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1. 发明申请

WO2023079181A1 PRIORITIZING OF BIOLOGICAL SAMPLES DURING AUTOMATIC PROCESSING 审中-公开
公开(公告)号：WO2023079181A1
公开(公告)日：2023-05-11
申请号：PCT/EP2022/081168
申请日：2022-11-08
申请人： RANDOX LABORATORIES LTD.
发明人： FAWL, Stephen , BELL, Colin
IPC分类号： G01N35/00 , B01L3/02 , G01N35/04
摘要： A method of monitoring and controlling the processing of biological samples, the method comprising the steps of: receiving (101) a plurality of sample containers, each containing biological material; assigning (102) a priority to each of the sample containers; queueing (103) the sample containers for analysis based on the assigned priorities; extracting (104) a biological sample from each of the plurality of sample containers based on said sample container's position in the queue; analysing (105) each biological sample; providing (106) either a valid result or an inconclusive result for each of the biological samples based on said analysing; for each biological sample for which an inconclusive result has been provided, assigning (109) a new priority to the respective sample container and repeating the queueing, extracting, analysing, and providing steps.

2. 发明申请

WO2023079108A1 METHOD OF PREPARING A MELT FOR THE PRODUCTION OF MAN-MADE MINERAL FIBRES 审中-公开
公开(公告)号：WO2023079108A1
公开(公告)日：2023-05-11
申请号：PCT/EP2022/080868
申请日：2022-11-04
申请人： ROCKWOOL A/S
发明人： ELMEKILDE HANSEN, Lars , ZHOU, Haosheng
IPC分类号： C03B5/12 , C03B5/235
摘要： The invention relates to a process for preparing a mineral melt in a cupola furnace that comprises, in the hot zone where the melt collects, a plurality of ceramic support bodies, with at least one plasma torch providing heat energy to the furnace. The combination of the plasma torch and ceramic support bodies reduces or substantially eliminates the need for coke to be used in the furnace. This reduces the formation of environmentally harmful gasses, such as CO and CO2, in the off-gas of the furnace.

3. 发明申请

WO2023067344A1 POSITIONING SYSTEM AND METHOD 审中-公开
公开(公告)号：WO2023067344A1
公开(公告)日：2023-04-27
申请号：PCT/GB2022/052676
申请日：2022-10-20
申请人： FOCAL POINT POSITIONING LTD.
发明人： FARAGHER, Ramsey , CROCKETT, Robert Mark , DUFFETT-SMITH, Peter
IPC分类号： G01S19/22 , G01S19/26 , G01S19/29 , G01S19/47
摘要： A method, performed in a positioning system, is disclosed. The method comprises: providing a local signal; receiving, at a receiver, a signal from a remote source in a first direction that is a straight line direction from the remote source to the receiver; measuring or assuming a movement of the receiver at a first rate; generating a motion-compensated correlation signal at a second rate that is lower than the first rate, wherein providing the motion-compensated correlation signal comprises correlating the local signal with the received signal and providing motion compensation of at least one of the local signal, the received signal, and the result of the correlation, based on the measured or assumed movement of the receiver in the first direction; obtaining, from the measured or assumed movement of the receiver, a first data set at the first rate that is indicative of the frequency shift or the change in the unambiguous phase of the received signal caused by the relative movement between the receiver and the remote source in the first direction; obtaining, from the motion- compensated correlation signal, a second data set at the second rate that is indicative of the frequency shift or the change in the unambiguous phase of the received signal caused by the relative movement between the receiver and the remote source in the first direction; and generating a processing output at a processing rate that is higher than the second rate based on the first data set and the second data set, whereby the processing output is indicative of the frequency shift or the change in the unambiguous phase of the received signal caused by the relative movement between the receiver and the remote source in the first direction. A corresponding position system is also disclosed.

