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1. 发明申请

WO2010066265A1 ANALYSIS OF RADIOGRAPHIC IMAGES 审中-公开
标题翻译：放射影像分析
公开(公告)号：WO2010066265A1
公开(公告)日：2010-06-17
申请号：PCT/EP2008/010396
申请日：2008-12-08
申请人： ELEKTA AB (publ) , BROWN, Kevin
发明人： BROWN, Kevin
IPC分类号： A61B5/08 , A61B5/113 , A61B6/03
CPC分类号： A61B6/032 , A61B5/113
摘要： The present invention therefore provides a method for the analysis of radiographic images, comprising the steps of acquiring a plurality of projection images of a patient, acquiring a surrogate signal indicative of the location of a target structure in the patient, reconstructing a plurality of volumetric images of the patient from the projection images, each volumetric image being reconstructed from projection images having a like breathing phase, identifying the position of the target structure such as a tumour in each volumetric image, associating a surrogate signal with each of the projection images, and determining a relationship between the surrogate signal and the position of the target structure. Multiple projection images having a like breathing phase can be grouped for reconstruction, to provide sufficient numbers for reconstruction. The analysis of the multiple values of the surrogate associated with each breathing phase can be used to determine the mean surrogate value and its variation. Multiple values of the surrogate signal associated with the same nominal breathing phase can be used to determine a mean value of the surrogate signal for the target position associated with that phase and a variation of the value of the surrogate signal for the target position associated with that phase. The breathing phase of specific projection images can be obtained by analysis of one or more features in the images, such as the method we described in US (7,356,112), or otherwise.
摘要翻译：因此，本发明提供了一种用于分析放射线图像的方法，包括以下步骤：获取患者的多个投影图像，获取指示患者中目标结构的位置的替代信号，重建多个体积图像从投影图像的患者的每个体积图像中，从具有相似呼吸相位的投影图像重建每个体积图像，识别每个体积图像中的诸如肿瘤的目标结构的位置，将替代信号与每个投影图像相关联，以及确定替代信号与目标结构的位置之间的关系。具有类似呼吸相位的多个投影图像可以被分组以进行重建，以提供足够数量的重建。可以使用与每个呼吸阶段相关联的替代物的多个值的分析来确定平均替代值及其变化。可以使用与相同标称呼吸相位相关联的替代信号的多个值来确定与该相位相关联的目标位置的替代信号的平均值，以及与该相位相关联的目标位置的替代信号的值的变化相。特定投影图像的呼吸阶段可以通过分析图像中的一个或多个特征来获得，例如我们在US（7,356,112）中描述的方法，或以其它方式。

2. 发明申请

WO2009056151A1 RADIOTHERAPY APPARATUS 审中-公开
标题翻译：放射治疗仪
公开(公告)号：WO2009056151A1
公开(公告)日：2009-05-07
申请号：PCT/EP2007/009404
申请日：2007-10-30
申请人： ELEKTA AB (publ) , BROWN, Kevin , STREAMER, Ralph , BOURNE, Duncan
发明人： BROWN, Kevin , STREAMER, Ralph , BOURNE, Duncan
IPC分类号： A61N5/10
CPC分类号： A61N5/1049 , A61N5/1042 , A61N5/1067 , A61N2005/1061
摘要： Realtime beam shape adjustment in response to (for example) online CT scanning of a patient during treatment is assisted by the radiotherapy apparatus comprising a source adapted to emit a beam of therapeutic radiation, a collimator for delimiting the radiation beam, the collimator comprising a plurality of leaves arranged alongside each other and be moveable longitudinally so that the tips of the leaves define a variable edge of the collimator, the leaves being mounted on a support that is moveable laterally with respect to the leaves. In this way, movements of the tumour that are perpendicular to the direction of leaf motion can be accommodated by simply moving the collimator bodily so as to accommodate this. It is preferred that the apparatus also includes a control means adapted to receive information as to the location of the target volume, and, on the basis of that information, control the longitudinal positions of the leaves and the lateral position of the support. It is also preferred that the support tilts as it moves laterally along a path. This can be achieved, by example, by bearings that are moveable on suitable guides, or by mounting the support on a plurality of pivot arms of unequal lengths. The lengths of such pivot arms can be adjusted as necessary.
摘要翻译：响应于（例如）治疗期间患者的在线CT扫描的实时波束形状调整由包括适于发射治疗辐射束的源的放射治疗装置辅助，用于限定辐射束的准直器，准直器包括多个的叶片彼此并排设置并且可纵向移动，使得叶片的尖端限定准直器的可变边缘，叶片安装在相对于叶片横向移动的支撑件上。以这种方式，垂直于叶片运动方向的肿瘤的运动可以通过简单地移动准直器以适应这种方式来适应。优选地，该装置还包括适于接收关于目标体积的位置的信息的控制装置，并且基于该信息来控制叶片的纵向位置和支撑件的横向位置。还优选的是，当支撑件沿着路径横向移动时，支撑件倾斜。这可以通过例如通过在合适的导轨上可移动的轴承，或者通过将支撑件安装在不等长度的多个枢轴臂上来实现。这种枢转臂的长度可以根据需要进行调节。

