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91. 发明申请

US20170166569A1 Asparagine Endopeptidase (AEP) Inhibitors for Managing Cancer and Compositions Related Thereto 审中-公开
公开(公告)号：US20170166569A1
公开(公告)日：2017-06-15
申请号：US15303481
申请日：2015-04-08
申请人： Emory University
发明人： Keqiang Ye , Haian Fu , Yuhong Du
IPC分类号： C07D473/06 , A61K31/522 , A61K31/433 , C07D285/135 , A61K31/4015 , C07D207/452 , A61K31/496 , C07D257/04 , A61K31/47 , C07D215/06 , A61K31/5355 , C07D273/02 , A61K31/4168 , C07D277/54 , C07D471/04 , A61K31/519 , A61K45/06
摘要： This disclosure relates to asparagine endopeptidase inhibitors for managing cancer and compositions related thereto. In certain embodiments, the asparagine endopeptidase inhibitors are substituted 3,7-dihydropurine-2,6-dione derivatives useful for treating or preventing metastasis, tumor growth, and/or cancer. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising an asparagine endopeptidase inhibitor and a pharmaceutically acceptable excipient. In certain embodiments, the disclosure relates to methods of treating a cancer comprising administering an effective amount of pharmaceutical composition a asparagine endopeptidase inhibitor disclosed herein to a subject in need thereof.

92. 发明授权

US09669092B2 Antagonism of the VIP signaling pathway 有权
公开(公告)号：US09669092B2
公开(公告)日：2017-06-06
申请号：US13979003
申请日：2012-01-31
申请人： Edmund K. Waller , Jian-Ming Li , Mohammad S. Hossain
发明人： Edmund K. Waller , Jian-Ming Li , Mohammad S. Hossain
IPC分类号： A61K39/395 , A61K35/14 , A61K38/04 , A61K39/245 , A61K38/22 , A61K38/16 , A61K35/17
CPC分类号： A61K39/3955 , A61K35/14 , A61K35/17 , A61K38/04 , A61K38/16 , A61K38/2278 , A61K39/245 , Y02A50/467
摘要： Inhibition of the VIP signaling pathway using VIP antagonists is contemplated. Methods of treating or preventing a viral infection comprising administering a VIP antagonist to a subject in need thereof are also contemplated.

93. 发明授权

US09662208B2 Devices and methods for surgical and percutaneous repair of heart valve lesions 有权
公开(公告)号：US09662208B2
公开(公告)日：2017-05-30
申请号：US13978904
申请日：2012-01-25
申请人： Saimuralidhar Padala , Vinod H. Thourani
发明人： Saimuralidhar Padala , Vinod H. Thourani
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/2454 , A61F2/2457 , A61F2/246 , A61F2250/0003
摘要： The devices and methods relate to surgical and percutaneous repair of heart valve regions. The devices may be structured to conform to the desired shape of a specific patient. The devices may include a frame and an artificial body onto which leaflets of the valve may coapt or rest.

94. 发明申请

US20170146520A1 METHODS FOR THE TREATMENT OF INFECTIONS AND TUMORS 审中-公开
公开(公告)号：US20170146520A1
公开(公告)日：2017-05-25
申请号：US15425856
申请日：2017-02-06
申请人： Emory University , Dana-Farber Cancer Institute, Inc.
发明人： Rafi Ahmed , Rama Amara , Vijayakumar Velu , Kehmia Titanji , Gordon Freeman
IPC分类号： G01N33/50 , A61K39/00 , A61K39/12 , C07K16/28 , C12N15/113
CPC分类号： G01N33/5052 , A61K31/7105 , A61K39/0011 , A61K39/12 , A61K39/39 , A61K39/39541 , A61K2039/505 , A61K2039/507 , A61K2039/55516 , C07K16/2803 , C07K16/2818 , C07K16/2827 , C07K2317/24 , C07K2317/74 , C07K2317/76 , C12N15/1138 , C12N2310/14 , C12N2760/10034 , G01N33/5088 , G01N33/56966 , G01N2333/52 , G01N2800/26 , Y02A50/41 , A61K2300/00
摘要： PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced using these PD-1 antagonists in conjunction with an antigen from the infectious agent or tumor. Thus, subjects with infections, such as persistent infections can be treated using PD-1 antagonists. In addition, subjects with tumors can be treated using the PD-1 antagonists. In several examples, subjects can be treated by transplanting a therapeutically effective amount of activated T cells that recognize an antigen of interest and by administering a therapeutically effective amount of a PD-1 antagonist. Methods are also disclosed for determining the efficacy of a PD-1 antagonist in a subject administered the PD-1 antagonist. In some embodiments, these methods include measuring proliferation of memory B cells in a sample from a subject administered the PD-1 antagonist.

