专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2017085691A1 MANUFACTURING DEVICE AND METHOD OF AN IMMUNOTHERAPEUTIC FORMULATION COMPRISING A RECOMBINANT LISTERIA STRAIN 审中-公开
标题翻译：包含重组李斯特氏菌菌株的免疫治疗制剂的制造装置和方法
公开(公告)号：WO2017085691A1
公开(公告)日：2017-05-26
申请号：PCT/IB2016/056980
申请日：2016-11-18
申请人： ADVAXIS, INC.
发明人： EAPEN, Anil , PETIT, Robert
IPC分类号： C12N15/74 , C07K14/195 , C07K14/705 , C07K14/71 , A61K38/16 , A61K38/17 , B01D61/14 , G01N21/59
CPC分类号： A61K38/16 , A61K38/17 , B01D61/18 , B01D61/22 , B01D65/08 , B01D2311/14 , B01D2311/16 , B01D2311/25 , B01D2313/50 , B01D2315/10 , B01D2315/16 , B01D2321/40 , C07K14/195 , C07K14/71 , C07K2319/00 , C12N9/12 , C12N9/6445 , C12Y207/10001 , G01N21/59
摘要： Provided herein are an apparatus and process for manufacturing a formulation comprising a drug substance, said drug substance comprising a recombinant Listeria strain comprising a prostate specific antigen (PSA) or a chimeric HER2 antigen fused to a Listeriolysin O (LLO) protein fragment.
摘要翻译：本文提供了用于制造包含药物的制剂的设备和方法，所述药物包含含有前列腺特异性抗原（PSA）或嵌合体的重组利斯特氏菌属菌株 HER2抗原与Listeriolysin O（LLO）蛋白片段融合。

2. 发明申请

WO2017060836A1 AN APPARATUS COMPRISING A WAVEGUIDE-MODULATOR AND LASER-DIODE AND A METHOD OF MANUFACTURE THEREOF 审中-公开
标题翻译：包含波导调制器和激光二极管的装置及其制造方法
公开(公告)号：WO2017060836A1
公开(公告)日：2017-04-13
申请号：PCT/IB2016/055967
申请日：2016-10-05
申请人： KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY , KING ABDULAZIZ CITY FOR SCIENCE AND TECHNOLOGY
发明人： OOI, Boon Siew , SHEN, Chao , NG, Tien Khee , ALYAMANI, Ahmed , ELDESOUKI, Munir
IPC分类号： H01S5/026 , H01S5/32 , H01S5/343 , H01S5/00
CPC分类号： H01S5/0265 , H01S5/0014 , H01S5/0264 , H01S5/3202 , H01S5/34333
摘要： Example apparatuses are provided for simultaneous generation of high intensity light and modulated light signals at low modulation bias operating characteristics. An example apparatus includes a semipolar or nonpolar GaN-based substrate, a reverse- biased waveguide modulator section, and a forward-biased gain section based on InGaN/GaN quantum-well active regions, wherein the forward-biased gain section is grown on the semipolar or nonpolar GaN-based substrate. Methods of manufacturing the apparatuses described herein are also contemplated and described herein.
摘要翻译：提供了用于以低调制偏压操作特性同时生成高强度光和调制光信号的示例性装置。示例性装置包括基于InGaN / GaN量子阱活性区域的半极性或非极性GaN基衬底，反向偏置波导调制器部分和正向偏置增益部分，其中正向偏置增益部分生长在半极性或非极性GaN基衬底。本文所述的制造装置的方法也在本文中考虑和描述。

