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81. 发明申请

WO2012120636A1 粒子線治療装置、および粒子線治療装置の照射線量設定方法审中-公开
标题翻译：颗粒治疗装置和设置颗粒治疗装置的辐射剂量的方法
公开(公告)号：WO2012120636A1
公开(公告)日：2012-09-13
申请号：PCT/JP2011/055347
申请日：2011-03-08
申请人：三菱電機株式会社 , 池田昌広 , 原田久 , 高橋理
发明人：池田　昌広 , 原田　久 , 高橋　理
IPC分类号： A61N5/10
CPC分类号： A61N5/1036 , A61N5/1043 , A61N2005/1087
摘要：　適切な線量校正を行うことができるスキャニング照射法による粒子線治療装置を得ることを目的とする。　ペンシルビームを進行方向に垂直な方向である横方向に移動させる照射ノズルと、照射ノズルから出射される粒子線の線量を測定する線量モニタと、照射目標に照射する照射線量設定値を設定する治療計画部と、線量モニタの測定値と治療計画部により設定される照射線量設定値とに基づいて照射目標に照射する照射線量を制御する照射線量制御器とを備えた治療制御部と、を有する粒子線治療装置において、治療計画部は、予め準備した深さ方向の吸収線量分布データであるＰＤＤを、ブラッグピーク位置よりもペンシルビームが入射する側の所定位置である基準深における吸収線量を基準として保存し、照射線量設定値を基準深における吸収線量を基準として算出する。
摘要翻译：本发明的目的是通过扫描照射来提供粒子治疗装置，该装置能够适当地校准剂量。也就是说，提供了一种颗粒治疗装置，包括：照射喷嘴，用于沿垂直于运动方向的方向沿横向移动笔形束; 用于测量离开照射喷嘴的粒子束的剂量的剂量监测器; 治疗计划部，用于设定照射剂量设定值以照射到照射对象物上; 以及治疗控制部，其包含照射剂量控制器，其用于根据由所述剂量监视器测量的值和由所述治疗计划部设定的照射剂量设定值，控制照射剂量照射到所述照射对象物，所述治疗计划部存储PDD ，其是在预先准备的深度方向上的吸收剂量分布数据，具有在参考深度而不是布拉格峰位置处的吸收剂量作为参考，参考深度是铅笔束进入的一侧上的预定位置，并以参考深度处的吸收剂量作为基准来计算照射剂量设定值。

82. 发明申请

WO2008039991A1 ARC-SEQUENCING TECHNIQUE FOR INTENSITY MODULATED ARC THERAPY 审中-公开
标题翻译：强度调制弧疗法的弧序测序技术
公开(公告)号：WO2008039991A1
公开(公告)日：2008-04-03
申请号：PCT/US2007/079914
申请日：2007-09-28
申请人： UNIVERSITY OF MARYLAND , SHEPARD, David, M. , EARL, Matthew, A. , CAO, Daliang
发明人： SHEPARD, David, M. , EARL, Matthew, A. , CAO, Daliang
IPC分类号： A61N5/10
CPC分类号： A61N5/1042 , A61N5/1036 , A61N5/1047
摘要： The invention is directed to a radiation therapy method and in particular, to a method of conducting an intensity modulated arc therapy (IMAT). The invention provides a planning technique that translates traditional static fixed-field IMRT plans into deliverable JMAT plans and allots IMAT to be realized as a routine clinical delivery technique.
摘要翻译：本发明涉及一种放射治疗方法，特别涉及一种进行强度调制电弧疗法（IMAT）的方法。本发明提供了一种将传统静态固定场IMRT计划转化为可交付的JMAT计划和分配IMAT作为常规临床递送技术实现的计划技术。

