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1. 发明申请

WO2008133636A1 DRIVING SCANNING FIBER DEVICES WITH VARIABLE FREQUENCY DRIVE SIGNALS 审中-公开
标题翻译：驱动扫描光纤设备与可变频率驱动信号
公开(公告)号：WO2008133636A1
公开(公告)日：2008-11-06
申请号：PCT/US2007/011480
申请日：2007-05-11
申请人： UNIVERSITY OF WASHINGTON , JOHNSTON, Richard, S.
发明人： JOHNSTON, Richard, S.
IPC分类号： G02B26/10 , G02B6/35 , G02B21/00
CPC分类号： G02B26/10 , A61B1/00006 , A61B1/00172 , G02B6/3508 , G02B21/002
摘要： Methods of moving or vibrating cantilevered optical fibers of scanning fiber devices are disclosed. In one aspect, a method may include vibrating the cantilevered optical fiber at an initial frequency that is substantially displaced from a resonant frequency of the cantilevered optical fiber. Then, the frequency of vibration of the cantilevered optical fiber may be changed over a period of time toward the resonant frequency. Light may be directed through an end of the cantilevered optical fiber while the cantilevered optical fiber is vibrated.
摘要翻译：公开了扫描光纤装置的悬臂光纤的移动或振动方法。在一个方面，一种方法可以包括以基本上从悬臂光纤的谐振频率位移的初始频率振动悬臂光纤。然后，悬臂光纤的振动频率可以在一段时间内朝向谐振频率变化。当悬臂光纤被振动时，光可以被引导通过悬臂光纤的一端。

2. 发明申请

WO2008121143A1 CATHETER WITH IMAGING CAPABILITY ACTS AS GUIDEWIRE FOR CANNULA TOOLS 审中-公开
标题翻译：具有成像能力的导管作为肛门工具的指南
公开(公告)号：WO2008121143A1
公开(公告)日：2008-10-09
申请号：PCT/US2007/065781
申请日：2007-04-02
申请人： UNIVERSITY OF WASHINGTON , SEIBEL, Eric, J. , JOHNSTON, Richard, S. , MELVILLE, Charles, David
发明人： SEIBEL, Eric, J. , JOHNSTON, Richard, S. , MELVILLE, Charles, David
IPC分类号： A61M25/04
CPC分类号： A61M25/01 , A61B10/0233 , A61B10/0266 , A61B10/06 , A61B17/32053 , A61B17/3421 , A61B18/24 , A61B2017/00685 , A61B2017/22038 , A61B2017/22039 , A61B2017/22042 , A61B2017/320008 , A61B2017/320012 , A61B2090/3614 , A61M25/09 , A61M2025/0096
摘要： A catheter having an imaging device on its distal end serves as a guidewire for cannula tools, enabling the tools to be advanced to a desired site in a patient's body. One exemplary embodiment of such a catheter is a scanning fiber endoscope. The images facilitate navigation through linked body lumens and also enable an operator to view a site where a biopsy sample is to be taken with a cannula tool. Exemplary cannula tools include bristles or sharp points that scrub cells from adjacent tissue, a biopsy needle that can be thrust into tissue, a loop that cuts away tissue, a cutting edge that slices tissue from a site, and forceps. The sample can be carried by a bodily or introduced fluid to a proximal end of the catheter through an annular gap between the catheter and the cannula tool, or the cannula tool can retain the sample.
摘要翻译：在其远端具有成像装置的导管用作插管工具的导丝，使得工具能够前进到患者身体中的期望位置。这种导管的一个示例性实施例是扫描光纤内窥镜。图像便于通过连接的体腔导航，并且还使得操作者能够观察使用套管工具将活检样本取出的位置。示例性的套管工具包括从相邻组织洗刷细胞的刷毛或尖锐点，可以推入组织的活检针，切除组织的环，切割来自部位的组织的切割边缘以及镊子。样品可以通过身体或引入的流体通过导管和套管工具之间的环形间隙携带到导管的近端，或者套管工具可以保持样品。

