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21. 发明授权

US09675736B2 Compounds and methods for biofilm disruption and prevention 有权
公开(公告)号：US09675736B2
公开(公告)日：2017-06-13
申请号：US13578228
申请日：2011-02-11
申请人： James Grant Burgess , Michael John Hall , Reindert Nijland
发明人： James Grant Burgess , Michael John Hall , Reindert Nijland
IPC分类号： A61K38/46 , A01P1/00 , A61L29/16 , C12N9/22 , C12N9/56 , A61P31/10 , A61P31/12 , A61P33/00 , A61K45/06
CPC分类号： A61L29/16 , A61K38/465 , A61K45/06 , A61L2300/252 , A61L2300/30 , A61L2300/404 , A61L2300/45 , C12N9/22 , C12Y301/27002 , C12Y301/31001
摘要： The invention relates to compounds, compositions and methods for biofilm disruption and prevention. In particular, the invention relates to pharmaceutical compositions for the disruption of biofilm and prevention of biofilm in patients. The invention also relates to anti-biofouling compositions for the disruption of biofilm and prevention of biofilm on surfaces. The invention also relates to the removal of biological material from surfaces. The compositions of the invention include microbial deoxyribonucleases.

22. 发明申请

US20160291704A1 DISAMBIGUATION OF STYLI BY CORRELATING ACCELERATION ON TOUCH INPUTS 审中-公开
标题翻译：通过关联触摸输入来加速STYLI
公开(公告)号：US20160291704A1
公开(公告)日：2016-10-06
申请号：US15035178
申请日：2014-11-07
申请人： UNIVERSITY OF NEWCASTLE UPON TYNE
发明人： Dan Jackson , Patrick Oliver , Ahmed Kharrufa , Nils Hammerla
IPC分类号： G06F3/038 , G06F21/36 , G06F3/0346 , G06F3/0354 , G06F3/01 , G06F3/041
CPC分类号： G06F3/0383 , G06F3/014 , G06F3/0346 , G06F3/03545 , G06F3/0416 , G06F21/36 , G06F2203/0331 , G06F2203/0382 , G06F2221/2103 , G06F2221/2139
摘要： A method for processing an input applied by an input object is provided. The method comprises the steps of receiving, from a motion unit, motion data comprising information indicating motion of the motion unit, wherein the motion unit is arranged to co-move with the input object; receiving, from the motion unit, identification information for identifying the motion unit; receiving input data, wherein the input data comprises information indicating characteristics of one or more inputs applied to an input unit; comparing the motion data with the input data; and outputting a signal for controlling processing of the inputs depending on a result of the comparison, and according to the identification information.
摘要翻译：提供了一种用于处理由输入对象应用的输入的方法。该方法包括以下步骤：从运动单元接收包括指示运动单元的运动的信息的运动数据，其中所述运动单元布置成与所述输入对象共同移动; 从运动单元接收用于识别运动单元的识别信息; 接收输入数据，其中所述输入数据包括指示应用于输入单元的一个或多个输入的特征的信息; 将运动数据与输入数据进行比较; 并输出用于根据比较结果控制输入处理的信号，并根据识别信息。

23. 发明申请

US20110015409A1 SYNTHESIS OF CYCLIC CARBONATES 审中-公开
公开(公告)号：US20110015409A1
公开(公告)日：2011-01-20
申请号：US12921264
申请日：2009-03-06
申请人： Michael North
发明人： Michael North
IPC分类号： C07D317/38 , C07F5/06
CPC分类号： C07D317/38 , C07B2200/11 , C07D317/34 , C07D317/36 , C07F5/069
摘要： A dimeric aluminium(salen) catalyst of formula I: wherein: Y-Q is CRC1═N or CRC1RC2—NRN1, where RC1, RC2 and RN1 are independently selected from H, halo, optionally substituted C1-20 alkyl, optionally substituted C5-20 aryl, ether and nitro; each of the substituents R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, and R16, is independently selected from H, halo, optionally substituted C1-20 alkyl, optionally substituted C5-20 aryl, optionally substituted C3-20 heterocyclyl, ether and nitro; X1 and X2 are independently either (i) a C2-5 alkylene chain, which is optionally substituted by one or more groups selected from C1-4 alkyl and C5-7 aryl, or a C1-3 bisoxyalkylene chain, which is optionally substituted by one or more groups selected from C1-4 alkyl and C5-7 aryl or (ii) represent a divalent group selected from C5-7 arylene, C5-7 cyclic alkylene and C3-7 heterocyclylene, which may be optionally substituted; (i) (a) at least one of R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, and R16 is selected from L-A, where L is a single bond or a C1-10 alkylene group and A is an ammonium group paired with a counterion selected from Cl, Br and I; and/or (b) at least one of X1 and X2 is a divalent C3-7 heterocyclene group, containing a ring atom which is a quaternary nitrogen atom paired with a counterion selected from Cl, Br and I; and/or (c) at least one of X1 and X2 is a C2-5 alkylene chain or a C1-3 bisoxyalkylene chain, substituted by a group -Q-L-A, where Q is either —C(═O)—O—, —C(═O)—NH—, or a single bond; and/or (ii) (a) one of R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, and R16 is L-A′, where L is as defined above and A′ is a ammonium linking group bound to a solid support and paired with a counterion selected from Cl, Br and I; or (b) one of X1 and X2 is a divalent C3-7 heterocyclene group, containing a ring atom which is a quaternary nitrogen forming part of an ammonium linking group bound to a solid support and paired with a counterion selected from Cl, Br and I; or (c) one of X1 and X2 is a C2-5 alkylene chain or a C1-3 bisoxyalkylene chain, substituted by a group -Q-L-A′.