3. 发明申请

WO2007084331A2 COMPOSITIONS AND METHODS FOR TREATMENT OF COUGHING, SNEEZING, RHINORRHEA, AND/OR NASAL OBSTRUCTION 审中-公开
标题翻译：用于治疗咳嗽，呕吐，恶心呕吐和/或鼻内阻塞的组合物和方法
公开(公告)号：WO2007084331A2
公开(公告)日：2007-07-26
申请号：PCT/US2007/000734
申请日：2007-01-11
申请人： EVERETT LABORATORIES, INC. , GIORDANO, John , BROWN, Kevin
发明人： GIORDANO, John , BROWN, Kevin
IPC分类号： A61K36/49 , A61K31/485 , A61K31/185 , A61K31/205 , A61K31/137
CPC分类号： A61K45/06 , A61K31/137 , A61K31/185 , A61K31/205 , A61K31/485 , A61K2300/00
摘要： The present invention relates to compositions that comprise an expectorant/an extended release antitussive, and an extended release decongestant, in liquid. Specifically, the compositions may comprise guaifenesin, and the tannate salts of phenylephrine and dextromethorphan. The present invention also includes methods for using these compositions for treatment of patients suffering from, for example and without limitation, coughing, sneezing, rhinorrhea, and/or nasal obstruction.
摘要翻译：本发明涉及包含液体中的祛痰剂/延长释放止咳剂和延长释放减充血剂的组合物。具体地，组合物可以包含愈创甘油醚和去氧肾上腺素和右美沙芬的鞣酸盐。本发明还包括使用这些组合物治疗患有例如但不限于咳嗽，打喷嚏，鼻漏和/或鼻塞的患者的方法。

4. 发明申请

WO2014102590A1 SUBSTITUTED PIPERIDIN-4-AMINO-TYPE COMPOUNDS AND USES THEREOF 审中-公开
标题翻译：取代的哌啶-4-氨基型化合物及其用途
公开(公告)号：WO2014102590A1
公开(公告)日：2014-07-03
申请号：PCT/IB2013/002875
申请日：2013-12-23
申请人： PURDUE PHARMA L.P. , SHIONOGI & CO., LTD. , BROWN, Kevin , TADESSE, Dawit , TSUNO, Naoki , TANAKA, Nobuyuki , ZHOU, Xiaoming
发明人： BROWN, Kevin , TADESSE, Dawit , TSUNO, Naoki , TANAKA, Nobuyuki , ZHOU, Xiaoming
IPC分类号： C07D471/08 , A61K31/4995 , A61P29/00
CPC分类号： C07D471/08 , C07C235/74 , C07C2602/46 , C07D211/58
摘要： The disclosure relates to Substituted Piperidin-4-amino-Type Compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof wherein R 1 , R 2 , R 3 , Q 1 , Q 2 , E 1 , E 2 , A, B, D, W, Z, a, b, n, and x are as defined herein, compositions comprising an effective amount of a Substituted Piperidin-4-amino-Type Compound, and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Substituted Piperidin-4-amino-Type Compound.
摘要翻译：本发明涉及式（I）的取代的哌啶-4-基型化合物及其药学上可接受的盐和溶剂合物，其中R1，R2，R3，Q1，Q2，E1，E2，A，B，D，W，Z， a，b，n和x如本文所定义，包含有效量的取代的哌啶-4-氨基型化合物的组合物，以及治疗或预防诸如疼痛的病症的方法，包括对需要的动物施用其有效量的取代的哌啶-4-氨基型化合物。