3. 发明申请

WO2006041452A1 REMAPPING METHODS TO REDUCE DISTORTIONS IN IMAGES 审中-公开
标题翻译：减少图像失真的重新取代方法
公开(公告)号：WO2006041452A1
公开(公告)日：2006-04-20
申请号：PCT/US2004/031999
申请日：2004-10-01
申请人： UNIVERSITY OF WASHINGTON , JOHNSTON, Richard, S.
发明人： JOHNSTON, Richard, S.
IPC分类号： H01J40/14
CPC分类号： A61B1/00172 , A61B1/00009 , A61B1/0002 , A61B1/00057 , A61B5/0062 , G02B2006/0098
摘要： The present invention provides software, methods, and systems for characterizing an actual scan pattern (60) of a scanning beam device (10). The characterization of the actual scan pattern (60) may be used in an image remapping method and/or a drive signal remapping method to reduce distortions in an image.
摘要翻译：本发明提供用于表征扫描光束装置（10）的实际扫描图案（60）的软件，方法和系统。实际扫描图案（60）的表征可以用于图像重映射方法和/或驱动信号重映射方法中以减少图像中的失真。

4. 发明申请

WO2008111970A1 SIDE VIEWING OPTICAL FIBER ENDOSCOPE 审中-公开
标题翻译：侧视光纤内窥镜
公开(公告)号：WO2008111970A1
公开(公告)日：2008-09-18
申请号：PCT/US2007/063698
申请日：2007-03-09
申请人： UNIVERSITY OF WASHINGTON , SEIBEL, Eric, J. , JOHNSTON, Richard, S. , MELVILLE, Charles, David , CROSSMAN-BOSWORTH, Janet, L.
发明人： SEIBEL, Eric, J. , JOHNSTON, Richard, S. , MELVILLE, Charles, David , CROSSMAN-BOSWORTH, Janet, L.
IPC分类号： A61B6/00
CPC分类号： A61B1/07 , A61B1/0008 , A61B1/00096 , A61B1/00098 , A61B1/00165 , A61B1/00172 , A61B1/00177 , A61B1/00179 , A61B1/05 , A61B1/051 , A61B1/0615 , A61B1/0623 , G02B23/2423 , G02B23/2469 , G02B23/2484 , G02B26/103
摘要： An optical fiber conveys light from a source at a proximal end, to a distal end, where a piezoelectric material tube applies a force that causes the distal end of the optical fiber to scan in a desired pattern. Light from the distal end of the optical fiber passes through a lens system and is at least partially reflected by a reflective surface toward a side of the scope, to illuminate tissue within a patient's body. Light received from the internal tissue is reflected back either to collection optical fibers, which convey the light to proximally disposed optical detectors, or directly toward distal optical detectors. The optical detectors produce electrical signals indicative of an intensity of the light that can be used for producing an image of the internal tissue. The light received from the tissue can be either scattered, polarized, fluorescent, or filtered, depending on the illumination light.
摘要翻译：光纤将光从近端传送到远端，其中压电材料管施加使光纤的远端以期望的图案扫描的力。来自光纤的远端的光通过透镜系统，并且至少部分地被反射表面朝向镜的一侧反射，以照射患者体内的组织。从内部组织接收的光被反射回收集光纤，其将光传送到近端设置的光学检测器，或直接朝向远端光学检测器。光学检测器产生指示可用于产生内部组织的图像的光强度的电信号。根据照明光，从组织接收的光可以是散射的，偏振的，荧光的或过滤的。

5. 发明申请

WO2008033168A1 TEMPERATURE ADJUSTMENT IN SCANNING BEAM DEVICES 审中-公开
标题翻译：扫描光束装置温度调整
公开(公告)号：WO2008033168A1
公开(公告)日：2008-03-20
申请号：PCT/US2007/009598
申请日：2007-04-20
申请人： UNIVERSITY OF WASHINGTON , JOHNSTON, Richard, S. , MELVILLE, Charles, David
发明人： JOHNSTON, Richard, S. , MELVILLE, Charles, David
IPC分类号： A61B1/00 , G02B23/24 , G02B26/10
CPC分类号： G02B7/008 , A61B1/06 , G02B26/10
摘要： Scanning beam devices are disclosed. In one aspect, an apparatus may include a housing having a transparent portion. A scanning optical element may be enclosed within the housing. Light may be directed between the scanning optical element and the transparent portion of the housing. The device may include a temperature adjustment device to adjust a temperature within the housing. Methods of using such apparatus are also disclosed, as are base stations to control the adjustment of the temperature.
摘要翻译：公开了扫描光束装置。一方面，装置可以包括具有透明部分的壳体。扫描光学元件可以封装在壳体内。光可以被引导在扫描光学元件和壳体的透明部分之间。该装置可以包括温度调节装置，以调节壳体内的温度。还公开了使用这种装置的方法，以及用于控制温度调节的基站也是如此。

