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1. 发明授权

US11337919B2 Modified release drug powder composition comprising gastro-retentive RAFT forming systems having trigger pulse drug release 有权
公开(公告)号：US11337919B2
公开(公告)日：2022-05-24
申请号：US16955377
申请日：2018-12-18
申请人： Tris Pharma, Inc.
发明人： Paras Rameshlal Jain , Sachin Vasant Chaudhari
IPC分类号： A61K9/00 , A61K31/00 , A61K47/58 , A61K9/16 , A61K45/06
摘要： An orally administrable drug powder composition which forms a gastro-retentive RAFT having at least two trigger pulses is provided. The composition contains, at a minimum, (a) at least one drug in an immediate release pulse release form; (b) at least one drug in a delayed trigger release form; (c) at least one non-toxic gas generating agent and (d) a RAFT system, wherein following oral ingestion, the composition provides a self-assembling gastro-retentive RAFT having entrapped therein, the at least one drug of (a) and (b) and the gas generated in situ by the non-toxic gas generating agent, thereby providing a floating gastro-retentive RAFT having a dual pulse system wherein at least the second pulse is a trigger pulse and which retains the at least one drug in the stomach for at least about 3 hours, provided that the composition does not include a gamma hydroxybutyrate and its salts, hydrates, tautomers, or solvates, or complexes thereof.

2. 发明授权

US10933143B2 Modified release formulations containing drug-ion exchange resin complexes 有权
公开(公告)号：US10933143B2
公开(公告)日：2021-03-02
申请号：US16719121
申请日：2019-12-18
申请人： Tris Pharma, Inc.
发明人： Ketan Mehta , Yu-Hsing Tu
IPC分类号： A61K47/58 , A61K31/135 , A61K31/137 , A61K31/155 , A61K31/192 , A61K31/216 , A61K31/485 , A61K9/00 , A61K9/10 , A61K9/16 , A61K9/20 , A61K47/69 , A61K9/50 , A61K31/4458 , A61K9/14 , A61K31/4402 , A61K47/32 , A61K31/24 , A61K9/48 , A61K47/14 , A61K45/06
摘要： An aqueous liquid suspension containing a coated drug-ion exchange resin complex comprising a core composed of an amphetamine complexed with a pharmaceutically acceptable ion-exchange resin and an uncoated amphetamine-ion exchange resin complex is provided. The coated amphetamine-ion exchange resin complex is in admixture with a polymer to form a matrix. Methods of making the coated complex and the liquid suspension are described.

3. 发明授权

US10138295B2 Compositions comprising AAV expressing dual antibody constructs and uses thereof 有权
公开(公告)号：US10138295B2
公开(公告)日：2018-11-27
申请号：US15310555
申请日：2015-05-13
申请人： The Trustees of the University of Pennsylvania
发明人： James M. Wilson , Anna Tretiakova
IPC分类号： A61K48/00 , C12N7/00 , C12Q1/68 , A61K38/00 , C07K16/00 , C07K16/10 , C12N15/86 , A61K39/00
摘要： A recombinant adeno-associated virus (AAV) having an AAV capsid and packaged therein a heterologous nucleic acid which expresses two functional antibody constructs in a cell is described. Also described are antibodies comprising a heavy chain and a light chain from a heterologous antibody. In one embodiment, the antibodies are co-expressed from a vector containing: a first expression cassette which encodes at least a first open reading frame (ORF) for a first immunoglobulin under the control of regulatory control sequences which direct expression thereof; and a second expression cassette which comprises a second ORF, a linker, and a third ORF under the control of regulatory control sequences which direct expression thereof, wherein the second and third ORF encode for a second and third immunoglobulin construct. The vector co-expressing these two antibody constructs is in one embodiment an AAV, in which the 5′ and 3′ ITRs flank the expression cassettes and regulatory sequences.

