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    • 2. 发明授权
    • Non-invasive liquid level sensing system and method
    • 非侵入式液位感测系统及方法
    • US08467981B2
    • 2013-06-18
    • US12772613
    • 2010-05-03
    • Somnath MukherjeeAjay Kumar Das
    • Somnath MukherjeeAjay Kumar Das
    • G01F23/00
    • G01F23/284G01F23/2845
    • A non-invasive liquid level sensing system for monitoring the amount of liquid in at least one container includes a platform for supporting the at least one container, at least one holder associated with the at least one container supported by the platform, a source for generating a radio frequency signal, circuitry in communication with the at least one holder for transmitting the radio frequency signal through the at least one holder into the at least one container and receiving a portion of the radio frequency signal reflected at a liquid-air interface in the at least one container, and circuitry for processing the reflected radio frequency signal and determining the amount of liquid in the at least one container.
    • 用于监测至少一个容器中的液体量的无创液位感测系统包括用于支撑所述至少一个容器的平台,与由所述平台支撑的所述至少一个容器相关联的至少一个保持器,用于产生 射频信号,与所述至少一个保持器通信的电路,用于通过所述至少一个保持器将所述射频信号发射到所述至少一个容器中,并接收在所述至少一个容器中的液 - 空界面处反射的射频信号的一部分, 至少一个容器,以及用于处理所述反射射频信号并确定所述至少一个容器中的液体量的电路。
    • 4. 发明授权
    • Liposomal, ring-opened camptothecins with prolonged, site-specific delivery of active drug to solid tumors
    • 脂质体,开环的喜树碱,具有延长的,定点特异性递送活性药物至实体瘤
    • US08067432B2
    • 2011-11-29
    • US12058794
    • 2008-03-31
    • Bradley D. AndersonVijay JoguparthiTian-Xiang Xiang
    • Bradley D. AndersonVijay JoguparthiTian-Xiang Xiang
    • A61K31/4745C07D471/14
    • A61K9/127A61K9/0019A61K9/1271A61K31/4745
    • A method for preparing a stable dispersion of a camptothecin, camptothecin prodrug, or analog thereof for administration to a patient in need thereof includes preparing a solution of the camptothecin, wherein the solution has a pH which places substantially an entirety of that camptothecin in a carboxylate form. The camptothecin may be a neutral camptothecin. The solution is next loaded into a liposome including at least one lipid, which may be a phospholipid. An intraliposomal pH is maintained which preserves substantially an entirety of the camptothecin in the carboxylate form. The liposomal dispersion is administered to an individual in need thereof, whereby the liposomes accumulate at and permeate into tumor tissue and an active, lactone form camptothecin is released in situ at the tumor site. Compositions formulated in accordance with the described method for treatment of a cancer in an animal in need thereof are provided also.
    • 制备喜树碱,喜树碱前药或其类似物稳定分散体给予有需要的患者的方法包括制备喜树碱溶液,其中所述溶液具有使所述喜树碱基本上全部置于羧酸盐中的pH值 形成。 喜树碱可以是中性喜树碱。 该溶液接下来加载到包含至少一种可以是磷脂的脂质的脂质体中。 维持脂内体内pH,其保留基本上全部的羧酸盐形式的喜树碱。 将脂质体分散体施用于有需要的个体,由此脂质体在肿瘤组织中积聚并渗透进入肿瘤组织,活性内酯形式喜树碱在肿瘤部位原位释放。 还提供了根据所述的用于治疗有需要的动物中的癌症的方法配制的组合物。