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21. 发明授权

US11759484B2 Compositions and uses thereof 有权
公开(公告)号：US11759484B2
公开(公告)日：2023-09-19
申请号：US17053446
申请日：2019-05-09
申请人： SkinBioTherapeutics PLC
发明人： Catherine O'Neill
IPC分类号： A61K39/00 , A61K35/747 , A61K8/99
CPC分类号： A61K35/747 , A61K8/99
摘要： The present invention relates to a composition comprising Lactobacillus rhamnosus GG (LGG) (ATCC 53103) and/or a bioactive extract of LGG to increase the expression of filaggrin or profilaggrin, for use in treating skin or mucosa barrier dysfunctions or defects. The present invention also comprises the use of a composition comprising Lactobacillus rhamnosus GG (LGG) (ATCC 53103) and/or a bioactive extract of LGG to increase the expression of filaggrin or profilaggrin, for use in the manufacture of a medicament for use in treating skin barrier dysfunctions. Also disclosed is a use of a composition comprising Lactobacillus rhamnosus GG (LGG) (ATCC 53103) and/or a bioactive extract of LGG to increase the expression of filaggrin or profilaggrin, for use in the manufacture of a cosmetic composition for use in improving the appearance and/or texture of the skin. The present invention also comprises a method of treating skin barrier dysfunctions comprising administering a composition comprising Lactobacillus rhamnosus GG (LGG) and/or a bioactive extract of LGG to increase the expression of filaggrin or profilaggrin.

22. 发明授权

US11752066B2 Fixture for light acupuncture 有权
公开(公告)号：US11752066B2
公开(公告)日：2023-09-12
申请号：US16811004
申请日：2020-03-06
申请人： Naomie Cayemitte-Rückner
发明人： Naomie Cayemitte-Rückner
IPC分类号： A61B5/00 , A61H39/00 , A61N5/06 , A61N5/067
CPC分类号： A61H39/00 , A61N5/0619 , A61H2039/005 , A61H2201/165 , A61H2205/02 , A61N5/067 , A61N2005/063 , A61N2005/0647
摘要： A fixture for light acupuncture on the head is provided. The fixture has a holding portion extending at least partially over the temporal bone above an ear when being in an attached position. The holding portion has one or several openings through which one optical wave guide each is pluggable so that its front end shining while in operation is attached to the head in the area of the temporal bone.

23. 发明授权

US11732246B2 Compositions useful in treatment of ornithine transcarbamylase (OTC) deficiency 有权
公开(公告)号：US11732246B2
公开(公告)日：2023-08-22
申请号：US16995572
申请日：2020-08-17
申请人： The Trustees of the University of Pennsylvania
发明人： Lili Wang , James M. Wilson
IPC分类号： A61K48/00 , A61P1/00 , A61P1/16 , A61P3/00 , A61P43/00 , A61P25/28 , C12N15/00 , C12N15/79 , C12N15/86 , C12N9/00 , C12N9/10
CPC分类号： C12N9/1018 , A61K48/0058 , C12N15/86 , C12Y201/03003 , C12N2710/10343 , C12N2740/15043 , C12N2750/14032 , C12N2750/14033 , C12N2750/14043 , C12N2750/14071 , C12N2750/14143 , C12N2800/22
摘要： Viral vectors comprising engineered hOTC DNA and RNA sequences are provided which when delivered to a subject in need thereof are useful for treating hyperammonemia, ornithine transcarbamylase deficiency and symptoms associated therewith. Also provided are methods of using hOTC for treatment of liver fibrosis and/or cirrhosis in OTCD patients by administering hOTC.

24. 发明授权

US11718835B2 Scalable purification method for AAV8 有权
公开(公告)号：US11718835B2
公开(公告)日：2023-08-08
申请号：US17328686
申请日：2021-05-24
申请人： The Trustees of the University of Pennsylvania
发明人： Martin Lock , Mauricio Alvira
IPC分类号： C12N7/02 , C12N7/00 , B01D15/38 , B01J20/281 , C12N15/864 , G01N21/33 , B01J41/05 , B01D15/16 , B01D15/36 , B01J41/20
CPC分类号： C12N7/02 , B01D15/3804 , B01J20/281 , C12N7/00 , C12N15/8645 , G01N21/33 , B01D15/166 , B01D15/363 , B01J41/05 , B01J41/20 , C12N2750/14143 , C12N2750/14151
摘要： A two-step chromatography purification scheme is described which selectively captures and isolates the genome-containing rAAV vector particles from the clarified, concentrated supernatant of a rAAV production cell culture. The process utilizes an affinity capture method performed at a high salt concentration followed by an anion exchange resin method performed at high pH to provide rAAV vector particles which are substantially free of rAAV intermediates.

