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1. 发明公开

EP0387026A3 Biosensor device 失效
标题翻译：生物传感器设备
公开(公告)号：EP0387026A3
公开(公告)日：1992-04-15
申请号：EP90302417.2
申请日：1990-03-07
申请人： GEC-MARCONI LIMITED , Lowe, Christopher Robin
发明人： Sethi, Rajinder Singh , Yonhin, Foo Yueh Yin , Lowe, Christopher Robin
IPC分类号： C12M1/40
CPC分类号： C12Q1/001
摘要： A biosensor device comprises two spaced pairs 6 of electrodes supported on a surface of electrical insulation material on a silicon substrate 2, one of said electrode pairs 6 including a body of an immobilized reagent material incorporating an active biological catalyst which body is positioned between the electrodes of said pair to constitute a working electrode structure. This can form an electrochemical cell where the reaction specific property of a biological catalyst can be utilised to permit analysis for a single component in a mixture.
摘要翻译：生物传感器装置包括支撑在硅基片2上的电绝缘材料表面上的两个隔开的电极对6，所述电极对6中的一个包括固定的试剂材料的主体，该主体结合活性生物催化剂，该主体位于电极的所述对构成工作电极结构。这可以形成电化学电池，其中生物催化剂的反应特性可用于允许分析混合物中的单一组分。

2. 发明公开

EP0387026A2 Biosensor device 失效
标题翻译：生物传感器Vorrichtung。
公开(公告)号：EP0387026A2
公开(公告)日：1990-09-12
申请号：EP90302417.2
申请日：1990-03-07
申请人： GEC-MARCONI LIMITED , Lowe, Christopher Robin
发明人： Sethi, Rajinder Singh , Yonhin, Foo Yueh Yin , Lowe, Christopher Robin
IPC分类号： C12M1/40
CPC分类号： C12Q1/001
摘要： A biosensor device comprises two spaced pairs 6 of electrodes supported on a surface of electrical insulation material on a silicon substrate 2, one of said electrode pairs 6 including a body of an immobilized reagent material incorporating an active biological catalyst which body is positioned between the electrodes of said pair to constitute a working electrode structure.
This can form an electrochemical cell where the reaction specific property of a biological catalyst can be utilised to permit analysis for a single component in a mixture.
摘要翻译：生物传感器装置包括支撑在硅基片2上的电绝缘材料表面上的两个隔开的电极对6，所述电极对6中的一个包括固定的试剂材料的主体，该主体结合活性生物催化剂，该主体位于电极的所述对构成工作电极结构。这可以形成电化学电池，其中生物催化剂的反应特性可用于允许分析混合物中的单一组分。

3. 发明专利

SE403292B 未知
公开(公告)号：SE403292B
公开(公告)日：1978-08-07
申请号：SE159872
申请日：1972-02-10
申请人： DEAN PETER DUNCAN GOODEARL , LOWE CHRISTOPHER ROBIN
发明人： SOK
IPC分类号： C12N9/00 , C12N9/04 , C12N9/06 , C07H19/00 , C07G7/02

4. 发明专利

DE2206636C3 未知
公开(公告)号：DE2206636C3
公开(公告)日：1981-05-27
申请号：DE2206636
申请日：1972-02-11
申请人： DEAN, PETER DUNCAN, GOODEARL, FORMBY, LANCASHIRE, GB , LOWE, CHRISTOPHER ROBIN, MAIDENHEAD, BERKSHIRE, GB
发明人： DEAN, PETER DUNCAN, GOODEARL, FORMBY, LANCASHIRE, GB , LOWE, CHRISTOPHER ROBIN, MAIDENHEAD, BERKSHIRE, GB
IPC分类号： C12N9/00 , C12N9/04 , C12N9/06 , C12N11/00

5. 发明申请

WO2005122099A3 HOLOGRAPHIC OR DIFFRACTION DEVICES 审中-公开
公开(公告)号：WO2005122099A3
公开(公告)日：2005-12-22
申请号：PCT/GB2005/002226
申请日：2005-06-06
申请人： CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LTD. , SMART HOLOGRAMS LIMITED , LOWE, Christopher, Robin , DAVIDSON, Colin, Alexander, Bennett , BLYTH, Jeffrey , KABILAN, Satyamoorthy , MARSHALL, Alexander, James , MILLINGTON, Roger, Bradley
发明人： LOWE, Christopher, Robin , DAVIDSON, Colin, Alexander, Bennett , BLYTH, Jeffrey , KABILAN, Satyamoorthy , MARSHALL, Alexander, James , MILLINGTON, Roger, Bradley
IPC分类号： G07D7/12 , B41M3/14 , G03H1/04 , G07D7/14 , B42D15/10 , G03H1/18
摘要： A holographic or diffraction device responsive to interrogation, the device comprising an image-former and an image-concealer; wherein the image-former is adapted such that light reflected from or transmitted through it forms at least one image; wherein the image-concealer acts to attenuate the image; and wherein the attenuation of the image by the image-concealer is alterable responsive to interrogation.