4. 发明申请

WO2023066770A1 POLLUTANT REMOVAL APPARATUS AND METHOD 审中-公开
公开(公告)号：WO2023066770A1
公开(公告)日：2023-04-27
申请号：PCT/EP2022/078459
申请日：2022-10-13
申请人： DAPHNE TECHNOLOGY SA
发明人： RAMSAY, William Jamieson , MICHAN, Juan Mario , IGLESIAS, Steven
IPC分类号： B01D53/50 , B01D53/26 , B01D53/58 , B01D53/76 , B01D53/77 , B01D53/92 , B01D53/34
摘要： There is provided an apparatus and for removing pollutants from a gas. The apparatus comprises a gas flow path along which gas passes from an inlet to an outlet in use; and a cooling device on the gas flow path and orientated so as to direct the gas flow path upward towards the outlet. The apparatus is arranged in use to provide water and gaseous reagent to gas upstream of the cooling device in quantities based on one or more properties of the gas and a cooling capability of the cooling device so as to cause the reagent to react with one or more constituents of the gas to produce a reaction product and to cause the gas to reach its saturation point when passing through the cooling device thereby causing water in the gas to capture the reaction product, condense and pass out of the gas.

5. 发明申请

WO2023057754A1 PROCESS 审中-公开
公开(公告)号：WO2023057754A1
公开(公告)日：2023-04-13
申请号：PCT/GB2022/052519
申请日：2022-10-05
申请人： CYCLADEX LTD
发明人： PETTMAN, Roger B.
IPC分类号： C22B3/04 , C02F1/76 , C22B3/06 , C22B3/42 , C22B11/00 , B09B2101/15 , B09B2101/16 , B09B2101/18 , B09B3/80 , C22B11/04 , H01M10/54 , H01M6/52
摘要： Disclosed herein is a method of extracting lithium from a lithium bearing material comprising the steps of: a) providing an aqueous oxidant mixture comprising water, an oxidising means, and a source of halide ion; b) contacting the aqueous oxidant mixture with the lithium bearing material to extract the lithium from the lithium bearing material and form a lithium halide solution.

6. 发明申请

WO2023041925A1 microRNA BIOMARKERS 审中-公开
公开(公告)号：WO2023041925A1
公开(公告)日：2023-03-23
申请号：PCT/GB2022/052352
申请日：2022-09-16
申请人： IMPERIAL COLLEGE INNOVATIONS LIMITED
发明人： KYRIACOU, Christopher , KIM, Sung Hye , MACINTYRE, David , BENNETT, Phillip , BOURNE, Tom , TERZIDOU, Vasso
IPC分类号： C12Q1/6883
摘要： The present invention provides a method for predicting an outcome of pregnancy, particular for predicting the likelihood of ectopic pregnancy (EP)or viable intrauterine pregnancy (VIUP), and methods for determining appropriate protocols for subjects with a pregnancy of unknown location (PUL) based on such an outcome, comprising determining the expression level of one or more specific miRNA molecules that are differentially expressed in scenarios of EP or VIUP, extracted from a biological sample obtained from said subject and comparing to a control value. The present invention also provides biochips and kits for use in carrying out the methods of the invention.

7. 发明申请

WO2023036620A1 SYSTEMS AND METHODS FOR IMPLEMENTING OFFLINE PAYMENT IN CBDC NETWORKS USING COLLATERAL CHAIN 审中-公开
公开(公告)号：WO2023036620A1
公开(公告)日：2023-03-16
申请号：PCT/EP2022/073613
申请日：2022-08-24
申请人： FLUENCY GROUP LTD
发明人： MULLINS, Inga , BRATANIEC, Pawel , JAMROZ, Kamil
IPC分类号： G06Q20/22 , G06Q20/02 , G06Q20/38 , G06Q20/40
摘要： The invention provides techniques for enabling offline devices that do not have an active connection to an account-based CBDC network to participate in CBDC network processes such as asset transfers. This is enabled by defining an offline protocol that governs the handling of such processes in an offline state. A collateral chain is provided by the CBDC network that links together multiple accounts so that an account lower down in the collateral chain can be used to settle a transaction in the case where an account higher up the chain does not hold sufficient CBDC to settle the transaction. On the device side, offline transaction messages are exchanged that enable either device to commit the transaction to the CBDC network once the device obtains an active connection to the CBDC network.