25. 发明授权

US11710541B2 Chemical pattern recognition method for evaluating quality of traditional Chinese medicine based on medicine effect information 有权
公开(公告)号：US11710541B2
公开(公告)日：2023-07-25
申请号：US17779835
申请日：2019-12-02
申请人： SHENZHEN INSTITUTE FOR DRUG CONTROL (SHENZHEN TESTING CENTER OF MEDICAL DEVICES)
发明人： Tiejie Wang , Yi Lu , Lijun Wang , Kun Jiang , Yang Wang , Jue Wang , Guo Yin , Yang Huang , Yibao Jin
IPC分类号： G16C20/20 , G01N30/86 , G16C20/70 , G01N30/02
CPC分类号： G16C20/20 , G01N30/8631 , G16C20/70 , G01N2030/027
摘要： A chemical pattern recognition method for evaluating the quality of a traditional Chinese medicine based on medicine effect information, comprising: collecting chemical information of a traditional Chinese medicine sample, obtaining medicine effect information reflecting a clinical therapeutic effect thereof, performing spectrum-effect relationship analysis on the chemical information and the medicine effect information, and obtaining an index significantly related to the medicine effect as a feature chemical index; dividing the traditional Chinese medicine sample into a training set and a test set; using a pattern recognition method to extract a feature variable from samples of the training set by taking the feature chemical index as an input variable; building a pattern recognition model using the feature variable; and substituting feature variable values of samples of the test set into the model, and completing chemical pattern recognition evaluation of the quality of the traditional Chinese medicine. According to the method, chemical reference substances are not needed, the chemical pattern recognition model is built on the basis of the feature chemical index reflecting the medicine effect, the one-sidedness and the subjectivity of the existing standards are overcome, and a traditional Chinese medicine quality evaluation system capable of reflecting both the clinical therapeutic effect and overall chemical composition information is finally formed.

26. 发明授权

US11690813B2 Aminothiol reduction of ischemia-reperfusion-induced cell death 有权
公开(公告)号：US11690813B2
公开(公告)日：2023-07-04
申请号：US16629851
申请日：2019-01-04
申请人： OBVIA PHARMACEUTICALS LTD
发明人： William E. Fahl , Ningfeng Li
IPC分类号： A61K31/145 , A01N1/02 , A61P9/10
CPC分类号： A61K31/145 , A01N1/0226 , A61P9/10
摘要： Members of the PrC-210 family of aminothiols, including PrC-211 and PrC-252, are shown to be highly effective in reducing ischemia-reperfusion injury in two preclinical models, including kidney transplant and myocardial infarct. Compositions and methods employing members of the PrC-210 family of aminothiols are disclosed for suppressing ischemia-reperfusion-induced cell and organ toxicities in a number of settings, significantly including organ transplant and myocardial infarct.

27. 发明授权

US11680274B2 Method of increasing the function of an AAV vector 有权
公开(公告)号：US11680274B2
公开(公告)日：2023-06-20
申请号：US16368758
申请日：2019-03-28
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： Luk Vandenberghe , Guangping Gao , James M. Wilson
IPC分类号： C12N15/00 , C12N15/86 , A61K48/00 , C07K14/005 , C12N7/00
CPC分类号： C12N15/86 , A61K48/005 , A61K48/0091 , C07K14/005 , C12N7/00 , A61K48/00 , C12N2750/14122 , C12N2750/14142 , C12N2750/14143 , C12N2750/14152
摘要： A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid sequences.

28. 发明授权

US11666546B2 GHB pharmaceutical compositions comprising a floating interpenetrating polymer network forming system 有权
公开(公告)号：US11666546B2
公开(公告)日：2023-06-06
申请号：US16955389
申请日：2018-12-18
申请人： Tris Pharma, Inc.
发明人： Paras Rameshlal Jain , Sachin Vasant Chaudhari
IPC分类号： A61K31/19 , A61K9/08 , A61K9/00 , A61K47/36
CPC分类号： A61K31/19 , A61K9/0053 , A61K9/08 , A61K47/36
摘要： GHB drug delivery systems comprising a floating interpenetrating network (IPN) are provided. The pharmaceutical compositions contain at least one IPN forming system, at least GHB drug, and at least one gas generating agent, such that upon oral ingestion of the compositions, a floating IPN is formed in situ. These floating IPN provide extended release of the GHB drug entrapped therein for at least about 3 hours.

29. 发明授权

US11591614B2 Gene therapy for ceroid lipofuscinoses 有权
公开(公告)号：US11591614B2
公开(公告)日：2023-02-28
申请号：US16611512
申请日：2018-05-11
申请人： The Trustees of the University of Pennsylvania
发明人： James M. Wilson , Nathan Katz , Christian Hinderer , Juliette Hordeaux
IPC分类号： C12N15/86 , A61K48/00 , C12N9/48 , A61K9/00
摘要： Provided herein are methods and compositions for treatment of Batten disease. Such compositions include a recombinant adeno-associated virus (rAAV), said rAAV comprising an AAV capsid, and a vector genome packaged therein, said vector genome comprising (a) an AAV 5′ inverted terminal repeat (ITR) sequence; (b) a promoter; (c) a CLN2 coding sequence encoding a human TPP1; (d) an AAV 3′ ITR.

30. 发明授权

US11560820B2 Static mixer for exhaust gas ducts of internal combustion engines, method of manufacturing thereof and exhaust unit incorporating the mixer 有权
公开(公告)号：US11560820B2
公开(公告)日：2023-01-24
申请号：US17262247
申请日：2019-07-23
申请人： Officine Metallurgiche G. Cornaglia S.p.A.
发明人： Alessandro Aru , Marco Barone , Pier Mario Cornaglia , Cristina Robino , Zakaria Tiji
IPC分类号： F01N3/28 , F01N3/20
摘要： A static mixer for exhaust gas ducts of internal combustion engines includes an elongated hollow metal body having a shape which, relative to a symmetry axis, substantially corresponds to a solid of revolution defining at its inside a cavity having opposite bases, at least one of which has an axial opening, and a closed lateral wall connecting the opposite bases and having at least one radial opening over which a concave blade is arranged extending radially outward from a portion of the peripheral edge of the radial opening and surrounding a portion of the radial opening so as to define, in a first angular direction relative to the symmetry axis, a corresponding concave screen or spoon and, in a second, opposite direction, a mouth intended for the passage of gases and located substantially in front of the concave screen or spoon.

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