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1. 发明专利

ES68747U Ventana de elemento deslizante 未知
公开(公告)号：ES68747U
公开(公告)日：1958-11-16
申请号：ES68747
申请日：1958-10-02
申请人： ETABLISSEMENTS GEORGE KLEIN & CIE S A
摘要： Ventana de elemento deslizante, caracterizada por que comprende un conjunto del género de los que incluyen dispositivos de fijación automática o autofijación, en particular con la ayuda de un resorte-freno u otro que asegura una fijación a cuña contra superficies de apoyo apropiadas, más especialmente ventana que incluye por lo menos un elemento deslizante y que por el dispositivo de autofijación está dispuesto de tal manera que asegura normalmente la fijación del citado árbol, pero que pueda vencerse esa fijación mediante un esfuerzo convenientemente aplicado, especialmente con la mano (sobre una empuñadura, un botón, etc.), sobre el referido elemento.

2. 发明专利

ES68745U Ventana de abertura total o media particularmente para coches de ferrocarril 未知
公开(公告)号：ES68745U
公开(公告)日：1958-11-16
申请号：ES68745
申请日：1958-10-02
申请人： ETABLISSEMENTS GEORGE KLEIN & CIE S A
摘要： Ventana de apertura total o media, particularmente para coches de ferrocarril, caracterizada por estar constituida por un conjunto de elementos deslizantes, los cuales comprenden por lo menos un árbol transversal para conjugar los desplazamientos de dos lados opuestos del elemento deslizante, y por que preferentemente se monta sobre este árbol por lo menos un resorte helicoidal que actúa por torsión y es apropiado para asegurar un equilibrio, parcial, al menos, del peso de dicho elemento.

3. 发明专利

ES68745Y Ventana de abertura total o media particularmente para coches de ferrocarril 未知
公开(公告)号：ES68745Y
公开(公告)日：1959-05-01
申请号：ES68745
申请日：1958-10-02
申请人： ETABLISSEMENTS GEORGE KLEIN & CIE S A

4. 发明专利

ES68747Y Ventana de elemento deslizante 未知
公开(公告)号：ES68747Y
公开(公告)日：1959-04-01
申请号：ES68747
申请日：1958-10-02
申请人： ETABLISSEMENTS GEORGE KLEIN & CIE S A

5. 发明申请

US20060078623A1 Pharmaceutical formulations containing microparticles or nanoparticles of a delivery agent 审中-公开
标题翻译：含有递送剂的微粒或纳米颗粒的药物制剂
公开(公告)号：US20060078623A1
公开(公告)日：2006-04-13
申请号：US11204778
申请日：2005-08-15
申请人： Nikhil Dhoot , Halina Levchik , Shingai Majuru , George Klein , Jamila Harris , Puchun Liu , Steven Dinh , Jun Liao , Jongbin Lee , Ehud Arbit , Nai Wang
发明人： Nikhil Dhoot , Halina Levchik , Shingai Majuru , George Klein , Jamila Harris , Puchun Liu , Steven Dinh , Jun Liao , Jongbin Lee , Ehud Arbit , Nai Wang
IPC分类号： A61K9/50 , A61K9/16 , A61K9/14
CPC分类号： A61K47/12 , A61K9/145 , A61K9/1617 , A61K9/2013 , A61K9/2027 , A61K9/2077 , A61K9/2081 , A61K9/2846 , A61K9/4858 , A61K38/28
摘要： This invention relates to microparticles and/or nanoparticles containing a delivery agent and/or an active agent. This invention also relates to pharmaceutical formulations and solid dosage forms, including controlled release solid dosage forms of active agent and a delivery agent.
摘要翻译：本发明涉及含有递送剂和/或活性剂的微粒和/或纳米颗粒。本发明还涉及药物制剂和固体剂型，包括活性剂的控释固体剂型和递送剂。