83. 发明申请

WO2007008899A2 VARIABLE FEATHERING FIELD SPLITTING FOR INTENSITY MODULATED FIELDS OF LARGE SIZE 审中-公开
标题翻译：大尺度强度调制场的变容层场分裂
公开(公告)号：WO2007008899A2
公开(公告)日：2007-01-18
申请号：PCT/US2006/026891
申请日：2006-07-11
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , KAMATH, Srijit , SAHNI, Sartaj, Kumar , LI, Jonathan , PALTA, Jatinder , RANKA, Sanjay
发明人： KAMATH, Srijit , SAHNI, Sartaj, Kumar , LI, Jonathan , PALTA, Jatinder , RANKA, Sanjay
IPC分类号： A61N5/10 , G21K1/02
CPC分类号： A61N5/1042 , A61N5/1036 , G21K1/04
摘要： A method and associated system (300) for delivering intensity-modulated radiation therapy (IMRT) uses variable feathering field splitting for intensity modulated fields of large size. Processor (112) controls a beam-shaping device (106) so that the beam-shaping device splits the radiation beam into a plurality of radiation fields delivered to the patient (102). Processor (112) in cooperation with beam-shaping device (106) implements a variable feathering method which includes the steps of providing an intensity matrix for the treatment of a patient, the intensity matrix having a plurality of rows and columns for spanning a prescribed radiation field including a prescribed field width. The prescribed width is compared to a maximum field width provided by the radiation treatment system. The intensity matrix is split into a plurality of spatially overlapping intensity submatrices when the prescribed width exceeds the maximum field width, wherein the splitting comprises variably feathering the intensity matrix. Radiotherapy is then provided to the patient (102) using a leaf sequencing method to generate the submatrices.
摘要翻译：用于传递强度调制放射治疗（IMRT）的方法和相关系统（300）对大尺寸的强度调制场使用可变羽化场分割。处理器（112）控制光束成形装置（106），使得光束成形装置将辐射光束分割成递送给患者（102）的多个辐射场。与光束成形装置（106）合作的处理器（112）实现可变羽化方法，该方法包括以下步骤：提供用于治疗患者的强度矩阵，该强度矩阵具有多个行和列以跨越规定的辐射字段包括规定的字段宽度。规定的宽度与放射治疗系统提供的最大视野宽度进行比较。当规定宽度超过最大场宽时，强度矩阵被分成多个空间重叠的强度子矩阵，其中分裂包括可变地羽化强度矩阵。然后使用叶测序方法向患者（102）提供放射疗法以生成子矩阵。

84. 发明申请

WO2005018742A1 METHOD AND APARATUS FOR OPTIMIZATION OF COLLIMATOR ANGLES IN INTENSITY MODULATED RADIATION THERAPY TREATMENT 审中-公开
标题翻译：强度调制辐射治疗方法和APARATUS优化收缩角
公开(公告)号：WO2005018742A1
公开(公告)日：2005-03-03
申请号：PCT/US2004/025922
申请日：2004-08-11
申请人： NOMOS CORPORATION , WANG, Duan, Q. , HILL, Robert, W. , LAM, Simon, Chun-Pin
发明人： WANG, Duan, Q. , HILL, Robert, W. , LAM, Simon, Chun-Pin
IPC分类号： A61N5/10
CPC分类号： A61N5/1031 , A61N5/1036 , A61N5/1042
摘要： A method and apparatus to determine an optimum collimator angle of a multi-leaf collimator having an opening and multiple leaf pairs for closing portions of the opening to form a radiation beam arrangement having multiple radiation beam segments. The method and apparatus include application of a cost function to determine a collimator angle which provides for delivery efficiency and target conformity. The user can preferentially either selectively enhance delivery efficiency of the radiation beam arrangement, reducing a number of radiation beam segments and reducing a number of radiation beam monitor units required for delivery of the desired prescription, or selectively enhance conformity of the radiation beam arrangement to a target shape. The optimum collimator angle is then used for delivery of an optimized radiation beam arrangement to a patient by a radiation delivery device.
摘要翻译：一种用于确定具有开口和多叶对的多叶准直器的最佳准直器角度的方法和装置，用于封闭所述开口的部分以形成具有多个辐射束段的辐射束布置。该方法和装置包括应用成本函数来确定提供输送效率和目标一致性的准直器角度。用户可优先地选择性地增强辐射束布置的传送效率，减少辐射束段的数量并减少递送所需处方所需的辐射束监视器单元的数量，或者选择性地增强辐射束装置的一致性目标形状。然后，最佳准直器角度用于通过辐射递送装置将优化的辐射束布置递送给患者。