3. 发明申请

WO2017056063A1 NITROGEN OXIDE OXIDATION ACTIVITY OF PSEUDO-BROOKITE COMPOSITIONS AS ZERO-PGM CATALYSTS FOR DIESEL OXIDATION APPLICATIONS 审中-公开
标题翻译：作为柴油氧化应用的ZERO-PGM催化剂的PSEUDO-BROOKITE组合物的氮氧化物氧化活性
公开(公告)号：WO2017056063A1
公开(公告)日：2017-04-06
申请号：PCT/IB2016/055882
申请日：2016-09-30
申请人： CLEAN DIESEL TECHNOLOGIES, INC.
发明人： NAZARPOOR, Zahra , GOLDEN, Stephen J.
IPC分类号： B01J23/34 , B01D53/94
CPC分类号： B01J23/34 , B01D53/944 , B01D2255/204 , B01D2255/2061 , B01D2255/2065 , B01D2255/20707 , B01D2255/2073 , B01D2255/20738 , B01D2255/20746 , B01D2255/20753 , B01D2255/65 , B01D2258/012 , B01J23/002 , B01J23/8892 , B01J2523/00 , B01J2523/36 , B01J2523/72 , B01J2523/842 , B01J2523/845 , B01J2523/847 , B01J2523/47 , B01J2523/24 , B01J2523/3712
摘要： Zero-PGM (ZPGM) catalyst materials including pseudo-brookite compositions for use in diesel oxidation catalyst (DOC) applications are disclosed. The disclosed doped pseudo-brookite compositions include A-site partially doped pseudo-brookite compositions, such as, Sr-doped and Ce-doped pseudo-brookite compositions, as well as B-site partially doped pseudo-brookite compositions, such as, Fe-doped, Co-doped, Ni-doped, and Ti-doped pseudo-brookite compositions. The disclosed doped pseudo-brookite compositions, including calcination at various temperatures, are subjected to a DOC standard light-off (LO) test methodology to assess/verify catalyst activity as well as to determine the effect of the use of a dopant in an A-site cation or a B- site cation within a pseudo-brookite composition. The disclosed doped pseudo-brookite compositions exhibit higher NO oxidation catalyst activities when compared to bulk powder pseudo-brookite, thereby indicating improved thermal stability and catalyst activity when using a dopant in an A-site cation or in a B-site cation within a pseudo-brookite composition.
摘要翻译：公开了包括用于柴油氧化催化剂（DOC）应用的假片钛矿组合物的零PGM（ZPGM）催化剂材料。所公开的掺杂的假褐煤矿组合物包括A位部分掺杂的假片状脆铁矿组合物，例如Sr-掺杂和Ce-掺杂的假片断铁矿组合物，以及B位部分掺杂的假片状脆铁矿组合物，例如Fe 掺杂的，掺钴的，掺杂Ni的和Ti掺杂的假片钛矿组合物。所公开的掺杂的假片钛矿组合物，包括在各种温度下的煅烧，经受DOC标准照明（LO）测试方法以评估/验证催化剂活性以及确定在A中使用掺杂剂的效果 - 位于阳离子或B-位点阳离子中。当与本体粉末假片状脆铁矿相比时，所公开的掺杂的假褐煤矿组合物表现出更高的NO氧化催化剂活性，从而表明当在A位点阳离子中使用掺杂剂时，表明改进的热稳定性和催化剂活性， - 布洛克组成。

4. 发明申请

WO2016207859A1 MANUFACTURING DEVICE AND PROCESS FOR PERSONALIZED DELIVERY VECTOR-BASED IMMUNOTHERAPY 审中-公开
标题翻译：用于个性化交付矢量的免疫学的制造设备和过程
公开(公告)号：WO2016207859A1
公开(公告)日：2016-12-29
申请号：PCT/IB2016/053791
申请日：2016-06-24
申请人： ADVAXIS, INC.
发明人： EAPEN, Anil , PETIT, Robert , PUJOLS, Mayo
IPC分类号： C12M1/00 , C12M1/02 , C12M1/34 , C12N1/36 , C12N15/74 , A61K35/74
CPC分类号： C12N1/20 , A61K35/74 , A61K39/0011 , B65B3/04 , B65B7/02 , B65B55/00 , C12M23/14 , C12M27/00 , C12M29/04 , C12M41/36 , C12M41/40 , C12M41/46 , C12N1/36
摘要： This invention provides a system of providing and a process of creating personalized immunotherapeutic compositions for a subject having a disease or condition, including therapeutic vaccine delivery vectors comprising gene expression constructs expressing peptides associated with one or more neo-epitopes or peptides containing mutations that are specific to an subject's cancer or unhealthy tissue. The invention further provides a scalable fully enclosed single use cell growth system, wherein the entire process of manufacturing of personalized immunotherapeutic compositions, up to and including dispensing said composition into containers for patient delivery is carried out within a single enclosed fluid flow path.
摘要翻译：本发明提供了一种为具有疾病或病症的受试者创造个性化的免疫治疗组合物的方法，该方法包括治疗性疫苗递送载体，所述治疗性疫苗递送载体包含表达与一个或多个新表位相关肽的基因表达构建体或含有特异性突变的肽对受试者的癌症或不健康的组织。本发明进一步提供了可扩展的全封闭单用途细胞生长系统，其中制造个性化免疫治疗组合物的整个过程直到并包括将所述组合物分配到用于患者输送的容器中，在单个封闭流体流动路径内进行。