6. 发明授权

US06730077B2 Catheter system 失效
公开(公告)号：US06730077B2
公开(公告)日：2004-05-04
申请号：US10237376
申请日：2002-09-09
申请人： Sean Carroll , George Klein , Marwan Abboud , Steven G. Arless , Fredric L. Milder , Dan Wittenberger
发明人： Sean Carroll , George Klein , Marwan Abboud , Steven G. Arless , Fredric L. Milder , Dan Wittenberger
IPC分类号： A61B1802
CPC分类号： A61B18/02 , A61B18/1492 , A61B2017/00026 , A61B2017/00084 , A61B2018/0212 , A61B2018/0262 , A61B2090/065
摘要： A cryocatheter for treatment of tissue has a tip adapted to provide a signal indicative of the quality and/or orientation of the tip contact with surrounding tissue. In one embodiment, a signal conductor extends through the catheter to the tip and connects to a thermally and electrically conductive shell or cap that applies an RF current to the region of tissue contacted by the tip. The tissue impedance path between the signal lead and a surface electrode mounted on the patient's skin is monitored to develop a quantitative measure of tissue contact at the distal tip, which is preferably displayed on the screen of a catheter monitoring console. In yet a further embodiment, the catheter is provided with a split tip having temperature monitoring sensors, such as thermistors, mounted on opposed halves of the tip so as to sense temperature on two sides of the catheter axis. The thermistor signals are processed to determine and display differential temperature between the two sides of the tip, thus revealing which side lies in contact. In yet a further aspect of the first embodiment, two separate and distinct high frequency electrical signals are applied to the two halves of a split metal shell or cap at the tip. Signals received at the surface electrode are filtered into first and second frequency components, and these are processed to determine the relative magnitude of the signal or the impedance of the path for each of the injected signals to determine and display the tissue contact orientation of the catheter. The catheter preferably has two separate cooling chambers within the cooling tip, positioned with one chamber on each side of the axis, and a separate cooling inlet to each chamber is switched on by a valve which directs the flow of coolant to the contact side during active cryotreatment. In another embodiment, the cap provides an RF electrode that may be opposed to the cooling side so that either the cryogenic or the RF ablation side may be rotated into contact to selectively heat or cool, or in representative protocol treat, then thaw, the same tissue site.

7. 发明申请

US20140200577A1 ABLATION GRASPER 审中-公开
标题翻译：排水砂浆
公开(公告)号：US20140200577A1
公开(公告)日：2014-07-17
申请号：US14115595
申请日：2012-05-03
申请人： George Klein , Harold Wodlinger , Steve Wayne Berhow , Douglas Scott Wahnschaffe
发明人： George Klein , Harold Wodlinger , Steve Wayne Berhow , Douglas Scott Wahnschaffe
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B18/1445 , A61B2018/00196 , A61B2018/00273 , A61B2018/00351 , A61B2018/00482 , A61B2018/00505 , A61B2018/00541 , A61B2218/002
摘要： The present invention provides improved catheters for ablative procedures for biological tissue, e.g., in the heart. The catheters allow active fixation to the tissue using a pair of jaws, and a sheath actuates the jaws, simplifying actuation. In particular embodiments, the pair of jaws provides additional stability in attachment to difficult ablation sites, e.g., along the ridges of cardiac structures.
摘要翻译：本发明提供了用于例如在心脏中的用于生物组织的烧蚀程序的改进的导管。导管允许使用一对钳口主动固定到组织，并且护套致动钳口，从而简化致动。在特定实施例中，该对钳口在附着到难消化部位（例如沿着心脏结构的脊）提供额外的稳定性。

