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81. 发明授权

US08629123B2 Use of dextran sulfate 有权
标题翻译：使用硫酸葡聚糖
公开(公告)号：US08629123B2
公开(公告)日：2014-01-14
申请号：US10535876
申请日：2003-11-26
申请人： Bo Nilsson , Olle Korsgren
发明人： Bo Nilsson , Olle Korsgren
IPC分类号： A61K31/721
CPC分类号： A61K31/737 , A61K31/721 , A61K35/39 , A61L27/3804 , A61L27/3839 , A61L27/54 , A61L2300/232 , A61L2300/41 , A61L2300/45 , A61L2300/64
摘要： The present invention refers to use of dextran sulfate, or a pharmaceutically acceptable derivate thereof, for manufacturing of a medicament for treatment of Instant Blood-Mediated Inflammatory Reaction (IBMIR). In addition, the invention refers to the use of dextran sulfate, or a pharmaceutically acceptable derivate thereof, for manufacturing of a medicament for treatment of morphological disruption of cell transplants and graft-rejection of cell transplants caused by IBMIR. The invention may be applied to patients suffering from type I diabetes, in which porcine islets of Langerhans are transplanted in their portal vein. Administration of dextran sulfate according to the invention inhibits and prevents rejection and destruction of the transplanted islets and makes normoglycemia in the patients possible.
摘要翻译：本发明涉及使用硫酸葡聚糖或其药学上可接受的衍生物来制备用于治疗即时血液介导的炎性反应（IBMIR）的药物。此外，本发明涉及硫酸葡聚糖或其药学上可接受的衍生物在制备用于治疗由IBMIR引起的细胞移植的形态学破坏和细胞移植的移植排斥的药物中的用途。本发明可以应用于患有I型糖尿病的患者，其中在其门静脉中移植了朗格汉斯猪胰岛。根据本发明的硫酸葡聚糖的施用抑制并防止移植胰岛的排斥和破坏，并使患者的血糖异常成为可能。

82. 发明授权

US08609135B2 Anthracycline derivatives 失效
标题翻译：蒽环类衍生物
公开(公告)号：US08609135B2
公开(公告)日：2013-12-17
申请号：US12578380
申请日：2009-10-13
申请人： Katarina Edwards , Stefan Sjöberg , Jörgen Carlsson , Lars Gedda
发明人： Katarina Edwards , Stefan Sjöberg , Jörgen Carlsson , Lars Gedda
IPC分类号： A61K9/127 , A01N43/04 , A61K31/70 , C07H15/24
CPC分类号： C07H15/24 , A61K9/1271 , A61K9/1278 , A61K31/70 , A61K31/704 , A61K51/0491
摘要： Anthracycline derivatives are suitable for use in cancer therapy and diagnosis. These anthracycline derivatives can be radiolabelled and used as an imaging agent in cancer diagnosis. The radiolabelled anthracycline derivatives can also be used together with a drug delivery system, in particular including a two-step targeting strategy, for treating solid and disseminated tumors. These drug delivery system can advantageously be used for treatment and diagnosis of breast cancer.
摘要翻译：蒽环类衍生物适用于癌症治疗和诊断。这些蒽环类衍生物可以放射性标记，并用作癌症诊断中的显像剂。放射性标记的蒽环类衍生物也可以与药物递送系统一起使用，特别是包括用于治疗固体和弥散性肿瘤的两步靶向策略。这些药物递送系统可以有利地用于乳腺癌的治疗和诊断。