5. 发明申请

WO2013000488A1 SYSTEMS AND METHODS FOR THE MANAGEMENT AND PROVISION OF RADIOTHERAPY 审中-公开
标题翻译：管理和放射治疗的系统和方法
公开(公告)号：WO2013000488A1
公开(公告)日：2013-01-03
申请号：PCT/EP2011/003170
申请日：2011-06-28
申请人： ELEKTA AB (publ) , BROWN, Kevin
发明人： BROWN, Kevin
IPC分类号： G06F19/00 , A61N5/10
CPC分类号： A61N5/1031 , A61N5/1036 , A61N5/1048 , A61N5/1071 , A61N5/1081 , A61N2005/1074 , G06F19/00 , G06F19/3481 , G16H40/63
摘要： The present invention provides methods and apparatus for the management and provision of radiotherapy, in which values for dosimetric parameters are re-evaluated just prior to treatment (on the basis of the treatment plan as loaded into the radiotherapy apparatus) and during treatment (on the basis of monitored machine parameters). By displaying dosimetric parameters rather than complicated machine parameters, the technician operating the radiotherapy apparatus is able to monitor the dose provided to a patient undergoing therapy. Misadministrations of radiation as a result of corrupted data or corrupted control signals are prevented.
摘要翻译：本发明提供了用于管理和提供放射治疗的方法和装置，其中剂量测量参数的值在治疗之前（基于装载到放射治疗装置中的治疗计划）和治疗期间（在监控机器参数的基础）。通过显示剂量测量参数而不是复杂的机器参数，操作放射治疗装置的技术人员能够监测提供给接受治疗的患者的剂量。由于数据损坏或控制信号损坏导致的辐射管理不当。

6. 发明申请

WO2011050887A1 RADIOTHERAPEUTIC APPARATUS 审中-公开
标题翻译：放射治疗仪
公开(公告)号：WO2011050887A1
公开(公告)日：2011-05-05
申请号：PCT/EP2010/005988
申请日：2010-10-01
申请人： ELEKTA AB (PUBL) , BROWN, Kevin , SMITH, Adrian Maxwell
发明人： BROWN, Kevin , SMITH, Adrian Maxwell
IPC分类号： A61N5/10
CPC分类号： A61N5/1042 , A61N5/1047
摘要： The ability to provide a fine resolution variation in the dose rate of radiotherapeutic apparatus would allow delivery times of VMAT and related techniques to be reduced significantly. A radiotherapeutic apparatus is described, comprising a source of radiation able to issue pulses of radiation at a base frequency, and a control apparatus arranged to permit pulses provided these match a pulse pattern chosen to achieve a selected time-averaged power level, the chosen pulse pattern being one selected from a plurality of pulse patterns that include patterns consisting of trains of pulses that include, relative to the base frequency, at least every n th and every m th pulse where n≠m and the n th and m th pulses are non-coincident. Essentially, such an apparatus issues a pulse if it is the n th or the m th or the k th (etc) where n, m, k... are selectable independently. The pulse pattern can be obtained resolving the selected power level as an integer representable as a binary number, and then inserting an n th pulse if the binary number has a 1 digit at the q th power of 2 where q is the n th digit of the binary carry sequence. The binary carry sequence can be repeated modulo the number of possible output power levels, assuming that the selected power level is one selected from a range of possible output power levels. The control apparatus can a memory in which a table is retained, the table containing the sequence of pulses to be issued. The table can be freshly populated with a sequence when a power level is selected, or the table can contain sequences for a plurality of (preferably all the) power levels and the control unit can be adapted to select a desired sequence.
摘要翻译：提供放射治疗仪器的剂量率的精细分辨率变化的能力将允许显着降低VMAT的传送时间和相关技术。描述了一种放射治疗装置，其包括能够以基本频率发出辐射脉冲的辐射源，以及控制装置，其布置成允许所提供的脉冲匹配所选择的脉冲图案以实现所选择的时间平均功率电平，所选择的脉冲图案是从多个脉冲图案中选出的图案，其包括由脉冲串组成的图案，所述图案包括相对于基本频率的至少每第n个和第m个脉冲，其中n？m和第n和第m个脉冲不重合。本质上，如果它是第n或第m或第k（等），其中n，m，k ...可独立选择，则发出脉冲。可以获得将所选择的功率电平解析为可表示为二进制数的整数的脉冲模式，然后如果二进制数在第二功率为2的第二功率为1的位置插入第n个脉冲，其中q是二进制运算的第n位数序列。假设所选择的功率电平是从可能的输出功率电平的范围中选择的一个，二进制进位序列可以重复模数可能的输出功率电平的数量。控制装置可以是其中保留有表的存储器，该表包含要发出的脉冲序列。当选择功率级时，该表可以用序列新鲜地填充，或者该表可以包含用于多个（优选全部）功率电平的序列，并且控制单元可以适于选择期望的序列。

