在多肽中确定赖氨酸残基的数目。

79. 发明申请

WO2002086946A1 METHOD AND APPARATUS FOR SEPARATING IONS IN TIME AS FUNCTIONS OF PRESELECTED ION MOBILITY AND ION MASS 审中-公开
标题翻译：时间分离离子的方法和装置作为离子交换和离子质量的函数
公开(公告)号：WO2002086946A1
公开(公告)日：2002-10-31
申请号：PCT/US2002/012390
申请日：2002-04-19
申请人： ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, INC. , CLEMMER, David, E.
发明人： CLEMMER, David, E.
IPC分类号： H01J49/40
CPC分类号： G01N27/622 , H01J49/004 , H01J49/38
摘要： An ion separation instrument includes an ion source coupled to at least a first ion mobility spectrometer having an ion outlet coupled to a mass spectrometer only ions defining a preselected ion mobility range. In one embodiment, the ion mobility spectrometer is provided with electronically controllable inlet and outlet gates as a function of ion drift time to thereby allow passage therethrough only of ions defining a mobility within the preselected ion mobility reange. In another embodiment, an ion trap is disposed between the ion mobility spectrometer and mass spectrometer and is controlled in such a manner so as to collect a plurality of ions defining a mobility within the preselected ion mobility range prior to injection of such ions into the mass spectrometer. In yet another embodiment, an ion inlet of the ion trap may be electronically controlled relative to operation of the ion mobility spectrometer as a function of ion drift time to thereby allow passage therein only of ions defining a mobility within the preselected ionmobility range. The mass spectrometer is preferably a Fourier Transform Ion Cyclotron Resonance mass spectrometer, and the resulting ion separation instrument may further include therein various combinations of ion fragmentation, ion mass filtering, ion trap, charge neutralization and/or mass reaction instrumentation.
摘要翻译：离子分离仪器包括耦合到至少第一离子迁移谱仪的离子源，其具有仅耦合到质谱仪的离子出口，仅限于限定预选离子迁移率范围的离子。在一个实施方案中，离子迁移谱仪具有作为离子漂移时间的函数的电子可控的入口和出口浇口，从而允许仅限定在预选离子迁移率范围内限定迁移率的离子。在另一个实施方案中，将离子阱设置在离子迁移谱仪和质谱仪之间，并以这样的方式进行控制，以便在将这样的离子注入质量之前收集限定预选离子迁移率范围内的迁移率的多个离子光谱仪。在另一个实施方案中，离子阱的离子入口可以相对于离子迁移谱仪的操作而电子控制，作为离子漂移时间的函数，从而允许仅限定在预选离子迁移范围内限定迁移率的离子。质谱仪优选为傅里叶变换离子回旋共振质谱仪，所得到的离子分离仪器还可以包括离子碎片化，离子质量过滤，离子阱，电荷中和和/或质量反应仪器的各种组合。

80. 发明申请

WO01057518A2 METHOD OF NON-TARGETED COMPLEX SAMPLE ANALYSIS 审中-公开
标题翻译：非定向复合样品分析方法
公开(公告)号：WO01057518A2
公开(公告)日：2001-08-09
申请号：PCT/CA2001/000111
申请日：2001-02-01
IPC分类号： G01N27/62 , C12Q1/68 , G01N33/68 , G06F19/00 , G06F19/18 , G06F19/28 , H01J49/42 , G01N33/00
CPC分类号： G01N33/6848 , G06F19/18 , G06F19/28 , G06F19/703 , G06F19/709 , H01J49/38 , Y10S707/99936 , Y10S707/99943
摘要： A method for non-targeted complex sample analysis which involves the following steps. A first step involves providing a database (16) containing identifying data of known molecules. A second step involves introducing a complex sample containing multiple unidentified molecules into a Fourier Transform Ion Cyclotron Mass Spectrometer (12) to obtain data regarding the molecules in the complex sample. A third step involves comparing the collected data regarding the molecules in the complex sample with the identifying data of known molecules in order to arrive at an identification through comparison of the molecules in the sample.
摘要翻译：一种非目标复杂样本分析方法，涉及以下步骤。第一步涉及提供包含已知分子的识别数据的数据库（16）。第二步涉及将含有多个不明分子的复杂样品引入傅里叶变换离子回旋加速器质谱仪（12），以获得有关复合物样品中分子的数据。第三步涉及将收集到的关于复合物样品中的分子的数据与已知分子的识别数据进行比较，以通过比较样品中的分子来获得鉴定。

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