6. 发明申请

WO2005121753A1 METHOD OF DETECTING AN ANALYTE USING A HOLOGRAPHIC SENSOR 审中-公开
标题翻译：使用全息传感器检测分析仪的方法
公开(公告)号：WO2005121753A1
公开(公告)日：2005-12-22
申请号：PCT/GB2005/002222
申请日：2005-06-06
申请人： CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LTD. , LOWE, Christopher, Robin , KABILAN, Satyamoorthy , LEE, Mei-Ching
发明人： LOWE, Christopher, Robin , KABILAN, Satyamoorthy , LEE, Mei-Ching
IPC分类号： G01N21/47
CPC分类号： G01N21/4788 , G01N21/75 , G03H1/0005 , G03H1/0011 , G03H1/0248 , G03H2001/0033 , G03H2210/55 , G03H2270/55 , Y10T436/20
摘要： A method for the detection of an analyte in a fluid, which comprises contacting the fluid with a holographic element comprising a medium and a hologram disposed throughout the volume of the medium, wherein an optical characteristic of the element changes as a result of a variation of a physical property occurring throughout the volume of the medium, and wherein the variation arises as a result of interaction between the medium and the analyte; and detecting any change of the optical characteristic of the element; wherein (a) the medium comprises a group which is capable of reacting with the analyte, wherein the analyte or the group is capable of existing in a plurality of forms, and the detecting is conducted in the presence of a first catalyst which is capable of catalysing the conversion of a relatively less reactive form of the analyte or group to a relatively more reactive form; or (b) the fluid comprises a component, other than the analyte, which is capable of interacting with the medium, and the detecting is conducted in the presence of a second catalyst capable of catalysing the removal of said component.
摘要翻译：一种用于检测流体中的分析物的方法，其包括使流体与包括介质的全息元件和设置在介质的整个体积中的全息图接触，其中元件的光学特性由于变化而变化在整个体积的介质中发生的物理性质，并且其中所述变化由于介质和分析物之间的相互作用而出现; 并检测元件的光学特性的任何变化; 其中（a）所述培养基包括能够与分析物反应的基团，其中所述分析物或所述基团能够以多种形式存在，并且所述检测在第一催化剂存在下进行，所述第一催化剂能够催化相对较少反应性形式的分析物或基团转化成相对更具反应性的形式; 或（b）流体包含能够与介质相互作用的分析物以外的成分，并且在能够催化去除所述组分的第二催化剂的存在下进行检测。

7. 发明申请

WO2004035199A1 AFFINITY ADSORBENTS FOR IMMUNOGLOBULINS 审中-公开
标题翻译：免疫调节剂的免疫调节剂
公开(公告)号：WO2004035199A1
公开(公告)日：2004-04-29
申请号：PCT/GB2003/004524
申请日：2003-10-21
申请人： CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED , INSTITUTO SUPERIOR TECNICO , LOWE, Christopher, Robin , MENESE DE OLIVEIRA, Maria, Angela, Cabral, Garcia, Taipa , ROQUE, Ana, Cecilia, Afonso
发明人： LOWE, Christopher, Robin , MENESE DE OLIVEIRA, Maria, Angela, Cabral, Garcia, Taipa , ROQUE, Ana, Cecilia, Afonso
IPC分类号： B01J20/32
CPC分类号： C07K16/065 , B01D15/3804 , B01J20/286 , B01J20/289 , B01J20/3212 , B01J20/3219 , B01J20/3255 , C07D251/44 , C07D251/50 , C07D251/54
摘要： Use of a compound of formula (I) wherein R 1 and R 2 are the same or different and are each optionally substituted alkyl or aryl; and R 3 is a solid support optionally attached via a spacer; for the affinity binding of an immunoglobulin or fragment thereof.
摘要翻译：其中R 1和R 2相同或不同并且各自为任选取代的烷基或芳基的式（I）化合物的用途; 并且R 3是通过间隔物任选地连接的固体支持物; 用于免疫球蛋白或其片段的亲和结合。