85. 发明申请

WO2004087254A2 RESIDUAL MAP SEGMENTATION METHOD FOR MULTI-LEAF COLLIMATOR-INTENSITY MODULATED RADIOTHERAPY 审中-公开
标题翻译：用于多叶片收缩强度调制放射治疗的残留分割方法
公开(公告)号：WO2004087254A2
公开(公告)日：2004-10-14
申请号：PCT/US2004/009904
申请日：2004-03-29
申请人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , CHANG, Sha
发明人： CHANG, Sha
IPC分类号： A61N
CPC分类号： G21K1/04 , A61N5/1036 , A61N5/1042 , G21K1/046
摘要： In a method for sequentially generating segment fields for use in delivering intensity modulated radiotherapy an input continuous intensity map is generated. A segment field is generated directly from the input intensity map. A residual continuous intensity map is generated that is based on the respective photon fluence contributions from the input intensity map and a fractionally intensity map corresponding to the segment field. These steps are repeated for a number of iterations to generate a like number of additional segment fields and residual maps derived therefrom. In each iteration, the residual map generated in the previous iteration is used as the input intensity map.
摘要翻译：在用于顺序产生用于递送强度调制放射治疗的分段场的方法中，生成输入连续强度图。直接从输入强度图生成段字段。生成残留连续强度图，其基于来自输入强度图的相应光子注量贡献和对应于分段场的分数强度图。重复这些步骤进行多次迭代以生成相似数量的附加段字段和从其导出的残差映射。在每次迭代中，将在前一次迭代中生成的残差图用作输入强度图。

86. 发明申请

WO0249044A3 RADIOTHERAPEUTIC APPARATUS COMPRISING MULTILEAF COLLIMATOR 审中-公开
标题翻译：包含多功能收缩机的放射治疗装置
公开(公告)号：WO0249044A3
公开(公告)日：2002-09-19
申请号：PCT/EP0114684
申请日：2001-12-13
申请人： ELEKTA AB , ALBER MARKUS
发明人： ALBER MARKUS
IPC分类号： A61N5/10 , G21K1/02 , G21K1/04
CPC分类号： A61N5/1031 , A61N5/1036 , G21K1/025
摘要： An optimisation method for a fluence pattern to be provided via a radiotherapeutic apparatus comprising a multi-leaf collimator comprises an iteration of a progressive solution (such as a gradient approach) of the fluence profile, at least some iterations including a weighted penalty function which varies between solutions favoured by the collimator design and solutions not so favoured, later iterations including the penalty function at a greater weight. Thus, the penalty function represents locally preferred solutions derived from the constraints of the multi-leaf collimator (MLC). As the iteration progresses, the greater weight assigned to the penalty function drives the method towards a solution which is possible given the MLC constraints. However, the lesser weight attached in the early stages of the iteration allows the method to settle towards a genuinely preferred solution. Overall, therefore, the method migrates towards a theoretically ideal solution and then diverts to a nearby practically possible solution. In this way, a solution is obtained which can be put into practice but is close to a theoretically ideal solution, i.e. a solution that would be preferred in the absence of MLC constraints.
摘要翻译：用于通过包括多叶准直器的放射治疗装置提供的注量图案的优化方法包括通量曲线的渐进方案（例如梯度方法）的迭代，至少一些迭代，包括变化的加权惩罚函数在准直器设计和解决方案所支持的解决方案之间不太受欢迎，后来的迭代包括更大的重量的惩罚功能。因此，惩罚函数表示从多叶准直器（MLC）的约束导出的局部优选解。随着迭代的进行，分配给惩罚函数的较大权重将驱动方法转向可能给出MLC限制的解决方案。然而，在迭代的早期阶段附着的较小的重量使得该方法可以达到真正优选的解决方案。因此，总的来说，该方法向理论上的理想解决方案迁移，然后转移到附近的实际可能的解决方案。以这种方式，可以获得可以付诸实践的解，但是接近理论上的理想解，即在不存在MLC约束的情况下将是优选的解。

