专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

US20090130131A1 Antigen-Drug Vehicle Enabling Switch From Selective Production of IgA Antibody to Production of Both of IgA and IgG Antibodies and Transnasal/Mucosal Vaccine Using the Same 有权
标题翻译：抗IgC抗体携带IgA抗体选择性生产的抗原 - 药物载体启动切换与IgA和IgG抗体的生产以及使用该抗体的跨膜/粘膜疫苗
公开(公告)号：US20090130131A1
公开(公告)日：2009-05-21
申请号：US11990001
申请日：2006-08-04
申请人： Hiroshi Kido , Dai Mizuno
发明人： Hiroshi Kido , Dai Mizuno
IPC分类号： A61K39/385
CPC分类号： A61K39/00 , A61K39/12 , A61K39/145 , A61K39/35 , A61K39/385 , A61K39/39 , A61K45/06 , A61K2039/5252 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/55516 , A61K2039/55555 , A61K2039/6031 , C07K14/47 , C12N2760/16134
摘要： In the aim of practical utilization of a safe and effective transnasal/inactivated/mucosal vaccine and establishment of a technology for imparting capacity of producing both of IgA and IgG antibodies to a conventional inactivated vaccine, toxoid; allergen, or the like, a means for prevention and treatment of allergy, and the like, it is intended to provide an antigen-drug vehicle (AD vehicle) enabling transnasal, transmucosal, and transdermal administrations, an inactivated vaccine simultaneously inducing a mucosal immunity and humoral immunity by using the AD vehicle, a production method of the inactivated vaccine, an AD vehicle enabling a switch from induction of selective production of IgA antibody to induction of both of IgA and IgG antibodies, and a transnasal vaccine, a mucosal vaccine, a therapeutic/prophylactic agent for allergy, and the like using the AD vehicle.
摘要翻译：为了实际应用安全有效的经鼻/灭活/粘膜疫苗和建立一种赋予常规灭活疫苗，类毒素的IgA和IgG抗体产生能力的技术的目的。过敏原等，预防和治疗过敏等的手段，旨在提供能够经鼻，经粘膜和透皮给药的抗原药物载体（AD载体），同时诱导粘膜免疫的灭活疫苗和使用AD载体的体液免疫，灭活疫苗的制备方法，能够从诱导选择性产生IgA抗体转变成诱导IgA和IgG抗体两者的AD载体，以及经鼻疫苗，粘膜疫苗，使用AD载体的用于过敏的治疗/预防剂等。

22. 发明申请

US20070141073A1 Antigen-drug vehicle enabling transmucosal and transdermal administration, and method of inducing mucosal immunity and mucosal vaccine and dds using the same 有权
标题翻译：能够进行经粘膜和透皮给药的抗原药物，以及诱导粘膜免疫和粘膜疫苗的方法和使用其的dds
公开(公告)号：US20070141073A1
公开(公告)日：2007-06-21
申请号：US11547650
申请日：2005-03-22
申请人： Hiroshi Kido , Dai Mizuno
发明人： Hiroshi Kido , Dai Mizuno
IPC分类号： A61K39/00
CPC分类号： A61K39/00 , A61K2039/541
摘要： Disclosed are an antigen-drug vehicle (AD vehicle) exerting a function of inducing the preferential and selective production of an antigen-specific secretory IgA antibody, local immunity or mucosal immunity; a method of inducing mucosal immunity, a mucosal vaccine and a preventive or a remedy for allergy using the above AD vehicle; and a transmucosal or transdermal DDS using the above vehicle.
摘要翻译：公开了具有诱导抗原特异性分泌型IgA抗体的优先选择性产生的功能的抗原 - 药物载体（AD载体），局部免疫或粘膜免疫; 使用上述AD载体诱导粘膜免疫的方法，粘膜疫苗和用于过敏的预防或补救措施; 和使用上述载体的经粘膜或透皮DDS。

23. 发明授权

US06388122B1 Tryptase inhibitor and novel guanidino derivatives 失效
标题翻译：胰蛋白酶抑制剂和新颖的胍基衍生物
公开(公告)号：US06388122B1
公开(公告)日：2002-05-14
申请号：US09155868
申请日：1998-10-07
申请人： Hiroshi Kido , Hisao Nakai
发明人： Hiroshi Kido , Hisao Nakai
IPC分类号： C07C22938
CPC分类号： C07D211/62 , A61K31/222 , A61K31/24 , A61K31/245 , A61K31/40 , A61K31/401 , A61K31/445 , A61K31/495 , C07C257/18 , C07C279/14 , C07C279/18 , C07C311/16 , C07C323/59 , C07D207/16 , C07D211/60
摘要： A tryptase inhibitor comprising as an active ingredient at least one member selected from among guanidinoaliphatic acid derivatives of the formula (I), guanidinobenzoic acid derivatives of the formula (II), guanidinophenol derivatives of the formula (III), amidinophenol derivatives of the formula (IV), and novel guanidinophenol derivatives of the formula (V) (in the formulae, Gu is guanidino).
摘要翻译：一种类胰蛋白酶抑制剂，其包含选自式（I）的胍基脂肪酸衍生物，式（II）的胍基苯甲酸衍生物，式（III）的胍基苯酚衍生物，式（III）的脒基苯酚衍生物， IV）和式（V）的新型胍基苯酚衍生物（在式中，Gu是胍基）。

