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1. 发明公开

EP4043015A1 DELTA-TOCOTRIENOL FOR TREATING CANCER 审中-公开
公开(公告)号：EP4043015A1
公开(公告)日：2022-08-17
申请号：EP22165861.0
申请日：2019-09-04
申请人： H. Lee Moffitt Cancer Center And Research Institute, Inc.
发明人： MALAFA, Mokenge, P.
IPC分类号： A61K31/355 , G01N33/50 , G01N33/574 , A61K31/616 , A61K45/06 , A61K9/00 , A61K31/713
摘要： Disclosed are compositions and methods for inhibiting cancer metastasis or a cancer recurrence in a subject following surgical removal or anti-cancer treatment of a cancer, comprising administering to the subject a composition comprising δ-tocotrienol (d-T3). Also disclosed are methods of determining if a subject is at risk for developing cancer metastasis or recurrence by measuring levels of hCAS expression and an optional treatment step if the subject is identified as being at risk for cancer metastasis or recurrence.

2. 发明公开

EP3648799A1 CHIMERIC ANTIGEN RECEPTORS WITH MUTATED CD28 COSTIMULATORY DOMAINS 审中-公开
公开(公告)号：EP3648799A1
公开(公告)日：2020-05-13
申请号：EP18828264.4
申请日：2018-07-06
申请人： H. Lee Moffitt Cancer Center And Research Institute, Inc.
发明人： DAVILA, Marco L.
IPC分类号： A61K48/00 , C12N5/071 , A61K39/00 , C12N15/00 , C12N5/16 , C07K16/00 , C07H21/04

3. 发明公开

EP3585403A1 TIM3-BINDING CHIMERIC ANTIGEN RECEPTORS 审中-公开
公开(公告)号：EP3585403A1
公开(公告)日：2020-01-01
申请号：EP18756629.4
申请日：2018-02-17
申请人： H. Lee Moffitt Cancer Center And Research Institute, Inc.
发明人： DAVILA, Marco, L.
IPC分类号： A61K35/17 , C07K16/00

4. 发明公开

EP3292494A1 SYSTEMS AND METHODS FOR PROVIDING PERSONALIZED RADIATION THERAPY 审中-公开
标题翻译：用于提供个性化辐射疗法的系统和方法
公开(公告)号：EP3292494A1
公开(公告)日：2018-03-14
申请号：EP16790104.0
申请日：2016-05-05
申请人： H. Lee Moffitt Cancer Center And Research Institute, Inc.
发明人： SCOTT, Jacob , TORRES-ROCA, Javier F.
IPC分类号： G06F19/24 , G06F19/20 , G06F19/12 , C12Q1/68
CPC分类号： C12Q1/6886 , A61N5/1031 , A61N2005/1032 , C12Q1/68 , C12Q2600/106 , C12Q2600/158 , G06F19/20 , G06F19/24 , G16H20/40
摘要： An example method of treating a subject having a tumor is described herein. The method can include determining a radiosensitivity index of the tumor, deriving a subject-specific variable based on the radiosensitivity index, and obtaining a genomic adjusted radiation dose effect value for the tumor. The radiosensitivity index can be assigned from expression levels of signature genes of a cell of the tumor. Additionally, the genomic adjusted radiation dose effect value can be predictive of tumor recurrence in the subject after treatment. The method can also include determining a radiation dose based on the subject-specific variable and the genomic adjusted radiation dose effect value.

5. 发明公开

EP3277325A1 COMBINATION IMMUNOTHERAPY FOR SMALL CELL LUNG CANCER 审中-公开
标题翻译：小细胞肺癌的联合免疫治疗
公开(公告)号：EP3277325A1
公开(公告)日：2018-02-07
申请号：EP16774419.2
申请日：2016-04-04
申请人： H. Lee Moffitt Cancer Center And Research Institute, Inc.
发明人： ANTONIA, Scott , CHIAPPORI, Alberto
IPC分类号： A61K48/00 , C12N5/071 , A61K39/00 , C12N15/00
摘要： A method is disclosed for treating small cell lung cancer (SCLC) in a subject that involves administering to the subject a therapeutically effective amount of dendritic cells engineered to overexpress p53. In some embodiments, the method further involves administering to the subject a therapeutically effective amount of all-trans-retinoic acid (ATRA). The method can also involve administering to the subject a therapeutically effective amount of an immune checkpoint inhibitor.

6. 发明公开

EP3119477A1 TUMOR-INFILTRATING LYMPHOCYTES FOR ADOPTIVE CELL THERAPY 审中-公开
标题翻译： TUMORINFILTRIERENDE LYMPHOZYTEN ZUR ADOPTIVEN ZELLTHERAPIE
公开(公告)号：EP3119477A1
公开(公告)日：2017-01-25
申请号：EP15765854.3
申请日：2015-03-20
申请人： H. Lee Moffitt Cancer Center And Research Institute, Inc. , University Of South Florida
发明人： SARNAIK, Amod A. , PILON-THOMAS, Shari , MCLAUGHLIN, Mark , LIU, Hao
IPC分类号： A61P35/00 , C07K14/705 , C12N5/0783
摘要： Disclosed are compositions and methods for ex vivo expansion of tumorinfiltrating lymphocytes for use in adoptive cell therapy (ACT). Also disclosed are compositions and method for identifying an agent for ex vivo expansion of tumorinfiltrating lymphocytes for use in ACT. Also disclosed are methods for treating cancer using tumor-infiltrating lymphocytes expanded by the disclosed methods.
摘要翻译：公开了用于过继细胞治疗（ACT）的肿瘤浸润淋巴细胞的离体扩增的组合物和方法。还公开了用于鉴定用于ACT的肿瘤浸润淋巴细胞的体外扩增剂的组合物和方法。还公开了通过所公开的方法扩增的使用肿瘤浸润淋巴细胞治疗癌症的方法。