87. 发明授权

US12064647B2 Method and apparatus to facilitate generating a leaf sequence for a multi-leaf collimator 有权
公开(公告)号：US12064647B2
公开(公告)日：2024-08-20
申请号：US17361817
申请日：2021-06-29
申请人： Siemens Healthineers International AG
发明人： Marko T. Rusanen , Jarkko Y. Peltola , Shahab Basiri , Esa Kuusela
IPC分类号： A61N5/10 , G05B13/02 , G06N3/09 , G06N3/092 , G16H20/40 , G16H40/63 , G16H50/20 , G16H50/70
CPC分类号： A61N5/1036 , A61N5/1031 , A61N5/1045 , G05B13/027 , G06N3/09 , G06N3/092 , G16H20/40 , G16H40/63 , G16H50/20 , G16H50/70
摘要： A memory has a fluence map that corresponds to a particular patient stored therein. This memory also has at least one deep learning model stored therein trained to deduce a leaf sequence for a multi-leaf collimator from a fluence map. A control circuit operably coupled to that memory iteratively optimizes a radiation treatment plan to administer therapeutic radiation to that patient by, at least in part, generating a leaf sequence as a function of the at least one deep learning model and the fluence map that corresponds to the patient.

88. 发明公开

US20240207646A1 SYSTEMS AND METHODS FOR MULTIPLANAR RADIATION TREATMENT 审中-公开
公开(公告)号：US20240207646A1
公开(公告)日：2024-06-27
申请号：US18433361
申请日：2024-02-05
申请人： SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.
发明人： Johannes STAHL , Jonathan MALTZ
IPC分类号： A61N5/10
CPC分类号： A61N5/1045 , A61N5/1036 , A61N5/1049 , A61N5/1031 , A61N2005/1032 , A61N2005/1035 , A61N5/1039 , A61N2005/1041 , A61N5/1077
摘要： A method for delivering radiation treatment may include defining a preliminary trajectory including a plurality of control points. Each control point may be associated with position parameters of a gantry and a couch. The method may also include generating a treatment plan based on the preliminary trajectory by optimizing an intensity and position parameters of a collimator and MLC leaves for each control point. The method may also include decomposing the treatment plan into a delivery trajectory including the plurality of control points. Each of the plurality of control points may be further associated with the optimized intensity, the optimized position parameters of the collimator and the MLC leaves, an output rate, and a motion parameter of each of the gantry, the couch, the collimator, and the MLC leaves. The method may further include instructing a radiation delivery device to deliver the treatment plan according to the delivery trajectory.

89. 发明授权

US11980775B2 Automatic generation of radiation treatment plan optimization objectives 有权
公开(公告)号：US11980775B2
公开(公告)日：2024-05-14
申请号：US17010184
申请日：2020-09-02
申请人： Varian Medical Systems International AG
发明人： Emmi Ruokokoski , Jarkko Y. Peltola , Esa Kuusela
IPC分类号： A61N5/10 , G06F21/84 , G06F30/30
CPC分类号： A61N5/1031 , A61N5/1036 , A61N5/1038 , A61N5/1037 , A61N2005/1041 , G06F21/84 , G06F30/30
摘要： Generally speaking, pursuant to these various embodiments a memory stores prescribed treatment instructions for a particular patient radiation therapy. Those treatment instructions specify clinical metrics for goals pertaining to at least one treatment volume for the particular patient. Either directly or inferentially those clinical metrics are prioritized. A control circuit automatically converts those treatment instructions into resultant radiation treatment plan optimization objectives where the automatic conversion can compatibly comprise a non-convex optimization objective. The control circuit then automatically iteratively optimizes the radiation treatment plan for the particular patient radiation therapy as a function, at least in part, of the aforementioned resultant optimization objectives to thereby produce an optimized radiation treatment plan for the particular patient that a radiation treatment platform then utilizes to administer therapeutic radiation to the particular patient.

90. 发明授权

US11759655B2 Method and apparatus for using a multi-layer multi-leaf collimation system 有权
公开(公告)号：US11759655B2
公开(公告)日：2023-09-19
申请号：US15794198
申请日：2017-10-26
申请人： Varian Medical Systems International AG
发明人： Janne I. Nord , Esa Kuusela , Jarkko Y. Peltola , Juha Kauppinen
IPC分类号： A61N5/10 , G21K1/04
CPC分类号： A61N5/1045 , A61N5/1047 , G21K1/046 , A61N5/1036
摘要： A multi-layer multi-leaf collimation system includes at least a two layers of collimation leaves. The first multi-leaf collimator layer is configured to primarily perform a first function to affect a radiation beam traveling from a radiation source to a target and a second multi-leaf collimator layer is configured to primarily perform a second function, different from the first function, to affect the radiation beam for the administration of a treatment plan.

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