8. 发明申请

US20120046666A1 ANCHORING CATHETER SHEATH 审中-公开
标题翻译：锚固导管
公开(公告)号：US20120046666A1
公开(公告)日：2012-02-23
申请号：US13202854
申请日：2010-02-24
申请人： George Klein
发明人： George Klein
IPC分类号： A61B17/00
CPC分类号： A61M25/0662 , A61B18/1492 , A61B2018/00214 , A61B2018/00285 , A61B2018/00898 , A61M25/0068 , A61M25/0082 , A61M25/01 , A61M25/04 , A61M25/10 , A61M2025/0681
摘要： In general, the invention provides improved sheaths for enhanced control over the relative position of the sheath or inserted catheter relative to a biological tissue. The invention also provides improved sheaths for controlling the longitudinal and axial movement of inserted catheters relative to the sheath. The sheaths include an active anchor at the distal end capable of reversibly adhering the sheath to a tissue. Exemplary active anchors include a reversibly inflatable balloon, a deflectable tip, a suction cup, a screw, and a barb.
摘要翻译：通常，本发明提供改进的护套，用于增强对鞘或插入的导管相对于生物组织的相对位置的控制。本发明还提供了改进的护套，用于控制插入的导管相对于护套的纵向和轴向运动。护套包括能够将护套可逆地粘附到组织的远端处的活性锚固件。示例性的活动锚固件包括可逆膨胀的气囊，可偏转的尖端，吸盘，螺钉和倒钩。

9. 发明申请

US20080103493A1 WIDE AREA ABLATION OF MYOCARDIAL TISSUE 有权
公开(公告)号：US20080103493A1
公开(公告)日：2008-05-01
申请号：US11969321
申请日：2008-01-04
申请人： Marwan ABBOUD , Fredric MILDER , George KLEIN
发明人： Marwan ABBOUD , Fredric MILDER , George KLEIN
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： The present invention advantageously provides a method and system for cryogenically ablating large areas of tissue within the left atrium. In an exemplary embodiment a cryotherapy device includes a catheter body having a substantially fixed diameter, a proximal end and a distal end; a first lumen for permitting passage of a cooling fluid from the proximal end to the distal end; a second lumen permitting return of the cooling fluid from the distal end to the proximal end; and an ablation element expandable from a first diameter that is substantially the same as the diameter of the catheter body to a second diameter that is at least twice the diameter of the catheter body, the ablation element having a surface portion that conforms to the uneven surface topography of the cardiac tissue. The ablation element can include one or more balloon and/or a flexible element that is deformed by moving the distal end of the catheter toward the proximal end of the catheter. The surface of the balloon can further be shaped by regulation of pressure within the one or more balloons. In an exemplary method a tissue ablation device is provided and tissue in the antrum of the left atrium is ablated with the device. In an exemplary method, only tissue in the antrum is ablated, and the ablation is created by freezing tissue.

10. 发明申请

US20080091180A1 WIDE AREA ABLATION OF MYOCARDIAL TISSUE 有权
公开(公告)号：US20080091180A1
公开(公告)日：2008-04-17
申请号：US11953189
申请日：2007-12-10
申请人： Marwan ABBOUD , Fredric MILDER , George KLEIN
发明人： Marwan ABBOUD , Fredric MILDER , George KLEIN
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： The present invention advantageously provides a method and system for cryogenically ablating large areas of tissue within the left atrium. In an exemplary embodiment a cryotherapy device includes a catheter body having a substantially fixed diameter, a proximal end and a distal end; a first lumen for permitting passage of a cooling fluid from the proximal end to the distal end; a second lumen permitting return of the cooling fluid from the distal end to the proximal end; and an ablation element expandable from a first diameter that is substantially the same as the diameter of the catheter body to a second diameter that is at least twice the diameter of the catheter body, the ablation element having a surface portion that conforms to the uneven surface topography of the cardiac tissue. The ablation element can include one or more balloon and/or a flexible element that is deformed by moving the distal end of the catheter toward the proximal end of the catheter. The surface of the balloon can further be shaped by regulation of pressure within the one or more balloons. In an exemplary method a tissue ablation device is provided and tissue in the antrum of the left atrium is ablated with the device. In an exemplary method, only tissue in the antrum is ablated, and the ablation is created by freezing tissue.

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