6. 发明申请

WO2007024221A1 DISTANCE DETERMINATION IN A SCANNED BEAM IMAGE CAPTURE DEVICE 审中-公开
标题翻译：扫描光束图像捕获设备中的距离确定
公开(公告)号：WO2007024221A1
公开(公告)日：2007-03-01
申请号：PCT/US2005/030109
申请日：2005-08-23
申请人： UNIVERSITY OF WASHINGTON , JOHNSTON, Richard, S.
发明人： JOHNSTON, Richard, S.
IPC分类号： G01N21/86
CPC分类号： G01S17/42 , G02B6/2817 , G02B6/3502 , G02B6/3566 , G02B6/3578
摘要： Methods, systems and devices can determine spatial relationships between a probe (100) and a target surface (74). Specular reflections from the target surface vary dramatically with small changes in angle between the scanning beam and the target surface, and as the geometry of the beam scanner (90) and light detector (92) of the probe are often known, and as the angle of the light beam projected from a scanner for accurately generating an image, the pattern of spectral light reflected from the light beam directly back to the detector allows the distance between the probe and the target surface, and/or the angular relationship between the probe and the target surface, to be calculated.
摘要翻译：方法，系统和装置可以确定探针（100）和目标表面（74）之间的空间关系。目标表面的镜面反射随着扫描光束与目标表面之间角度的小变化而急剧变化，并且由于探头的光束扫描器（90）和光检测器（92）的几何形状常常是已知的，并且作为角度从扫描仪投影的光束以精确地产生图像，从光束直接反射到检测器的光谱图的图案允许探针与目标表面之间的距离和/或探针与目标表面之间的角度关系目标表面，待计算。

7. 发明申请

WO2013109978A1 DENTAL DEMINERALIZATION DETECTION, METHODS AND SYSTEMS 审中-公开
标题翻译：牙齿脱细胞检测，方法和系统
公开(公告)号：WO2013109978A1
公开(公告)日：2013-07-25
申请号：PCT/US2013/022286
申请日：2013-01-18
申请人： UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION , SEIBEL, Eric, J. , ZHANG, Liang , JOHNSTON, Richard, S. , MELVILLE, Charles, D. , NELSON, Leonard , LEE, Cameron, M. , BERG, Joel
发明人： SEIBEL, Eric, J. , ZHANG, Liang , JOHNSTON, Richard, S. , MELVILLE, Charles, D. , NELSON, Leonard , LEE, Cameron, M. , BERG, Joel
IPC分类号： G01J3/40
CPC分类号： A61B5/0088 , A61B1/00009 , A61B1/00096 , A61B1/00142 , A61B1/015 , A61B1/07 , A61B1/247 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/4547 , A61C19/04 , G01J3/0205 , G01J3/0218 , G01J3/06 , G01J3/10 , G01J3/4406 , G01N21/645 , G01N21/6486 , G01N2021/6421 , G01N2021/6484 , G01N2021/6493
摘要： Methods and systems for detecting early stage dental caries and decays are provided. In particular, in an embodiment, laser-induced autofluorescence (AF) from multiple excitation wavelengths is obtained and analyzed. Endogenous fluorophores residing in the enamel naturally fluoresce when illuminated by wavelengths ranging from ultraviolet into the visible spectrum. The relative intensities of the AF emission changes between different excitation wavelengths when the enamel changes from healthy to demineralized. By taking a ratio of AF emission spectra integrals between different excitation wavelengths, a standard is created wherein changes in AF ratios within a tooth are quantified and serve as indicators of early stage enamel demineralization. The techniques described herein may be used in conjunction with a scanning fiber endoscope (SFE) to provide a reliable, safe and low-cost means for identifying dental caries or decays.
摘要翻译：提供了检测早期龋齿和衰老的方法和系统。特别地，在一个实施例中，获得并分析来自多个激发波长的激光诱导自发荧光（AF）。当从紫外线到可见光谱的波长照射时，驻留在釉质中的内源性荧光团自然发荧光。当釉质从健康变为软化时，AF发射的相对强度在不同的激发波长之间变化。通过采用不同激发波长之间的AF发射光谱积分的比例，创建了一个标准，其中牙齿内AF比的变化被量化并用作早期釉质脱矿质的指标。本文描述的技术可以与扫描光纤内窥镜（SFE）一起使用，以提供用于识别龋齿或衰变的可靠，安全和低成本的方法。

