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81. 发明申请

WO2012085507A2 UPSTREAM DIRECT X-RAY DETECTION 审中-公开
标题翻译： UPSTREAM直接X射线探测
公开(公告)号：WO2012085507A2
公开(公告)日：2012-06-28
申请号：PCT/GB2011/001747
申请日：2011-12-21
申请人： THE UNIVERSITY OF BRISTOL , SWANSEA UNIVERSITY , UNIVERSITY HOSPITALS BRISTOL NHS FOUNDATION TRUST , VELTIUS, Jaap , HUGTENBURG, Richard, Peter , HALL, Catherine , PAGE, Ryan , STEVENS, Paul
发明人： VELTIUS, Jaap , HUGTENBURG, Richard, Peter , HALL, Catherine , PAGE, Ryan , STEVENS, Paul
IPC分类号： A61N5/10
CPC分类号： A61N5/1071 , A61N5/1047 , A61N5/1065 , A61N5/1075 , G01T1/24
摘要： A radiation beam, for example a therapeutic radiation beam such as an IMRT or VMAT X-ray beam is monitored using a Monolithic Active Pixel Sensor (MAPS) detector. Photons of the radiation beam can interact with the MAPS detector, and the radiation beam configuration can be estimated from the determined positions of the interactions. The detector is made sufficiently thin that it interacts only very weakly with the X-ray photons. For example, less than 1 in 10 3 of the X-ray photons might interact with the detector. Hence, the disturbance to the X-ray beam is negligible.
摘要翻译：使用单片有源像素传感器（MAPS）检测器来监测辐射束，例如治疗辐射束，例如IMRT或VMAT X射线束。辐射束的光子可以与MAPS检测器相互作用，并且可以从确定的相互作用位置估计辐射束配置。检测器制得足够薄，使得它与X射线光子非常弱地相互作用。例如，103个X射线光子中少于1个可能与检测器相互作用。因此，对X射线束的干扰可以忽略不计。

82. 发明申请

WO2012024448A2 AUTOMATED TREATMENT PLANNING FOR RADIATION THERAPY 审中-公开
标题翻译：自动治疗辐射治疗计划
公开(公告)号：WO2012024448A2
公开(公告)日：2012-02-23
申请号：PCT/US2011/048151
申请日：2011-08-17
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , ZHANG, Xiaodong , PAN, Xiaoning , LI, Yupeng , LI, Xiaoqiang , MOHAN, Radhe
发明人： ZHANG, Xiaodong , PAN, Xiaoning , LI, Yupeng , LI, Xiaoqiang , MOHAN, Radhe
IPC分类号： A61N5/01
CPC分类号： A61N5/103 , A61N5/1031 , A61N5/1047 , A61N2005/1041 , A61N2005/1087
摘要： This patent generally relates to developing treatment plans for use in external beam radiation therapy, and more particularly to a method, a system and a computer readable media that contains programming for the development of external beam radiation therapy treatment plans. Embodiments of the invention include (1) automatically setting beam angles based on a beam angle automation algorithm, (2) judiciously designing planning structures and (3) automatically adjusting the objectives of the objective function based on a parameter automation algorithm.
摘要翻译：该专利通常涉及开发用于外部束放射治疗的治疗计划，更具体地涉及包含用于开发外部束放射治疗计划的程序的方法，系统和计算机可读介质。本发明的实施例包括（1）基于束角自动化算法自动设置光束角度，（2）明智地设计规划结构，以及（3）基于参数自动化算法自动调整目标函数的目标。

83. 发明申请

WO2011139863A2 OPTIMIZATION PROCESS FOR VOLUMETRIC MODULATED ARC THERAPY 审中-公开
标题翻译：用于体积调节电弧治疗的优化过程
公开(公告)号：WO2011139863A2
公开(公告)日：2011-11-10
申请号：PCT/US2011/034402
申请日：2011-04-28
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , JIANG, Steve, B. , MEN, Chunhua , JIA, Xun
发明人： JIANG, Steve, B. , MEN, Chunhua , JIA, Xun
IPC分类号： A61N5/06 , A61N5/00 , A61B18/18
CPC分类号： A61N5/1031 , A61N5/1042 , A61N5/1047
摘要： Systems, techniques, and processes are disclosed for implementing aperture-based optimization techniques. In one aspect, a method performed by an aperture -based radiation treatment system includes implementing a volumetric modulated arc therapy (VMAT) treatment plan by generating apertures at beam angles. Beam intensities of the generated apertures are determined, which can be used to control generation of a radiation dose in a radiation therapy.
摘要翻译：公开了用于实现基于孔径的优化技术的系统，技术和过程。一方面，通过基于孔径的辐射治疗系统执行的方法包括通过以光束角度产生孔径来实施体积调制电弧治疗（VMAT）治疗计划。确定所产生的孔径的束强度，其可用于控制辐射治疗中辐射剂量的产生。

