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1. 发明专利

JP2015034797A 抗体固定化担体およびその製造方法审中-公开
标题翻译：抗体固定载体及其生产方法
公开(公告)号：JP2015034797A
公开(公告)日：2015-02-19
申请号：JP2013167088
申请日：2013-08-09
申请人：日本電信電話株式会社 , Nippon Telegr & Teleph Corp , 国立大学法人東京大学 , Univ Of Tokyo , 国立大学法人東京大学
发明人： HAYASHI KATSUYOSHI , IWASAKI GEN , INOE SUZUYO , TAMECHIKA EMI , TAKAI MADOKA , CHIMURA YUSUKE
IPC分类号： G01N33/543 , G01N37/00
摘要：【課題】抗体の認識部位を測定試料側に配向させ、非特異吸着を抑制した状態で、測定領域に抗体を固定できるようにする。【解決手段】固定層103は、互いに異なる表面自由エネルギーを持つ少なくとも第1ブロック鎖および第2ブロック鎖から構成されたブロック共重合体より構成され、ミクロ相分離されて、第1ブロック鎖の相よりなる疎水性の複数の第1パターン領域104および第2ブロック鎖の相よりなる親水性の第2パターン領域105を備える。また、第1パターン領域104に固定され、検出対象となるタンパク質と特異的に相互作用する抗体106を備える。【選択図】図1
摘要翻译：要解决的问题：在抗体的识别位点取向于测量样品侧的状态下将抗体固定在测量区域上以抑制非特异性吸附。解决方案：固定床103由嵌段共聚物构成至少第一块链和第二块链彼此具有不同的表面自由能，并且包括多个包含第一块链的相的疏水性第一图案区104和多个亲水性第二区105，第二嵌段链通过微观相分离，并且还包括固定在第一图案区域104上并与作为检测对象的蛋白质特异性相互作用的抗体106。

2. 发明专利

JP2014006226A Biomolecule immobilization carrier and biomolecule immobilization method 有权
标题翻译：生物分子固定载体和生物分子固定方法
公开(公告)号：JP2014006226A
公开(公告)日：2014-01-16
申请号：JP2012144028
申请日：2012-06-27
申请人： Nippon Telegr & Teleph Corp , 日本電信電話株式会社
发明人： INOE SUZUYO , HAYASHI KATSUYOSHI , SEYAMA MICHIKO , TAMECHIKA EMI
IPC分类号： G01N33/547 , C12M1/00 , C12N15/09 , G01N33/543
摘要： PROBLEM TO BE SOLVED: To provide a biomolecule immobilization carrier and a biomolecule immobilization method which can achieve the immobilization of a desired functional biomolecule in a minuter region.SOLUTION: A biomolecule immobilization carrier includes: a specific bond part 101 made of any one of an aptamer and a peptide tag; a first molecular chain 102 whose one end is bonded to one end of the specific bond part 101: a second molecular chain 104 whose one end is bonded to the other end of the specific bond part 101 via a photofragmentation molecule 103; and a third molecular chain 105 whose one end is bonded to the other end of the first molecular chain 102.
摘要翻译：要解决的问题：提供生物分子固定化载体和能够实现所需功能性生物分子在小肠区域中的固定的生物分子固定化方法。解决方案：生物分子固定化载体包括：由以下任何一种制成的特异性结合部分101 适体和肽标签; 第一分子链102，其一端键合在特定键部分101的一端;第二分子链104，其一端通过光致分散分子103键合到特定键部分101的另一端; 和第一分子链105，其一端与第一分子链102的另一端结合。

