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31. 发明授权

US08343759B2 Mammalian cell line expressing inducible c-Src 有权
标题翻译：表达诱导型c-Src的哺乳动物细胞系
公开(公告)号：US08343759B2
公开(公告)日：2013-01-01
申请号：US12333652
申请日：2008-12-12
申请人： Naoto Yamaguchi
发明人： Naoto Yamaguchi
IPC分类号： C12N5/00 , C07H21/04
CPC分类号： C07K14/82
摘要： The present invention is directed to a unique mammalian cell line expressing inducible c-Src, and, particularly, a unique human cell line overexpressing c-Src in an inducible manner.
摘要翻译：本发明涉及一种独特的哺乳动物细胞系，其表达可诱导的c-Src，特别是以可诱导的方式过表达c-Src的独特的人细胞系。

32. 发明申请

US20120322963A1 METHOD FOR CHEMICALLY PRODUCING POLY(N-ALKYLCARBAZOLE) COLUMNAR STRUCTURE 有权
标题翻译：化学式（N-AlKYLCARBAZOLE）柱结构的生产方法
公开(公告)号：US20120322963A1
公开(公告)日：2012-12-20
申请号：US13517616
申请日：2012-06-14
申请人： KATSUYOSHI HOSHINO , TAKUYA TOKUDA , KATSUYUKI MURASHIRO , TOSHIKI KOMATSU
发明人： KATSUYOSHI HOSHINO , TAKUYA TOKUDA , KATSUYUKI MURASHIRO , TOSHIKI KOMATSU
IPC分类号： C08F126/06
CPC分类号： C08F126/06
摘要： A novel nanosized or microsized material having electroconductivity that can be produced simply and in a large amount is provided. A method for producing a poly(N-alkylcarbazole) columnar structure having electroconductivity obtained by chemically polymerizing N-alkylcarbazole including alkyl having 1 to 4 carbons by adding an oxidizing agent to a solution obtained by dissolving the N-alkylcarbazole in a solvent is provided.
摘要翻译：提供了具有可以简单且大量生产的具有导电性的新型纳米尺寸或微尺寸材料。提供了通过在通过将N-烷基咔唑溶解在溶剂中获得的溶液中加入氧化剂来制备具有导电性的聚（N-烷基咔唑）柱状结构的方法，该聚（N-烷基咔唑）柱状结构通过将包括具有1至4个碳的烷基的N-烷基咔唑化学聚合而获得的导电性。

33. 发明申请

US20120276195A1 Indole Alkaloid Derivatives Having Opioid Receptor Agonistic Effect, And Therapeutic Compositions And Methods Relating To Same 有权
标题翻译：具有阿片样物质受体激动作用的吲哚类生物碱衍生物和与之相关的治疗组合物和方法
公开(公告)号：US20120276195A1
公开(公告)日：2012-11-01
申请号：US13549564
申请日：2012-07-16
申请人： Hiromitsu Takayama , Mariko Kitajima , Kenjiro Matsumoto , Syunji Horie
发明人： Hiromitsu Takayama , Mariko Kitajima , Kenjiro Matsumoto , Syunji Horie
IPC分类号： A61K31/439 , A61K9/48 , A61P25/04 , C07D491/22
CPC分类号： C07D471/04 , C07D459/00
摘要： Indole alkaloid derivatives having an opioid receptor agonistic effect, their synthesis, and therapeutic compositions containing these derivatives, and methods of treating conditions with these compounds and therapeutic compositions, are provided.
摘要翻译：提供具有阿片受体激动作用的吲哚生物碱衍生物，其合成和含有这些衍生物的治疗组合物，以及使用这些化合物和治疗组合物治疗病症的方法。