84. 发明申请

WO2010014288A1 RADIATION THERAPY IMAGING AND DELIVERY UTILIZING COORDINATED MOTION OF JAWS, GANTRY, AND COUCH 审中-公开
标题翻译：辐射治疗成像和运输利用协调运动的J S，Y CH CH CH CH CH CH
公开(公告)号：WO2010014288A1
公开(公告)日：2010-02-04
申请号：PCT/US2009/043611
申请日：2009-05-12
申请人： TOMOTHERAPY INCORPORATED , LU, Weiguo , CHEN, Yu , CHEN, Mingli , CHEN, Quan , OLIVERA, Gustavo, H. , REITZ, Graham , RUCHALA, Kenneth, J. , SCHNARR, Eric
发明人： LU, Weiguo , CHEN, Yu , CHEN, Mingli , CHEN, Quan , OLIVERA, Gustavo, H. , REITZ, Graham , RUCHALA, Kenneth, J. , SCHNARR, Eric
IPC分类号： A61N5/10 , A61B5/05
CPC分类号： A61N5/1042 , A61N5/1047 , A61N5/1069
摘要： A method of delivering a radiation therapy treatment plan to a treatment area of a patient. The treatment plan is delivered using a radiation therapy system including a moveable support for supporting a patient, and a gantry moveable relative to the support. The gantry supports a radiation source, a set of jaws having a jaw width and a multi-leaf collimator for modulating the radiation during delivery of the treatment plan. The support is moved during delivery of the treatment plan to the treatment area, and the width of the jaws is dynamically adjusted during delivery of the treatment plan to the treatment area.
摘要翻译：一种向患者的治疗区域递送辐射治疗计划的方法。治疗计划使用包括用于支撑患者的可移动支撑物的放射治疗系统和相对于支撑件可移动的台架进行。台架支撑辐射源，具有钳口宽度的一组钳口和用于在处理计划的递送期间调节辐射的多叶准直器。在将治疗计划交付到治疗区域期间移动支持，并且在将治疗计划递送到治疗区域期间动态地调整钳口的宽度。

85. 发明申请

WO2007124760A1 RADIOTHERAPEUTIC APPARATUS 审中-公开
标题翻译：放射治疗仪
公开(公告)号：WO2007124760A1
公开(公告)日：2007-11-08
申请号：PCT/EP2006/003901
申请日：2006-04-27
申请人： ELEKTA AB (PUBL) , BROWN, Kevin , STREAMER, Ralph , BOXALL, Paul , BOURNE, Duncan
发明人： BROWN, Kevin , STREAMER, Ralph , BOXALL, Paul , BOURNE, Duncan
IPC分类号： A61N5/10
CPC分类号： A61N5/103 , A61N5/1036 , A61N5/1042 , A61N5/1047
摘要： A radiotherapeutic apparatus comprises a source able to emit a beam of therapeutic radiation along a beam axis, a multi-leaf collimator arranged to collimate the beam to a desired shape, wherein the source is rotateable about a rotation axis that is substantially orthogonal and intersects with the beam axis thereby to describe an arc around that axis, and further comprises a control means able to control the dose/time rate of the source, the rotation speed of the source, and the multi-leaf collimator position. The control means is arranged to receive a treatment plan in which the arc is divided into a plurality of notional arc-segments, and specifying the total dose for the arc-segment and a start and end MLC position. It then controls the source in accordance with that plan over an first arc-segment such that at least one of the rotation speed and dose rate are constant and the multi-leaf collimator changes shape, and a second arc segment such that at least one of the rotation speed and dose rate are constant at a level different to the constant level adopted during the first arc-segment. It achieves this by calculating the total time required for the arc segment for a plurality of factors including an MLC leaf movement from a prescribed position at the start of the arc-segment to a prescribed position at the end of the arc- segment, at a maximum leaf speed, rotation of the source from the start to the end of the arc-segment at a maximum source rotation speed, delivery of the dose at a maximum dose rate per time, selecting the factor dictating the longest time, and controlling the apparatus so that the selected factor operates at its respective maximum and the remaining factors are operated at a reduced rate selected to match that longest time.
摘要翻译：放射治疗装置包括能够沿着光束轴发射治疗辐射束的源，多叶准直器，其布置成将光束准直到期望的形状，其中源可绕旋转轴线旋转，旋转轴线基本上正交并与光束轴由此描述围绕该轴的弧，并且还包括能够控制源的剂量/时间速率，源的旋转速度和多叶准直器位置的控制装置。控制装置被设置成接收处理计划，其中弧被分成多个概念弧段，并且指定弧段的总剂量以及开始和结束MLC位置。然后，它根据该计划在第一弧段上控制源，使得旋转速度和剂量率中的至少一个恒定，并且多叶准直器改变形状;以及第二弧段，使得至少一个旋转速度和剂量率恒定在与第一弧段期间采用的恒定水平不同的水平。它通过计算多个因素所需的总时间来实现，其包括从弧段开始处的规定位置到弧段末端处的规定位置的MLC叶移动，最大叶片速度，源以最大源旋转速度从弧段的开始到结束的旋转，以每时间最大剂量率递送剂量，选择规定最长时间的因子，以及控制装置使得所选择的因子在其各自的最大值下操作，并且剩余因子以选择以匹配最长时间的降低的速率操作。