95. 发明授权

US09616070B2 Use of GABAA receptor antagonists for the treatment of excessive sleepiness and disorders associated with excessive sleepiness 有权
公开(公告)号：US09616070B2
公开(公告)日：2017-04-11
申请号：US12922044
申请日：2009-03-12
申请人： Kathy P. Parker , David B. Rye , Andrew Jenkins
发明人： Kathy P. Parker , David B. Rye , Andrew Jenkins
IPC分类号： A61K31/5517 , A61K31/70
CPC分类号： A61K31/5517 , A61K9/0014 , A61K9/0019 , A61K9/006 , A61K9/06 , A61K9/08 , A61K9/20 , A61K31/70
摘要： GABAA receptor mediated hypersomnia can be treated by administering a GABAA receptor antagonist (e.g., flumazenil; clarithromycin; picrotoxin; bicuculline; cicutoxin; and oenanthotoxin). In some embodiments, the GABAA receptor antagonist is flumazenil or clarithromycin. The GABAA receptor mediated hypersomnia includes shift work sleep disorder, obstructive sleep apnea/hypopnea syndrome, narcolepsy, excessive sleepiness, hypersomnia (e.g., idiopathic hypersomnia; recurrent hypersonmia; endozepine related recurrent stupor; and amphetamine resistant hypersonmia), and excessive sleepiness associated with shift work sleep disorder, obstructive sleep apnea/hypopnea syndrome, and hypersomnia (e.g., idiopathic hypersomnia; recurrent hypersomnia; endozepine related recurrent stupor; and amphetamine resistant hypersomnia.

96. 发明授权

US09593125B2 Heterocyclic flavone derivatives, compositions, and methods related thereto 有权
标题翻译：杂环黄酮衍生物，组合物及其相关方法
公开(公告)号：US09593125B2
公开(公告)日：2017-03-14
申请号：US14410756
申请日：2013-07-25
申请人： EMORY UNIVERSITY
发明人： Keqiang Ye
IPC分类号： C07D491/052 , A61K45/06 , C07D491/06 , A61K31/353 , C07D311/30 , A61K31/4188
CPC分类号： A61K31/352 , A61K31/353 , A61K31/407 , A61K31/4188 , A61K31/5377 , A61K45/06 , C07D311/30 , C07D491/052 , C07D491/06 , A61K2300/00
摘要： In certain embodiments, the disclosure relates to heterocyclic flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of 5 treating or preventing diseases or conditions related to BDNF and TrkB activity, such as depression, stroke, Rett syndrome, Parkinson's disease, and Alzheimer's disease by administering effective amounts of pharmaceutical compositions comprising compounds disclosed herein to a subject in need thereof.
摘要翻译：在某些实施方案中，本公开涉及杂环黄酮衍生物，例如由本文提供的式所述的那些，药物组合物及其相关方法。在某些实施方案中，本公开涉及通过施用有效量的包含本文公开的化合物的药物组合物来治疗或预防与BDNF和TrkB活性相关的疾病或病症，例如抑郁症，中风，Rett综合征，帕金森病和阿尔茨海默氏病的方法涉及有需要的受试者。

97. 发明授权

US09592226B2 Solenopsin and derivatives, therapeutic compositions; and methods related thereto 有权
标题翻译：索伦膦及其衍生物，治疗组合物; 和相关的方法
公开(公告)号：US09592226B2
公开(公告)日：2017-03-14
申请号：US14794094
申请日：2015-07-08
申请人： EMORY UNIVERSITY , MERCER UNIVERSITY , UNION UNIVERSITY
发明人： Jack L. Arbiser , J. Philip Bowen , E. Blake Watkins
IPC分类号： A61K31/445 , C07D211/10 , A61K45/06 , C07D211/40 , C07D211/22
CPC分类号： A61K31/445 , A61K45/06 , C07D211/10 , C07D211/22 , C07D211/40 , A61K2300/00
摘要： This disclosure relates to solenopsin derivatives, pharmaceutical compositions, and therapeutic uses related thereto. In certain embodiments, the disclosure relates to compounds of the following formula: or salts, esters or prodrugs thereof as described herein.
摘要翻译：本公开内容涉及与其相关的依卡鲁汀衍生物，药物组合物和治疗用途。在某些实施方案中，本公开涉及如本文所述的下式的化合物或其盐，酯或前药。

