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81. 发明申请

US20160236011A1 ION GENERATING APPARATUS, AND TREATING APPARATUS AND TREATING METHOD USING THE SAME 有权
标题翻译：离子发生装置，以及使用其的处理装置和处理方法
公开(公告)号：US20160236011A1
公开(公告)日：2016-08-18
申请号：US15044986
申请日：2016-02-16
申请人： ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
发明人： Moon Youn JUNG , Won Bae CHO
IPC分类号： A61N5/10
CPC分类号： A61N5/1077 , A61N5/1075 , A61N2005/1052 , A61N2005/1088
摘要： Provided is a treating apparatus including an ion generating apparatus configured to inject ionized elements into a diagnosis subject to remove a tumor in the diagnosis subject, and an image photographing apparatus configured to measure positions of the ionized elements in the diagnosis subject. The ion generating apparatus includes a target including a first element and a first isotope that is a radioactive isotope of the first element, and a laser configured to allow a laser beam to be incident on the target and thus ionize the first element and the first isotope.
摘要翻译：本发明提供一种处理装置，其包括：离子发生装置，被配置为将离子化元素注入到诊断对象中以去除诊断对象中的肿瘤;以及图像拍摄装置，被配置为测量诊断对象中的电离元件的位置。离子产生装置包括：靶，其包括第一元素和作为第一元素的放射性同位素的第一同位素;以及激光，被配置为允许激光束入射到靶上，从而使第一元素和第一同位素。

82. 发明授权

US09211419B2 Treatments of disease or disorders using nanoparticles for focused hyperthermia to increase therapy efficacy 有权
标题翻译：使用纳米颗粒治疗疾病或病症，用于聚焦热疗，以提高疗效
公开(公告)号：US09211419B2
公开(公告)日：2015-12-15
申请号：US13742446
申请日：2013-01-16
申请人： Sunil Krishnan , Parmeswaran Diagaradjane , Jon Alexander Schwartz , James Chunjay Wang
发明人： Sunil Krishnan , Parmeswaran Diagaradjane , Jon Alexander Schwartz , James Chunjay Wang
IPC分类号： A61N2/00 , A61N5/10 , A61K41/00 , A61K47/48 , A61N1/40 , A61N5/06 , A61N7/00 , A61N5/067
CPC分类号： A61N2/002 , A61K41/0052 , A61K47/60 , A61N1/406 , A61N5/062 , A61N5/0625 , A61N5/1077 , A61N7/00 , A61N2005/0659 , A61N2005/067 , A61N2005/1088 , A61N2005/1098
摘要： Methods are provided for the treatment of diseases and disorders using systematically-introduced nanoparticles to create a focused localized hyperthermia in a target area to enhance the effect of additional treatment therapies such as ionizing radiation. Advantages include an enhancement of the therapeutic effect of other therapies by increasing perfusion or reducing hypoxia in the treatment area, further, the methods herein may also result in the disruption of the vasculature, which provide further impetus for such treatments, singly and in combination with conventional therapies such as chemotherapy and radiation therapy. Methods for treating a target area may comprise systemically introducing nanoparticles into an organism; allowing the nanoparticles to preferentially accumulate in the target area, applying an external energy where the nanoparticles are adapted to transduce at least a portion of the external energy into a heat energy so as to create a focused localized hyperthermia; and applying a subsequent additional therapy.
摘要翻译：提供了使用系统引入的纳米颗粒治疗疾病和病症的方法，以在目标区域中产生聚焦的定位性热疗，以增强额外的治疗疗法如电离辐射的作用。优点包括通过增加灌注或减少治疗区域中的缺氧来增强其他疗法的治疗效果，此外，本文的方法还可能导致脉管系统的破坏，这为进行这种治疗提供了进一步的动力，并且与常规疗法如化疗和放射治疗。用于治疗靶区域的方法可以包括将纳米颗粒系统地引入生物体中; 允许纳米颗粒优先地积聚在目标区域中，施加外部能量，其中纳米颗粒适于将至少一部分外部能量转换成热能，从而产生聚焦的局部热疗; 并应用随后的额外疗法。