7. 发明公开

EP3097088A1 ICARIIN DERIVATIVES 审中-公开
标题翻译：淫羊藿苷衍
公开(公告)号：EP3097088A1
公开(公告)日：2016-11-30
申请号：EP15740729.7
申请日：2015-01-23
申请人： H. Lee Moffitt Cancer Center And Research Institute, Inc.
发明人： WEI, Sheng , LIST, Alan , LAWRENCE, Nicholas
IPC分类号： C07D311/26
CPC分类号： C07D311/30 , C07D239/91 , C07D311/62 , C07H17/07
摘要： Disclosed are derivatives of icariin. Disclosed are compounds having Formula I-VIII as defined herein. Methods of using these compounds for the treatment of cancer and inflammation are also disclosed.
摘要翻译：披露的是淫羊藿苷的衍生物。公开了具有本文定义的式I-VIII的化合物。还公开了使用这些化合物治疗癌症和炎症的方法。

8. 发明公开

EP2822926A1 SELECTIVE HISTONE DEACTYLASE 6 INHIBITORS 审中-公开
标题翻译：选择性组蛋白deactylase-6抑制剂
公开(公告)号：EP2822926A1
公开(公告)日：2015-01-14
申请号：EP13758416.5
申请日：2013-03-07
申请人： H. Lee Moffitt Cancer Center And Research Institute, Inc. , BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
发明人： SOTOMAYOR, Eduardo M. , BERGMAN, Joel , KOZIKOWSKI, Alan , WOAN, Karrune Veeraprasert , VILLAGRA, Alejandro V.
IPC分类号： C07C275/34 , C07C275/28 , C07D209/08 , A61K31/155
CPC分类号： A61K45/06 , A61K31/437 , C07C275/24 , C07C275/28 , C07C275/30 , C07C275/34 , C07D209/14 , C07D213/75 , C07D233/72 , C07D233/78 , C07D235/26 , C07D239/42 , C07D261/14 , C07D295/13
摘要： Disclosed are selective histone deactylase inhibitors (HDACi) that having Formula (I). Methods of making and using these inhibitors for the treatment of cancer, in particular melanoma are also disclosed.

9. 发明公开

EP2820423A1 MATERIALS AND METHODS FOR DIFFERENTIAL TREATMENT OF CANCER 审中-公开
标题翻译：材料和差别待遇的癌症的方法
公开(公告)号：EP2820423A1
公开(公告)日：2015-01-07
申请号：EP13755515.7
申请日：2013-03-01
申请人： H. Lee Moffitt Cancer Center And Research Institute, Inc. , Serametrix Corporation
发明人： SOLIMAN, Hatem , BONNER-FERRABY, Phoebe , HEPBURNE-SCOTT, Henry , ANTONIA, Scott, J.
IPC分类号： G01N33/574 , G01N33/53 , G01N33/50 , G01N33/68
CPC分类号： C12Q1/6886 , C07K16/18 , C07K16/2818 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , G01N33/5023 , G01N33/574 , G01N33/57484 , G01N2800/52
摘要： The present invention concerns differential therapeutic treatment of cancer patients based on prognostic antigen/antibody profiles used for predicting (prognosticating) a clinical response (efficacy) and/or adverse event to an immunotherapy for treatment of a malignancy in a subject, and for treating or delaying the onset or relapse of a malignancy in a subject.

10. 发明公开

EP2625546A2 METHOD AND APPARATUS FOR DETECTION OF RADIOACTIVE ISOTOPES 审中-公开
标题翻译：方法和设备检测的放射性同位素
公开(公告)号：EP2625546A2
公开(公告)日：2013-08-14
申请号：EP11831712.2
申请日：2011-10-07
申请人： H. Lee Moffitt Cancer Center And Research Institute, Inc.
发明人： FORSTER, Kenneth
IPC分类号： G01T1/16 , G01T7/00
CPC分类号： G01T1/167 , G01T1/17 , G01T1/20 , G01T1/36 , G01T3/00 , G01V5/0091
摘要： Embodiments of the invention relate to a method and apparatus for detecting an isotope. Specific embodiments can detect radioactive isotopes. Embodiments of the invention can utilize a detector that incorporates at least two sub-detectors. Each sub-detector can receive energy from an isotope and create a signal corresponding to the received energy. Each sub-detector can incorporate a detector element, such as a detector element incorporating one or more diodes, a detector element incorporating a crystal, a detector element incorporating a solid-state device, or a detector element incorporating a scintillator. The sub-detectors can be configured such that for each isotope to be detected at least two of the sub-detectors produce different output signals, or readings. In a specific embodiment, each sub-detector is configured such that when there are at least two sub- detectors exposed to the isotope each of the corresponding readings from the sub-detectors are different from each of the other readings. The different readings of the sub-detectors for the same isotope can be due to a filter being placed between the isotope being detected and one of the sub-detector's detector element; due to using detector elements with different detector materials, different detector designs, or other detector element differences; or other differences that produce different readings for the same radioactive isotope.

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