7. 发明申请

WO2011050822A1 RADIOTHERAPEUTIC APPARATUS 审中-公开
标题翻译：放射治疗仪
公开(公告)号：WO2011050822A1
公开(公告)日：2011-05-05
申请号：PCT/EP2009/007641
申请日：2009-10-26
申请人： ELEKTA AB (publ) , BROWN, Kevin , SMITH, Adrian, Maxwell
发明人： BROWN, Kevin , SMITH, Adrian, Maxwell
IPC分类号： A61N5/10
CPC分类号： A61N5/1042 , A61N5/1047
摘要： The ability to provide a fine resolution variation in the dose rate of radiotherapeutic apparatus would allow delivery times of VMAT and related techniques to be reduced significantly. A radiotherapeutic apparatus is described, comprising a source of radiation able to issue pulses of radiation at a base frequency, and a control apparatus arranged to permit pulses provided these match a pulse pattern chosen to achieve a selected time-averaged power level, the chosen pulse pattern being one selected from a plurality of pulse patterns that include patterns consisting of trains of pulses that include, relative to the base frequency, at least every n th and every m th pulse where n≠m. Essentially, such an apparatus issues a pulse if it is the n th or the m th or the kth (etc) where n, m, k... are selectable independently. The pulse pattern can be obtained resolving the selected power level as an integer representable as a binary number, and then inserting an n th pulse if the binary number has a 1 digit at the q th power of 2 where q is the n th digit of the binary carry sequence. The binary carry sequence can be repeated modulo the number of possible output power levels, assuming that the selected power level is one selected from a range of possible output power levels. The control apparatus can a memory in which a table is retained, the table containing the sequence of pulses to be issued. The table can be freshly populated with a sequence when a power level is selected, or the table can contain sequences for a plurality of (preferably all the) power levels and the control unit can be adapted to select a desired sequence.
摘要翻译：提供放射治疗仪器的剂量率的精细分辨率变化的能力将允许显着降低VMAT的传送时间和相关技术。描述了一种放射治疗装置，其包括能够以基本频率发出辐射脉冲的辐射源，以及控制装置，其布置成允许所提供的脉冲匹配所选择的脉冲图案以实现所选择的时间平均功率电平，所选择的脉冲模式是从包括由相对于基本频率包括相对于基本频率的脉冲串构成的图案的多个脉冲图案中选择的至少每n个和第m个脉冲，其中n？m。本质上，如果它是第n或第m或第k（等），其中n，m，k ...可独立选择，则发出脉冲。可以获得将所选择的功率电平解析为可表示为二进制数的整数的脉冲模式，然后如果二进制数在第二功率为2的第二功率为1的位置插入第n个脉冲，其中q是二进制运算的第n位数序列。假设所选择的功率电平是从可能的输出功率电平的范围中选择的一个，二进制进位序列可以重复模数可能的输出功率电平的数量。控制装置可以是其中保留有表的存储器，该表包含要发出的脉冲序列。当选择功率级时，该表可以用序列新鲜地填充，或者该表可以包含用于多个（优选全部）功率电平的序列，并且控制单元可以适于选择期望的序列。