3. 发明专利

JP2013257154A Measurement chip 审中-公开
标题翻译：测量芯片
公开(公告)号：JP2013257154A
公开(公告)日：2013-12-26
申请号：JP2012131568
申请日：2012-06-11
申请人： Nippon Telegr & Teleph Corp , 日本電信電話株式会社
发明人： INOE SUZUYO , HAYASHI KATSUYOSHI , SEYAMA MICHIKO , IWASAKI GEN , HORIUCHI TSUTOMU , TAMECHIKA EMI
IPC分类号： G01N21/27 , G01N21/05 , G01N33/483 , G01N33/86 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To quickly measure blood coagulation ability with a low sample consumption even in emergency etc.SOLUTION: A measurement chip includes a transparent substrate 101, a metal layer 103 formed in a measurement region 102 of the substrate 101 and serving for surface plasmon resonance measurement, and a glass layer 104 formed on the metal layer 103 in the measurement region 102 and brought into contact with blood plasma as an analyte. It is important that the glass layer 104 has a thickness within a range for measurement of the blood plasma through the surface plasmon resonance measurement.
摘要翻译：要解决的问题：即使在紧急情况下也能以低样本消耗快速测量凝血能力。解决方案：测量芯片包括透明基板101，形成在基板101的测量区域102中并用于表面的金属层103 等离子体共振测量，以及形成在测量区域102中的金属层103上并与作为分析物的血浆接触的玻璃层104。重要的是，玻璃层104具有通过表面等离子体共振测量来测量血浆的范围内的厚度。

4. 发明专利

JP2011141299A Flow cell 有权
标题翻译：流通池
公开(公告)号：JP2011141299A
公开(公告)日：2011-07-21
申请号：JP2011096904
申请日：2011-04-25
申请人： Nippon Telegr & Teleph Corp , 日本電信電話株式会社
发明人： MIURA TATSU , HORIUCHI TSUTOMU , HAYASHI KATSUYOSHI , CAMOU SERGE , SEYAMA TOMOKO , IWASAKI GEN
IPC分类号： G01N21/05 , G01N21/27
摘要： PROBLEM TO BE SOLVED: To provide a flow cell through which a sample can flow at a desired flow rate. SOLUTION: In the flow cell, a resistance channel 15 is prepared between an intake 14 and a measurement channel 17 through a liquid pool 16. Thus, a flow rate of a sample passing through the resistance channel 15 can be controlled by appropriately setting a length, a width, a planar shape and the inner wettability of a meander groove 132 forming the resistance channel 15. As a result, a sample solution injected into the intake 14 can be made to flow at a desired flow rate. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种流动池，通过该流动池，样品可以以期望的流速流动。解决方案：在流通池中，通过液池16在进气口14和测量通道17之间制备电阻通道15.因此，可以通过适当地控制通过电阻通道15的样品的流量设置形成电阻通道15的曲折槽132的长度，宽度，平面形状和内部润湿性。结果，可以使注入到进气口14中的样品溶液以期望的流速流动。版权所有（C）2011，JPO＆INPIT

5. 发明专利

JP2009142322A Component concentration measuring apparatus 有权
标题翻译：组件浓度测量装置
公开(公告)号：JP2009142322A
公开(公告)日：2009-07-02
申请号：JP2007319679
申请日：2007-12-11
申请人： Nippon Telegr & Teleph Corp , 日本電信電話株式会社
发明人： OKABE YUICHI , TAJIMA TAKURO , NAGANUMA KAZUNORI , HAYASHI KATSUYOSHI , SHIMADA JUNICHI , HAGA TSUNEYUKI
IPC分类号： A61B5/145 , G01N21/00
摘要： PROBLEM TO BE SOLVED: To provide a component concentration measuring apparatus using a photoacoustic method which measures the concentration of a subject component stably by keeping the distance between surfaces of a biological subject constant in order to avoid problems, such as differences in standing waves generated within a biological subject according to the distances between the surfaces of the biological subject and differences in sonic waves generated within the biological subject according to the distances between the surfaces of the biological subject.
SOLUTION: The component concentration measuring apparatus 310 comprises a pair of holding means 311a and 311b for sandwiching and holding a biological subject 110 in order to keep the distance between surfaces of the biological subject 110 constant and a distance measuring means 312 for measuring the distance between the holding means 311a and 311b. Because the apparatus comprises a means to keep the distance between the surfaces of the biological subject constant 110, the apparatus can measure the concentration of an object component stably.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种使用光声法的成分浓度测量装置，其通过保持生物学对象的表面之间的距离而恒定地测量被摄体成分的浓度，以避免诸如站立差异等问题根据生物学对象的表面之间的距离和在生物学对象内产生的声波的差异，生物对象内生成的波根据生物学对象的表面之间的距离。解决方案：组分浓度测量装置310包括一对夹持和保持生物体110以保持生物体110的表面之间的距离恒定的保持装置311a和311b以及用于测量生物体110的距离测量装置312 保持装置311a和311b之间的距离。因为该装置包括使生物体的表面之间的距离保持恒定的装置110，所以该装置可以稳定地测量物体成分的浓度。版权所有（C）2009，JPO＆INPIT