83. 发明授权

US08555873B2 Exposure system 有权
标题翻译：曝光系统
公开(公告)号：US08555873B2
公开(公告)日：2013-10-15
申请号：US12666808
申请日：2008-06-27
申请人： Per Gerde
发明人： Per Gerde
IPC分类号： A61M11/00
CPC分类号： A61D7/04 , A61B5/0813 , A61B5/087 , A61B5/097 , A61B2503/40 , A61M15/00
摘要： A system and a method for studying or predicting the interaction between a lung and an aerosolized agent. The system comprises an aerosol generator (10) sealingly connected to an exposure arrangement adapted to provide a transport aerosol flow from an aerosol holding chamber of the aerosol generator (10) to a flow junction; and an exposure aerosol flow from the flow junction for distribution to an exposure organ with breathing capacity thereby a providing a residual aerosol flow transported away from the flow junction. The exposure arrangement further comprises a flow rate monitoring device located upstream the flow junction for monitoring the transport aerosol flow, a device for measuring the aerosol particle concentration located downstream the flow rate monitoring device, and optionally a flow control function for controlling the transport aerosol flow. Using the system for predicting the interaction between a lung and an aerosolized agent minimizes the loss of the agent.
摘要翻译：用于研究或预测肺和雾化剂之间的相互作用的系统和方法。该系统包括密封地连接到暴露装置的气溶胶发生器（10），该曝光装置适于提供从气溶胶发生器（10）的气溶胶容纳室到流动结的运输气溶胶流; 以及来自流动接合点的暴露气溶胶流动，以分配到具有呼吸能力的暴露器官，从而提供从流动结点输送的残留气溶胶流。曝光装置还包括位于流动接头上游的用于监测运输气溶胶流的流量监测装置，用于测量位于流速监测装置下游的气溶胶颗粒浓度的装置，以及可选地用于控制运输气溶胶流的流量控制功能。使用该系统来预测肺和雾化剂之间的相互作用使得药剂的损失最小化。

84. 发明授权

US08511002B2 Magnetic bird screen 有权
标题翻译：磁鸟屏
公开(公告)号：US08511002B2
公开(公告)日：2013-08-20
申请号：US12790156
申请日：2010-05-28
申请人： John M. Bowie , Matthew W. Lewellyn , Rodney D. Holbert
发明人： John M. Bowie , Matthew W. Lewellyn , Rodney D. Holbert
IPC分类号： E04B1/72
CPC分类号： E04B1/72 , A01M29/32 , E01D19/00
摘要： A magnetic bird screen for an opening of a steel structure such as a bridge or the like includes a magnetic sheet sized to cover the access opening and at least partially overlap the steel structure at the opening so that the sheet is magnetically secured to the steel structure. The sheet has a plurality of spaced-apart holes sized sufficiently large to permit the passage of air and water therethrough and to be used as finger holes for installation and removal and sized sufficiently small to prevent the passage of pigeons therethrough. The sheet can be folded or rolled upon itself so that the sheet remains secured at one side of the opening or the sheet can be entirely removed when it is desired to have access through the opening.
摘要翻译：用于诸如桥梁等的钢结构的开口的磁性鸟屏幕包括磁性片，其尺寸设置成覆盖进入开口，并且在开口处至少部分地与钢结构重叠，使得片被磁性地固定到钢结构。片材具有多个间隔开的孔，其尺寸足够大以允许空气和水通过其中并被用作用于安装和拆卸的指孔，并且尺寸足够小以防止鸽子通过。片材可以自身折叠或卷起，使得片材保持固定在开口的一侧，或者当需要通过开口进入时，片材可以被完全去除。

85. 外观设计

USD687626S1 Survival kit 有权
公开(公告)号：USD687626S1
公开(公告)日：2013-08-13
申请号：US29437988
申请日：2012-11-23
申请人： Mike Roundhouse
设计人： Mike Roundhouse

86. 外观设计

USD683064S1 Light fixture 有权
公开(公告)号：USD683064S1
公开(公告)日：2013-05-21
申请号：US29434008
申请日：2012-10-09
申请人： Richard G. Tuck
设计人： Richard G. Tuck

87. 外观设计

USD680301S1 Jersey for a college and/or professional team 有权
公开(公告)号：USD680301S1
公开(公告)日：2013-04-23
申请号：US29393584
申请日：2011-06-07
申请人： Eric D. Gooch
设计人： Eric D. Gooch

88. 外观设计

USD680300S1 Jersey for a college and/or professional team 有权
标题翻译：球衣为大学和/或专业团队
公开(公告)号：USD680300S1
公开(公告)日：2013-04-23
申请号：US29393561
申请日：2011-06-07
申请人： Eric D. Gooch
设计人： Eric D. Gooch