34. 发明申请

US20120121503A1 Inhibition Of CD69 For Treatment Of Inflammatory Conditions 有权
标题翻译：抑制CD69用于治疗炎症状况
公开(公告)号：US20120121503A1
公开(公告)日：2012-05-17
申请号：US12945153
申请日：2010-11-12
申请人： Toshinori Nakayama , Akihiro Hasegawa , Mutsunori Shirai
发明人： Toshinori Nakayama , Akihiro Hasegawa , Mutsunori Shirai
IPC分类号： A61K39/395 , A61P1/16 , A61K31/195 , A61P29/00 , A61K51/10 , A61K31/713
CPC分类号： A61K39/3955 , A61K31/00 , A61K45/06 , A61K47/6849 , A61K2039/505 , C07K16/2851 , C07K16/2896
摘要： A method of treating or reducing at least one inflammatory condition or the susceptibility to at least one inflammatory condition is provided involving administering at least one CD69 antagonist to a subject, wherein the subject has been diagnosed with at least one inflammatory condition, or a susceptibility to the same. CD69 antagonists can include one or more of an anti-CD69 antibody, an anti-CD69 aptamer, a CD69 mRNA antagonist, and a small molecule pharmaceutical.
摘要翻译：提供治疗或减少至少一种炎性病症或对至少一种炎性病症的易感性的方法，包括对受试者施用至少一种CD69拮抗剂，其中所述受试者已被诊断患有至少一种炎性病症或易感性一样。 CD69拮抗剂可以包括一种或多种抗CD69抗体，抗CD69适体，CD69mRNA拮抗剂和小分子药物。

35. 发明授权

US08106726B2 Elastic surface wave device comprising dummy electrodes 有权
标题翻译：包含虚拟电极的弹性表面波装置
公开(公告)号：US08106726B2
公开(公告)日：2012-01-31
申请号：US11814368
申请日：2006-01-17
申请人： Kenya Hashimoto , Masatsune Yamaguchi , Tatsuya Omori , Naofumi Yokoyama , Kenji Matsuda
发明人： Kenya Hashimoto , Masatsune Yamaguchi , Tatsuya Omori , Naofumi Yokoyama , Kenji Matsuda
IPC分类号： H03H9/145 , H03H9/25 , H03H9/64
CPC分类号： H03H9/02992 , H03H9/14532 , H03H9/14538 , H03H9/14567 , H03H9/1457
摘要： A surface acoustic wave device includes a pair of reflectors and an interdigital transducer having a cross electrode having a interdigitated portion and a dummy portion and a dummy electrode. The dummy electrode has a length different from the length of the dummy portion of the cross electrode arranged adjacent to the dummy electrode.
摘要翻译：表面声波装置包括一对反射器和具有交叉电极的交叉电极的叉指式换能器，该交叉电极具有交错部分，虚拟部分和虚拟电极。虚拟电极的长度不同于与虚拟电极相邻布置的交叉电极的虚拟部分的长度。

36. 发明申请

US20120014977A1 NOVEL ALTERNATIVE SPLICING VARIANT OF OATP1B3 mRNA 有权
标题翻译： OATP1B3 mRNA的新的替代性分离变异
公开(公告)号：US20120014977A1
公开(公告)日：2012-01-19
申请号：US13030485
申请日：2011-02-18
申请人： Tomomi Furihata , Sayaka Matsumoto , Miki Nagai , Kan Chiba
发明人： Tomomi Furihata , Sayaka Matsumoto , Miki Nagai , Kan Chiba
IPC分类号： A61K39/00 , C07H21/02 , C07K7/06 , C07K14/00 , A61P35/00 , C12N15/12 , C12N15/63 , C12N5/00 , C12N1/00 , C07K16/18 , C12Q1/68 , C07K7/08
CPC分类号： C12Q1/6886 , A61K39/00 , C07K14/4748 , C07K2319/21 , C07K2319/41 , C07K2319/42 , C07K2319/43 , C07K2319/60 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/5011
摘要： [PROBLEM TO BE SOLVED] An object of the present invention is to provide a novel tumor marker and use thereof. In more detail, the present invention provides a novel tumor marker, a method for measuring said tumor marker and a measurement kit, a method for detecting cancer using the same, a kit for detecting cancer, a method for screening a preventive and/or therapeutic agent for cancer, as well as a medicament such as cancer vaccine.[SOLUTION] According to the present invention, a method for measuring an alternative splicing variant of OATP1B3 mRNA in a sample to be examined is provided. Said measurement method comprises measuring mRNA comprising a nucleotide sequence represented by SEQ ID NO: 1 in the sequence listing table in a sample to be examined isolated from living organism with differentiation from a mRNA comprising a nucleotide sequence represented by SEQ ID NO: 2. Said measurement method is useful for detecting cancer or screening a preventive and/or therapeutic agent.[SELECTED DRAWING] FIG. 5.
摘要翻译： [待解决的问题]本发明的目的是提供一种新的肿瘤标志物及其用途。更详细地，本发明提供了一种新的肿瘤标志物，用于测量所述肿瘤标志物的方法和测量试剂盒，使用该试剂盒检测癌症的方法，用于检测癌症的试剂盒，用于筛选预防和/或治疗的方法癌症药物，以及诸如癌症疫苗的药物。 [解决方案]根据本发明，提供了用于测量待检样品中OATP1B3 mRNA的可变剪接变体的方法。所述测量方法包括在从包含SEQ ID NO：2所示的核苷酸序列的mRNA分化的活体中分离的待检验样品中的序列表中的SEQ ID NO：1所示的核苷酸序列的mRNA中测量mRNA。测量方法可用于检测癌症或筛选预防和/或治疗剂。 [选择的图] 5。