83. 发明授权

US09022914B2 Laser accelerator driven particle brachytherapy devices, systems, and methods 有权
标题翻译：激光加速器驱动的颗粒近距离放射治疗装置，系统和方法
公开(公告)号：US09022914B2
公开(公告)日：2015-05-05
申请号：US13251014
申请日：2011-09-30
申请人： James E. Clayton , Paul A. Lovoi
发明人： James E. Clayton , Paul A. Lovoi
IPC分类号： A61N5/00 , G21K1/02 , H05H15/00 , A61N5/10 , G21K1/00
CPC分类号： G21K1/025 , A61N5/1001 , A61N5/1017 , A61N5/103 , A61N5/1067 , A61N5/1071 , A61N2005/1022 , A61N2005/1088 , A61N2005/1089 , A61N2005/109 , G21K1/00 , H05H15/00
摘要： A laser accelerator driven electronic brachytherapy system, device, and method for particle based treatment of a tumor or other human diseases and conditions.
摘要翻译：激光加速器驱动的电子近距离放射治疗系统，装置和方法，用于基于颗粒的治疗肿瘤或其他人类疾病和病症。

84. 发明授权

US08872127B2 Beam current controller for laser ion source 有权
标题翻译：光束电流控制器用于激光离子源
公开(公告)号：US08872127B2
公开(公告)日：2014-10-28
申请号：US13398553
申请日：2012-02-16
申请人： Masahiro Okamura
发明人： Masahiro Okamura
IPC分类号： H01J27/24 , H05H1/10 , A61N5/10 , H05H7/08
CPC分类号： H01J27/24 , A61N5/10 , A61N2005/1074 , A61N2005/1088 , H05H2007/082
摘要： The present invention relates to the design and use of an ion source with a rapid beam current controller for experimental and medicinal purposes. More particularly, the present invention relates to the design and use of a laser ion source with a magnetic field applied to confine a plasma flux caused by laser ablation.
摘要翻译：本发明涉及具有用于实验和药用目的的快速束流控制器的离子源的设计和使用。更具体地，本发明涉及具有施加磁场的激光离子源的设计和使用，以限制由激光烧蚀引起的等离子体通量。

85. 发明申请

US20140243576A1 PARTICLE ACCELERATOR AND MEDICAL EQUIPMENT 有权
标题翻译：颗粒加速器和医疗设备
公开(公告)号：US20140243576A1
公开(公告)日：2014-08-28
申请号：US14171910
申请日：2014-02-04
申请人： Kabushiki Kaisha Toshiba
发明人： Akiko Kakutani , Kiyokazu Sato , Takeshi Yoshiyuki , Takashi Yazawa
IPC分类号： H05H13/04 , A61N5/10
CPC分类号： H05H13/04 , A61N5/1077 , A61N2005/1088
摘要： One embodiment of a particle accelerator includes: a particle source from which a particle beam is extracted with a beam pulse width of not greater than 2 μsec; a linear accelerator for accelerating the particle beam extracted from the particle source; a synchrotron for receiving the particle beam transported thereto from the linear accelerator and causing the particle beam to circulate in order to accelerate it until it gets to a predetermined energy level; a bump electromagnet for shifting the circulating path of the particle beam each time it makes a full turn; and a control unit for controlling the extent of magnetic excitation of the bump electromagnet and for controlling the timing of magnetic excitation of the bump electromagnet according to the pulse timing of the particle source.
摘要翻译：粒子加速器的一个实施例包括：粒子束以束脉冲宽度不大于2微秒从其中提取出的粒子束; 用于加速从粒子源提取的粒子束的线性加速器; 同步加速器，用于接收从线性加速器传送到其上的粒子束，并使粒子束循环，以加速它直至达到预定的能级; 用于在每次完全转动时移动粒子束的循环路径的凸块电磁体; 以及控制单元，用于控制凸块电磁体的磁激励程度，并根据粒子源的脉冲定时来控制凸块电磁体的磁激励定时。