24. 发明授权

US4904771A Pseudouridine derivative 失效
标题翻译：伪嘌呤衍生物
公开(公告)号：US4904771A
公开(公告)日：1990-02-27
申请号：US142856
申请日：1987-12-03
申请人： Nobuhiko Katsunuma , Hiroshi Kido , Ikutoshi Matsuura , Yoshihiko Ishitani
发明人： Nobuhiko Katsunuma , Hiroshi Kido , Ikutoshi Matsuura , Yoshihiko Ishitani
IPC分类号： A61K31/505 , A61P5/38 , C07D405/04
CPC分类号： C07D405/04
摘要： 5'-Pseudouridyl-N-oleoyl carbamate represented by the formula: ##STR1## This compound is physiologically active in that it markedly enhances the actions of glucocorticoids and hence is useful as an alternative to conventional steroid drugs.

25. 发明授权

US09540420B2 Mucosal vaccines 有权
标题翻译：粘膜疫苗
公开(公告)号：US09540420B2
公开(公告)日：2017-01-10
申请号：US13582160
申请日：2011-03-01
申请人： Hiroshi Kido , Dai Mizuno
发明人： Hiroshi Kido , Dai Mizuno
IPC分类号： A61K39/395 , C07K14/005 , A61K9/00 , A61K39/145 , A61K39/12 , A61K39/00 , A61K47/32
CPC分类号： C07K14/005 , A61K9/0043 , A61K39/00 , A61K39/12 , A61K39/145 , A61K47/32 , A61K2039/541 , A61K2039/543 , A61K2039/55516 , A61K2039/55555 , A61K2039/55561 , C12N2760/16122 , C12N2760/16134 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/396 , Y02A50/466
摘要： A mucosal vaccine producing an antigen-specific mucosal IgA and a blood IgG in the levels capable of exerting an effective immune induction and an infection-preventing effect, which comprises: (a) an AD vehicle consisting of a synthetic peptide and a lipid(s), wherein the synthetic peptide consisting of the amino acid sequence KnLm (wherein n is 4 to 8 and m is 11 to 20); (b) a carboxylvinyl polymer; and, (c) an antigenic protein, in an amount incapable of producing a sufficient mucosal IgA and blood IgG for exerting an effective immune induction and an infection-preventing effect when used by itself. The mucosal vaccine of the invention has an antibody producing ability which is more potent than those of mucosal vaccines of the prior art, and as a result it can exert an excellent effect even with an extremely small amount of an antigen.
摘要翻译：本发明的粘膜疫苗具有比现有技术的粘膜疫苗更有效的抗体生成能力，结果即使使用极少量的抗原也能发挥优异的效果。

26. 发明授权

US08421360B2 Load determination device and illumination apparatus using same 有权
标题翻译：负载确定装置和使用其的照明装置
公开(公告)号：US08421360B2
公开(公告)日：2013-04-16
申请号：US13071762
申请日：2011-03-25
申请人： Masanori Mishima , Hiroshi Kido , Shohei Yamamoto , Masanao Okawa , Hirofumi Konishi , Katunobu Hamamoto
发明人： Masanori Mishima , Hiroshi Kido , Shohei Yamamoto , Masanao Okawa , Hirofumi Konishi , Katunobu Hamamoto
IPC分类号： H01J7/42
CPC分类号： H05B33/0848 , H05B33/08 , H05B33/0896 , Y02B20/32
摘要： An illumination load determination device includes an illumination load; a voltage applying unit for applying a voltage to the illumination load; a connection unit for connecting the illumination load and the voltage applying unit; a detection unit for detecting at least one of a current flowing through the illumination load and a voltage across the illumination load when the voltage is applied to the illumination load from the voltage applying unit via the connection unit; and a determination unit for determining a type of the illumination load based on an output from the detection unit. The determination unit has a comparator for comparing a detection value detected by the detection unit to a predetermined threshold, and determines that the illumination load has a capacitance based on an output of the comparator. The voltage applying unit lights on the determined illumination load with a rated driving voltage.
摘要翻译：照明负载确定装置包括照明负载; 电压施加单元，用于向照明负载施加电压; 用于连接照明负载和电压施加单元的连接单元; 检测单元，用于当电压经由连接单元从电压施加单元施加到照明负载时，检测流过照明负载的电流和照明负载两端的电压中的至少一个; 以及确定单元，用于基于来自检测单元的输出来确定照明负载的类型。确定单元具有用于将由检测单元检测的检测值与预定阈值进行比较的比较器，并且基于比较器的输出确定照明负载具有电容。电压施加单元以额定驱动电压对确定的照明负载点亮。

