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81. 发明申请

WO2006074148A2 METHOD AND STRUCTURE FOR REDUCING PARASITIC INFLUENCES OF DEFLECTION DEVICES ON SPATIAL LIGHT MODULATORS 审中-公开
标题翻译：用于降低空间光调制器上偏转装置的PARASITIC影响的方法和结构
公开(公告)号：WO2006074148A2
公开(公告)日：2006-07-13
申请号：PCT/US2006000057
申请日：2006-01-03
申请人： MIRADIA INC , YANG XIAO
发明人： YANG XIAO
IPC分类号： G02B26/00
CPC分类号： G02B26/0841
摘要： A spatial light modulator is provided. The spatial light modulator includes a first substrate, the first substrate comprising a plurality of electrodes adapted to receive control signals, and a bias grid coupled to the first substrate and electrically isolated from the plurality of electrodes. The spatial light modulator also includes a mirror plate electrically coupled to the bias grid and adapted to rotate from a first orientation to a second orientation in response to the control signals received by the plurality of electrodes. The spatial light modulator further includes a landing post support structure coupled to the first substrate and electrically coupled to the bias grid and a landing post coupled to the landing post support structure. The landing post is electrically coupled to the bias grid and adapted to make contact with the mirror plate positioned at the first orientation.
摘要翻译：提供了空间光调制器。空间光调制器包括第一衬底，第一衬底包括适于接收控制信号的多个电极以及耦合到第一衬底并与多个电极电隔离的偏置栅极。空间光调制器还包括电耦合到偏置栅极并且响应于由多个电极接收的控制信号而从第一取向旋转到第二取向的镜板。空间光调制器还包括联接到第一基板并电耦合到偏置栅极的着陆柱支撑结构和联接到着陆柱支撑结构的着陆柱。着陆柱电耦合到偏置栅格并适于与位于第一取向的反射板接触。

82. 发明申请

WO2006068953A2 ANTIBODIES DIRECTED TO ANGIOPOIETIN-2 AND USES THEREOF 审中-公开
标题翻译：抗体依赖于ANGIOPOIETIN-2的抗体及其用途
公开(公告)号：WO2006068953A2
公开(公告)日：2006-06-29
申请号：PCT/US2005/045657
申请日：2005-12-19
申请人： ABGENIX, INC. , ASTRAZENECA AB , GREEN, Larry L. , ZHOU, Qing , KEYT, Bruce, A. , YANG, Xiao-dong , EMERY, Stephen, Charles , BLAKEY, David C.
发明人： GREEN, Larry L. , ZHOU, Qing , KEYT, Bruce, A. , YANG, Xiao-dong , EMERY, Stephen, Charles , BLAKEY, David C.
IPC分类号： C07K16/22 , C07K16/28 , C12N15/13 , C12N15/85
CPC分类号： C07K16/22 , A61K39/39558 , A61K2039/505 , C07K14/515 , C07K2317/21 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要： Antibodies directed to the antigen Ang-2 and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen Ang-2. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementary determining regions (CDR’s), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobin molecules and monoclonal antibodies.
摘要翻译：描述针对抗原Ang-2的抗体和这种抗体的用途。特别是针对抗原Ang-2的完全人单克隆抗体。编码重组和轻链免疫球蛋白分子的核苷酸序列和氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。杂交瘤或表达这种免疫球蛋白分子的其它细胞系和单克隆抗体。

83. 发明申请

WO2005116946A3 METHOD AND APPARATUS FOR DEACTIVATING AN EAS DEVICE 审中-公开
标题翻译：用于消除易损器件的方法和装置
公开(公告)号：WO2005116946A3
公开(公告)日：2006-06-01
申请号：PCT/US2005017203
申请日：2005-05-17
申请人： YANG XIAO HUI , FUSS ARTHUR B
发明人： YANG XIAO HUI , FUSS ARTHUR B
IPC分类号： G08B13/14 , G08B13/24 , H01F13/00
CPC分类号： G08B13/2471 , G08B13/2411 , G08B13/2474 , H01F13/006
摘要： A deactivator for deactivating label-style EAS devices is claimed. A preferred embodiment employs a microprocessor unit to control two transceiver coils, and a deactivation coil in series with a capacitor. The two transceiver coils are essentially two flat figure eights arranged concentrically but rotated through some angle with respect to each other. The transceiver coils are operated alternatively, first transmitting an interrogation signal and then listening for a response. When an EAS device is detected, the microprocessor unit drives the capacitor and deactivation coil at the system's resonant frequency to generate a high amplitude magnetic field then shifts the frequency of the driving current away from the resonant frequency to attenuate the magnetic field. A field sensor or current sensor provides feedback to the microprocessor to determine the resonant frequency of the system during a frequency sweep.
摘要翻译：要求用于停用标签式EAS设备的去激活器。优选实施例采用微处理器单元来控制两个收发器线圈和与电容器串联的去激活线圈。两个收发器线圈基本上是两个同心地布置的平面图形，但相对于彼此旋转一定角度。收发器线圈交替操作，首先发送询问信号，然后收听响应。当检测到EAS设备时，微处理器单元以系统谐振频率驱动电容器和去激活线圈，以产生高幅度磁场，然后将驱动电流的频率偏离谐振频率以衰减磁场。现场传感器或电流传感器向微处理器提供反馈，以确定频率扫描期间系统的谐振频率。

