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1. 发明申请

WO2003105192A3 APPARATUS AND METHOD FOR CASSETTE-LESS TRANSFER OF WAFERS 审中-公开
公开(公告)号：WO2003105192A3
公开(公告)日：2003-12-18
申请号：PCT/US2003/018384
申请日：2003-06-09
申请人： AKRION, LLC , FIX, Edward, R. , VASHRO, Michael, J. , FARNLUND, Douglas, R. , EVERS, Sven , MOHLER, Todd, C.
发明人： FIX, Edward, R. , VASHRO, Michael, J. , FARNLUND, Douglas, R. , EVERS, Sven , MOHLER, Todd, C.
IPC分类号： B65G65/30
摘要： The invention is a method and apparatus for transferring one or more wafers (20) through chemical processing so as to reduce the problem of chemical cross-contamination. The invention utilizes a separate wafer basket (21) for each chemical process tank and an apparatus comprising: a gripper (12, 13) having an open position and a closed position; a lifter (11) having a lowered and a raised position and means (18) to engage a wafer basket; means (16, 17) to open and close the gripper; means (15) to raise and lower the lifter; and wherein the lifter and gripper are arranged so that when a loaded wafer basket is engaged by the means to engage and the gripper is in the open position, and upon the gripper being closed to the closed position, the gripper grips and unloads the wafers from the loaded wafer basket upon the lifter being lowered.

2. 发明申请

WO2003102244A1 ANTISENSE MODULATION OF BETA-SITE APP-CLEAVING ENZYME EXPRESSION 审中-公开
标题翻译： BETA-SITE APP-CLEAVING ENZYME EXPRESSION的抗原调节
公开(公告)号：WO2003102244A1
公开(公告)日：2003-12-11
申请号：PCT/US2003/017290
申请日：2003-05-30
申请人： ISIS PHARMACEUTICALS, INC. , DOBIE, Kenneth, W.
发明人： DOBIE, Kenneth, W.
IPC分类号： C12Q1/68
CPC分类号： C12N15/1137 , A61K38/00 , A61K48/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of beta-site APP-cleaving enzyme. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding beta-site APP-cleaving enzyme. Methods of using these compounds for modulation of beta-site APP-cleaving enzyme expression and for treatment of diseases associated with expression of beta-site APP-cleaving enzyme are provided.
摘要翻译：提供反义化合物，组合物和方法用于调节β-位点APP切割酶的表达。组合物包含靶向编码β-位点APP切割酶的核酸的反义化合物，特别是反义寡核苷酸。提供了使用这些化合物调节β位点APP切割酶表达和治疗与β-位点APP切割酶表达相关的疾病的方法。

3. 发明申请

WO2003102019A2 ANTISENSE MODULATION OF STEROL REGULATORY ELEMENT-BINDING PROTEIN-1 EXPRESSION 审中-公开
标题翻译：甾体调节元件结合蛋白-1表达的抗原调节
公开(公告)号：WO2003102019A2
公开(公告)日：2003-12-11
申请号：PCT/US2003/017638
申请日：2003-06-04
申请人： ISIS PHARMACEUTICALS, INC. , FRIER, Susan, M. , BAKER, Brenda, F. , DOBIE, Kenneth, W.
发明人： FRIER, Susan, M. , BAKER, Brenda, F. , DOBIE, Kenneth, W.
IPC分类号： C07K
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of sterol regulatory element-binding protein-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acides encoding sterol regulatory element-binding protein-1. Methods of using these compounds for modulation of sterol regulatory element-binding protein-1 expression and for treatment of diseases associated with expression of sterol regulatory element-binding protein-1 are provided.
摘要翻译：提供反义化合物，组合物和方法用于调节甾醇调节元件结合蛋白-1的表达。组合物包含靶向编码固醇调节元件结合蛋白-1的核酸的反义化合物，特别是反义寡核苷酸。提供了使用这些化合物调节固醇调节元件结合蛋白-1表达和治疗与甾醇调节元件结合蛋白-1的表达相关的疾病的方法。