86. 发明申请

WO2015193162A1 SYSTEM AND COMPUTER PROGRAM PRODUCT FOR RADIATION INVERSE TREATMENT PLANNING 审中-公开
标题翻译：用于辐射反转治疗计划的系统和计算机程序产品
公开(公告)号：WO2015193162A1
公开(公告)日：2015-12-23
申请号：PCT/EP2015/063008
申请日：2015-06-11
申请人： SWISS SUMMIT SERVICE CENTER SA
发明人： MARTIN, André , SALZMANN, Daniel
IPC分类号： A61N5/10
CPC分类号： A61N5/1031 , A61B6/5294 , A61B6/54 , A61N5/103 , A61N5/1038 , A61N5/1042 , A61N5/1047 , A61N5/1071 , A61N5/1075 , G01T1/2914 , G05B2219/33079 , G06F17/16 , G06F17/30271
摘要： The present invention concerns a radiation inverse treatment planning system for a linear accelerator, comprising: - a radiation source, configured for delivering individual dose shots (a j ), each individual dose shot having a predetermined location and incidence angle inside and/or outside a target area, a size and a shape - at least a data bus system (102), - a memory (106) coupled to the data bus system (102), wherein the memory (106) comprises a computer usable program code, and - a processing unit (104) coupled to the data bus system (102), wherein the processing unit (104) is configured to execute the computer usable program code to - pre-compute (10) a set of individual dose shots (a j ), - associate (40) a weight (s j ) to each individual dose shot (a j ), based on one or more constraints (20), characterised in that the processing unit (104) executes the computer usable program code to - find (30) the sparsest subset of individual dose shots, to satisfy said one or more constraints (20).
摘要翻译：本发明涉及一种用于线性加速器的辐射反向治疗计划系统，包括： - 辐射源，其被配置用于传送各个剂量射击（aj），每个单独的剂量射击在靶内和/或外部具有预定位置和入射角区域，大小和形状 - 至少数据总线系统（102）， - 耦合到数据总线系统（102）的存储器（106），其中存储器（106）包括计算机可用程序代码，以及 - 处理单元（104），其耦合到所述数据总线系统（102），其中所述处理单元（104）被配置为执行所述计算机可用程序代码以预先计算（10）一组单独剂量镜头（aj）， - 基于一个或多个约束（20）将每个单独剂量镜头（aj）的重量（sj）关联（40），其特征在于，所述处理单元（104）执行所述计算机可用程序代码以找到（30）满足所述一个或多个约束（2 0）。

87. 发明申请

WO2015062093A1 一种多用途放射治疗系统审中-公开
公开(公告)号：WO2015062093A1
公开(公告)日：2015-05-07
申请号：PCT/CN2013/086462
申请日：2013-11-01
申请人：西安大医数码技术有限公司
发明人：刘海峰
IPC分类号： A61N5/10
CPC分类号： A61N5/1081 , A61N5/1039 , A61N5/1042 , A61N5/1047 , A61N5/1082 , A61N5/1084
摘要：一种多用途放疗系统，包括：底座、运动床、滚筒以及治疗头。所述运动床和滚筒设置在底座上，治疗头安装在滚筒上。治疗头包括多源聚焦治疗头和适形调强治疗头。所述多源聚焦治疗头与适形调强治疗头分布在滚筒轴心两侧，并通过圆弧导轨与滚筒相连。该多用途放疗系统实现了在同一台设备上进行立体定向多源聚焦治疗和适形调强治疗的目的。