84. 发明申请

WO2006052591A2 ANTI-PROPERDIN ANTIBODIES, AND METHODS FOR MAKING AND USING SAME 审中-公开
标题翻译：抗自身抗体，以及制备和使用它们的方法
公开(公告)号：WO2006052591A2
公开(公告)日：2006-05-18
申请号：PCT/US2005039628
申请日：2005-11-02
申请人： ABGENIX INC , GAZIT-BORNSTEIN GADI , SENALDI GIORGIO , YANG XIAO-DONG , KEYT BRUCE , ZAPATA GERARDO
发明人： GAZIT-BORNSTEIN GADI , SENALDI GIORGIO , YANG XIAO-DONG , KEYT BRUCE , ZAPATA GERARDO
IPC分类号： A61K39/395 , C07K16/44 , C07K16/46
CPC分类号： C07K16/18 , C07K2317/21 , C07K2317/54 , C07K2317/76
摘要： The present invention is related to antibodies directed to the antigen properdin and uses of such antibodies. In particular, n accordance with the present invention, there are provided fully human monoclonal antibodies directed tot he antigen properdin. Nucleotide sequences encoding, and polypeptides comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provide. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
摘要翻译：本发明涉及针对抗原适配体的抗体和这种抗体的用途。特别地，根据本发明，提供了针对抗原纯合子的完全人单克隆抗体。编码重组和轻链免疫球蛋白分子的核苷酸序列，特别是对应于横跨框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3，提供。还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

85. 发明申请

WO2004000102A3 METHOD FOR PREDICTING RESPONSE TO EPIDERMAL GROWTH FACTOR RECEPTOR-DIRECTED THERAPY 审中-公开
标题翻译：预防抗生殖因子受体指导治疗的方法
公开(公告)号：WO2004000102A3
公开(公告)日：2005-12-15
申请号：PCT/US0319698
申请日：2003-06-19
申请人： ABGENIX INC , IMMUNEX CORP , BACUS SARAH S , LOCKBAUM PAMELA , SCHWAB GISELA , YANG XIAO-DONG , LYNCH DAVID HASKETT
发明人： BACUS SARAH S , LOCKBAUM PAMELA , SCHWAB GISELA , YANG XIAO-DONG , LYNCH DAVID HASKETT
IPC分类号： A61B20060101 , A61K38/17 , A61K38/18 , C07H21/02 , C07H21/04 , C07K16/28 , C12N5/00 , C12N15/00 , C12P19/34 , C12Q1/68 , G01N33/53 , G01N33/536 , G01N33/541 , G01N33/574
CPC分类号： A61K38/1808 , A61K2039/505 , C07K16/2863
摘要： The invention provides methods for determining or predicting response to cancer therapy in an individual.
摘要翻译：本发明提供了确定或预测个体对癌症治疗的反应的方法。

86. 发明申请

WO2005116946A2 METHOD AND APPARATUS FOR DEACTIVATING AN EAS DEVICE 审中-公开
标题翻译：用于消除易损器件的方法和装置
公开(公告)号：WO2005116946A2
公开(公告)日：2005-12-08
申请号：PCT/US2005/017203
申请日：2005-05-17
申请人： YANG, Xiao Hui , FUSS, Arthur, B.
发明人： YANG, Xiao Hui , FUSS, Arthur, B.
IPC分类号： G08B13/14
CPC分类号： G08B13/2471 , G08B13/2411 , G08B13/2474 , H01F13/006
摘要： A deactivator for deactivating label-style EAS devices is claimed. A preferred embodiment employs a microprocessor unit to control two transceiver coils, and a deactivation coil in series with a capacitor. The two transceiver coils are essentially two flat figure eights arranged concentrically but rotated through some angle with respect to each other. The transceiver coils are operated alternatively, first transmitting an interrogation signal and then listening for a response. When an EAS device is detected, the microprocessor unit drives the capacitor and deactivation coil at the system's resonant frequency to generate a high amplitude magnetic field then shifts the frequency of the driving current away from the resonant frequency to attenuate the magnetic field. A field sensor or current sensor provides feedback to the microprocessor to determine the resonant frequency of the system during a frequency sweep.
摘要翻译：要求用于停用标签式EAS设备的去激活器。优选实施例采用微处理器单元来控制两个收发器线圈和与电容器串联的去激活线圈。两个收发器线圈基本上是两个同心地布置的平面图形，但相对于彼此旋转一定角度。收发器线圈交替操作，首先发送询问信号，然后收听响应。当检测到EAS设备时，微处理器单元以系统谐振频率驱动电容器和去激活线圈，以产生高幅度磁场，然后将驱动电流的频率偏离谐振频率以衰减磁场。现场传感器或电流传感器向微处理器提供反馈，以确定频率扫描期间系统的谐振频率。

