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1. 发明申请

WO2012161856A1 BLOCKADE OF TL1A-DR3 INTERACTIONS TO AMELIORATE T CELL MEDIATED DISEASE PATHOLOGY AND ANTIBODIES THEREOF 审中-公开
标题翻译： TL1A-DR3的相互作用相互影响细胞介导性疾病病理及其抗体
公开(公告)号：WO2012161856A1
公开(公告)日：2012-11-29
申请号：PCT/US2012/028926
申请日：2012-03-13
申请人： GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , SIEGEL, Richard M. , MEYLAN, Francoise , SONG, Yun-Jeong
发明人： SIEGEL, Richard M. , MEYLAN, Francoise , SONG, Yun-Jeong
IPC分类号： A61K39/395 , C12N15/62 , A61P11/06 , A61P19/02
CPC分类号： C07K16/2875 , C07K2317/76 , G01N2500/02 , G01N2800/7095
摘要： Provided are methods and compositions for treating inflammatory or autoimmune diseases in a subject comprising blocking the interaction between DR3 and TL1A. The interaction between DR3 and TL1A can be blocked by reducing expression of TL1A. The interaction between DR3 and TL1A can be blocked by administration of anti-DR3 antibodies. The interaction between DR3 and TL1A can be blocked by administration of anti-TL1A antibodies. In the methods of treating inflammatory or autoimmune disease, the inflammatory or autoimmune disease can be an autoimmune disease with a T cell component. In the methods of treating inflammatory or autoimmune disease, the inflammatory or autoimmune disease can be asthma, multiple sclerosis, rheumatoid arthritis, type 1 diabetes, graft versus host disease or inflammatory bowel disease (IBD).
摘要翻译：本发明提供用于治疗受试者的炎性或自身免疫性疾病的方法和组合物，包括阻断DR3和TL1A之间的相互作用。通过减少TL1A的表达可以阻止DR3和TL1A之间的相互作用。通过施用抗DR3抗体可以阻断DR3和TL1A之间的相互作用。通过施用抗TL1A抗体可以阻断DR3和TL1A之间的相互作用。在治疗炎性或自身免疫性疾病的方法中，炎性或自身免疫性疾病可以是具有T细胞成分的自身免疫性疾病。在治疗炎性或自身免疫疾病的方法中，炎性或自身免疫性疾病可以是哮喘，多发性硬化，类风湿性关节炎，1型糖尿病，移植物抗宿主病或炎症性肠病（IBD）。

2. 发明授权

US11636077B2 Methods, devices, and systems for processing sensor data of vehicles 有权
公开(公告)号：US11636077B2
公开(公告)日：2023-04-25
申请号：US16241845
申请日：2019-01-07
申请人： NIO Technology (Anhui) Co., Ltd.
发明人： SatyaShiva Komala , Michael A. Richmond , Ashok Kumar Madhavi Selvaraj
IPC分类号： G06F16/00 , G06F16/22 , G06F16/27 , H04L67/12
摘要： A device includes a communications interface that receives sensor data sensed by a plurality of sensors sensing an environment of a vehicle. The device includes a processor and a memory including instructions that when executed by the processor, cause the processor to access a first timestamp, a second timestamp, and a third timestamp of a sensor signal from a selected sensor of a plurality of sensors. The instructions cause the processor to calculate a first midpoint between the first timestamp and the second timestamp, calculate a second midpoint between the second timestamp and the third timestamp, create a first data bucket for at least some of the sensor data based on the first and second midpoints, generate a data structure using the first data bucket, and store the data structure in a storage system.

3. 发明授权

US11626737B2 Photovoltaic power plant energy harvest optimization—capacity factor, delta-P loss and ramp rate compensation 有权
公开(公告)号：US11626737B2
公开(公告)日：2023-04-11
申请号：US17130970
申请日：2020-12-22
申请人： Also Energy, Inc.
发明人： Zachary M. Wenrick
IPC分类号： H02J3/46 , H02J3/38 , G05B15/02 , H02M7/44
摘要： A method of controlling a renewable energy power plant is provided. The method includes retrieving output power measurement values for each inverter of a total number of inverters from a plurality of sensors provided at a location proximal to each inverter and retrieving a point of interconnection (POI) output measurement value for the renewable energy power plant based on a plurality of ON inverters of the total number of inverters. The method also includes calculating a POI measured setpoint for the renewable energy power plant based on a difference between a power reference value for the renewable energy power plant and the retrieved POI output measurement value for the renewable energy power plant, assigning a setpoint to each of the ON inverters and classifying each ON inverter as either a TRACKING ON inverter or a NON-TRACKING ON inverter based on whether each ON inverter is tracking at the setpoint.

4. 发明授权

US11583152B2 Method of operating a cleaning system, base station and filter apparatus 有权
公开(公告)号：US11583152B2
公开(公告)日：2023-02-21
申请号：US16846560
申请日：2020-04-13
申请人： Vorwerk & Co. Interholding GmbH
发明人： Georg Hackert , Uwe Kemker
IPC分类号： A47L9/14 , A47L7/00
摘要： A method for operating a cleaning system with a plurality of mobile cleaning devices and a base station for the cleaning devices as well as a base station for a plurality of mobile cleaning devices are proposed, wherein the cleaning devices can be emptied by the base station and/or filled with a cleaning agent by the base station simultaneously and/or according to a prioritization. In addition, a filter apparatus for a base station is proposed which has a plurality of connection openings in order to be able to empty a plurality of cleaning devices.

