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91. 发明授权

US08487118B2 Cyclic diones and their use as insecticides, acaricides and/or fungicides 失效
标题翻译：环己二酮及其作为杀虫剂，杀螨剂和/或杀真菌剂的用途
公开(公告)号：US08487118B2
公开(公告)日：2013-07-16
申请号：US13145195
申请日：2010-01-14
申请人： Thomas Bretschneider , Reiner Fischer , Stefan Lehr , Jürgen Benting , Arnd Voerste
发明人： Thomas Bretschneider , Reiner Fischer , Stefan Lehr , Jürgen Benting , Arnd Voerste
IPC分类号： C07D311/00 , C07C39/00 , A01N25/34 , A01M1/24
CPC分类号： A01N35/06 , A01N41/10 , A01N43/16 , A01N43/18
摘要： The present invention relates to the use of compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, X, n and G have the meanings given above as insecticides and/or acaricides and/or fungicides.
摘要翻译：本发明涉及式（I）化合物的用途，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，X，n和G具有上述作为杀虫剂和/或杀螨剂和/ 杀菌剂。

92. 发明授权

US08481760B2 Inhibition and treatment of prostate cancer metastasis 有权
标题翻译：抑制和治疗前列腺癌转移
公开(公告)号：US08481760B2
公开(公告)日：2013-07-09
申请号：US12578137
申请日：2009-10-13
申请人： Raymond C. Bergan , Karl A. Scheidt
发明人： Raymond C. Bergan , Karl A. Scheidt
IPC分类号： C07D311/00 , A61K31/35
CPC分类号： C07D311/38 , A61K31/37
摘要： The present invention provides compounds and methods of inhibiting and treating metastatic prostate cancer. The compounds include MEK4 inhibitors. In another aspect the invention provides methods of identifying inhibitors of metastatic prostate cancer by screening for inhibitors of MEK4.
摘要翻译：本发明提供了抑制和治疗转移性前列腺癌的化合物和方法。这些化合物包括MEK4抑制剂。另一方面，本发明提供通过筛选MEK4抑制剂来鉴定转移性前列腺癌抑制剂的方法。

93. 发明授权

US08461361B2 Chroman derivatives, medicaments and use in therapy 有权
公开(公告)号：US08461361B2
公开(公告)日：2013-06-11
申请号：US13415697
申请日：2012-03-08
申请人： Andrew Heaton , Alan Husband
发明人： Andrew Heaton , Alan Husband
IPC分类号： C07D311/00 , C07D307/77
CPC分类号： A61K31/353 , A23L33/105 , A61K31/282 , A61K31/337 , A61K31/37 , A61K31/4745 , A61K31/655 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K41/0038 , A61N5/10 , A61N2005/1098 , C07D311/38 , C07D311/58 , C07D311/62
摘要： Novel chroman derivatives and intermediate compounds, compositions containing same, methods for their preparation and uses thereof as therapeutic agents particularly as anti-cancer and chemotherapeutic selective agents are described.

94. 发明授权

US08431727B2 Process for the manufacture of chroman derivatives, especially α-tocopherol and alka-noates thereof 有权
公开(公告)号：US08431727B2
公开(公告)日：2013-04-30
申请号：US12381127
申请日：2009-03-06
申请人： Werner Bonrath , Yann Foricher , Thomas Netscher , Angela Wildermann
发明人： Werner Bonrath , Yann Foricher , Thomas Netscher , Angela Wildermann
IPC分类号： C07D311/00 , B01J27/06 , B01J27/135
CPC分类号： C07D311/72
摘要： The present invention relates to novel processes for the manufacture of chroman derivatives such as α-tocopherol (TCP) and alkanoates thereof, especially α-tocopheryl acetate (TCPA), whereby at least one step of the processes is carried out in the presence of a Lewis acid or a mixture of a Lewis acid with a Bronsted acid as the catalyst under pressure, preferably at an absolute pressure of at least 1.1 bar.As starting materials for the manufacture of TCP and its alkanoates either a mixture of 2,3,5-trimethylhydroquinone (TMHQ) or 2,3,6-trimethylhydroquinone-1-alkanoate (TMHQA) and a compound selected from the group consisting of phytol (PH), isophytol (IP) and (iso)phytol derivatives or 2-phytyl-3,5,6-trimethyl-hydroquinone (PTMHQ)/3-phytyl-2,5,6-trimethylhydroquinone-1-alkanoate (PTMHQA) and/or an isomer thereof are used.Suitable Lewis acids are indium(III) salts and scandium(III) salts. Suitable acid mixtures are iron/iron(II) chloride/hydrogen chloride and zinc(II) chloride/hydrogen chloride.