27. 发明申请

US20130071866A1 METHOD FOR TESTING THE SEVERTIY OF AN ILLNESS 审中-公开
标题翻译：测试误差的方法
公开(公告)号：US20130071866A1
公开(公告)日：2013-03-21
申请号：US13700334
申请日：2011-05-27
申请人： Hiroshi Kido , Masaji Nishimura , Junji Chida
发明人： Hiroshi Kido , Masaji Nishimura , Junji Chida
IPC分类号： G01N33/50
CPC分类号： G01N33/50 , G01N33/5735 , G01N2800/00
摘要： An object of the present invention is directed to a method for assaying the severity of an illness in real time and is to provide a testing method capable of assessing the severity of an illness in more detail than the conventional APACHE II and SOFA scores. The established method can accurately measure an ATP level in a sample, thereby accurately and quickly deducing the “state of intracellular energy required for living organisms” from the ATP level, and by extension, determining the severity of an illness. The present invention further provides a novel biomarker ATP-lactate energy risk score (A-LES) value that is capable of determining the severity of an illness by the reevaluation, with the ATP concentration as an index (specifically, on the basis of a lactic acid level (mM)/ATP concentration (mM) ratio), of the level of lactic acid that accumulates in the sample due to the breakdown of in vivo metabolic balance accompanied by the increased severity of the illness. The present invention also provides a novel biomarker ATP-ketone energy risk score (A-KES) value that is capable of determining the severity of an illness by the reevaluation of a ketone body level in the sample with the ATP concentration as an index (specifically, on the basis of a ketone body level (mM)/ATP concentration (mM) ratio).
摘要翻译：本发明的目的是针对实时测定疾病严重性的方法，并提供能够比常规APACHE II和SOFA得分更详细地评估疾病的严重程度的测试方法。已建立的方法可以准确测量样品中的ATP水平，从而准确，快速地从ATP水平推测生物体所需的细胞内能量的状态，并通过扩展来确定疾病的严重程度。本发明还提供了一种新的生物标志物ATP-乳酸能量风险评分（A-LES）值，其能够通过重新评估来确定疾病的严重程度，其中ATP浓度作为指标（具体地，基于乳酸酸浓度（mM）/ ATP浓度（mM）比），由于体内代谢平衡的崩溃伴随着疾病严重程度的增加，样品中积累的乳酸水平。本发明还提供了一种新的生物标志物ATP-酮能量风险评分（A-KES）值，其能够通过以ATP浓度作为指标重新评价样品中的酮体水平来确定疾病的严重程度，基于酮体水平（mM）/ ATP浓度（mM）比）。

28. 发明授权

US08310162B2 Lighting apparatus and lighting fixture 有权
标题翻译：照明设备和照明灯具
公开(公告)号：US08310162B2
公开(公告)日：2012-11-13
申请号：US12858646
申请日：2010-08-18
申请人： Akira Nakajo , Hiroshi Kido , Ryusuke Ura , Hidenori Kakehashi , Kohji Hiramatsu , Katsuyoshi Goto
发明人： Akira Nakajo , Hiroshi Kido , Ryusuke Ura , Hidenori Kakehashi , Kohji Hiramatsu , Katsuyoshi Goto
IPC分类号： H05B37/04 , H05B37/03
CPC分类号： H05B37/03
摘要： A lighting apparatus includes a lighting circuit unit, a timer unit, a life judgment unit, a timing adjustment unit, and an indication unit. The lighting circuit unit is configured to activate a light source. The timer unit is configured to measure accumulated operation time of the lighting circuit unit. The life judgment unit is configured to store a first judgment time and a second judgment time longer than the first judgment time. The life judgment unit is configured to compare the accumulated operation time with the first judgment time and output a first judgment signal when the accumulated operation time becomes equal to the first judgment time. The life judgment unit is configured to compare the accumulated operation time with the second judgment time and output a second judgment signal when the accumulated operation time becomes equal to the second judgment time. The timing adjustment unit is configured to vary timing at which the life judgment unit outputs the first judgment signal. The timing adjustment unit is configured to vary timing at which the life judgment unit outputs the second judgment signal. The indication unit is configured to indicate, upon receiving the first judgment signal from the life judgment unit, a first level of the end of life with the light source kept turned on. The indication unit is configured to indicate, upon receiving the second judgment signal from the life judgment unit, a second level of the end of life. The second level of the end of life is later than the first level of the end of life.
摘要翻译：照明装置包括照明电路单元，定时器单元，寿命判断单元，定时调整单元和指示单元。照明电路单元被配置为激活光源。定时器单元被配置为测量点亮电路单元的累积操作时间。寿命判断单元被配置为存储比第一判断时间长的第一判断时间和第二判断时间。寿命判断单元被配置为将累积操作时间与第一判断时间进行比较，并且当累积操作时间等于第一判断时间时输出第一判断信号。寿命判断单元被配置为将累积操作时间与第二判断时间进行比较，并且当累积操作时间等于第二判断时间时输出第二判断信号。定时调整单元被配置为改变寿命判断单元输出第一判断信号的定时。定时调整单元被配置为改变寿命判断单元输出第二判断信号的定时。指示单元被配置为在从生命判断单元接收到第一判断信号时指示保持开启的光源的寿命的第一级。指示单元被配置为在从生命判断单元接收到第二判断信号时指示寿命结束的第二级。生命的第二个水平晚于生命的第一个水平。