6. 发明专利

JP2009136323A Component concentration measuring apparatus 审中-公开
标题翻译：组件浓度测量装置
公开(公告)号：JP2009136323A
公开(公告)日：2009-06-25
申请号：JP2007312389
申请日：2007-12-03
申请人： Nippon Telegr & Teleph Corp , 日本電信電話株式会社
发明人： OKABE YUICHI , TAJIMA TAKURO , NAGANUMA KAZUNORI , HAYASHI KATSUYOSHI , SHIMADA JUNICHI , HAGA TSUNEYUKI
IPC分类号： A61B5/145 , G01N21/00 , G01N29/00 , G01N33/66 , G01N33/92
摘要： PROBLEM TO BE SOLVED: To stabilize the intensity of the light emitted from a light emitting means even if the light emitting means vibrates because the intensity of sonic waves generated in a measured object depends also on the intensity of the light to be applied to the measured object though the concentration of a target component is measured based on the intensity of sonic waves generated in the measured object, and the concentration of the target component can not be accurately measured if the intensity of the light applied to the measured object varies.
SOLUTION: The component concentration measuring apparatus 235 related to this invention is characterized by an unnecessary mode eliminating means 237 for eliminating an unnecessary mode of an optical fiber 236 for guiding light to an irradiation head 112. By eliminating the unnecessary mode of the optical fiber 236, the intensity of the light emitted from the irradiation head 112 can be stabilized even if the bending state of the optical fiber 236 varies.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：为了稳定由发光装置发射的光的强度，即使发光装置振动，因为在测量对象中产生的声波的强度也取决于被施加的光的强度对于测量对象，尽管基于在被测物体中产生的声波的强度来测量目标分量的浓度，并且如果施加到被测物体的光的强度变化，则不能精确地测量目标成分的浓度。解决方案：与本发明相关的部件浓度测量装置235的特征在于，用于消除用于将光引导到照射头112的光纤236的不必要模式的不必要的模式消除装置237.通过消除不必要的模式即使光纤236的弯曲状态发生变化，也能够稳定从照射头112射出的光的强度。版权所有（C）2009，JPO＆INPIT

7. 发明专利

JP2008304270A Fluid measuring substrate, analyzer and analysis method 有权
标题翻译：流体测量基板，分析仪和分析方法
公开(公告)号：JP2008304270A
公开(公告)日：2008-12-18
申请号：JP2007150798
申请日：2007-06-06
申请人： Nippon Telegr & Teleph Corp , 日本電信電話株式会社
发明人： OKABE YUICHI , HAYASHI KATSUYOSHI , IWASAKI GEN , HAYASHI TAKESHI
IPC分类号： G01N35/08 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide an inexpensive fluid measuring substrate having a simple structure, capable of introducing a directly sampled measuring object solution, an analyzer equipped therewith, and an analysis method that uses the analyzer.
SOLUTION: In this fluid measuring substrate having a reference solution injection port for sending reference solution, a measuring object solution injection port for injecting the measuring object solution, and a discharge port for discharging the reference solution and/or the measuring object solution, the reference solution injection port, the measuring object solution injection port and the discharge port are bonded together through a sealed channel. The reference solution injection port and the measuring object solution injection port are arranged so that the reference solution and the measuring object solution flow into the discharge port from the same direction.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种具有简单的结构，能够引入直接取样的测量对象溶液的液体测量基板，配备有分析仪的分析仪和使用分析器的分析方法。解决方案：在具有用于发送参考溶液的参考溶液注入口的流体测量基底中，用于注射测量对象溶液的测量对象溶液注入口和用于排出参考溶液和/或测量对象溶液的排出口参考溶液注入口，测量对象溶液注入口和排出口通过密封通道结合在一起。参考溶液注入口和测量对象溶液注入口被布置成使得参考溶液和测量对象溶液从相同的方向流入排出口。版权所有（C）2009，JPO＆INPIT