95. 发明授权

US08420838B2 Process for the rectification of mixtures of high-boiling air- and/or temperature-sensitive useful products 有权
标题翻译：高沸点空气和/或温度敏感有用产品混合物的精馏方法
公开(公告)号：US08420838B2
公开(公告)日：2013-04-16
申请号：US12911200
申请日：2010-10-25
申请人： Juan Herguijuela , Werner Pietzonka , Angela Wildermann , Thomas Wolf
发明人： Juan Herguijuela , Werner Pietzonka , Angela Wildermann , Thomas Wolf
IPC分类号： C07D311/00 , B01D3/14
CPC分类号： B01D3/143 , B01D3/32 , B01D5/0063 , C07D311/72
摘要： According to the invention, a process for the rectification of mixtures of high-boiling air- and/or temperature-sensitive substances which require a high separation efficiency is proposed, in particular a process for the working-up of a VE- or VEA-containing product stream. The process is characterized in particular in that, in a first purification stage, low-boiling products and unspecified isomers of the useful product are separated from the product stream virtually without loss of useful product and that, in a second purification stage, the useful product is removed in a stream having a purity of >97% by weight and a further stream having a purity of >92% by weight. A preferred embodiment of the process serves for working up VEA, in which the loss of useful product in the first purification stage is less than 5%, based on that amount of VEA in the feed which is added to the purification stage per unit time. Furthermore, the first purification stage may comprise a rectification column (1), from the top (1a) of which the low-boiling products and the unspecified isomers of VEA are taken off, a stream containing the useful product in purified form being taken off at the side (15) and/or at the bottom (1b) of the column (1).
摘要翻译：根据本发明，提出了需要高分离效率的高沸点空气和/或温度敏感物质的混合物的精馏方法，特别是用于处理VE-或VEA- 含有产品流。该方法的特征在于，在第一纯化阶段中，将有用产物的低沸点产物和未指定的异构体与产物流分离，实际上不损失有用的产物，并且在第二纯化阶段中，有用的产物在纯度> 97％重量的物流中除去，另一种纯度> 92％（重量）的物流。该方法的优选实施方案用于处理VEA，其中基于每单位时间添加到纯化阶段的进料中的VEA量，第一纯化阶段中有用产物的损失小于5％。此外，第一纯化阶段可以包括精馏塔（1），从其顶部（1a）排出低沸点产物和VEA的未指定的异构体，将含有纯化形式的有用产物的料流取出在塔（1）的侧面（15）和/或底部（1b）处。

96. 发明授权

US08329927B2 Water-soluble and water-insoluble, ring opening metathesis polymerization products, monomers and related methods 有权
标题翻译：水溶性和水不溶性，开环易位聚合产物，单体及相关方法
公开(公告)号：US08329927B2
公开(公告)日：2012-12-11
申请号：US12234180
申请日：2008-09-19
申请人： Gregory N. Tew , Ahmad Emad-Eldin Madkour , Sterling Fitzgerald Alfred , Paralee Patten King , Semra Colak
发明人： Gregory N. Tew , Ahmad Emad-Eldin Madkour , Sterling Fitzgerald Alfred , Paralee Patten King , Semra Colak
IPC分类号： C07D311/00 , C07C69/753
CPC分类号： C08F232/08 , C07C229/14 , C07C309/14 , C07C2602/42 , C07D493/08 , C07D493/18 , C07D519/00 , C07F9/3808 , C08F232/04 , C08F234/02 , C08G61/08 , C08G61/12
摘要： The invention provides certain novel water-soluble and water-insoluble monomers for ring opening metathesis polymerization and novel polymers, compositions and products, and related methods thereof.
摘要翻译：本发明提供一些用于开环易位聚合的新型水溶性和水不溶性单体，以及新型聚合物，组合物和产品及其相关方法。