37. 发明申请

US20100129339A1 NKT CELL-STIMULATING AGENT FOR ADMINISTRATION THROUGH UPPER RESPIRATORY TRACT MUCOUS MEMBRANE 审中-公开
标题翻译： NKT细胞刺激剂通过上呼吸道麻醉膜进行管理
公开(公告)号：US20100129339A1
公开(公告)日：2010-05-27
申请号：US12089230
申请日：2006-10-06
申请人： Masaru Taniguchi , Shigetoshi Horiguchi , Yoshitaka Okamoto
发明人： Masaru Taniguchi , Shigetoshi Horiguchi , Yoshitaka Okamoto
IPC分类号： A61K45/00 , A61P37/04
CPC分类号： A61K35/15 , A61K2035/124 , C12N5/0639
摘要： The present invention provides an NKT cell stimulating agent containing antigen-presenting cells pulsed with an NKT cell ligand, to be administered submucosally in the upper airway. By submucosal administration in the upper airway, it is possible to stimulate NKT cells and stimulate immune reactions extremely efficiently with a small number of NKT cell ligand-pulsed antigen-presenting cells. By submucosal administration in the upper airway, NKT cells can be induced selectively in cervical lymph nodes.
摘要翻译：本发明提供含NKT细胞配体脉冲的抗原呈递细胞的NKT细胞刺激剂，其在上呼吸道中粘膜下施用。通过在上呼吸道中的粘膜下给药，可以刺激NKT细胞并且用少量NKT细胞配体脉冲的抗原呈递细胞极其有效地刺激免疫反应。通过在上呼吸道粘膜下给药，可以选择性诱导NKT细胞在子宫颈淋巴结中。

38. 发明授权

US07534920B2 Optically-active bis(alkynylphosphino) ethane-borane derivative and process for producing the same 失效
标题翻译：光学活性双（炔基膦基）乙烷 - 硼烷衍生物及其制备方法
公开(公告)号：US07534920B2
公开(公告)日：2009-05-19
申请号：US12073415
申请日：2008-03-05
申请人： Tsuneo Imamoto , Kazuhiro Yoshida , Youichi Saitoh , Aya Koide
发明人： Tsuneo Imamoto , Kazuhiro Yoshida , Youichi Saitoh , Aya Koide
IPC分类号： C07F9/02
CPC分类号： C07F9/5027 , C07B53/00 , C07F9/5013
摘要： An optically-active bis(alkynylphosphino)ethane-borane derivative represented by formula (1): wherein R1 and R2, which may be the same or different, each represent an alkyl group, a phenyl group, an alkylsilyl group or a hydrogen atom; R3 represents a branched alkyl group, an alicyclic hydrocarbon group or an aromatic hydrocarbon group; and the asterisk * indicates an optically-active site. The derivative (1) is prepared by bromination of, e.g., an (S)-t-butylmethylphosphine-borane, reaction with an alkynyl lithium, deprotonation, followed by oxidative coupling. Deprotection of the derivative (1) by deboranation gives an optically-active bis(alkynylphosphino)ethane derivative useful as a ligand providing an asymmetric catalyst for catalytic asymmetric synthesis. The asymmetric catalyst having the ligand exhibits high selectivity and catalyst activity.
摘要翻译：由式（1）表示的光学活性双（炔基膦基）乙烷 - 硼烷衍生物：其中R1和R2可以相同或不同，各自表示烷基，苯基，烷基甲硅烷基或氢原子; R3表示支链烷基，脂环族烃基或芳香族烃基; 星号*表示光学活性位点。衍生物（1）通过例如（S） - 叔丁基甲基膦 - 硼烷的溴化，与炔基锂的反应，去质子化，然后进行氧化偶联来制备。衍生物（1）通过脱硼脱保护得到用作催化不对称合成的不对称催化剂的配体的光学活性双（炔基膦基）乙烷衍生物。具有配体的不对称催化剂表现出高选择性和催化剂活性。