29. 发明授权

US08268321B2 Antigen-drug vehicle enabling transmucosal and transdermal administration, and method of inducing mucosal immunity and mucosal vaccine and DDS using the same 有权
标题翻译：能够进行经粘膜和透皮给药的抗原药物，以及诱导粘膜免疫和粘膜疫苗的方法和使用其的DDS
公开(公告)号：US08268321B2
公开(公告)日：2012-09-18
申请号：US11547650
申请日：2005-03-22
申请人： Hiroshi Kido , Dai Mizuno
发明人： Hiroshi Kido , Dai Mizuno
IPC分类号： A61K39/00 , A61K39/38 , A61K39/12 , A61K39/145
CPC分类号： A61K39/00 , A61K2039/541
摘要： Disclosed are an antigen-drug vehicle (AD vehicle) exerting a function of inducing the preferential and selective production of an antigen-specific secretory IgA antibody, local immunity or mucosal immunity; a method of inducing mucosal immunity, a mucosal vaccine and a preventive or a remedy for allergy using the above AD vehicle; and a transmucosal or transdermal DDS using the above vehicle.
摘要翻译：公开了具有诱导抗原特异性分泌型IgA抗体的优先选择性产生的功能的抗原 - 药物载体（AD载体），局部免疫或粘膜免疫; 使用上述AD载体诱导粘膜免疫的方法，粘膜疫苗和用于过敏的预防或补救措施; 和使用上述载体的经粘膜或透皮DDS。

30. 发明授权

US07545107B2 Electrodeless discharge lamp lighting device and lighting apparatus 有权
标题翻译：无极放电灯照明装置及照明装置
公开(公告)号：US07545107B2
公开(公告)日：2009-06-09
申请号：US11909853
申请日：2006-03-28
申请人： Shohei Yamamoto , Hiroshi Kido , Akira Nakajo
发明人： Shohei Yamamoto , Hiroshi Kido , Akira Nakajo
IPC分类号： H01J15/04
CPC分类号： H05B41/2806 , Y02B20/22
摘要： There is provided an electrodeless discharge lamp lighting device with small size and low cost by simplifying a noise suppression part and a lighting apparatus having the electrodeless discharge lamp lighting device. A counter circuit of a frequency signal generating circuit repeatedly generates a frequency signal of which the amplitude is varied in a multi-step shape on the basis of an oscillation period of an oscillation circuit. An oscillation circuit outputs an oscillation signal of a frequency corresponding to the amplitude of the frequency signal. A drive circuit drives a switching element of an inverter circuit at the frequency of the oscillation signal and the inverter circuit applies a high-frequency voltage generated by the switching operation of the switching element to an induction coil to start up and light the electrodeless discharge lamp. That is, a high-frequency voltage which is varied at three discrete frequencies f1, f2, and f3 is repeatedly and periodically applied to the induction coil and thus a magnetic-component noise generated from a discharge lamp lighting device is distributed into three frequency components.
摘要翻译：通过简化噪声抑制部件和具有无电极放电灯点亮装置的照明装置，提供了一种小型且低成本的无电极放电灯点亮装置。频率信号发生电路的计数器电路基于振荡电路的振荡周期重复地产生振幅以多步形状变化的频率信号。振荡电路输出与频率信号的振幅对应的频率的振荡信号。驱动电路以振荡信号的频率驱动逆变器电路的开关元件，并且逆变器电路将由开关元件的开关操作产生的高频电压施加到感应线圈，以起动并点亮无电极放电灯。也就是说，在三个离散频率f1，f2和f3处变化的高频电压被重复地周期性地施加到感应线圈，因此从放电灯点亮装置产生的磁分量噪声被分配成三个频率分量。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式