4. 发明申请

WO2003070904A3 HUMAN RNASE III AND COMPOSITIONS AND USES THEREOF 审中-公开
公开(公告)号：WO2003070904A3
公开(公告)日：2003-08-28
申请号：PCT/US2003/004912
申请日：2003-02-19
申请人： ISIS PHARMACEUTICALS, INC. , CROOKE, Stanley, T.
发明人： CROOKE, Stanley, T.
IPC分类号： C07H21/04
摘要： The present invention provides polynucleotides encoding human RNase III and polypeptides encoded thereby. Methods of using said polynucleotides and polypeptides are also provided.

5. 发明申请

WO2004009024A2 MODULATION OF PROTEIN KINASE C-IOTA EXPRESSION 审中-公开
标题翻译：蛋白激酶C-10TA表达的调节
公开(公告)号：WO2004009024A2
公开(公告)日：2004-01-29
申请号：PCT/US2003/022651
申请日：2003-07-18
申请人： ISIS PHARMACEUTICALS, INC. , COWSERT, Lex, M. , FREIER, Susan, M. , DOBIE, Kenneth, W.
发明人： COWSERT, Lex, M. , FREIER, Susan, M. , DOBIE, Kenneth, W.
IPC分类号： A61K
CPC分类号： C12N15/1137 , A61K38/00 , A61K48/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y207/11013 , Y02P20/582 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of protein kinase C-iota. The compositions comprise oligonucleotides, targeted to nucleic acid encoding protein kinase C-iota. Methods of using these compounds for modulation of protein kinase C-iota expression and for diagnosis and treatment of disease associated with expression of protein kinase C-iota are provided.
摘要翻译：提供了用于调节蛋白激酶C-iota表达的化合物，组合物和方法。该组合物包含靶向编码蛋白激酶C-iota的核酸的寡核苷酸。提供了使用这些化合物调节蛋白激酶C-iota表达并用于诊断和治疗与蛋白激酶C-iota表达相关的疾病的方法。

6. 发明申请

WO2003099851A3 METHODS AND COMPOSITIONS FOR INHIBITING HIV REPLICATION 审中-公开
公开(公告)号：WO2003099851A3
公开(公告)日：2003-12-04
申请号：PCT/US2003/016524
申请日：2003-05-23
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , WEINER, David, B.
发明人： WEINER, David, B.
IPC分类号： A61K39/00
摘要： Pharmaceutial composition comprising compounds and/or compositions useful to inhibit HIV replication are disclosed. Methods of treating individuals infected with HIV are disclosed. Methods of preventing HIV infection in high-risk individuals are disclosed.

7. 发明申请

WO2003068799A3 OLIGOMERIC MOLECULES AND USES THEREOF 审中-公开
公开(公告)号：WO2003068799A3
公开(公告)日：2003-08-21
申请号：PCT/US2003/004037
申请日：2003-02-11
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , UNIVERSITE DE MONTREAL , INSTITUT DE RECHERCHES CLINIQUES DE MONTREAL , WEINER, David, B. , SEKALY, Rafick, P.
发明人： WEINER, David, B. , SEKALY, Rafick, P.
IPC分类号： C12P21/08
摘要： The present invention relates to novel oligomers that comprise a plurality of monomers that comprises an active moiety and a scaffold moiety. The oligomers may comprise 6-12 monomers or more. The active moiety comprises sequences that interact with other proteins. The scaffold moiety comprises sequences that interact with sequences of scaffold moieties from other monomers to form oligomers.