8. 发明申请

WO2009045199A1 REDUCING DISTORTION IN SCANNING FIBER DEVICES 审中-公开
标题翻译：减少扫描光纤设备的失真
公开(公告)号：WO2009045199A1
公开(公告)日：2009-04-09
申请号：PCT/US2007/021604
申请日：2007-10-09
申请人： UNIVERSITY OF WASHINGTON , JOHNSTON, Richard, S. , MELVILLE, Charles, David
发明人： JOHNSTON, Richard, S. , MELVILLE, Charles, David
IPC分类号： G02B26/10 , G02B23/26 , A61B1/045 , A61B1/05 , A61B1/07
CPC分类号： G02B26/101 , A61B1/00096 , A61B1/00172 , A61B1/07 , G02B23/2469 , G02B23/2476 , G02B26/103
摘要： Methods of reducing distortion in scanning fiber devices are disclosed. In one aspect, a method includes changing an intensity of light transmitted through a cantilevered optical fiber (134) of a scanning fiber device (130). The method also includes changing a setpoint temperature for the scanning fiber device based at least in part on the change in the intensity of the light. Other methods, apparatus, systems, and machine-readable mediums are also disclosed.
摘要翻译：公开了减少扫描光纤器件失真的方法。一方面，一种方法包括改变透过扫描光纤装置（130）的悬臂光纤（134）的光的强度。该方法还包括至少部分地基于光的强度变化来改变扫描光纤装置的设定点温度。还公开了其它方法，装置，系统和机器可读介质。

9. 发明申请

WO2008136800A1 COORDINATING IMAGE ACQUISITION AMONG MULTIPLE ENDOSCOPES 审中-公开
标题翻译：在多个内镜下协调图像采集
公开(公告)号：WO2008136800A1
公开(公告)日：2008-11-13
申请号：PCT/US2007/011479
申请日：2007-05-11
申请人： UNIVERSITY OF WASHINGTON , JOHNSTON, Richard, S. , KARASAWA, Satoshi
发明人： JOHNSTON, Richard, S. , KARASAWA, Satoshi
IPC分类号： A61B1/045 , A61B5/00
CPC分类号： A61B1/045 , A61B1/00172 , A61B5/0062 , A61B5/0084
摘要： Coordinating image acquisition among multiple endoscopes is disclosed. A method may include acquiring an image of a surface with a first endoscope system by illuminating the surface with light, collecting backscattered light, and generating the image based on the collected backscattered light. An intensity of the light from the first endoscope system may be reduced. While the intensity of the light is reduced, an image of the surface may be acquired with a second, scanning beam endoscope system by scanning a beam of light over the surface and collecting backscattered light at different times while the beam is scanned over the surface. In one aspect, a coordination signal may be exchanged between the endoscope systems to coordinate the image acquisition. In another aspect, the image acquisition may be coordinated through the scanning beam endoscope system detecting the intensity reduction. Apparatus useful in performing such methods are also disclosed.
摘要翻译：公开了多个内窥镜之间的协调图像采集。方法可以包括通过用光照射表面来采集第一内窥镜系统的图像，收集反向散射的光，并且基于所收集的反向散射光产生图像。可以减少来自第一内窥镜系统的光的强度。当光的强度降低时，可以用第二扫描光束内窥镜系统通过在表面上扫描光束并在波束在表面上扫描的同时收集反向散射光，从而获得表面的图像。在一个方面，可以在内窥镜系统之间交换协调信号以协调图像采集。另一方面，可以通过检测强度降低的扫描光束内窥镜系统来协调图像采集。还公开了用于执行这些方法的装置。

10. 发明申请

WO2008085186A1 SCANNING BEAM DEVICE CALIBRATON 审中-公开
标题翻译：扫描光束设备校准
公开(公告)号：WO2008085186A1
公开(公告)日：2008-07-17
申请号：PCT/US2007/009597
申请日：2007-04-20
申请人： UNIVERSITY OF WASHINGTON , JOHNSTON, Richard, S.
发明人： JOHNSTON, Richard, S.
IPC分类号： A61B1/00 , A61B19/00
CPC分类号： G06T7/11 , A61B1/00057 , A61B1/00096 , A61B1/00172 , A61B5/0062 , G06K9/209 , G06K9/30 , G06T7/80 , G06T2207/10068
摘要： Scanning beam device calibration using a calibration pattern is disclosed. In one aspect, a method may include acquiring an image of a calibration pattern using a scanning beam device. The acquired image may be compared with a representation of the calibration pattern. The scanning beam device may be calibrated based on the comparison. Software and apparatus to perform these and other calibration methods are also disclosed.
摘要翻译：公开了使用校准图案扫描光束装置校准。在一个方面，一种方法可以包括使用扫描光束装置获取校准图案的图像。所获取的图像可以与校准图案的表示进行比较。可以基于比较来校准扫描光束装置。还公开了执行这些和其他校准方法的软件和装置。

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