4. 发明授权

US09884071B2 Compositions and methods for altering tissue specificity and improving AAV9-mediated gene transfer 有权
公开(公告)号：US09884071B2
公开(公告)日：2018-02-06
申请号：US13985630
申请日：2012-02-17
申请人： James M. Wilson , Christie L. Bell , Luc H. Vandenberghe
发明人： James M. Wilson , Christie L. Bell , Luc H. Vandenberghe
IPC分类号： C12N15/86 , A61K48/00 , C07K14/005 , C12N7/00 , C12N15/85 , A61K31/7088 , A61K31/685 , A61K38/47
CPC分类号： A61K31/7088 , A61K31/685 , A61K38/47 , C12N15/86 , C12N2750/14043 , C12N2750/14045 , C12N2810/6027
摘要： A method of altering the targeting and/or cellular uptake efficiency of an adeno-associated virus (AAV) viral vector having a capsid containing an AAV9 cell surface binding domain is described. The method involves modifying a clade F cell surface receptor which comprises a glycan having a terminal sialic acid residue and a penultimate β-galactose residue. The modification may involve retargeting the vector by temporarily functionally ablate AAV9 binding in a subset of cells, thereby redirecting the vector to another subset of cells. Alternatively, the modification may involve increasing cellular update efficiency by treating the cells with a neuraminidase to expose cell surface β-galactose. Also provided are compositions containing the AAV9 vector and a neuraminidase. Also provided is a method for purifying AAV9 using β-galactose linked to solid support. Also provided are mutant vectors which have been modified to alter their targeting specificity, including mutant AAV9 in which the galactose binding domain is mutated and AAV in which an AAV9 galactose binding domain is engineered.

5. 发明授权

US07192956B2 Methods of treating hormone-related conditions using cyclothiocarbamate derivatives 有权
标题翻译：使用环硫代氨基甲酸酯衍生物治疗激素相关病症的方法
公开(公告)号：US07192956B2
公开(公告)日：2007-03-20
申请号：US10601481
申请日：2003-06-23
申请人： Andrew Fensome , Gary S. Grubb , Diane Deborah Harrison , Richard Craig Winneker , Puwen Zhang , Jeffrey Curtis Kern , Eugene Anthony Terefenko
发明人： Andrew Fensome , Gary S. Grubb , Diane Deborah Harrison , Richard Craig Winneker , Puwen Zhang , Jeffrey Curtis Kern , Eugene Anthony Terefenko
IPC分类号： A61K31/535 , A61K31/445 , A61K31/135
CPC分类号： A61K31/426 , A61K31/536 , A61K31/54 , A61K31/554 , A61K31/565 , A61K2300/00
摘要： The present invention provides methods of inducing contraception which includes delivering to a female a composition containing a compound of formula I or formula II, or tautomers thereof, in a regimen which involves delivering one or more of a selective estrogen receptor modulator, wherein formula I is: and wherein R1–R5 and Q1 are defined as described herein. Methods of providing hormone replacement therapy and for treating carcinomas, dysfunctional bleeding, uterine leiomyomata, endometriosis, and polycystic ovary syndrome is provided which includes delivering a compound of formula I and a selective estrogen receptor modulator are also described.
摘要翻译：本发明提供诱导避孕的方法，其包括递送给女性含有式I或式II化合物或其互变异构体的组合物，其方案包括递送一种或多种选择性雌激素受体调节剂，其中式I为：其中R 1〜Z 5和Q 1如本文所述定义。提供了提供激素替代疗法和治疗癌症，功能障碍性出血，子宫平滑肌瘤，子宫内膜异位症和多囊卵巢综合征的方法，其包括递送式I化合物和选择性雌激素受体调节剂。

6. 发明授权

US07137916B2 Movable guide for transmission device 失效
标题翻译：传动装置可动导轨
公开(公告)号：US07137916B2
公开(公告)日：2006-11-21
申请号：US10718958
申请日：2003-11-21
申请人： Junya Kurohata , Atsushi Kumakura
发明人： Junya Kurohata , Atsushi Kumakura
IPC分类号： F16H7/08 , F16H7/18
CPC分类号： F16H7/18 , F16H2007/0872
摘要： In a pivoting guide for a traveling transmission chain, composed of a synthetic resin body having a shoe and a slotted reinforcement, and a plate fitting into the slot, the plate has a mounting hole received on a boss formed on the guide body and coaxial with a mounting hole on the guide body which receives a pivot shaft. This structure facilitates assembly and mounting because the plate is securely attached to the guide body before the assembly is mounted. The plate does not contact the pivot shaft, and therefore full advantage is taken of the self-lubricating property of the synthetic resin. The boss may be elongated so that the length of the mounting hole of the guide body is greater than the width of the shoe so that wear in of the guide body due to biased loads is dispersed, and the useful life of the guide is extended.
摘要翻译：在由具有鞋和合成树脂制的行走传动链的枢转引导件中，该合成树脂本体具有鞋和开槽的加强件以及与该槽相配合的板，该板具有安装孔，该安装孔容纳在形成于引导体上的凸台上，引导体上的安装孔，该安装孔容纳枢转轴。这种结构便于组装和安装，因为在安装组件之前，板被牢固地附接到引导体。板不接触枢轴，因此充分利用合成树脂的自润滑性能。凸台可以是细长的，使得引导体的安装孔的长度大于鞋的宽度，使得由于偏置的负载引起的引导体的磨损被分散，并且引导件的使用寿命延长。