86. 发明申请

US20140235918A1 LASER ION SOURCE AND HEAVY PARTICLE BEAM THERAPY EQUIPMENT 有权
标题翻译：激光离子源和重粒子束治疗设备
公开(公告)号：US20140235918A1
公开(公告)日：2014-08-21
申请号：US14175054
申请日：2014-02-07
申请人： Kabushiki Kaisha Toshiba
发明人： Akiko KAKUTANI , Takayuki SAKO , Kiyokazu SATO , Yoshiharu KANAI , Takeshi YOSHIYUKI , Tsutomu KURUSU
IPC分类号： H01J27/24 , A61N5/10
CPC分类号： H01J27/24 , A61N5/1077 , A61N2005/1088
摘要： One embodiment of a particle accelerator includes: a vacuum container with its inside evacuated to produce vacuum, the vacuum container being formed with a laser beam entrance window for allowing a laser beam to enter; a target arranged in the vacuum container so as to be irradiated with a laser beam to generate ions; and a condenser lens for focusing the laser beam onto the target. The condenser lens is arranged at the laser beam entrance window of the vacuum container, and takes a role of a vacuum bulkhead.
摘要翻译：颗粒加速器的一个实施例包括：真空容器，其内部被抽真空以产生真空，真空容器形成有用于允许激光束进入的激光入射窗口; 设置在真空容器中以使其被激光束照射以产生离子的靶; 以及用于将激光束聚焦到目标上的聚光透镜。聚光透镜布置在真空容器的激光入射窗处，起到真空隔板的作用。

87. 发明授权

US08796639B2 Target for generating positive ions, method of fabricating the same, and treatment apparatus using the target 有权
标题翻译：用于产生正离子的靶，其制造方法和使用靶的处理装置
公开(公告)号：US08796639B2
公开(公告)日：2014-08-05
申请号：US13919960
申请日：2013-06-17
申请人： Electronics and Telecommunications Research Institute
发明人： Moon Youn Jung , Hyeon-Bong Pyo , Dong-Ho Shin , Seunghwan Kim
IPC分类号： H01J27/24 , H01J3/04 , H01J27/02
CPC分类号： H01J3/04 , A61N5/10 , A61N2005/1088 , H01J27/02 , H01J27/022 , H01J27/24
摘要： Provided is an ion beam treatment apparatus. The treatment apparatus includes a target for generating positive ions including a thin film for generating positive ions and nanowires disposed on at least one side of the thin film for generating positive ions, and a laser for emitting a laser beam incident on nanowires to project positive ions to a tumor region of a patient by generating the positive ions from the thin film for generating positive ions. Each of the nanowires may include a metal nanocore and a polymer shell surrounding the metal nanocore. The laser beam incident on the nanowires forms surface plasmon resonance, a near field having an intensity enhanced more than an intensity of the laser beam is formed by the surface plasmon resonance, and the positive ions are emitted from the thin film for generating positive ions by the near field.
摘要翻译：提供了一种离子束处理装置。该处理装置包括用于产生正离子的目标物，其包括用于产生正离子的薄膜和设置在该薄膜的至少一侧上的用于产生正离子的纳米线，以及用于发射入射到纳米线上以投射正离子的激光束的激光通过从薄膜产生正离子以产生正离子到患者的肿瘤区域。每个纳米线可以包括金属纳米孔和围绕金属纳米孔的聚合物壳。入射到纳米线上的激光束形成表面等离子体共振，通过表面等离子体共振形成具有比激光束强度增强的强度的近场，并且从薄膜发射正离子以产生正离子近场。