5. 发明申请

WO2016183361A1 IMMUNOGENIC LISTERIA-BASED COMPOSITIONS COMPRISING TRUNCATED ACTA-ANTIGEN FUSIONS AND METHODS OF USE THEREOF 审中-公开
标题翻译：包含截短的ACTA抗原融合物的基于免疫原性的基于LISTERIA的组合物及其使用方法
公开(公告)号：WO2016183361A1
公开(公告)日：2016-11-17
申请号：PCT/US2016/032182
申请日：2016-05-12
申请人： ADVAXIS, INC.
发明人： WALLECHA, Anu , MOLLI, Poonam , PETIT, Robert
IPC分类号： C12N1/20 , C12N15/74 , C07K14/195 , C12N9/10 , C12N9/90 , A61K35/74 , A61K39/00
CPC分类号： A61K35/74 , A61K39/0011 , A61K2039/523 , A61K2039/6068 , C07K14/195 , C07K16/1296 , C07K2317/732 , C07K2319/33 , C12N1/36 , C12N9/10 , C12N9/90 , C12N15/74
摘要： The present invention relates to compositions comprising a recombinant attenuated Listeria strain expressing a truncated ActA and fusion proteins thereof and methods of using the same for inducing anti-disease immune responses, and treatment of the same, including a tumor growth or cancer. In particular, the invention relates to the treatment of a tumor growth or cancer using a live attenuated recombinant Listeria strain that expresses a fusion protein of a truncated ActA fused to an antigen.
摘要翻译：本发明涉及包含表达截短的ActA的重组减毒李斯特氏菌菌株及其融合蛋白的组合物和使用该菌株诱导抗疾病免疫应答的方法及其治疗方法，包括肿瘤生长或癌症。特别地，本发明涉及使用表达与抗原融合的截短的ActA的融合蛋白的活减毒重组利斯特氏菌菌株来治疗肿瘤生长或癌症。

6. 发明申请

WO2016178145A1 METHOD, APPARATUS AND COMPUTER PROGRAM PRODUCT FOR RESERVATIONS, INVENTORY CONTROL, SHOPPING, AND BOOKING WITH ATTRIBUTE BASED PRICING 审中-公开
标题翻译：方法，装置和计算机程序产品的保留，库存控制，购物和预订与基于属性的价格
公开(公告)号：WO2016178145A1
公开(公告)日：2016-11-10
申请号：PCT/IB2016/052517
申请日：2016-05-03
申请人： SABRE GLBL INC.
发明人： VINOD, Ben , HOBT, David
IPC分类号： G06Q10/02 , G06Q50/12
CPC分类号： G06Q10/02 , G06F17/30342 , G06Q50/12
摘要： A method is provided for booking a hotel room that improves the satisfaction level for a consumer and increases revenue for the hotelier. Consumers may benefit from being able to select property-specific and room-specific attributes for which they perceive enhanced value, while property-specific and room-specific attributes that a consumer does not particularly value may be avoided in an effort for the consumer to spend on features they desire. Further, hoteliers may benefit from being able to offer room-specific attributes and add-on features that create additional revenue streams for the hotel. Additionally, the transparency afforded the consumer of the room-specific attributes available versus those selected provides the consumer with a level of expectation that is more aligned with the hotel and the specific room they selected, thereby improving customer satisfaction.
摘要翻译：提供一种用于预订酒店房间的方法，其提高消费者的满意度并且增加酒店经营者的收入。消费者可以从能够选择属性特定的和特定于房间的属性来获益，因为他们认为增强的价值，而消费者不具有特殊价值的特定于房屋和房间的属性可能会被避免，以便消费者花费对他们所期望的功能。此外，酒店经营者可以从能够提供房间特定的属性和附加功能中获益，从而为酒店创造额外的收入来源。此外，透明度为消费者提供了与房间相关的属性，而选择的则为消费者提供了与酒店和所选房间更一致的期望水平，从而提高了客户满意度。