8. 发明申请

WO2003068799A2 OLIGOMERIC MOLECULES AND USES THEREOF 审中-公开
标题翻译：低分子量分子及其用途
公开(公告)号：WO2003068799A2
公开(公告)日：2003-08-21
申请号：PCT/US2003/004037
申请日：2003-02-11
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , UNIVERSITE DE MONTREAL , INSTITUT DE RECHERCHES CLINIQUES DE MONTREAL , WEINER, David, B. , SEKALY, Rafick, P.
发明人： WEINER, David, B. , SEKALY, Rafick, P.
IPC分类号： C07K
CPC分类号： C07K14/52 , A61K38/00 , C07K14/475 , C07K14/521 , C07K14/70546 , C07K14/71 , C07K14/715 , C07K16/00 , C07K19/00
摘要： The present invention relates to novel oligomers that comprise a plurality of monomers that comprises an active moiety and a scaffold moiety. The oligomers may comprise 6-12 monomers or more. The active moiety comprises sequences that interact with other proteins. The scaffold moiety comprises sequences that interact with sequences of scaffold moieties from other monomers to form oligomers.
摘要翻译：本发明涉及包含多个包含活性部分和支架部分的单体的新型低聚物。低聚物可以包含6-12个或更多个单体。活性部分包含与其它蛋白质相互作用的序列。支架部分包含与来自其它单体的支架部分序列相互作用以形成低聚物的序列。

9. 发明申请

WO2003066246A1 CAPILLARY DRYING OF SUBSTRATES 审中-公开
标题翻译：基片毛细干燥
公开(公告)号：WO2003066246A1
公开(公告)日：2003-08-14
申请号：PCT/US2003/003561
申请日：2003-02-05
申请人： AKRION, LLC , MYLAND, Lawrence, J.
发明人： MYLAND, Lawrence, J.
IPC分类号： B08B7/00
CPC分类号： H01L21/67313 , H01L21/67034
摘要： An apparatus and method for drying substrates. The inventive apparatus comprises: an object support member for supporting at least one substrate in a process tank having one or more support sections comprising capillary material. The inventive method is a method of removing liquid from a wet substrate in a process tank comprising contacting the wet substrate with capillary material. In another aspect, the invention is a method of drying at least one substrate having a surface in a process tank comprising: submerging the substrate in a liquid having a liquid level; supporting the submerged substrates in the process tank; supplying a drying vapor above the liquid level; lowering the liquid level or raising the substrate so that the liquid level is below the substrate, thereby removing a major portion of liquid from the substrate surface; and removing remaining liquid from the substrate surface with capillary material.
摘要翻译：一种用于干燥基材的设备和方法。本发明的装置包括：用于在具有包括毛细管材料的一个或多个支撑部分的处理罐中支撑至少一个基板的物体支撑构件。本发明的方法是在处理罐中从湿底物中除去液体的方法，包括使湿底物与毛细管材料接触。在另一方面，本发明是一种干燥至少一种在工艺罐中具有表面的基材的方法，该方法包括：将基材浸没在具有液位的液体中，所述液体具有将浸没的基底支撑在处理槽中，所述液体在液面上提供干燥蒸气，降低液位或升高基板，使液面低于基板，从而从基板表面去除大部分液体，并用毛细管材料从基板表面去除剩余的液体。

10. 发明申请

WO2004005554A2 ANTISENSE MODULATION OF LIVIN EXPRESSION 审中-公开
标题翻译：反义调节活体表达
公开(公告)号：WO2004005554A2
公开(公告)日：2004-01-15
申请号：PCT/US2003/020821
申请日：2003-07-02
申请人： ISIS PHARMACEUTICALS, INC. , BENNETT, C., Frank , DOBIE, Kenneth, W.
发明人： BENNETT, C., Frank , DOBIE, Kenneth, W.
IPC分类号： C12Q21/00
CPC分类号： C12N15/113 , A61K38/00 , C07H21/04 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Livin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Livin. Methods of using these compounds for modulation of Livin expression and for treatment of diseases associated with expression of Livin are provided.
摘要翻译：提供了用于调节Livin表达的反义化合物，组合物和方法。该组合物包含靶向编码Livin的核酸的反义化合物，特别是反义寡核苷酸。提供了使用这些化合物调节Livin表达和治疗与Livin表达相关的疾病的方法。

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