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1. 发明申请

WO2012040456A3 HUMAN B1 CELLS AND USES THEREOF 审中-公开
标题翻译：人类B1细胞及其用途
公开(公告)号：WO2012040456A3
公开(公告)日：2012-06-07
申请号：PCT/US2011052750
申请日：2011-09-22
申请人： THE FEINSTEIN INST MEDICAL RES , ROTHSTEIN THOMAS L , GRIFFIN DANIEL O , HOLODICK NICHOL E
发明人： ROTHSTEIN THOMAS L , GRIFFIN DANIEL O , HOLODICK NICHOL E
IPC分类号： G01N33/00 , A61K39/00 , A61K39/395
CPC分类号： C12N5/0635 , A61K35/17 , A61K39/3955 , A61K2035/124 , G01N33/564 , G01N33/56972 , G01N33/57426 , G01N33/6893 , G01N2333/70507 , G01N2333/70553
摘要： The present invention is directed to isolated populations of human natural immunoglobulin-producing B1 lymphocytes, wherein the B1 lymphocytes display surface biomarkers CD20, CD43 and CD27 and are either CD11b+ or GD11b-. The present invention is also directed to a method of isolating human natural immunoglobulin- producing B1 lymphocytes from a blood sample comprising isolating B lymphocytes from the sample that express surface biomarkers CD20, CD43 and CD27, and, optionally, CD11b. In addition, the present invention is directed to a methods for diagnosing a B1 cell disorder in a patient, determining the prognosis of a patient having a B1 cell disorder, and treating a patient having a B1 cell disorder.
摘要翻译：本发明涉及分离的人天然免疫球蛋白生成B1淋巴细胞群，其中B1淋巴细胞显示表面生物标志物CD20，CD43和CD27，并且是CD11b +或GD11b-。本发明还涉及从血液样品中分离人天然免疫球蛋白产生性B 1淋巴细胞的方法，包括从样品中分离表达表面生物标志物CD20，CD43和CD27以及任选的CD11b的B淋巴细胞。另外，本发明涉及诊断患者的B1细胞疾病，确定具有B1细胞疾病的患者的预后以及治疗患有B1细胞疾病的患者的方法。

2. 发明申请

WO2011034582A3 HIV-1 ANTIBODIES 审中-公开
标题翻译： HIV-1抗体
公开(公告)号：WO2011034582A3
公开(公告)日：2011-09-15
申请号：PCT/US2010002515
申请日：2010-09-16
申请人： UNIV DUKE , US GOV HEALTH & HUMAN SERV , THE FEINSTEIN INST MEDICAL RES , HAYNES BARTON F , TOMARAS GEORGIA , SHEN SHAUNNA , DIMITROV DIMITER S , ZHU ZHONGYU , HWANG KWAN-KI , CHIORAZZI NICHOLAS
发明人： HAYNES BARTON F , TOMARAS GEORGIA , SHEN SHAUNNA , DIMITROV DIMITER S , ZHU ZHONGYU , HWANG KWAN-KI , CHIORAZZI NICHOLAS
IPC分类号： A61K39/42 , A61P31/18 , C07K16/10 , C12N5/07
CPC分类号： C07K16/1063 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/76
摘要： The present invention relates, in general, to HIV-1 specific antibodies and, in particular, to broadly neutralizing HIV-1 specific antibodies that target the gp41 membrane-proximal external region (MPER). The present invention also relates to a cell culture system, more specifically, to a method of rendering chronic lymphocytic leukemia B-cells immortal and to a method of isolating anti-viral antibodies from clones of such cells.
摘要翻译：本发明一般涉及HIV-1特异性抗体，特别涉及广泛中和靶向gp41膜近端外部区域（MPER）的HIV-1特异性抗体。本发明还涉及细胞培养系统，更具体地说，涉及使慢性淋巴细胞白血病B细胞永生的方法，以及从这些细胞的克隆中分离抗病毒抗体的方法。