8. 发明申请

WO2023031440A1 2-AMINO-5,5-DIMETHYLHEXANOIC ACID DERIVATIVES AS SORTILIN MODULATORS FOR USE IN THE TREATMENT OF DISEASE OF THE CENTRAL NERVOUS SYSTEM 审中-公开
公开(公告)号：WO2023031440A1
公开(公告)日：2023-03-09
申请号：PCT/EP2022/074536
申请日：2022-09-02
申请人： INSUSENSE APS
发明人： LITTLE, Paul Brian , CASES-THOMAS, Manuel Javier , KJØLBY, Mads Fuglsang , NYKJÆR, Anders
IPC分类号： A61K31/44 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/28 , C07D417/04
摘要： The present invention relates to a compound that binds to and modulates the activity of sortilin, wherein the compound has a blood-to-brain Kpuu greater than 0.1. The compounds are capable of crossing the blood brain barrier and are suitable for use in the treatment of a disease of the central nervous system. The invention also relates to compounds of formula (I), which are modulators of sortilin activity, pharmaceutical compositions comprising these compounds and the use of these compounds in the treatment or prevention of medical conditions where modulation of sortilin activity is beneficial.

9. 发明申请

WO2023006879A1 CANCER THERAPY WITH LIVE ATTENUATED BACTERIA 审中-公开
公开(公告)号：WO2023006879A1
公开(公告)日：2023-02-02
申请号：PCT/EP2022/071198
申请日：2022-07-28
申请人： PROKARIUM LIMITED
发明人： DEBAN, Livija , GLANVILLE, Nicholas
IPC分类号： A61K35/74 , A61K39/112 , A61P35/00 , A61K39/00
摘要： The present invention relates to the field of cancer therapy. In particular, the present invention relates to a first composition comprising a live attenuated bacterium for use in the treatment, prevention, reduction, inhibition, prevention of recurrence, or control of a neoplastic disease in a subject being or intended to be administered a second composition comprising a live attenuated bacterium, said bacterium being the same or different to that of the first composition and methods thereof.

10. 发明申请

WO2023002226A1 IMPROVED NAVIGATION FOR ELECTRON MICROSCOPY 审中-公开
公开(公告)号：WO2023002226A1
公开(公告)日：2023-01-26
申请号：PCT/GB2022/051946
申请日：2022-07-25
申请人： OXFORD INSTRUMENTS NANOTECHNOLOGY TOOLS LIMITED
发明人： STATHAM, Peter , PINARD, Philippe
IPC分类号： H01J37/22 , H01J37/26 , H01J37/28 , G01N23/2252
摘要： A method for analyzing a specimen in a microscope is described. The method comprises: acquiring a series of compound image frames using a first detector and a second detector, different from the first detector and displaying the series of compound image frames in real-time on a visual display, wherein the visual display is updated to show each compound image frame in sequence. Acquiring a compound image frame comprises: causing a charged particle beam to traverse a region of a specimen, the region corresponding to a configured field of view of the microscope, wherein: when a mode parameter has a first value, the traversal of the beam is along a first traversal path on the region and is according to a first set of traversal conditions, and when the mode parameter has a second value, the traversal of the beam is along a second traversal path on the region and is according to a second set of traversal conditions, wherein a first total time required for the beam to traverse the entire first traversal path according to a first set of traversal conditions is less than a second total time required for the beam to traverse the entire second traversal path according to the second set of traversal conditions; monitoring a first set of resulting particles generated within the specimen at a first plurality of locations within the region using the first detector so as to obtain a first image frame, the first image frame comprising a plurality of pixels corresponding to, and having values derived from the monitored particles generated at, the first plurality of locations, monitoring a second set of resulting particles generated within the specimen at a second plurality of locations within the region using the second detector, so as to obtain a second image frame, the second image frame comprising a plurality of pixels corresponding to, and having respective sets of values derived from the monitored particles generated at, the second plurality of locations, and combining the first image frame and the second image frame so as to produce the compound image frame, such that the compound image frame provides data derived from particles generated at the first and second pluralities of locations within the region and monitored by each of the first detector and the second detector.

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