87. 发明申请

WO2005010151A3 ANTIBODIES DIRECTED TO THE DELETION MUTANTS OF EPIDERMAL GROWTH FACTOR RECEPTOR AND USES THEREOF 审中-公开
公开(公告)号：WO2005010151A3
公开(公告)日：2005-02-03
申请号：PCT/US2004/020295
申请日：2004-06-25
申请人： ABGENIX, INC , WEBER, Richard , FENG, Xiao , FOORD, Orit , GREEN, Larry , GUDAS, Jean , KEYT, Bruce , LIU, Ying , RATHANASWAMI, Palani , RAYA, Robert , YANG, Xiao, Dong , CORVALAN, Jose , FOLTZ, Ian , JIA, Xiao-Chi , KANG, Jaspal , KING, Chadwick, T. , KLAKAMP, Scott, L. , SU, Qiaojuan, Jane
发明人： WEBER, Richard , FENG, Xiao , FOORD, Orit , GREEN, Larry , GUDAS, Jean , KEYT, Bruce , LIU, Ying , RATHANASWAMI, Palani , RAYA, Robert , YANG, Xiao, Dong , CORVALAN, Jose , FOLTZ, Ian , JIA, Xiao-Chi , KANG, Jaspal , KING, Chadwick, T. , KLAKAMP, Scott, L. , SU, Qiaojuan, Jane
IPC分类号： A61K39/395
摘要： The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.

88. 发明申请

WO02088380A9 IMMUNOGENIC TUMOR ANTIGENS: NUCLEIC ACIDS AND POLYPEPTIDES ENCODING THE SAME AND METHODS OF USE THEREOF 审中-公开
标题翻译：免疫原性肿瘤抗原：核酸和多核苷酸编码它们及其使用方法
公开(公告)号：WO02088380A9
公开(公告)日：2004-04-29
申请号：PCT/US0213693
申请日：2002-05-02
申请人： DANA FARBER CANCER INST INC , RITZ JEROME , YANG XIAO-FENG , WU CATHERINE J
发明人： RITZ JEROME , YANG XIAO-FENG , WU CATHERINE J
IPC分类号： A61K38/00 , A61K39/00 , C07K14/47 , C07K16/30 , A61K39/395 , C07K16/00
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K2039/505 , A61K2039/53 , C07K16/3061
摘要： The invention provides human chronic myelocytic leukemia-like proteins (CML protein) and isolated nucleic acid molecules encoding the same. Also provided are antibodies that immunospecifically-bind to CML polypeptides or polynucleotides, or derivatives, variants, mutants, or fragments thereof. The invention additionally provides methods in which CML polypeptides, polynucleotides, and antibodies are used in the detection, prevention, and treatment of a broad range of pathological states, and methods of treating malignancy-related disorders by modulating activity or expression of CML proteins.
摘要翻译：本发明提供人类慢性骨髓性白血病样蛋白（CML蛋白）和编码其的分离的核酸分子。还提供了免疫特异性结合CML多肽或多核苷酸或其衍生物，变体，突变体或其片段的抗体。本发明还提供了CML多肽，多核苷酸和抗体用于检测，预防和治疗广泛病理状态的方法，以及通过调节CML蛋白的活性或表达来治疗恶性肿瘤相关疾病的方法。

89. 发明申请

WO2004000102A2 METHOD FOR PREDICTING RESPONSE TO EPIDERMAL GROWTH FACTOR RECEPTOR-DIRECTED THERAPY 审中-公开
标题翻译：预防抗生殖因子受体指导治疗的方法
公开(公告)号：WO2004000102A2
公开(公告)日：2003-12-31
申请号：PCT/US2003/019698
申请日：2003-06-19
申请人： ABGENIX, INC. , IMMUNEX CORPORATION , BACUS, Sarah, S. , LOCKBAUM, Pamela , SCHWAB, Gisela , YANG, Xiao-dong , LYNCH, David Haskett
发明人： BACUS, Sarah, S. , LOCKBAUM, Pamela , SCHWAB, Gisela , YANG, Xiao-dong , LYNCH, David Haskett
IPC分类号： A61B
CPC分类号： A61K38/1808 , A61K2039/505 , C07K16/2863
摘要： The invention provides methods for determining or predicting response to cancer therapy in an individual.
摘要翻译：本发明提供了确定或预测个体对癌症治疗的反应的方法。

90. 发明申请

WO2003099205A3 TREATMENT OF RENAL CARCINOMA USING ANTIBODIES AGAINST THE EGFR 审中-公开
公开(公告)号：WO2003099205A3
公开(公告)日：2003-12-04
申请号：PCT/US2003/015734
申请日：2003-05-19
申请人： ABGENIX, INC. , IMMUNEX CORPORATION , SCHWAB, Gisela , YANG, Xiao-dong
发明人： SCHWAB, Gisela , YANG, Xiao-dong
IPC分类号： C07K16/00
摘要： Methods of treating renal carcinoma are described using fully human monoclonal antibodies ABX-EGF against the epidermal growth factor receptor (EGFr) and antigen binding fragments thereof. Methods of using these renal carcinoma treatments specifically as a monotherapy are also described. In addition, a kit and an article of manufacture for the treatment of renal carcinoma treatment are provided.

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