3. 发明申请

WO2007027910A3 PEPTIDE MIMICS OF MELANOCYTE STIMULATING HORMONE 审中-公开
标题翻译： MELANOCYTE刺激激素肽肽
公开(公告)号：WO2007027910A3
公开(公告)日：2009-05-07
申请号：PCT/US2006034054
申请日：2006-09-01
申请人： THE FEINSTEIN INST MEDICAL RES , ROTH JESSE
发明人： ROTH JESSE
IPC分类号： C07K14/435 , C12N15/12 , C12N15/74
CPC分类号： C07K14/68 , A61K38/00
摘要： Provided are peptides having melanocyte stimulating hormone activity. Also provided are vectors encoding these peptides and transgenic cells comprising the above vectors. Additionally, methods of reducing or preventing release of an inflammatory cytokine from mammalian cells are provided, as are methods for treating a mammal suffering from, or at risk for, a condition mediated by an inflammatory cytokine cascade. Further provided are methods of reducing levels of an inflammatory cytokine in a mammal, methods of treating an overweight mammal, methods of decreasing food intake in a mammal and methods of inhibiting innate immunity in the digestive system of a mammal.
摘要翻译：提供了具有促进黑素细胞激素活性的肽。还提供了编码这些肽的载体和包含上述载体的转基因细胞。此外，提供了减少或预防来自哺乳动物细胞的炎性细胞因子释放的方法，以及用于治疗患有由炎性细胞因子级联介导的病症或具有风险的哺乳动物的方法。还提供了减少哺乳动物炎症细胞因子水平的方法，治疗超重哺乳动物的方法，减少哺乳动物食物摄入的方法以及抑制哺乳动物消化系统中先天免疫的方法。

4. 发明申请

WO2007145888A3 OXIME DERIVATIVES AS INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR 审中-公开
标题翻译： OXIME衍生物作为MACROPHAGE MIGRATION INHIBITORY因子的抑制剂
公开(公告)号：WO2007145888A3
公开(公告)日：2008-07-17
申请号：PCT/US2007013139
申请日：2007-06-04
申请人： THE FEINSTEIN INST MEDICAL RES , AL-ABED YOUSEF
发明人： AL-ABED YOUSEF
IPC分类号： A01N57/00 , A61K31/66
CPC分类号： C07C291/04 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14
摘要： Provided are compounds of formula (I) and other compounds. Also provided are pharmaceutical compositions comprising these compounds. Additionally, methods of inhibiting macrophage migration inhibitory factor (MIF) activity in a mammal are provided, as are methods of treating or preventing inflammation in a mammal, and methods of treating a mammal having sepsis, septicemia, and/or endotoxic shock.
摘要翻译：提供式（I）化合物和其它化合物。还提供了包含这些化合物的药物组合物。此外，提供了哺乳动物抑制巨噬细胞迁移抑制因子（MIF）活性的方法，以及治疗或预防哺乳动物炎症的方法，以及治疗具有败血症，败血病和/或内毒素性休克的哺乳动物的方法。