5. 发明授权

US11571699B2 Melting device and melting method 有权
公开(公告)号：US11571699B2
公开(公告)日：2023-02-07
申请号：US17014610
申请日：2020-09-08
申请人： TERUMO KABUSHIKI KAISHA
发明人： Yusuke Nozaki
IPC分类号： B01L7/04
摘要： A melting device is provided that melts a bio-derived frozen product contained in a container including a heat transfer section comprising at least two heating bags, each of which is filled with a heating liquid and is capable of sandwiching the container between the at least two heating bags and a suction mechanism that sucks air from a space between the at least two heating bags and surrounding the container.

6. 发明授权

US11553846B2 Myocardial infarction detection method, apparatus, and medical device 有权
公开(公告)号：US11553846B2
公开(公告)日：2023-01-17
申请号：US16363101
申请日：2019-03-25
申请人： TERUMO KABUSHIKI KAISHA
发明人： Yusuke Nozaki , Shigeru Tamatsukuri
IPC分类号： A61B5/0215 , A61B5/01 , A61B5/00 , A61B5/02 , A61B5/11 , A61B5/103 , A61B5/1455
摘要： A myocardial infarction detection method and apparatus is described that includes a stiffness measurement step of measuring myocardial stiffness of a cardiac muscle of a subject, and a determination step of determining, based on the myocardial stiffness, whether or not infarction is present in the cardiac muscle.

7. 发明授权

US11551017B2 RFID system with improved signal transmission characteristics 有权
公开(公告)号：US11551017B2
公开(公告)日：2023-01-10
申请号：US17296381
申请日：2019-12-03
申请人： PRAGMATIC PRINTING LTD.
发明人： Joao De Oliveira
IPC分类号： G06K7/10 , G06K19/07 , G06K19/077 , H04B5/00
摘要： A RFID (Radio Frequency Identification) system is provided, comprising at least one tag assembly having at least one tag inductance element that is operatively coupled to an integrated circuit (IC). The RFID system further comprises at least one reader assembly having at least one reader inductance element that is configured to operatively and communicatively couple with the tag assembly, and a resonance assembly having at least one first resonance element that is inductively coupleable to the at least one tag inductance element and/or at least one second resonance element that is inductively coupleable to the at least one reader inductance element, and which is adapted to provide coupled magnetic resonance signal transmission between the reader assembly and the tag assembly.

8. 发明授权

US11517385B2 Medical instrument 有权
公开(公告)号：US11517385B2
公开(公告)日：2022-12-06
申请号：US17584952
申请日：2022-01-26
申请人： KARL STORZ SE & Co. KG
发明人： Jochen Stefan
IPC分类号： A61B34/00 , A61B34/30
摘要： The disclosure relates to an actuation unit (16) for a medical instrument (10) and to a medical instrument (10) with a shaft (12) which extends between a proximal end (20) and a distal end (22), wherein the instrument (10) is designed at the distal end (22) to receive an end effector (14), an actuation unit (16, 216) which is assigned to the proximal end of the shaft (12), and which has a plurality of drives (50, 52, 54, 56), and with at least two control trains (100, 102, 104, 106, 108, 110, 112, 114) which extend through the shaft (12), wherein the at least two control trains (100, 102, 104, 106, 108, 110, 112, 114) can be used for controlling at least one degree of freedom of the instrument, in particular for deflecting the end effector (14), wherein the at least two control trains (100, 102, 104, 106, 108, 110, 112, 114) comprise a first control train (100, 104, 108, 112) and a second control train (102, 106, 110, 114), and wherein the first control train (100, 104, 108, 112) is coupled to a first carrier (70, 74, 78, 82) and the second control train (102, 106, 110, 114) is coupled to a second carrier (72, 76, 80, 84), on which a drive (50, 52, 54, 56) acts for generating a pushing movement or pulling movement of the carrier (70, 72, 74, 76, 78, 80, 82, 84).

9. 发明授权

US11490791B2 Positioning system 有权
公开(公告)号：US11490791B2
公开(公告)日：2022-11-08
申请号：US16868015
申请日：2020-05-06
申请人： KARL STORZ SE & Co. KG
发明人： Robin Kielack , Steffen Nann , Michael Sauer
IPC分类号： A61B1/31 , A61B17/34 , A61B17/17 , A61B90/50 , A61B1/00 , A61B1/06 , A61B1/317
摘要： A positioning system comprising a first working element having a first tubular shaft, a second working element having a second tubular shaft, an arcuate element having a holding element and an arcuate rail, wherein the arcuate rail is disposed on the holding element and the holding element is adapted to be fixed on the receiving section by means of a fastening element, and a guiding element having a holding section and a guiding section, wherein the holding section is guided on the rail and the guiding section receives the second shaft, the holding section having a locking element securing the guiding element to the rail, wherein the locking element in a locking position blocks displacement of the holding section in a transverse direction and in a release position allows displacement of the holding section in the transverse direction.

10. 发明授权

US11471014B2 Suction cleaning attachment 有权
公开(公告)号：US11471014B2
公开(公告)日：2022-10-18
申请号：US16765194
申请日：2019-12-19
申请人： Mr. Wash Autoservice AG
发明人： Richard Enning , Cornelis van de Pol
IPC分类号： A47L9/02 , A47L5/38 , A47L9/24 , B60S3/00
摘要： The invention relates to a suction cleaning attachment (1) of a cleaning device (2) for use for the interior cleaning of motor vehicles by means of a suction air flow and provided for insertion and for holding in a quiver (3) when not in use, with a housing (5) having an internal suction channel (4) for guiding the suction air flow and a grip region (6) provided on the outside of the housing (5), wherein the suction channel (4) leads into a suction opening (8) at its outer end (7). According to the invention it is proposed that on the outside of the housing (5) between the suction opening (8) and the grip region (6), a stop (9) constructed as a step or a stop (9) projecting beyond the grip region (6) is provided for interaction with the outer edge (10) of the quiver (3).

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