24. 发明申请

US20060205195A1 Method of forming an ohmic contact in wide band semiconductor 有权
标题翻译：在宽带半导体中形成欧姆接触的方法
公开(公告)号：US20060205195A1
公开(公告)日：2006-09-14
申请号：US11159264
申请日：2005-06-23
申请人： Rajesh Malhan , Yuichi Takeuchi , Irina Nikitina , Konstantin Vassilevski , Nicholas Wright , Alton Horsfall
发明人： Rajesh Malhan , Yuichi Takeuchi , Irina Nikitina , Konstantin Vassilevski , Nicholas Wright , Alton Horsfall
IPC分类号： H01L21/28
CPC分类号： H01L29/7802 , H01L21/0485 , H01L29/41766 , H01L29/45 , H01L29/66068 , H01L29/7395
摘要： A method of forming an ohmic contact on a substrate composed of a wide-band gap semiconductor material includes: depositing a transition metal group metal on the substrate; annealing the substrate at a high temperature to cause a solid state chemical reaction between the substrate and the deposited metal that forms a modified layer in the substrate having modified properties different than the substrate, and by-products composed of a silicide and a nanocrystalline graphite layer; selectively etching the substrate to remove one or more of the by-products of the solid state chemical reaction from a surface of the substrate; and depositing a metal film composed of a transition group metal over the modified layer on the substrate to form the ohmic contact. The modified layer permits formation of the ohmic contact without high temperature annealing after depositing the metal film.
摘要翻译：在由宽带隙半导体材料构成的衬底上形成欧姆接触的方法包括：在衬底上沉积过渡金属组金属; 在高温下使基板退火，从而在基板和沉积金属之间产生固态化学反应，所述金属在衬底中形成改性的特性，其具有不同于衬底的改性，以及由硅化物和纳米晶体石墨层组成的副产物 ; 选择性地蚀刻所述基板以从所述基板的表面去除所述固态化学反应的一种或多种副产物; 以及在所述基板上在所述改性层上沉积由过渡金属组成的金属膜以形成欧姆接触。在沉积金属膜之后，改性层允许形成欧姆接触而不进行高温退火。

25. 发明申请

US20230122227A1 BODY TISSUE MONITOR, BODY TISSUE PRESERVATION SYSTEM AND CORRESPONDING METHOD 有权
公开(公告)号：US20230122227A1
公开(公告)日：2023-04-20
申请号：US17913933
申请日：2021-03-26
申请人： UNIVERSITY OF NEWCASTLE UPON TYNE
发明人： William Earl SCOTT, III , Leo FREITAS
IPC分类号： A01N1/02
摘要： A body tissue preservation system for storage and preservation of body tissue, the system comprising a body tissue monitor to determine a status of the body tissue, wherein the body tissue monitor comprises: at least one sensor configured to obtain sensor data based on a plurality of measurements of the body tissue and/or the environment surrounding the body tissue; and a controller arranged to receive the sensor data from the at least one sensor, wherein the controller is configured to: detect one or more trigger events in the sensor data, wherein each trigger event comprises sensor data which satisfies a first threshold criterion; select, for each of the one or more trigger events, a window of the sensor data associated with the trigger event; identify, for each of the one or more windows, a subset of the sensor data corresponding to the selected window; determine, for each of the one or more selected windows, whether the corresponding identified subset of sensor data satisfies a second threshold criterion; determine a status of the body tissue based on identified subsets which satisfied the second threshold criterion; and provide a status output signal based on the determined status of the body tissue.

26. 发明申请

US20220315888A1 CULTURE METHOD FOR RETINAL ORGANOIDS 有权
公开(公告)号：US20220315888A1
公开(公告)日：2022-10-06
申请号：US17642199
申请日：2020-09-11
申请人： University of Newcastle Upon Tyne
发明人： Majlinda LAKO , Darin ZERTI , Birthe HILGEN
IPC分类号： C12N5/0793 , C12N5/071 , C12N5/079 , A61K35/30
摘要： A method of producing a synthetic retina, including differentiating a stem cell culture in a culture medium and supplementing the culture with: (i) Triiodothyronine from about day 18 of cell differentiation; and (ii) retinoic acid for a first time period.