5. 发明申请

WO2007112036A3 MODIFIED MACROPHAGE MIGRATION INHIBITORY FACTOR INHIBITORS 审中-公开
标题翻译：改性MACROPHAGE移动抑制因子抑制剂
公开(公告)号：WO2007112036A3
公开(公告)日：2008-01-03
申请号：PCT/US2007007319
申请日：2007-03-23
申请人： THE FEINSTEIN INST MEDICAL RES , AL-ABED YOUSEF
发明人： AL-ABED YOUSEF
IPC分类号： A61K31/496 , C07D413/02 , C07D413/04
CPC分类号： C07D261/04 , A61K31/42 , A61K31/421 , A61K45/06 , A61K2300/00
摘要： Provided are various compounds of Formula I (I). Also provided are various compounds of Formula II (II). Also provided are pharmaceutical compositions comprising the above compounds. Additionally, methods of inhibiting macrophage migration inhibitory factor (MIF) activity in a mammal are provided, as are methods of treating or preventing inflammation in a mammal. Further provided are methods of treating a mammal having sepsis, septicemia, and/or endotoxic shock. Also provided are methods of treating a mammal having an autoimmune disease, and methods of treating a mammal having a tumor.
摘要翻译：提供式I（I）的各种化合物。还提供式II（II）的各种化合物。还提供了包含上述化合物的药物组合物。此外，提供了哺乳动物抑制巨噬细胞迁移抑制因子（MIF）活性的方法，以及治疗或预防哺乳动物炎症的方法。还提供了治疗具有败血症，败血病和/或内毒素性休克的哺乳动物的方法。还提供了治疗具有自身免疫疾病的哺乳动物的方法以及治疗具有肿瘤的哺乳动物的方法。

6. 发明申请

WO2007130725A3 USE OF HMGB1 FOR PROTECTION AGAINST ISCHEMIA REPERFUSION INJURY 审中-公开
标题翻译：使用HMGB1防止ISCHEMIA REPERFUSION INJURY伤害
公开(公告)号：WO2007130725A3
公开(公告)日：2008-04-10
申请号：PCT/US2007061709
申请日：2007-02-06
申请人： UNIV PITTSBURGH , THE FEINSTEIN INST MEDICAL RES , TSUNG ALLAN , BILLIAR TIMOTHY R , FINK MITCHELL P , TRACEY KEVIN J
发明人： TSUNG ALLAN , BILLIAR TIMOTHY R , FINK MITCHELL P , TRACEY KEVIN J
IPC分类号： A61K38/17 , A61P37/02
CPC分类号： A61K38/17 , A01N1/02 , A01N1/0226
摘要： Methods and compositions are disclosed for protecting an organ or tissue from inflammation and organ injury following ischemia, reperfusion, and trauma through the administration of an HMGB1 protein within a time period sufficient to protect the organ or tissue from injury.
摘要翻译：公开的方法和组合物通过在足以保护器官或组织免受损伤的时间段内通过施用HMGB1蛋白来保护器官或组织免受缺血，再灌注和创伤后的炎症和器官损伤。

7. 发明申请

WO2007059203A3 TREATING INFLAMMATORY DISORDERS WITH ANTIBODIES TO THE ALPHA-7 NICOTINIC RECEPTORS 审中-公开
标题翻译：治疗炎性疾病的抗体与α-7烟碱受体
公开(公告)号：WO2007059203A3
公开(公告)日：2007-07-19
申请号：PCT/US2006044329
申请日：2006-11-15
申请人： THE FEINSTEIN INST MEDICAL RES , YOUNG LIHONG , TRACEY KEVIN J
发明人： YOUNG LIHONG , TRACEY KEVIN J
IPC分类号： A61K39/395 , A61P29/00 , A61P37/06
CPC分类号： C07K16/286 , A61K2039/505 , C07K2317/34 , C07K2317/75 , C07K2317/76 , H04L12/1813 , H04L51/04
摘要： An antibody or an antigen binding fragment thereof which binds to mammalian a7 subunit of a nicotinic acetylcholine receptor or its functional variant and which is an agonist of said receptor or variant. Pharmaceutical compositions comprising same. A method of treating a subject suffering from an inflammatory condition comprising administering to said subject an antibody or an antigen-binding fragment as described herein.
摘要翻译：的抗体或其能够结合烟碱乙酰胆碱受体的哺乳动物A7亚基或其功能变体和其抗原结合片段是所述受体或变体的激动剂。包含其的药物组合物。治疗患有炎性病症的受试者的方法，包括对所述受试者施用如本文所述的抗体或抗原结合片段。