88. 发明授权

US08618521B2 Pluridirectional very high electron energy radiation therapy systems and processes 有权
公开(公告)号：US08618521B2
公开(公告)日：2013-12-31
申请号：US13765017
申请日：2013-02-12
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： Billy Wiseman Loo , Peter G. Maxim , Valery A. Dolgashev
IPC分类号： G21K5/04
CPC分类号： A61N5/1064 , A61N5/1043 , A61N5/1065 , A61N5/1081 , A61N2005/1051 , A61N2005/1058 , A61N2005/1061 , A61N2005/1076 , A61N2005/1088 , A61N2005/1089 , G21K5/04
摘要： A compact high-gradient, very high energy electron (VHEE) accelerator and delivery system (and related processes) capable of treating patients from multiple beam directions with great speed, using all-electromagnetic or radiofrequency deflection steering is provided, that can deliver an entire dose or fraction of high-dose radiation therapy sufficiently fast to freeze physiologic motion, yet with a better degree of dose conformity or sculpting than conventional photon therapy. In addition to the unique physical advantages of extremely rapid radiation delivery, there may also be radiobiological advantages in terms of greater tumor or other target control efficacy for the same physical radiation dose.

89. 发明申请

US20110101244A1 TARGET MATERIALS FOR GENERATING PROTONS AND TREATMENT APPARATUSES INCLUDING THE SAME 审中-公开
标题翻译：用于产生原子和处理装置的目标材料，包括它们
公开(公告)号：US20110101244A1
公开(公告)日：2011-05-05
申请号：US12845148
申请日：2010-07-28
申请人： Moon Youn JUNG , Nam Soo Myung , Hyun Woo Song , Hyeon-Bong Pyo , Seon-Hee Park , Gun Yong Sung
发明人： Moon Youn JUNG , Nam Soo Myung , Hyun Woo Song , Hyeon-Bong Pyo , Seon-Hee Park , Gun Yong Sung
IPC分类号： A61N5/00 , B32B15/04 , C23C16/00 , H05H1/24
CPC分类号： H05H6/00 , A61N5/10 , A61N2005/1087 , A61N2005/1088 , C23C16/24
摘要： Provided is a treatment apparatus including a target material for generating protons. The treatment apparatus includes a cylindrical bore member having an inner space to receive a patient; a proton generating target material provided to an inner surface of the bore member; and a laser adapted to supply a laser beam to the proton generating target material so that protons are generated from the proton generating target material and projected to a tumor site of the patient. The proton generating target material includes a supporting film and a hydrogenated amorphous silicon (a-Si:H) film provided on the supporting film.
摘要翻译：提供了包括用于产生质子的靶材料的处理装置。处理装置包括具有用于接收患者的内部空间的圆柱形孔构件; 设置在所述孔构件的内表面上的质子产生靶材料; 以及适于将激光束提供给质子产生靶材料的激光，使得质子从质子产生靶材料产生并投射到患者的肿瘤部位。质子产生靶材料包括支撑膜和设置在支撑膜上的氢化非晶硅（a-Si：H）膜。

90. 发明授权

US07348569B2 Acceleration of charged particles using spatially and temporally shaped electromagnetic radiation 失效
标题翻译：使用空间和时间成形的电磁辐射加速带电粒子
公开(公告)号：US07348569B2
公开(公告)日：2008-03-25
申请号：US11155011
申请日：2005-06-16
申请人： Thomas Feurer , Darius H. Torchinsky , Keith A. Nelson
发明人： Thomas Feurer , Darius H. Torchinsky , Keith A. Nelson
IPC分类号： G01K1/08 , H01J3/14 , H01J3/26
CPC分类号： G21K1/00 , A61N2005/1088 , G21K1/08 , H05H15/00
摘要： A method and apparatus for accelerating charged particles are disclosed, wherein the method comprises using at least a transverse component of a temporally and spatially shaped electromagnetic field to accelerate one or more charged particles.
摘要翻译：公开了一种用于加速带电粒子的方法和装置，其中该方法包括至少使用时间和空间形状的电磁场的横向分量来加速一个或多个带电粒子。

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