97. 发明授权

US08263790B2 Method for enantioselective hydrogenation of chromenes 有权
标题翻译：色烯的对映选择性氢化方法
公开(公告)号：US08263790B2
公开(公告)日：2012-09-11
申请号：US13150414
申请日：2011-06-01
申请人： Kenneth David Reginald Setchell , Victor Dmitrievich Sorokin
发明人： Kenneth David Reginald Setchell , Victor Dmitrievich Sorokin
IPC分类号： C07D311/00
CPC分类号： C07D311/58 , C07D311/04 , C07D311/38
摘要： A method for preparing an enantiomeric chromane, by asymmetrically hydrogenating a chromene compound in the presence of an Ir catalyst having a chiral ligand. The method includes the enantioselective preparation of enantiomeric equol. A preferred Ir catalyst has a chiral phosphineoxazoline ligand. Enantiomeric chromanes of high stereoselective purity can be obtained.
摘要翻译：通过在具有手性配体的Ir催化剂的存在下不对称地氢化色烯化合物来制备对映异构体色烷的方法。该方法包括对映体雌马酚的对映选择性制备。优选的Ir催化剂具有手性膦腈恶唑啉配体。可以获得高立体选择性纯度的对映异构体。

98. 发明申请

US20120192880A1 TOBACCO-DERIVED CASING COMPOSITION 有权
标题翻译：烟草衍生化妆品组合物
公开(公告)号：US20120192880A1
公开(公告)日：2012-08-02
申请号：US13015744
申请日：2011-01-28
申请人： Michael Francis Dube , William Monroe Coleman, III
发明人： Michael Francis Dube , William Monroe Coleman, III
IPC分类号： A24B15/30 , C07D401/04 , C07C45/90 , C07D307/48 , C07D311/00 , A24B15/10 , C07D213/63
CPC分类号： A24B13/00 , A24B15/10 , A24B15/24 , A24B15/302
摘要： The invention provides a tobacco composition for use in a smoking article or a smokeless tobacco composition that comprises an extract derived from a component of a plant of the Nicotiana species. The invention also provides smoking articles and smokeless tobacco compositions that include the extracts described herein, and methods for preparing extracts derived from a component of a plant of the Nicotiana species for addition to a tobacco composition.
摘要翻译：本发明提供一种用于吸烟制品或无烟烟草组合物的烟草组合物，其包含衍生自烟草属植物的组分的提取物。本发明还提供了包含本文所述提取物的吸烟制品和无烟烟草组合物，以及用于制备来自烟草属植物的组分的提取物的方法，用于添加到烟草组合物中。

99. 发明申请

US20120123129A1 Cyclopentanedione Compounds and Their Use as Insecticides, Acaricides and/or Fungicides 有权
标题翻译：环戊二酮化合物及其作为杀虫剂，杀螨剂和/或杀真菌剂的用途
公开(公告)号：US20120123129A1
公开(公告)日：2012-05-17
申请号：US13319035
申请日：2010-04-28
申请人： Alfred ANGERMANN
发明人： Alfred ANGERMANN
IPC分类号： C07D311/00 , C07D405/10 , C07D407/10 , C07D409/10
CPC分类号： A01N43/90
摘要： The present invention relates to the use of compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R3, R9, R10, R11, R12 and G have the meanings given above as insecticides and/or acaricides and/or fungicides.
摘要翻译：本发明涉及式（I）化合物的用途，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 3，R 9，R 10，R 11，R 12和G具有上述作为杀虫剂和/ 杀螨剂和/或杀真菌剂。

100. 发明授权

US08080675B2 Chroman derivatives, medicaments and use in therapy 有权
标题翻译：色原衍生物，药物和用于治疗
公开(公告)号：US08080675B2
公开(公告)日：2011-12-20
申请号：US11230505
申请日：2005-09-21
申请人： Andrew Heaton , Alan Husband
发明人： Andrew Heaton , Alan Husband
IPC分类号： C07D311/00 , A61K31/35
CPC分类号： A61K31/353 , A23L33/105 , A61K31/282 , A61K31/337 , A61K31/37 , A61K31/4745 , A61K31/655 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K41/0038 , A61N5/10 , A61N2005/1098 , C07D311/38 , C07D311/58 , C07D311/62
摘要： Novel chroman derivatives and intermediate compounds, compositions containing same, methods for their preparation and uses thereof as therapeutic agents particularly as anti-cancer and chemotherapeutic selective agents are described.
摘要翻译：描述了新型色氨酸衍生物和中间体化合物，含有它们的组合物，其制备方法及其作为治疗剂的治疗剂，特别是作为抗癌剂和化疗选择剂。

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