8. 发明申请

WO2003087899A1 METHOD OF DETECTING AN ANALYTE IN A FLUID 审中-公开
标题翻译：检测流体中分析物的方法
公开(公告)号：WO2003087899A1
公开(公告)日：2003-10-23
申请号：PCT/GB2003/001499
申请日：2003-04-04
申请人： SMART HOLOGRAMS LIMITED , LOWE, Christopher, Robin , DAVIDSON, Colin, Alexander, Bennett , BLYTH, Jeffrey , KABILAN, Satyamoorthy , MARSHALL, Alexander, James , MADRIGAL GONZALEZ, Blanca , JAMES, Anthony, Peter
发明人： LOWE, Christopher, Robin , DAVIDSON, Colin, Alexander, Bennett , BLYTH, Jeffrey , KABILAN, Satyamoorthy , MARSHALL, Alexander, James , MADRIGAL GONZALEZ, Blanca , JAMES, Anthony, Peter
IPC分类号： G02B5/32
CPC分类号： G02B5/32 , G01N21/05 , G01N21/4788 , G01N2021/7723 , G03H1/0248 , G03H2001/0044 , Y10S435/808 , Y10S436/805
摘要： A method for the detection of an analyte in a fluid, comprising contacting the fluid with a holographic element comprising a medium and a hologram disposed throughout the volume of the medium, wherein an optical characteristic of the element changes as a result of a variation of a physical property occurring throughout the volume of the medium, wherein the variation arises as a result of interaction between the medium and the analyte, and wherein the reaction and the variation are reversible; and detecting any change of the optical characteristic.
摘要翻译：一种用于检测流体中的分析物的方法，包括使所述流体与包括介质的全息元件和设置在所述介质的整个体积中的全息图接触，其中所述元件的光学特性由于a的变化而变化在介质的整个体积中发生的物理性质，其中由于介质和分析物之间的相互作用而产生变化，并且其中反应和变化是可逆的; 并检测光学特性的任何变化。

9. 发明申请

WO9903684A8 THE PRODUCTION OF MICROSTRUCTURES FOR USE IN ASSAYS 审中-公开
标题翻译：用于测定的微结构的生产
公开(公告)号：WO9903684A8
公开(公告)日：1999-06-17
申请号：PCT/GB9802161
申请日：1998-07-20
申请人： CAMBRIDGE SENSORS LTD , YON HIN BERNADETTE , MCCANN JAMES , EAPEN SAJI , LOWE CHRISTOPHER ROBIN
发明人： YON-HIN BERNADETTE , MCCANN JAMES , EAPEN SAJI , LOWE CHRISTOPHER ROBIN
IPC分类号： G01N31/20 , B01J19/00 , B01L7/00 , B41M1/12 , B41M3/00 , B81C1/00 , G01N27/447 , G01N37/00 , G03F1/00 , G03F7/26
CPC分类号： B81C1/00119 , B01J19/0093 , B01J2219/00783 , B01J2219/00831 , B01J2219/00833 , B01J2219/00891 , B01J2219/00909 , B01L7/525 , B41M1/12 , B41M3/00 , B81B2203/0338 , B81C2201/0184
摘要： A process for the production of a device having a surface microstructure of wells or channels, comprises one or more steps of screen-printing the microstructure as a curable material onto a plastics substrate, and curing the material. Such a device may also be obtained by applying onto a substrate a material that is polymerisable or depolymerisable by irradiation, applying a negative or positive photoresist respectively, irradiating the structure and removing the unpolymerised or depolymerised material.
摘要翻译：一种用于生产具有孔或通道的表面微观结构的装置的方法包括将微结构作为可固化材料丝网印刷到塑料基材上的一个或多个步骤，以及固化该材料。这样的器件也可以通过在衬底上施加通过照射可聚合或可解聚的材料，分别施加负性或正性光致抗蚀剂，照射结构并除去未聚合或解聚的材料来获得。

10. 发明申请

WO2007023282A1 USE OF HOLOGRAPHIC SENSOR 审中-公开
标题翻译：全息传感器的使用
公开(公告)号：WO2007023282A1
公开(公告)日：2007-03-01
申请号：PCT/GB2006/003156
申请日：2006-08-23
申请人： CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LTD. , LOWE, Christopher, Robin , MARSHALL, Alexander, James
发明人： LOWE, Christopher, Robin , MARSHALL, Alexander, James
IPC分类号： G01N21/47 , G01N33/543
CPC分类号： C12Q1/6825 , G01N21/4788 , G01N33/54373 , Y10S436/805 , Y10T436/25
摘要： The present invention relates to a process for the detection of an analyte in a sample, comprising a) bringing the sample into contact with a first ligand which binds specifically to the analyte and which is immobilised on a substrate; and b) prior to or subsequent to step (a), bringing the sample into contact with a second ligand which binds specifically to the analyte and which includes a label; wherein the substrate comprises a holographic sensor comprising a support medium having a hologram disposed therein or thereon and the label causes an optical property of the sensor to change by interaction of the sensor with the label or, following the additional step of contacting the substrate with a reagent, by interaction of the sensor with a species produced by reaction of the label with the reagent, thereby indicating the presence of bound analyte.
摘要翻译：本发明涉及一种用于检测样品中分析物的方法，包括：a）使样品与特异性结合分析物结合并固定在基底上的第一配体接触; 和b）在步骤（a）之前或之后，使样品与特异性结合分析物并包括标签的第二配体接触; 其中所述基底包括全息传感器，所述全息传感器包括具有设置在其中或其上的全息图的支撑介质，并且所述标签使得所述传感器的光学特性通过所述传感器与所述标签的相互作用而改变，或者在所述基板与试剂，通过传感器与通过标记物与试剂反应产生的物质的相互作用，从而指示结合的分析物的存在。

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