7. 发明申请

WO2016088052A1 METHOD AND APPARATUS FOR DETERMINING LOCATION-BASED VEHICLE BEHAVIOR 审中-公开
标题翻译：用于确定基于位置的车辆行为的方法和装置
公开(公告)号：WO2016088052A1
公开(公告)日：2016-06-09
申请号：PCT/IB2015/059267
申请日：2015-12-01
申请人： HERE GLOBAL B.V. , NOKIA USA INC.
发明人： TENNENT, Toby , FILLEY, George , BELKIN, Anatoly , MORAN, Kevin
IPC分类号： G08G1/123
CPC分类号： G08G1/096775 , B60W40/09 , B60W2050/0031 , B60W2550/12 , B60W2550/40 , B60W2550/402 , G01C21/00 , G06Q40/08 , G08G1/0112 , G08G1/0129 , G08G1/0141 , G08G1/0145 , G08G1/08 , G08G1/096716 , G08G1/096758 , G08G1/123
摘要： A method, apparatus and computer program product are described so as to provide more additional information regarding vehicular behavior. In the context of a method, information is received regarding a location of the vehicle at a plurality of instances in time. The plurality of instances in time define a time period. The method also includes determining an environmental condition at the location during the time period and comparing the behavior of the vehicle to that of other vehicles at the location that are also subjected to the environmental condition. Additionally, the method may determine a score for the vehicle in relation to a risk factor based upon the behavior of the vehicle and the comparison to other vehicles at the location that are also subjected to the environmental condition.
摘要翻译：描述了一种方法，装置和计算机程序产品，以便提供关于车辆行为的更多附加信息。在方法的上下文中，在多个时间点处接收关于车辆的位置的信息。时间上的多个实例定义了时间段。该方法还包括在该时间段内确定该位置处的环境状况，并将车辆的行为与其他车辆的行为进行比较，该车辆也处于环境状况的位置。此外，该方法可以基于车辆的行为以及在还受到环境条件的位置与其他车辆的比较来确定车辆相对于风险因子的得分。

8. 发明申请

WO2015140771A1 METHOD, APPARATUS, AND COMPUTER PROGRAM PRODUCT FOR FACILITATING LOAD BASED CHANGES OF DATA OFFLOADING THRESHOLDS 审中-公开
标题翻译：方法，装置和计算机程序产品，用于加快数据卸载阈值的负载变化
公开(公告)号：WO2015140771A1
公开(公告)日：2015-09-24
申请号：PCT/IB2015/052070
申请日：2015-03-20
申请人： NOKIA TECHNOLOGIES OY , NOKIA USA INC.
发明人： DALSGAARD, Lars , KOSKINEN, Jussi-pekka , KAIKKONEN, Jorma
IPC分类号： H04W36/30 , H04W36/24 , H04W28/08 , H04W36/22 , H04W36/08
CPC分类号： H04W28/0221 , H04L5/0051 , H04W24/10 , H04W28/0236 , H04W28/08
摘要： Methods, apparatuses, and computer program products are provided to facilitate load based changes in data offloading thresholds. In the context of a method, the method includes causing measurement of a reference signal received power of a serving cell in the first network to be performed (504); causing measurement of a reference signal received quality of a serving cell in the first network to be performed (506); and causing one or more network metrics for a second network to be acquired. The method further includes determining, by a processor, whether the measured reference signal received quality is lower than a reference signal received quality threshold (508); determining, by the processor, whether the measured reference signal received power is lower than a reference signal received power threshold (516); and in the case where the measured reference signal received quality is lower than the reference signal received quality threshold: causing the reference signal received power threshold to be adjusted; determining, by the processor, whether each of the acquired network metrics for the second network meet an associated network metric condition; and if all the associated network metric conditions are met, data offloading can be performed from the first network to the second network (512); and in the case where the measured reference signal received power is lower than the reference signal received power threshold: causing the reference signal received quality threshold to be adjusted; determining, by the processor, whether each of the acquired network metrics for the second network meet an associated network metric condition; and if all the associated network metric conditions are met, data offloading can be performed from the first network to the second network (518). A corresponding apparatus and a computer program product are also provided.
摘要翻译：提供了方法，设备和计算机程序产品，以便于数据卸载阈值中的基于负载的更改。在方法的上下文中，所述方法包括：对要执行的第一网络中的服务小区的参考信号接收功率进行测量（504）; 使得要执行的所述第一网络中的服务小区的参考信号接收质量的测量（506）; 并且导致获取第二网络的一个或多个网络度量。该方法还包括由处理器确定所测量的参考信号接收质量是否低于参考信号接收质量阈值（508）; 由所述处理器确定所测量的参考信号接收功率是否低于参考信号接收功率阈值（516）; 并且在所测量的参考信号接收质量低于参考信号接收质量阈值的情况下：使参考信号接收功率阈值被调整; 由处理器确定用于第二网络的所获取的网络度量中的每一个是否满足相关联的网络度量条件; 并且如果满足所有相关联的网络度量条件，则可以从第一网络到第二网络（512）执行数据卸载; 并且在所测量的参考信号接收功率低于参考信号接收功率阈值的情况下：使得参考信号接收质量阈值被调整; 由处理器确定用于第二网络的所获取的网络度量中的每一个是否满足相关联的网络度量条件; 并且如果满足所有相关联的网络度量条件，则可以从第一网络到第二网络执行数据卸载（518）。还提供了相应的装置和计算机程序产品。