39. 发明申请

US20090030231A1 PROCESS OF PREPARING OPTICALLY ACTIVE B-HYDROXYCARBOXYLIC ACID DERIVATIVE 失效
标题翻译：制备光活性B-羟基羧酸衍生物的方法
公开(公告)号：US20090030231A1
公开(公告)日：2009-01-29
申请号：US12179088
申请日：2008-07-24
申请人： Tsuneo IMAMOTO , Kazuhiro YOSHIDA , Miwako NISHIMURA , Aya KOIDE
发明人： Tsuneo IMAMOTO , Kazuhiro YOSHIDA , Miwako NISHIMURA , Aya KOIDE
IPC分类号： C07C51/00
CPC分类号： C07C45/64 , C07B53/00 , C07B2200/07 , C07C67/31 , C07C231/12 , C07C231/16 , C07C69/675 , C07C69/732 , C07C69/734 , C07C235/06
摘要： Disclosed is a process of preparing an optically active β-hydroxycarboxylic acid derivative comprising asymmetrically hydrogenating a β-keto compound in the presence of a catalyst comprising a transition metal complex compound having a 2,3-bis(dialkylphosphino)pyrazine derivative as a ligand. The pyrazine derivative is preferably a quinoxaline derivative, and the transition metal is preferably ruthenium. Preferred examples of the quinoxaline derivative are (S,S)-2,3-bis(tert-butylmethylphosphino)quinoxaline, (R,R)-bis(tert-butylmethylphosphino)quinoxaline, (S,S)-bis(tert-adamantylmethylphosphino)quinoxaline, and (R,R)-bis(adamantylmethylphosphino)quinoxaline.
摘要翻译：公开了一种制备光学活性β-羟基羧酸衍生物的方法，包括在包含具有2,3-双（二烷基膦基）吡嗪衍生物作为配体的过渡金属络合物的催化剂存在下不对称氢化β-酮化合物的方法。吡嗪衍生物优选为喹喔啉衍生物，过渡金属优选为钌。喹喔啉衍生物的优选实例是（S，S）-2,3-双（叔丁基甲基膦基）喹喔啉，（R，R） - 双（叔丁基甲基膦基）喹喔啉，（S，S） - 双（叔 - 金刚烷基甲基膦基）喹喔啉和（R，R） - 双（金刚烷基甲基膦基）喹喔啉。

40. 发明申请

US20230127080A1 NOVEL CATIONIC LIPID HAVING CYSTINE SKELETON 有权
公开(公告)号：US20230127080A1
公开(公告)日：2023-04-27
申请号：US17907368
申请日：2021-03-19
申请人： NOF CORPORATION , NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
发明人： Shinya TAMAGAWA , Kota TANGE , Yuta NAKAI , Masamichi TAMADA , Hidetaka AKITA , Hiroki TANAKA , Yu SAKURAI
IPC分类号： A61K9/51 , A61K47/54 , A61K48/00 , C12N15/88
摘要： The present invention provides, a cationic lipid represented by the formula (1) (wherein each symbol is as defined in the specification), a lipid membrane structure using the aforementioned cationic lipid, a nucleic acid-introducing agent using the aforementioned cationic lipid, and a method for introducing a nucleic acid by using the aforementioned nucleic acid-introducing agent.

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