89. 发明授权

US08389707B2 Oligonucleotides related to lipid membrane attachments 有权
标题翻译：与脂质膜附着有关的寡核苷酸
公开(公告)号：US08389707B2
公开(公告)日：2013-03-05
申请号：US10590877
申请日：2005-02-28
申请人： Indriati Pfeiffer , Fredrick Höök
发明人： Indriati Pfeiffer , Fredrick Höök
IPC分类号： C07H21/04 , C07H21/02 , C12Q1/68
CPC分类号： B01J19/0046 , A61K47/549 , A61K47/554 , C07H21/00
摘要： Oligonucleotide structures are provided that are capable of forming more stable bonds to a lipid membrane and thereby generate an improved control of the process whereby oligonucleotide linkers are introduced to lipid membranes. Methods of forming lipid membrane oligonucleotide attachments are provided including lipid vesicles. The oligonucleotides typically comprise at least two hydrophobic anchoring moieties capable of being attached to a lipid membrane. Said moieties may be attached at the terminal ends of an oligonucleotide or, in the case of a first and second strand forming a duplex, at the same terminal end one of the strands other end not being part of the duplex leaving it free to hybridize to additional strands. The lipid vesicles attached with the oligonucleotide can be used in biosensors and may contain membrane proteins.
摘要翻译：提供寡核苷酸结构，其能够形成与脂质膜更稳定的键，从而产生对寡核苷酸接头引入脂质膜的方法的改进控制。提供形成脂质膜寡核苷酸附着物的方法包括脂质囊泡。寡核苷酸通常包含能够连接到脂质膜上的至少两个疏水性锚定部分。所述部分可以连接在寡核苷酸的末端，或者在第一和第二链形成双链体的情况下，在相同的末端，另一端的另一端不是双链体的一部分，留下它可以与附加股。与寡核苷酸连接的脂质囊泡可用于生物传感器中并且可以含有膜蛋白质。

90. 发明授权

US08377969B2 Compounds for use in the treatment of cancer 有权
标题翻译：用于治疗癌症的化合物
公开(公告)号：US08377969B2
公开(公告)日：2013-02-19
申请号：US12808144
申请日：2008-12-12
申请人： Jan Olof G. Karlsson , Tino Kurz , Rolf Andersson
发明人： Jan Olof G. Karlsson , Tino Kurz , Rolf Andersson
IPC分类号： A61K31/444 , A61K31/506
CPC分类号： A61K31/444 , A61K31/44 , A61K31/675
摘要： Compound of Formula I or a salt thereof for treating cancer, wherein X represents CH or N; R1 represents hydrogen or —CH2COR5; R5 represents hydroxy, optionally hydroxylated alkoxy, amino or alkylamido; R2 represents ZYR6; Z represents a bond, or a C1-3 alkylene or oxoalkylene group optionally substituted by R7; Y represents a bond, an oxygen atom or NR6; R6 is a hydrogen atom, COOR8, an alkyl, alkenyl, cycloalkyl, aryl or aralkyl group optionally substituted by one or more selected from COOR8, CONR82, NR82, OR8, ═NR8, ═O, OP(O)(OR8)R7 and OSO3M; R7 is hydroxy, an optionally hydroxylated, optionally alkoxylated alkyl or aminoalkyl group; R8 is a hydrogen atom or an optionally hydroxylated, optionally alkoxylated alkyl group; M is a hydrogen atom or one equivalent of a physiologically tolerable cation; R3 represents C1-8 alkylene, 1,2-cykloalkylene, or 1,2-arylene, optionally substituted with R7; and R4 represents hydrogen or C1-3 alkyl.
摘要翻译：式I化合物或其盐用于治疗癌症，其中X表示CH或N; R1表示氢或-CH2COR5; R5表示羟基，任选羟基化的烷氧基，氨基或烷基酰氨基; R2表示ZYR6; Z表示键或任选被R 7取代的C 1-3亚烷基或氧代亚烷基; Y表示键，氧原子或NR 6; R6是氢原子，COOR8，烷基，烯基，环烷基，芳基或芳烷基，任选被一个或多个选自COOR8，CONR82，NR82，OR8，... NR8，= O，OP（O）（OR8）R7和 OSO3M; R7是羟基，任选羟基化，任选烷氧基化的烷基或氨基烷基; R8是氢原子或任选羟基化，任选烷氧基化的烷基; M是氢原子或1当量的生理上可耐受的阳离子; R 3表示任选被R 7取代的C 1-8亚烷基，1,2-亚环烷基或1,2-亚芳基; 并且R 4表示氢或C 1-3烷基。

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