98. 发明授权

US09510948B2 Systems, devices and methods for repair of heart valve lesions 有权
标题翻译：用于修复心脏瓣膜病变的系统，装置和方法
公开(公告)号：US09510948B2
公开(公告)日：2016-12-06
申请号：US14343183
申请日：2012-09-07
申请人： Saimuralidhar Padala
发明人： Saimuralidhar Padala
IPC分类号： A61F2/24
CPC分类号： A61F2/2457 , A61F2/246 , A61F2/2463 , A61F2/2466 , A61F2230/0054 , A61F2230/0093 , A61F2250/0003 , A61F2250/006
摘要： The systems and devices and methods relate to surgical and percutaneous repair of heart valve regions. The systems and devices are structured to conform to the desired shape of a specific patient. The devices may include a mounting structure and a valve support onto which leaflets of the valve may coapt or rest. The devices may be structured to be mounted directly onto a leaflet of the valve.
摘要翻译：系统和装置和方法涉及心脏瓣膜区域的手术和经皮修复。系统和装置被构造成符合特定患者的期望形状。这些装置可以包括安装结构和阀支撑件，瓣膜的小叶可以在其上进行辅助或休息。这些装置可以被构造成直接安装在瓣膜的小叶上。

99. 发明授权

US09499489B2 Myxovirus therapeutics, compounds, and uses related thereto 有权
标题翻译：粘液病毒治疗剂，化合物和与之相关的用途
公开(公告)号：US09499489B2
公开(公告)日：2016-11-22
申请号：US14352176
申请日：2012-10-24
申请人： Richard K. Plemper , James P. Snyder , Aiming Sun
发明人： Richard K. Plemper , James P. Snyder , Aiming Sun
IPC分类号： C07D231/14 , C07D401/12
CPC分类号： C07D231/14 , A61K31/635 , A61K47/10 , A61K47/40 , C07D401/12
摘要： This disclosure relates to antiviral compounds disclosed herein and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions. Typically, the pharmaceutical composition comprises a compound of formula I: Formula I, or salt, prodrug, or ester thereof wherein X, Y, and R1 and R10 to R13 are described herein.

100. 发明授权

US09486643B2 Methods, systems and computer readable storage media storing instructions for image-guided treatment planning and assessment 有权
标题翻译：方法，系统和计算机可读存储介质存储图像指导治疗计划和评估的指令
公开(公告)号：US09486643B2
公开(公告)日：2016-11-08
申请号：US14100584
申请日：2013-12-09
申请人： EMORY UNIVERSITY
发明人： Timothy H. Fox , Eduard Schreibmann
IPC分类号： G06K9/00 , A61N5/10
CPC分类号： A61N5/1031
摘要： Methods, systems and computer-readable storage media relate to image-guided treatment planning and treatment assessment. The methods, systems, and the computer-readable storage medias according to embodiments can analyze treatment response and can determine an accurate, outcome-based response assessment of treatment (e.g., radiation treatment). The methods may include a method for determining a treatment response. The method may include registering at least a first image data and a second image data of a subject, the first image data corresponding to a first time point, the second image data corresponding to a second time point, the first time point and the second time point being different with respect to a treatment session and/or treatment stage. The method may include processing the registered image to determine a treatment response. The registering may be based on deformable registration.
摘要翻译：方法，系统和计算机可读存储介质涉及图像指导治疗计划和治疗评估。根据实施例的方法，系统和计算机可读存储介质可以分析治疗响应并且可以确定治疗（例如，放射治疗）的准确的基于结果的响应评估。所述方法可以包括用于确定治疗反应的方法。该方法可以包括登记对象的至少第一图像数据和第二图像数据，对应于第一时间点的第一图像数据，对应于第二时间点的第二图像数据，第一时间点和第二时间点在治疗阶段和/或治疗阶段是不同的。该方法可以包括处理注册的图像以确定治疗响应。注册可以基于可变形注册。

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