9. 发明申请

WO2015140602A1 METHOD AND APPARATUS FOR CONTROLLING SMART OBJECTS WITH A COLLAGE USER INTERFACE USING NORMALIZED USER INTERFACE DESCRIPTORS 审中-公开
标题翻译：使用正规化用户界面描述符控制带有使用者界面的智能对象的方法和装置
公开(公告)号：WO2015140602A1
公开(公告)日：2015-09-24
申请号：PCT/IB2014/060046
申请日：2014-03-21
申请人： NOKIA TECHNOLOGIES OY , NOKIA, INC.
发明人： SAVOLAINEN, Teemu Ilmari , PALIN, Arto , REUNAMÄKI, Jukka
IPC分类号： G06F3/048 , G06F7/00
CPC分类号： G06F3/14 , G06F3/0482 , G06F3/0484 , G06F8/38 , G06F9/451 , G06F17/2247 , G06F2203/04803 , H04L67/02 , H04L67/125
摘要： A method, apparatus and computer program product are provided for controlling smart objects with a collage user interface using normalized user interface descriptors. A method is provided for receiving user interface description data from a plurality of utility devices. The user interface description data includes access and control data associated with the respective utility device. The method also includes generating a collaged user interface based on the user interface description data; receiving a signal associated with a first user interface description data associating the first user interface description data with a second user interface description data; and causing the collaged user interface to be displayed on a user equipment user interface.
摘要翻译：提供了一种使用规范化的用户界面描述符来使用拼贴用户界面来控制智能对象的方法，装置和计算机程序产品。提供一种用于从多个实用设备接收用户界面描述数据的方法。用户界面描述数据包括与相应的实用设备相关联的访问和控制数据。该方法还包括：基于用户界面描述数据生成被标记的用户界面; 接收与将所述第一用户界面描述数据与第二用户界面描述数据相关联的第一用户界面描述数据相关联的信号; 并且使得用户设备用户界面上显示被标记的用户界面。

10. 发明申请

WO2015089047A1 ULTRASOUND-GUIDED VASCULAR DEVICE FOR EXTRACORPOREAL MEMBRANE OXYGENATION 审中-公开
标题翻译：用于超声波膜氧化的超声引导血管装置
公开(公告)号：WO2015089047A1
公开(公告)日：2015-06-18
申请号：PCT/US2014/069308
申请日：2014-12-09
申请人： THE CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY D/B/A CAROLINAS HEALTHCARE SYSTEM , RYAN, Liam P.
发明人： RYAN, Liam P. , MADJAROV, Jeko Metodiev , HEFFNER, Alan C.
IPC分类号： A61B8/12 , A61B8/00 , A61M1/16
CPC分类号： A61M1/3666 , A61B8/0841 , A61B8/0883 , A61B8/0891 , A61B8/12 , A61B8/445 , A61B8/4472 , A61B8/4477 , A61M2205/3375
摘要： A vascular device and method for positioning a vascular device within a patient's vasculature for use in extracorporeal membrane oxygenation (ECMO) are described that make use of one or more ultrasound transducers supported by the vascular device to visualize the location and orientation of the vascular device. An ultrasound transducer may be provided at a port of the vascular device that infuses oxygenated blood into the patient's vasculature to allow the operator of the vascular device to align the port with a particular structure in the patient's body, such as the tricuspid valve of the heart. Another ultrasound transducer may additionally or alternatively be provided at a distal end of the vascular device to facilitate insertion of the vascular device with minimal injury or trauma to the patient and to allow advancement of the device to the correct location. The imaging may be continuous and may be provided in real-time.
摘要翻译：描述了用于将血管装置定位在用于体外膜氧合（ECMO）的患者脉管系统内的血管装置和方法，其利用由血管装置支撑的一个或多个超声换能器来显现血管装置的位置和取向。可以在血管装置的端口处设置超声换能器，其将氧合血液注入到患者的脉管系统中，以允许血管装置的操作者将该口与患者体内的特定结构对准，例如心脏的三尖瓣。另外或替代地，还可以在血管装置的远端设置另一个超声换能器，以便于以最小的损伤或损伤向患者插入血管装置，并允许将装置推进到正确的位置。成像可以是连续的并且可以实时提供。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式