7. 发明授权

US07132417B2 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents 有权
标题翻译： 2-苯基-1- [4-（2-氨基乙氧基） - 苄基] - 吲哚作为雌激素剂
公开(公告)号：US07132417B2
公开(公告)日：2006-11-07
申请号：US11302036
申请日：2005-12-13
申请人： Chris P. Miller , Michael D. Collini , Bach D. Tran , Arthur A. Santilli
发明人： Chris P. Miller , Michael D. Collini , Bach D. Tran , Arthur A. Santilli
IPC分类号： A61P5/32
CPC分类号： C07D403/12 , A61K31/404 , A61K31/405 , A61K31/4523 , A61K31/454 , A61K31/496 , A61K31/55 , C07D209/08 , C07D209/10 , C07D209/12 , C07D209/30 , C07D209/42 , C07D405/04 , C07D405/12
摘要： The present invention relates to new 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds having the general structures below: which are useful in treating uterine leiomyoma.
摘要翻译：本发明涉及具有以下一般结构的新的2-苯基-1- [4-（2-氨基乙氧基） - 苄基] - 吲哚类化合物：其可用于治疗子宫平滑肌瘤。

8. 发明授权

US07132130B1 Method for providing a chrome finish on a substrate 有权
标题翻译：在基材上提供镀铬处理的方法
公开(公告)号：US07132130B1
公开(公告)日：2006-11-07
申请号：US11134106
申请日：2005-05-20
申请人： Terence J. Kloss
发明人： Terence J. Kloss
IPC分类号： B05D3/00 , C23C14/00 , C23C14/06
CPC分类号： C23C14/14 , C23C14/024 , Y10T428/12736
摘要： An environmentally-friendly process for applying a chrome finish on a substrate is provided. The chrome finish comprises a thin film of aluminum and chromium deposited onto the substrate by physical vapor deposition (PVD) techniques. The thin layer can consist of three separately deposited metallic layers including a chromium layer sandwiched between a pair of aluminum layers or can consist of a single, simultaneously co-deposited layer of aluminum and chromium in a ratio of 10% to 70% by weight chromium and 30% to 90% aluminum. The structure of a coated substrate is also disclosed.
摘要翻译：提供了一种在基板上施加铬涂层的环保工艺。镀铬处理包括通过物理气相沉积（PVD）技术沉积到衬底上的铝和铬的薄膜。薄层可以由三个分开沉积的金属层组成，包括夹在一对铝层之间的铬层，或者可以由10％至70％重量的铬的单一同时共沉积的铝和铬层组成和30％至90％的铝。还公开了涂覆的基底的结构。

9. 发明授权

US07121969B2 Roller chain 有权
标题翻译：滚子链
公开(公告)号：US07121969B2
公开(公告)日：2006-10-17
申请号：US10723869
申请日：2003-11-26
申请人： Arimasa Kaga , Kazuhiko Shimaya
发明人： Arimasa Kaga , Kazuhiko Shimaya
IPC分类号： F16G13/06 , F16G13/02
CPC分类号： F16G13/06
摘要： In a roller chain, the outside diameters D of the rollers and the outside diameters d of the pins extending through bushings on which the rollers are disposed satisfy the relationships 0.72P≦D≦0.79P and 0.40P≦d≦0.44P where P is the pitch of the roller chain. The height H of the inner plates of the chain satisfies the relationship 0.96P≦H. The elongation ratio of the chain is significantly reduced, and improvements in breaking strength of the pin and in the rotational fatigue of the chain are realized. Consequently wear resistance, strength, and endurance of the chain are significantly improved, making the chain suitable for use as a timing chain in an engine that rotates at high speed.
摘要翻译：在滚子链中，滚子的外径D和延伸穿过其上布置的套管的销的外径d满足关系0.72P <= D <= 0.79P和0.40P <= d <= 0.44 P其中P是滚子链的间距。链条内板的高度H满足0.96P <= H的关系。链的伸长率显着降低，并且实现了销的断裂强度和链的旋转疲劳的提高。因此，链条的耐磨性，强度和耐久性得到显着提高，使链条适用于在高速旋转的发动机中的正时链条。

10. 外观设计

USD527213S1 Basket for merchandising display 有权
公开(公告)号：USD527213S1
公开(公告)日：2006-08-29
申请号：US29244203
申请日：2005-12-07
申请人： Frans Lennart Axhamre
设计人： Frans Lennart Axhamre

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