88. 发明申请

WO2014191204A1 DEVICE FOR DETERMINING ILLUMINATION DISTRIBUTIONS FOR IMRT 审中-公开
标题翻译：用于确定IMRT照明分布的装置
公开(公告)号：WO2014191204A1
公开(公告)日：2014-12-04
申请号：PCT/EP2014/059807
申请日：2014-05-14
申请人： KONINKLIJKE PHILIPS N.V. , PHILIPS GMBH
发明人： ISOLA, Alfonso Agatino , NEUKIRCHEN, Christoph , WEESE, Juergen , BAL, Matthieu Frédéric
IPC分类号： A61N5/10
CPC分类号： A61N5/1036 , A61N5/1045 , A61N5/1047 , A61N2005/1074
摘要： The invention relates to a device for determining illumination distributions (18) for IMRT. A layered graph structure is used, which considers which extensions of an illumination distribution along a respective line and thus which illumination distributions are realizable, for determining extensions for the illumination distributions. Moreover, second weights defining fluences of the illumination distributions are determined such that a deviation between a provided fluence map and a fluence map formed by a combination of illumination distributions, which are defined by the respective determined extensions and the respective second weight, is minimized. This determination procedure leads to illumination distributions, which very well correspond to the provided fluence map and which are automatically realizable by the radiation device. This leads to an improved IMRT, wherein a post-processing of the determined illumination distributions for ensuring that the determined illumination distributions are really realizable is not necessarily required.
摘要翻译：本发明涉及一种用于确定IMRT的照明分布（18）的装置。使用分层图结构，其考虑沿着相应行的照明分布的哪些延伸，并且因此考虑哪些照度分布是可实现的，以确定照明分布的扩展。此外，确定照明分布的通量的第二权重被确定为使得通过由相应的确定的扩展和相应的第二权重定义的由照明分布的组合形成的所提供的注量图与通量密度图之间的偏差被最小化。该确定过程导致照明分布，其非常对应于所提供的注量图并且可由辐射装置自动实现。这导致改进的IMRT，其中对确定的确定的照明分布真正可实现的所确定的照明分布的后处理不一定是必需的。

89. 发明申请

WO2014167461A1 ISODOSE OPTIMIZATION 审中-公开
标题翻译： ISODOSE优化
公开(公告)号：WO2014167461A1
公开(公告)日：2014-10-16
申请号：PCT/IB2014/060391
申请日：2014-04-03
申请人： KONINKLIJKE PHILIPS N.V.
发明人： BZDUSEK, Karl, Antonin , FRIGO, Sean
IPC分类号： A61N5/10
CPC分类号： A61N5/1031 , A61N5/1047 , A61N2005/1074
摘要： A radiation therapy planning system (10) includes an isodose line unit (36), a region of interest unit (52), and an optimization unit (58). The isodose line unit (36) receives isodose lines planned for a volume of a subject. The region of interest unit (52) defines at least one isodose region of interest based on the received isodose lines. The optimization unit (58) generates an optimized radiation therapy plan based on the at least one defined isodose region of interest and at least one dose objective for the defined region of interest.
摘要翻译：放射治疗计划系统（10）包括等剂量线单元（36），感兴趣区域单元（52）和优化单元（58）。等剂量线单元（36）接收针对受试者体积计划的等剂量线。感兴趣区域（52）基于接收到的等剂量线定义至少一个等剂量的感兴趣区域。优化单元（58）基于所述至少一个所定义的目的等剂量区域和所述定义的感兴趣区域的至少一个剂量目标产生优化的放射治疗计划。

90. 发明申请

WO2013105994A3 MULTI-SOURCE RADIATION SYSTEM AND METHOD FOR INTERWOVEN RADIOTHERAPY AND IMAGING 审中-公开
标题翻译：多源放射治疗系统和方法用于室内放射治疗和成像
公开(公告)号：WO2013105994A3
公开(公告)日：2013-10-10
申请号：PCT/US2012025382
申请日：2012-02-16
申请人： SLOAN KETTERING INST CANCER , VARIAN MED SYS INC , LING C CLIFTON , HUNT MARGIE A , ZHANG PENGPENG , ETMEKTZOGLOU ATHANASIOS , SHAPIRO EDWARD
发明人： LING C CLIFTON , HUNT MARGIE A , ZHANG PENGPENG , ETMEKTZOGLOU ATHANASIOS , SHAPIRO EDWARD
IPC分类号： A61N5/00 , A61B6/00 , A61N5/10
CPC分类号： A61N5/1047 , A61B6/032 , A61B6/4085 , A61N5/1065 , A61N2005/1061
摘要： An arc radiotherapy and imaging system is provided which includes a first radiation source and a second radiation source. The first radiation source is suitable for treating a region of a patient, and the second radiation source is suitable for imaging the region of the patient. A control is also provided for automatically adjusting system operation, according to a defined schedule, between treating the region of the patient using the first radiation source and imaging the region of the patient using the second radiation source, thereby facilitating both treating and imaging of the region of the patient.
摘要翻译：提供一种电弧放射治疗和成像系统，其包括第一辐射源和第二辐射源。第一辐射源适用于治疗患者的区域，并且第二辐射源适于对患者的区域进行成像。还提供了一种控制，用于根据定义的时间表，在使用第一辐射源处理患者的区域和使用第二辐射源对患者的区域成像之间进行自动调整系统操作，从而便于治疗和成像患者的区域。

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