8. 发明申请

WO2006138429A3 ANTIBODIES AGAINST HMGB1 AND FRAGMENTS THEREOF 审中-公开
标题翻译：抗HMGB1及其片段的抗体
公开(公告)号：WO2006138429A3
公开(公告)日：2007-06-21
申请号：PCT/US2006023255
申请日：2006-06-15
申请人： THE FEINSTEIN INST MEDICAL RES , MESSMER DAVORKA
发明人： MESSMER DAVORKA
IPC分类号： C07K16/00 , A61K39/395 , A61P37/02 , C07K16/24 , G01N33/53
CPC分类号： C07K16/18 , C07K14/4718
摘要： In various embodiments, the present invention is drawn to antibodies or antigen-binding fragments thereof that bind to particular fragments of HMGBl, methods of treating a condition in a subject characterized by activation of an inflammatory cytokine cascade, methods of detecting and/or identifying an agent that binds to an HMGBl polypeptide or fragment thereof, and methods of detecting HMGBl in a sample.
摘要翻译：在各种实施方案中，本发明涉及结合HMGB1的特定片段的抗体或其抗原结合片段，治疗受试者特征在于炎性细胞因子级联活化的病症的方法，检测和/或鉴定与HMGB1多肽或其片段结合的试剂，以及检测样品中HMGB1的方法。

9. 发明申请

WO2006122327A8 MILK FAT GLOBULE EPIDERMAL GROWTH FACTOR-FACTOR VIII AND SEPSIS 审中-公开
公开(公告)号：WO2006122327A8
公开(公告)日：2007-05-24
申请号：PCT/US2006018774
申请日：2006-05-12
申请人： THE FEINSTEIN INST MEDICAL RES , WANG PING
发明人： WANG PING
IPC分类号： A61K38/18 , C07K14/475
CPC分类号： C07K14/705 , A61K38/00
摘要： Provided are methods of treating a mammal undergoing sepsis or at risk for sepsis. Also provided are methods of preventing or treating a physiologic effect of sepsis in a mammal. Additionally provided is the use of milk fat globule epidermal growth factor-factor VIII (MFG- E8) for the manufacture of a medicament for preventing or treating a physiologic effect of sepsis in a mammal, and the use of milk fat globule epidermal growth factor-factor VIII (MFG-E8) for the treatment of a mammal having sepsis or at risk for sepsis.
摘要翻译：提供了治疗脓毒症或有败血症风险的哺乳动物的方法。还提供了预防或治疗哺乳动物败血症的生理作用的方法。另外提供的是使用乳脂肪球表皮生长因子因子VIII（MFG-E8）来制备用于预防或治疗哺乳动物败血症的生理作用的药物，以及使用乳脂肪球表皮生长因子 - 因子VIII（MFG-E8）用于治疗具有败血症或有败血症风险的哺乳动物。

10. 发明申请

WO2007038501A2 RHEUMATOID ARTHRITIS MARKERS 审中-公开
标题翻译：湿疹斑块标记
公开(公告)号：WO2007038501A2
公开(公告)日：2007-04-05
申请号：PCT/US2006037461
申请日：2006-09-27
申请人： THE FEINSTEIN INST MEDICAL RES , GREGERSEN PETER K , BATLIWALLA FRANAK
发明人： GREGERSEN PETER K , BATLIWALLA FRANAK
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2800/102 , G01N2800/52
摘要： Provided are methods of predicting responsiveness to TNF blockade therapy in a subject with rheumatoid arthritis (RA). Also provided are methods of determining the effectiveness of TNF blockade therapy in a subject with RA. Additionally, methods of diagnosis of RA in a subject and method of determining whether a subject is at risk for RA are provided.
摘要翻译：提供了预测类风湿性关节炎（RA）患者TNF阻滞治疗反应性的方法。还提供了确定具有RA的受试者中TNF阻断治疗的有效性的方法。此外，提供了受试者中RA的诊断方法和确定受试者是否处于RA风险的方法。

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