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    • 4. 发明专利
    • A Signalling System for Motor Vehicles.
    • GB1156797A
    • 1969-07-02
    • GB2839766
    • 1966-06-28
    • YANG WANG
    • YANG WANG
    • B60Q1/44
    • 1,156,797. Vehicle signalling arrangements. WANG, YANG. 28 June, 1966, No. 28397/66. Heading G4Q. A vehicle signalling arrangement includes a switch responsive to motion of the vehicle and a switch responsive to actuation of the brakes, connected so that a " normal " light is shown to the rear when the vehicle is in motion with the brakes released, and a " warning " light is shown to the rear when the vehicle is stationary and/or the brakes are applied. Fig. 1 shows the condition with the vehicle at rest with the brakes off, a red light 19 appearing at the rear and a green light 15 at the sides. When the vehicle is in motion above a critical speed a governor switch 49 (Fig. 3, not shown) disconnects these lights and turns on a green light 18 at the rear and a red light 16 at the sides. When the brakes are applied, irrespective of motion, switch 36 (Fig. 2, not shown) connects a red light 20 at the rear and a red light 17 at the sides in place of those previously lit.
    • 9. 发明公开
    • SPECIFIC TARGETING OF RNA EXPANDED REPEAT SEQUENCES
    • 特异性靶向VON RNA扩增重复序列
    • EP3022219A2
    • 2016-05-25
    • EP14825696.9
    • 2014-07-15
    • The Scripps Research InstituteDisney, Matthew D.Guan, LiruiYang, Wang-yong
    • DISNEY, Matthew D.GUAN, LiruiYANG, Wang-Yong
    • C07K5/06
    • G01N33/5308A61K48/00C07D403/14C07D495/04C07D519/00G01N2500/04G01N2500/10
    • The present invention provides small molecule compounds that can form covalent adducts with specific sequences of RNA, such as the hairpin loop r(CUG)exp sequence which is a cause of myotonic dystrophy type 1 (DM1), or the r(CGG)exp sequence which is a cause of fragile X-associated tremor/ataxia syndrome (FXTAS); to methods of making the small molecule compounds; and to methods of using the small molecular compounds in the treatment of DM1 or of FXTAS in patients afflicted therewith. The invention further provides a method for identifying an RNA target of a small molecule drug in vivo, using a small molecule drug conjugated to an RNA-reactive crosslinker group and a reporter group, contacting a cell or nucleic acid extract with the small molecule drug conjugate, then separating RNA targets crosslinked to the small molecule drug conjugate by interaction of the affinity group with a complementary affinity group.
    • 本发明提供可以形成具有特定RNA序列的共价加合物的小分子化合物,例如作为强直性营养不良型1(DM1)或r(CGG)exp序列的发夹环r(CUG)exp序列 这是造成脆弱X型震颤/共济失调综合征(FXTAS)的原因; 制备小分子化合物的方法; 以及使用小分子化合物治疗患有DM1或FXTAS的患者的方法。 本发明还提供了使用与RNA反应性交联剂基团和报道基团缀合的小分子药物,使细胞或核酸提取物与小分子药物缀合物接触的方法,用于在体内鉴定小分子药物的RNA靶标的方法 ,然后通过亲和基团与互补亲和基团的相互作用分离与小分子药物偶联物交联的RNA靶标。
    • 10. 发明公开
    • SPECIFIC TARGETING OF RNA EXPANDED REPEAT SEQUENCES
    • SPEZIFISCHES靶向VON RNA扩增重复序列
    • EP3022219A4
    • 2017-07-26
    • EP14825696
    • 2014-07-15
    • SCRIPPS RESEARCH INSTDISNEY MATTHEW DGUAN LIRUIYANG WANG-YONG
    • DISNEY MATTHEW DGUAN LIRUIYANG WANG-YONG
    • C07K5/06A61K48/00C07D403/14C07D495/04C07D519/00
    • G01N33/5308A61K48/00C07D403/14C07D495/04C07D519/00G01N2500/04G01N2500/10
    • The present invention provides small molecule compounds that can form covalent adducts with specific sequences of RNA, such as the hairpin loop r(CUG)exp sequence which is a cause of myotonic dystrophy type 1 (DM1), or the r(CGG)exp sequence which is a cause of fragile X-associated tremor/ataxia syndrome (FXTAS); to methods of making the small molecule compounds; and to methods of using the small molecular compounds in the treatment of DM1 or of FXTAS in patients afflicted therewith. The invention further provides a method for identifying an RNA target of a small molecule drug in vivo, using a small molecule drug conjugated to an RNA-reactive crosslinker group and a reporter group, contacting a cell or nucleic acid extract with the small molecule drug conjugate, then separating RNA targets crosslinked to the small molecule drug conjugate by interaction of the affinity group with a complementary affinity group.
    • 本发明提供了可以与特定RNA序列形成共价加合物的小分子化合物,例如为肌强直性肌营养不良1型(DM1)的发夹环r(CUG)exp序列或r(CGG)exp序列 这是脆性X相关性震颤/共济失调综合征(FXTAS)的原因; 涉及制备小分子化合物的方法; 以及使用该小分子化合物治疗患有DM1或FXTAS的患者的方法。 本发明进一步提供了使用与RNA反应性交联剂基团和报道基团缀合的小分子药物,使细胞或核酸提取物与小分子药物缀合物接触,从而体内鉴定小分子药物的RNA靶标的方法 然后通过亲和基团与互补亲和基团的相互作用分离与小分子药物缀合物交联的RNA靶标。