8. 发明专利

JP2008089499A Cellulose-based material and biosensor using it 有权
标题翻译：使用纤维素的材料和生物传感器
公开(公告)号：JP2008089499A
公开(公告)日：2008-04-17
申请号：JP2006272865
申请日：2006-10-04
申请人： Nippon Telegr & Teleph Corp , 日本電信電話株式会社
发明人： SEYAMA TOMOKO , IWASAKI GEN , MIURA TATSU , HAYASHI KATSUYOSHI , HAGA TSUNEYUKI
IPC分类号： G01N33/548 , G01N33/543 , G01N33/545 , G01N33/553
摘要： PROBLEM TO BE SOLVED: To provide a new material for a sensor film of a biosensor forming a film of low density, fixing a biomolecule selectivity material by covalent bonding, restraining adsorption of impurities, and having a liquid feeding function.
SOLUTION: A cellulose-based material includes long-chain surface active polymer having fixing functional groups contributing to fixation of a biomaterial and cellulose derivatives.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：为了形成低密度膜的生物传感器的传感器膜提供新的材料，通过共价键固定生物分子选择性材料，抑制杂质的吸附并具有液体馈送功能。解决方案：纤维素基材料包括具有固定官能团的长链表面活性聚合物，其有助于生物材料和纤维素衍生物的固定。版权所有（C）2008，JPO＆INPIT

9. 发明专利

JP2007163441A Electrochemical measuring microelectrode and electrochemical measuring method 有权
标题翻译：电化学测量微电子和电化学测量方法
公开(公告)号：JP2007163441A
公开(公告)日：2007-06-28
申请号：JP2005364061
申请日：2005-12-16
申请人： Nippon Telegr & Teleph Corp , 日本電信電話株式会社
发明人： HAYASHI KATSUYOSHI , IWASAKI GEN , HAGA TSUNEYUKI , TAKAHASHI JUNICHI
IPC分类号： G01N27/28 , G01N27/30 , G01N27/333 , G01N27/416
摘要： PROBLEM TO BE SOLVED: To provide an electrochemical measuring microelectrode capable of being stably operated for a long time, and an electrochemical measuring method. SOLUTION: The electrochemical measuring microelectrode related to one embodiment is equipped with a substrate 1, the flow channel 7a, through which a saturated potassium solution flows, formed to the substrate 1, the silver thin film 2 formed in the flow channel 7a as a reference electrode and the flow channel 7b formed to the substrate 1 separately from the flow channel 7a to allow a measuring sample to flow. COPYRIGHT: (C)2007,JPO&INPIT

10. 发明专利

JP2007163439A Sensor electrode and its manufacturing method 有权
标题翻译：传感器电极及其制造方法
公开(公告)号：JP2007163439A
公开(公告)日：2007-06-28
申请号：JP2005364059
申请日：2005-12-16
申请人： Nippon Telegr & Teleph Corp , 日本電信電話株式会社
发明人： HAYASHI KATSUYOSHI , IWASAKI GEN , TAKAHASHI JUNICHI , HAGA TSUNEYUKI
IPC分类号： G01N27/404 , A61B5/1473
摘要： PROBLEM TO BE SOLVED: To provide a sensor electrode capable of suppressing a decrease of a sensor capacity caused by damage even if physical damage is produced in the electrode by the deformation of a sensor element, and its manufacturing method. SOLUTION: The sensor electrode related to one embodiment is used for performing electrochemical measurement and equipped with a polyimide substrate 1 having flexibility, the platinum layer 3 for an acting electrode formed on the polyimide substrate 1 and a silver layer 6 for a reference electrode. A gold layer 2 having an expansibility higher than the platinum layer 3 and conductivity is formed so as to be brought into contact with the undersurface of the platinum layer 3. Further, a gold layer 5 having an expansibility higher than the silver layer 6 and conductivity is formed so as to be brought into contact with the undersurface of the silver layer 6. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种传感器电极，其能够抑制由于传感器元件的变形而导致的电极中产生物理损伤而导致的传感器容量的降低，及其制造方法。解决方案：与一个实施方案相关的传感器电极用于进行电化学测量并配备有具有柔性的聚酰亚胺基底1，用于形成在聚酰亚胺基底1上的作用电极的铂层3和用于参考的银层6 电极。形成具有高于铂层3的可膨胀性的金层2和导电性，以便与铂层3的下表面接触。此外，具有高于银层6的膨胀性的金层5和导电性形成为与银层6的下表面接触。版权所有：（C）2007，JPO＆INPIT

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