8. 发明申请

WO2009073167A2 IDENTIFICATION AND DIAGNOSIS OF PULMONARY FIBROSIS USING MUCIN GENES, AND RELATED METHODS AND COMPOSITIONS 审中-公开
标题翻译：用粘蛋白基因鉴定和诊断肺纤维化，及相关的方法和组合物
公开(公告)号：WO2009073167A2
公开(公告)日：2009-06-11
申请号：PCT/US2008/013271
申请日：2008-12-02
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , SCHWARTZ, David A. , BURCH, Lauranell , STEELE, Mark P. , HERRON, Aretha J. , BROWN, Kevin , SCHWARZ, Marvin I. , LLOYD, James E.
发明人： SCHWARTZ, David A. , BURCH, Lauranell , STEELE, Mark P. , HERRON, Aretha J. , BROWN, Kevin , SCHWARZ, Marvin I. , LLOYD, James E.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： Individuals with polymorphisms in MUC5AC are more likely to develop idiopathic interstitial pneumonia (IIP) or pulmonary fibrosis. This discovery provides methods to identify susceptible individuals, and also provides approaches to treatment in this life threatening disease that previously had no known beneficial therapy. Given the relatively high prevalence of some of these SNPs in the general population, it is likely that variants MUC5AC result in susceptibility to other fibroproliferative lung diseases, including asthma, chronic obstructive lung disease, granulomatous lung diseases, and pneumonconioses.
摘要翻译：具有MUC5AC多态性的个体更可能发展特发性间质性肺炎（IIP）或肺纤维化。这一发现提供了识别易感个体的方法，并且还提供了治疗这种危及生命的疾病的方法，而这种疾病以前没有已知的有益疗法。鉴于一般人群中这些SNP中一些SNP的相对较高的流行率，变体MUC5AC可能导致对其他纤维增殖性肺病（包括哮喘，慢性阻塞性肺病，肉芽肿性肺病和肺炎）的易感性。

9. 发明申请

WO2005104429A2 MANAGEMENT AND/OR DISCARD OF STORED DATA 审中-公开
标题翻译：存储数据的管理和/或查询
公开(公告)号：WO2005104429A2
公开(公告)日：2005-11-03
申请号：PCT/US2005/013944
申请日：2005-04-21
申请人： DECRU, INC. , PLOTKIN, Serge , BOJINOV, Hristo, Iankov , BROWN, Kevin
发明人： PLOTKIN, Serge , BOJINOV, Hristo, Iankov , BROWN, Kevin
IPC分类号： H04L9/00
CPC分类号： H04L9/0836 , H04L9/0894
摘要： Embodiments of methods, devices and/or systems for a method of managing the retention and/or discarding of stored data are described.
摘要翻译：描述了用于管理存储数据的保留和/或丢弃的方法的方法，设备和/或系统的实施例。

10. 发明申请

WO2012131520A3 CONTRAST-DEPENDENT RESOLUTION IMAGE 审中-公开
公开(公告)号：WO2012131520A3
公开(公告)日：2012-10-04
申请号：PCT/IB2012/051266
申请日：2012-03-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BROWN, Kevin
发明人： BROWN, Kevin
IPC分类号： G06T5/50 , G06T11/00
摘要： A method for processing one or more reconstructed images includes receiving a first reconstructed image having a first image resolution and receiving a second reconstructed image having a second image resolution. The first resolution is greater than the second resolution. The method further includes generating a contrast-dependent resolution image by combining the first and second reconstructed images single image so that the first reconstructed image contributes to a greater degree to the contrast-dependent resolution image for higher contrasts regions of the images and the second reconstructed image contributes to a greater degree to the contrast-dependent resolution image for lower contrasts regions of the images.

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