27. 发明授权

US11336137B2 Rotor assembly 有权
公开(公告)号：US11336137B2
公开(公告)日：2022-05-17
申请号：US16069726
申请日：2017-01-10
申请人： UNIVERSITY OF NEWCASTLE UPON TYNE
发明人： James Dumesnil Widmer , Mohammad Kimiabeigi
IPC分类号： H02K1/28 , H02K1/276 , H02K1/2753
摘要： A rotor assembly (10) has a rotor support hub (12) which includes a plurality of first connection parts arranged about a periphery the rotor support hub. The rotor assembly further has a plurality of rotor segments (14) each having a second connection part. Each of the second connection parts are cooperable with at least one of the plurality of first connection parts to connect each of the rotor segments about the periphery the rotor support hub. A plurality of fixing parts (26) are each configured to be received between cooperating first and second connection parts and to form an inference fit therebetween so as to secure the rotor segments to the rotor support hub. The rotor support hub may comprise a plurality of laminations.

28. 发明授权

US11005343B2 Electrical sub-assembly 有权
公开(公告)号：US11005343B2
公开(公告)日：2021-05-11
申请号：US16088782
申请日：2017-03-28
申请人： University of Newcastle upon Tyne
发明人： James Dumesnil Widmer , Richard Martin , Barrie Charles Mecrow
IPC分类号： H02K11/33 , H02K11/04 , H02K11/049 , H02K9/00 , H02K3/28 , H02P25/08 , H02K19/10 , H02K3/50 , H02K9/19 , H02K37/02
摘要： An electrical sub-assembly comprises a stator having a plurality of coils and a cooling means attached to the stator. The electrical sub-assembly further comprises a plurality of pairs of diodes attached to the cooling means, each pair of diodes being in antiparallel configuration and having three electrical terminals. One of the three electrical terminals is a common terminal shared by both diodes in each pair of diodes. A plurality of busbars electrically connect each of the diodes to at least one of the plurality of coils via one or more of the electrical terminals. In use, the cooling means is configured to simultaneously cool the stator and the plurality of diodes. The electrical sub-assembly may have particular application as a part of a switched reluctance machine.

29. 发明授权

US10982188B2 Synthetic retina 有权
公开(公告)号：US10982188B2
公开(公告)日：2021-04-20
申请号：US15118610
申请日：2015-02-16
申请人： University of Newcastle Upon Tyne
发明人： Majlinda Lako , Carla Mellough
IPC分类号： C12N5/079 , C12N5/0793 , A61K35/30 , A61L27/36 , A61L27/54 , G01N33/50
摘要： The invention provides a method of producing a synthetic retina, comprising: i) providing a three dimensional stem cell culture throughout the differentiation time course, ii) differentiating the three dimensional stem cell culture for a first time period in a first neural cell culture medium comprising: a) L-glutamine; b) B27 supplement; and c) an IGF-1 receptor agonist, iii) subsequently differentiating the three dimensional stem cell culture for a second time period in a second neural cell culture medium comprising: a) L-glutamine; b) B27 supplement; c) N2 supplement; and d) an IGF-1 receptor agonist, wherein said synthetic retina contains laminated retinal tissue comprising.

30. 发明申请

US20200259662A1 AUTHENTICATION OF PHYSICAL OBJECT USING INTERNAL STRUCTURE 审中-公开
公开(公告)号：US20200259662A1
公开(公告)日：2020-08-13
申请号：US16860698
申请日：2020-04-28
申请人： University of Newcastle Upon Tyne
发明人： Feng Hao , Ehsan Toreini , Siamak F. Shahandashti
IPC分类号： H04L9/32 , H04L9/08 , G09C5/00 , G06K9/00
摘要： A method for preventing counterfeiting of an object includes capturing an image of at least a portion of the object that is at least partially transparent. The captured image includes features of the internal structure of the object. Based on the image, a code is generated that encodes features of the internal structure of the object. The code is recorded. Generating the code includes applying a filter to the image to obtain a filtered image, and processing the filtered image to obtain a binary code. A random key, k, is generated, and a codeword fp is obtained by applying an error-correction encoding scheme, ErrorCC, to the random key according to fp=ErrorCC(k), wherein fp has the same size as the binary code fa. An encrypted binary code, r, is computed according r=fa⊕fp, where ⊕ denotes modulo-2 addition. A hash value, h, is computed according to h=H(k), where H is a one-way hash function. Recording the code comprises recording the encrypted binary code r and the hash value h. A digital signature, s, is computed based on r and h, wherein recording the code comprises recording the digital signature, s.

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